157 results on '"Bernard Fraysse"'
Search Results
2. Quels indicateurs de développement professionnel en formation technologique supérieure ?
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Raquel Becerril Ortega and Bernard Fraysse
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graduate studies in technology ,professional training ,professional context ,activities ,Education - Abstract
The article proposes an indicator which measures the reciprocal relationship between graduate studies in technology and the professional world. The chosen theoretical framework conceives professional activity as a source of professional competence development. The results of the analysis show that there are different ways of managing the classroom coactivity between the teacher and the students which are related to professional development and students’ profile.
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- 2009
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3. Pre-, per- and postoperative factors affecting performance of postlinguistically deaf adults using cochlear implants: a new conceptual model over time.
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Diane S Lazard, Christophe Vincent, Frédéric Venail, Paul Van de Heyning, Eric Truy, Olivier Sterkers, Piotr H Skarzynski, Henryk Skarzynski, Karen Schauwers, Stephen O'Leary, Deborah Mawman, Bert Maat, Andrea Kleine-Punte, Alexander M Huber, Kevin Green, Paul J Govaerts, Bernard Fraysse, Richard Dowell, Norbert Dillier, Elaine Burke, Andy Beynon, François Bergeron, Deniz Başkent, Françoise Artières, and Peter J Blamey
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Medicine ,Science - Abstract
ObjectiveTo test the influence of multiple factors on cochlear implant (CI) speech performance in quiet and in noise for postlinguistically deaf adults, and to design a model of predicted auditory performance with a CI as a function of the significant factors.Study designRetrospective multi-centre study.MethodsData from 2251 patients implanted since 2003 in 15 international centres were collected. Speech scores in quiet and in noise were converted into percentile ranks to remove differences between centres. The influence of 15 pre-, per- and postoperative factors, such as the duration of moderate hearing loss (mHL), the surgical approach (cochleostomy or round window approach), the angle of insertion, the percentage of active electrodes, and the brand of device were tested. The usual factors, duration of profound HL (pHL), age, etiology, duration of CI experience, that are already known to have an influence, were included in the statistical analyses.ResultsThe significant factors were: the pure tone average threshold of the better ear, the brand of device, the percentage of active electrodes, the use of hearing aids (HAs) during the period of pHL, and the duration of mHL.ConclusionsA new model was designed showing a decrease of performance that started during the period of mHL, and became faster during the period of pHL. The use of bilateral HAs slowed down the related central reorganization that is the likely cause of the decreased performance.
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- 2012
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4. Des références pour des pratiques de formation
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Raquel Becerril Ortega, Bernard Calmettes, Bernard Fraysse, and Pierre Lagarrigue
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professional didactics ,higher education ,references ,transpositional process ,practical knowledge ,computer simulation ,Psychology ,BF1-990 ,Social Sciences - Abstract
This research focuses on the relations between professional context and higher technological education context during the development of a machine tool simulator. The conceptual framework outlines the context of higher technological education and articulates the didactical concepts, such as the transposition and the references in the composition of educational situations. In this perspective, an analysis of the epistemological roots of practical knowledge is presented, through the specific disciplinary action and the relationship of such knowledge with professional practice. The methodology is driven by the choice of learning content, through two interviews with two teachers and two simulator designers and then by analysing the development of teaching content (the “knowledge to teach”) in two cases. The adopted methodology involves a number of tools developed within professional education: professional contexts analysis and the situation’s conceptual structure. The results presented provide an understanding of the transpositional process through computer simulation and introduce some possible ways of operating that give continuity to this work.
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- 2009
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5. Apprentissage technologique, un simulateur comme outil d’évaluation des compétences
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Bernard Fraysse
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Évaluation ,innovation ,compétences ,activités ,formation technologique ,Evaluation ,skills ,activities ,technological training ,Avaliação ,inovação ,competências ,actividades ,formação tecnológica ,Education - Abstract
L’article présente une tentative d’innovation en formation technologique d’un simulateur de machine outil à commande numérique. Il s’agit évaluer les effets de cette formation afin d’optimiser aussi bien le processus technique que de formation. Le travail est mené par une équipe multidisciplinaire de chercheurs en génie mécanique et en sciences de l’éducation. Le point de départ est la question des compétences traitée en contexte de formation technologique sous l’angle des activités. Les premiers résultats sont présentés et analysés, ouvrant des perspectives de recherche prometteuses.
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- 2005
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6. Stapedotomy Versus Hearing Aids in the Management of Conductive Hearing Loss Caused by Otosclerosis: A Prospective Comparative Study
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Charles-Edouard, Molinier, Yohan, Gallois, Olivier, Deguine, Gaetan, Iversenc, Olivier, Vales, Soumia, Taoui, Benoit, Lepage, Bernard, Fraysse, and Mathieu, Marx
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Adult ,Hearing Loss, Conductive ,Stapes Surgery ,Sensory Systems ,Cohort Studies ,Tinnitus ,Otosclerosis ,Treatment Outcome ,Otorhinolaryngology ,Quality of Life ,Audiometry, Pure-Tone ,Humans ,Prospective Studies ,Neurology (clinical) - Abstract
To compare the outcomes of patients with unilateral otosclerosis treated consecutively by a hearing aid then stapedotomy.Monocentric, nonrandomized, prospective, longitudinal, cohort study.Tertiary university hospital.Adult patients with a unilateral conductive hearing loss of at least 30 dB caused by otosclerosis.Consecutive treatment by an external hearing aid followed by stapedotomy.Differences between hearing aids and stapedotomy in quality of life, pure-tone audiometry, binaural hearing, tinnitus severity, and patient satisfaction.Twenty-two patients were included, of which 20 (91%) underwent stapedotomy. Stapedotomy demonstrated increased quality of life according to Glasgow Health Status Inventory scores versus hearing aids (+10.4 ± 9.4 [p = 0.0001]). Stapedotomy versus hearing aids showed improved pure-tone averages (-11.1 ± 11.0 dB [p = 0.002]) and air-bone gaps (-11.8 ± 10.7 dB [p = 0.0006]). Stapedotomy was superior to hearing aids for speech-in-noise recognition in the reverse dichotic condition (-8.4 ± 26.9 dB [p = 0.004]) and showed improved sound localization accuracy in root mean square error (-14.5 ± 24.5 degrees [p = 0.02]). Stapedotomy, but not hearing aids, showed improved patient self-evaluated tinnitus after baseline adjustment according to the Tinnitus Handicap Inventory (-8.0 ± 13.4 [p = 0.02]) and visual analog scale for tinnitus intensity (-28.7 ± 34.1 [p = 0.006]). Overall, patients were more satisfied with surgery versus hearing aids.Stapedotomy remains more effective compared with hearing aids with greater improvements in quality of life, patient satisfaction, hearing outcomes, and self-evaluated tinnitus.
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- 2022
7. Quality of life of children treated for unilateral hearing loss: a systematic review and meta-analysis
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Bernard Fraysse, Marie-Noëlle Calmels, Mathieu Marx, Yohan Gallois, Olivier Deguine, and Sarah Nicolas
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Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Population ,Psychological intervention ,MEDLINE ,Hearing Loss, Unilateral ,03 medical and health sciences ,0302 clinical medicine ,Bias ,Quality of life ,Academic Performance ,Outcome Assessment, Health Care ,Prevalence ,Humans ,Medicine ,Child ,030223 otorhinolaryngology ,education ,education.field_of_study ,Rehabilitation ,business.industry ,Confounding ,medicine.disease ,Meta-analysis ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Physical therapy ,Female ,Unilateral hearing loss ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveTo evaluate the treatments’ consequences for unilateral hearing loss in children.DesignSystematic review and meta-analysis (CRD42018109417). The MEDLINE, CENTRAL, ISRCTN and ClinicalTrials databases were searched between September 2018 and May 2019. Articles were screened and data were collected independently by two authors following the Cochrane and Preferred Reporting Items for Systematic review and Meta-Analysis guidelines. The risk of bias was evaluated using the Cochrane tool, the Newcastle-Ottawa Scale, the National Institute of Health, USA tool and considering the risk of confounding. In the studies with the lowest risk of bias, a meta-analysis was conducted.InterventionsValidated hearing rehabilitation devices.Patients6–15 years old children with moderate to profound unilateral hearing loss.Main outcome measuresThe primary study outcome was children’s quality of life. Academic performances were studied as an additional outcome.Results731 unique articles were identified from the primary search. Of these, 18 articles met the Population, Intervention, Control, Outcomes and Study design selection criteria. In the eight studies with the lowest risk of bias, two meta-analysis were conducted. There was not enough data on academic results to conduct a meta-analysis. In 73 children included in a fixed effect meta-analysis (two studies), no effect of treatment could be shown (g=−0.20, p=0.39). In 61 children included in a random-effect meta-analysis (six studies), a strong positive effect of hearing treatment on quality of life was demonstrated (g=1.32, pConclusionsThe treatment of unilateral hearing loss seems to improve children’s quality of life. Further research is needed to identify the most effective treatment and its corresponding indications.
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- 2021
8. La charte éthique humanitaire et d’entraide médicale ORL. L’éthique au cœur des missions
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E. Rial-Sebbag, B. Gardini, l’Action d’entraide globale Orl française, Thierry Mom, and Bernard Fraysse
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03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Surgery ,030223 otorhinolaryngology - Abstract
Resume L’action medicale humanitaire, au sens large, englobant les missions d’entraide globale entre medecins ORL, est effective depuis de nombreuses annees. Ces missions, qui reposent sur la volonte propre des participants, n’ont pas ete encadrees par des regles specifiques, sur le plan medical, social, ni ethique. Le temoignage de medecins de certains pays « receveurs » de missions, notamment lors du dernier congres de l’IFOS (International Federation of Otorhinolaryngological Societies), en 2017 a Paris, a mis en exergue l’importance de la bonne coordination des missions entre les equipes fournissant de l’aide et les equipes receveuses. Plusieurs reflexions ethiques ont ete publiees sur le sujet, mais peu concernent les missions d’entraide humanitaire en ORL. Nous presentons une mise au point sur ce sujet, a partir de reflexions menees au sein de la SFORL (Societe francaise d’oto-rhino-laryngologie et de chirurgie de la face et du cou) et de l’IFOS, de l’experience de nombreuses missions et d’une revue de la litterature. Une charte specifique de missions d’entraide medicale et humanitaire en ORL a ete elaboree. Cette mise au point est essentielle pour ameliorer la diffusion des connaissances et la formation en ORL a travers le monde en respectant les regles ethiques et socioculturelles indispensables.
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- 2021
9. The humanitarian and outreach ethics charter in ENT. Ethics at the heart of missions
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B. Gardini, Thierry Mom, Bernard Fraysse, and E. Rial-Sebbag
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Paris ,Medical education ,medicine.medical_specialty ,business.industry ,Charter ,Outreach ,Otolaryngology ,03 medical and health sciences ,0302 clinical medicine ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,medicine ,Head and neck surgery ,Humans ,Surgery ,Humanitarian action ,030223 otorhinolaryngology ,business ,Sociocultural evolution ,Medical ethics - Abstract
Humanitarian action, in the broad sense, including global outreach missions by ENT physicians, has been effective for many years. These volunteer missions have not had any specific regulatory framework, be it medical, social or above all ethical. The testimony of ENT physicians in certain "recipient" countries, in particular during the 2017 Paris Congress of the International Federation of Otorhinolaryngological Societies (IFOS), revealed the importance of adequate coordination between "provider" and "recipient" teams. Several ethical reports have been made, but few specifically focused on ENT outreach. The present review is based on feedback from several missions given to the French Society of OtoRhinoLaryngology and Head and Neck Surgery (SFORL) and IFOS, and on a review of the literature. A specific charter of global outreach and humanitarian missions in ENT has been drawn up. This review is essential for optimizing the sharing of knowledge and training in otorhinolaryngology across the world while respecting mandatory sociocultural and ethical rules.
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- 2021
10. YO-IFOS educational video special issue, part 2: Head and neck
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Bernard Fraysse, Nicolas Fakhry, Jerome R. Lechien, M. Profant, Tareck Ayad, Natacha Teissier, Shazia Peer, Vincent Couloigner, and François Simon
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medicine.medical_specialty ,Otorhinolaryngology ,business.industry ,MEDLINE ,Physical therapy ,medicine ,Humans ,Surgery ,Head and neck ,business ,Head ,Neck - Published
- 2021
11. YO-IFOS educational video special issue, part 1: Pediatrics
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Bernard Fraysse, Jerome R. Lechien, Nicolas Fakhry, Vincent Couloigner, Shazia Peer, François Simon, and M. Profant
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Medical education ,Otolaryngology ,Otorhinolaryngology ,business.industry ,Medicine ,Humans ,Surgery ,business ,Child ,Pediatrics - Published
- 2021
12. Les sciences de l'éducation dans les champs de formation: Quelles mobilisation et légitimation ?
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Bernard Fraysse and Bernard Fraysse
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- 2011
13. Professionnalisation des élèves ingénieurs
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Bernard Fraysse and Bernard Fraysse
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- 2006
14. Long-term Vertigo Control and Vestibular Function After Low-dose On-demand Transtympanic Gentamicin for Refractory Menière's Disease
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Michel Kmeid, Bernard Fraysse, Sarah Nicolas, Charles Mansour, Mathieu Marx, Marie-José Esteve Fraysse, and Olivier Deguine
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Adult ,Male ,Caloric test ,03 medical and health sciences ,0302 clinical medicine ,Refractory ,Recurrence ,Vertigo ,Caloric Tests ,medicine ,Humans ,030223 otorhinolaryngology ,Meniere Disease ,Retrospective Studies ,Vestibular system ,Injection, Intratympanic ,biology ,business.industry ,Low dose ,Retrospective cohort study ,Middle Aged ,medicine.disease ,biology.organism_classification ,Sensory Systems ,Anti-Bacterial Agents ,Otorhinolaryngology ,Anesthesia ,Female ,Gentamicin ,Neurology (clinical) ,Gentamicins ,business ,030217 neurology & neurosurgery ,Meniere's disease ,medicine.drug - Abstract
Objective To describe the long-term clinical vertigo control along with measured lateral canal vestibular function in patients with unilateral refractory Meniere's disease (MD) treated with gentamicin transtympanic injections (TTI). Study design Retrospective analytic study. Setting Tertiary referral center. Patients Thirty-eight patients treated by TTI for medically refractory unilateral MD, defined by the 1995 AAO-HNS criteria, between May 2006 and December 2012. Intervention(s) One-year course of treatment with gentamicin TTI following a low dose on-demand protocol. TTI were repeated in new courses of treatment when MD recurrence occurred. Main outcome measure(s) AAO-HNS class of control, caloric tests (CalT), recurrence rate. Results After an average clinical follow-up of 71 months, all patients entered a class of control A (78%) or B (22%), with an average of 2.3 TTI received. The mean maximal obtained deficit was 88.5%, and the mean long-term deficit was 85.5%. Ten (26%) patients had disease recurrence requiring a new course of treatment. A value of the first CalT in the 3 months following the first TTI strictly higher than 78% was significantly associated with disease control and the absence of symptom recurrence (p≤0.01). In the "recurrence" group, four patients had a significantly lower mean value of all CalT performed after the first TTI when compared with other patients (p≤0.001), indicating gentamicin resistance CONCLUSION:: Achieving a sustainable vestibular deficit on caloric testing is key for MD symptom control after gentamicin TTI. Gentamicin resistance must be diagnosed early to adapt therapeutic strategies.
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- 2019
15. YO-IFOS educational video special issue, part 4: Rhinology and Plastics
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Bernard Fraysse, Jerome R. Lechien, François Simon, Shazia Peer, Vincent Couloigner, M. Profant, and Nicolas Fakhry
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Rhinology ,medicine.medical_specialty ,Medical education ,Otorhinolaryngology ,business.industry ,medicine ,Animals ,Humans ,Surgery ,Rhinoplasty ,business - Published
- 2021
16. Cochlear Implantation and Other Treatments in Single-Sided Deafness and Asymmetric Hearing Loss: Results of a National Multicenter Study Including a Randomized Controlled Trial
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Alain Uziel, Sébastien Schmerber, Bernard Fraysse, Daniele Bernardeschi, M. Marx, Nicolas-Xavier Bonne, Isabelle Mosnier, Frédéric Venail, David Bakhos, Michel Mondain, Christophe Vincent, Emmanuel Lescanne, Olivier Deguine, Yann Nguyen, Benoit Lepage, Olivier Sterkers, Benoit Godey, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Service d'Oto-Rhino-Laryngologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service ORL et chirurgie cervico-faciale [Tours], Hôpital Bretonneau-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Centre de recherche cerveau et cognition (CERCO UMR5549), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Toulouse Mind & Brain Institut (TMBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Institut des Neurosciences de Montpellier (INM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Gestionnaire, HAL Sorbonne Université 5
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Adult ,Quality of life ,medicine.medical_specialty ,Physiology ,Visual analogue scale ,medicine.medical_treatment ,Asymmetric hearing loss ,Deafness ,Audiology ,Hearing Loss, Unilateral ,law.invention ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Randomized controlled trial ,law ,Cochlear implant ,Bone-anchored hearing system ,medicine ,otorhinolaryngologic diseases ,Humans ,Prospective Studies ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,Hearing Loss ,030223 otorhinolaryngology ,business.industry ,Cochlear Implantation ,Sensory Systems ,Confidence interval ,Treatment Outcome ,Otorhinolaryngology ,[SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,Speech Perception ,Cochlear implants ,Contralateral routing of the signal hearing Aids ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Tinnitus ,Research Article ,Cohort study - Abstract
Introduction: Cochlear implantation is a recent approach proposed to treat single-sided deafness (SSD) and asymmetric hearing loss (AHL). Several cohort studies showed its effectiveness on tinnitus and variable results on binaural hearing. The main objective of this study is to assess the outcomes of cochlear implantation and other treatment options in SSD/AHL on quality of life. Methods: This prospective multicenter study was conducted in 7 tertiary university hospitals and included an observational cohort study of SSD/AHL adult patients treated using contralateral routing of the signal (CROS) hearing aids or bone-anchored hearing systems (BAHSs) or who declined all treatments, and a randomized controlled trial in subjects treated by cochlear implantation, after failure of CROS and BAHS trials. In total, 155 subjects with SSD or AHL, with or without associated tinnitus, were enrolled. After 2 consecutive trials with CROS hearing aids and BAHSs on headband, all subjects chose any of the 4 treatment options (abstention, CROS, BAHS, or cochlear implant [CI]). The subjects who opted for a CI were randomized between 2 arms (CI vs. initial observation). Six months after the treatment choice, quality of life was assessed using both generic (EuroQoL-5D, EQ-5D) and auditory-specific quality-of-life indices (Nijmegen Cochlear implant Questionnaire [NCIQ] and Visual Analogue Scale [VAS] for tinnitus severity). Performances for speech-in-noise recognition and localization were measured as secondary outcomes. Results: CROS was chosen by 75 subjects, while 51 opted for cochlear implantation, 18 for BAHSs, and 11 for abstention. Six months after treatment, both EQ-5D VAS and auditory-specific quality-of-life indices were significantly better in the “CI” arm versus “observation” arm. The mean effect of the CI was particularly significant in subjects with associated severe tinnitus (mean improvement of 20.7 points ± 19.7 on EQ-5D VAS, 20.4 ± 12.4 on NCIQ, and 51.4 ± 35.4 on tinnitus). No significant effect of the CI was found on binaural hearing results. Before/after comparisons showed that the CROS and BAHS also improved significantly NCIQ scores (for CROS: +7.7, 95% confidence interval [95% CI] = [4.5; 10.8]; for the BAHS: +14.3, 95% CI = [7.9; 20.7]). Conclusion: Cochlear implantation leads to significant improvements in quality of life in SSD and AHL patients, particularly in subjects with associated severe tinnitus, who are thereby the best candidates to an extension of CI indications.
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- 2021
17. CT Scan Showing Ossicular Chain Arthritis Associated With Ossifying Labyrinthitis as Rare Signs of Relapsing Polychondritis
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Yohan Gallois, Marie Françoise Thiercelin, Bernard Fraysse, Alexandra Weckel, and Charles-Edouard Molinier
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medicine.medical_specialty ,Ossicular chain ,medicine.diagnostic_test ,business.industry ,Arthritis ,Labyrinth Diseases ,Computed tomography ,medicine.disease ,Sensory Systems ,Labyrinthitis ,Otorhinolaryngology ,medicine ,Humans ,Neurology (clinical) ,Radiology ,Polychondritis, Relapsing ,business ,Tomography, X-Ray Computed ,Relapsing polychondritis - Published
- 2021
18. YO-IFOS educational video special issue, part 3: Otology and laryngology
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Bernard Fraysse, Nicolas Fakhry, M. Profant, Jerome R. Lechien, Shazia Peer, Leigh J. Sowerby, Paul Hong, François Simon, and Vincent Couloigner
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Otolaryngology ,medicine.medical_specialty ,Otorhinolaryngology ,Laryngology ,business.industry ,Otology ,General surgery ,medicine ,MEDLINE ,Humans ,Surgery ,business - Published
- 2021
19. Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis
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Christian Renard, Christine Petit, Yosra Bouyacoub, Sedigheh Delmaghani, Magali Niasme-Grare, Nicolas Michalski, Hung Thai-Van, Olivier Deguine, Anne Aubois, Arnaud Deveze, Jean-Pierre Lavieille, Valérie Franco-Vidal, Anne-Laure Roudevitch-Pujol, Amrit Singh-Estivalet, Arnaud Coez, Vincent Michel, Christophe Vincent, Hugues Aschard, Claire Thibult-Apt, Amel Bahloul, Sophie Boucher, E. Ionescu, Bernard Fraysse, Fabienne Wong Jun Tai, Fabrice Giraudet, Vincent Darrouzet, Typhaine Dupont, Nicolas Wolff, Didier Bouccara, Lionel Collet, Crystel Bonnet, Gaelle M. Lefèvre, Jean-Louis Kemeny, Andrea Lelli, Eric Bizaguet, Paul Avan, Institut de l'Audition [Paris] (IDA), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), ED 515 - Complexité du vivant, Sorbonne Université (SU), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Université d'Angers (UA), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Récepteurs Canaux - Channel Receptors, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Toulouse [Toulouse], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hôpital Edouard Herriot [CHU - HCL], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Université Clermont Auvergne (UCA), Hôpital Nord [CHU - APHM], Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Hôpital Roger Salengro [Lille], Laboratoire d’Audiologie Renard, Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Laboratoire de correction auditive Eric Bizaguet, CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Chaire Génétique et physiologie cellulaire, Collège de France (CdF (institution)), This work was supported by a grant from Fondation pour l’Audition (to C.P.), LabEx Lifesenses Grant ANR-10-LABX-65, and Light4deaf Grant ANR-15-RHUS-0001., We thank the patients for participating in this study and Céline Trébeau for technical assistance. S.B. received funding from the University of Angers (Medical School), the University Hospital of Angers, and the Collège Français d’oto-rhino-laryngologistes., ANR-10-LABX-0065,LIFESENSES,DES SENS POUR TOUTE LA VIE(2010), ANR-15-RHUS-0001,LIGHT4DEAF,ECLAIRER LA SURDITÉ : UNE APPROCHE HOLISTIQUE DU SYNDROME D'USHER(2015), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Collège de France - Chaire Génétique et physiologie cellulaire, Bonnet, Crystel, DES SENS POUR TOUTE LA VIE - - LIFESENSES2010 - ANR-10-LABX-0065 - LABX - VALID, and ECLAIRER LA SURDITÉ : UNE APPROCHE HOLISTIQUE DU SYNDROME D'USHER - - LIGHT4DEAF2015 - ANR-15-RHUS-0001 - RHUS - VALID
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0301 basic medicine ,Presbycusis ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,Deafness ,Cohort Studies ,Mice ,0302 clinical medicine ,MESH: Presbycusis ,MESH: Animals ,Age of Onset ,MESH: Cohort Studies ,Genes, Dominant ,Early onset ,MESH: Heterozygote ,Genetics ,Multidisciplinary ,monogenic disorder ,Age Factors ,Biological Sciences ,Phenotype ,MESH: Case-Control Studies ,Mitochondria ,3. Good health ,age-related hearing loss ,symbols ,MESH: Membrane Proteins ,medicine.symptom ,Heterozygote ,MESH: Mutation ,Hearing loss ,MESH: Mitochondria ,MESH: Age of Onset ,MESH: Deafness ,Biology ,03 medical and health sciences ,symbols.namesake ,MESH: Whole Exome Sequencing ,Exome Sequencing ,medicine ,Animals ,Humans ,Allele frequency ,Gene ,ultrarare variants ,MESH: Mice ,MESH: Age Factors ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,MESH: Humans ,Membrane Proteins ,Tmc1 ,medicine.disease ,Comorbidity ,MicroRNAs ,030104 developmental biology ,Case-Control Studies ,Mutation ,Mendelian inheritance ,MESH: Genes, Dominant ,presbycusis ,MESH: MicroRNAs ,030217 neurology & neurosurgery - Abstract
International audience; Presbycusis, or age-related hearing loss (ARHL), is a major public health issue. About half the phenotypic variance has been attributed to genetic factors. Here, we assessed the contribution to presbycusis of ultrarare pathogenic variants, considered indicative of Mendelian forms. We focused on severe presbycusis without environmental or comorbidity risk factors and studied multiplex family age-related hearing loss (mARHL) and simplex/sporadic age-related hearing loss (sARHL) cases and controls with normal hearing by whole-exome sequencing. Ultrarare variants (allele frequency [AF] < 0.0001) of 35 genes responsible for autosomal dominant early-onset forms of deafness, predicted to be pathogenic, were detected in 25.7% of mARHL and 22.7% of sARHL cases vs. 7.5% of controls ( P = 0.001); half were previously unknown (AF < 0.000002). MYO6 , MYO7A , PTPRQ , and TECTA variants were present in 8.9% of ARHL cases but less than 1% of controls. Evidence for a causal role of variants in presbycusis was provided by pathogenicity prediction programs, documented haploinsufficiency, three-dimensional structure/function analyses, cell biology experiments, and reported early effects. We also established Tmc1 N321I/+ mice, carrying the TMC1 :p.(Asn327Ile) variant detected in an mARHL case, as a mouse model for a monogenic form of presbycusis. Deafness gene variants can thus result in a continuum of auditory phenotypes. Our findings demonstrate that the genetics of presbycusis is shaped by not only well-studied polygenic risk factors of small effect size revealed by common variants but also, ultrarare variants likely resulting in monogenic forms, thereby paving the way for treatment with emerging inner ear gene therapy.
- Published
- 2020
20. Treatment choice in single‐sided deafness and asymmetric hearing loss. A prospective, multicentre cohort study on 155 patients
- Author
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David Bakhos, Alain Uziel, M. Marx, Frédéric Venail, Benoit Godey, Christophe Vincent, Isabelle Mosnier, Nicolas-Xavier Bonne, Jonathan Flament, Daniele Bernardeschi, Olivier Deguine, Bernard Fraysse, Sébastien Schmerber, Benoit Lepage, Michel Mondain, Emmanuel Lescanne, Olivier Sterkers, Hôpital Pierre-Paul Riquet [Toulouse], CHU Toulouse [Toulouse], Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Unité d’Otologie, implants auditifs et chirurgie de la base du crâne [CHU Pitié-Salpêtrière], Service d'Oto-Rhino-Laryngologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service ORL et chirurgie cervico-faciale [Tours], Hôpital Bretonneau-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université Fédérale Toulouse Midi-Pyrénées, CHU Pontchaillou [Rennes], CHU Grenoble, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Centre de recherche cerveau et cognition (CERCO UMR5549), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CIC AP-HP [CHU Pitié-Salpêtrière], Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service ORL [Hôpital Gui de Chauliac] (CHRU de Montpellier), Hôpital Gui de Chauliac [CHU Montpellier], and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
- Subjects
Male ,medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,asymmetric hearing loss ,single-sided deafness ,Audiology ,Hearing Loss, Unilateral ,Choice Behavior ,03 medical and health sciences ,0302 clinical medicine ,Bone conduction ,Hearing Aids ,Quality of life ,Cochlear implant ,medicine ,otorhinolaryngologic diseases ,Humans ,Prospective Studies ,[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,030223 otorhinolaryngology ,Prospective cohort study ,Speech Reception Threshold Test ,business.industry ,cochlear implant ,single‐ ,sided deafness ,Retention rate ,Middle Aged ,CROS hearing aids ,BAHA ,Cochlear Implants ,Otorhinolaryngology ,binaural hearing ,quality of life ,Cohort ,Female ,France ,medicine.symptom ,business ,Bone Conduction ,030217 neurology & neurosurgery ,Tinnitus ,Cohort study - Abstract
Objectives: To describe the treatment choice in a cohort of subjects with single-sided deafness (SSD) and asymmetric hearing loss (AHL). To assess the reliability of the treatment trials. Design: In this national, multicentre, prospective study, the choice of subjects was made after two consecutive trials of Contralateral Routing Of the Signal (CROS) hearing aids and a Bone Conduction Device (BCD) on a headband. Subjects could proceed with one of these two options, opt for cochlear implantation or decline all treatments. Setting: Seven tertiary university hospitals. Participants: One hundred fifty-five subjects with SSD or AHL fulfilling the candidacy criteria for cochlear implantation, with or without associated tinnitus. Main outcome measures: After the two trials, the number of subjects choosing each option was described. Repeated assessments of both generic and auditory-specific quality of life were conducted, as well as hearing assessments (speech recognition in noise and horizontal localization). Results: CROS was chosen by 75 subjects, followed by cochlear implantation (n = 51), BCD (n = 18) and abstention (n = 11). Patients who opted for cochlear implantation had a poorer quality of life (P = .03). The improvement of quality of life indices after each trial was significantly associated with the final treatment choice (P = .008 for generic indices, P = .002 for auditory-specific indices). The follow-up showed that this improvement had been overestimated in the CROS group, with a long-term retention rate of 52.5%. Conclusions: More than one third of SSD/AHL subjects are unsatisfied after CROS and BCD trials. Repeated quality of life assessments help counselling the patient for his/her treatment choice.
- Published
- 2020
21. Vestibular disorders: clinician ENT perspective on the need for research and innovation
- Author
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C. Chabbert, M. J. Esteve Fraysse, Mathieu Marx, Bernard Fraysse, Y. Gallois, A. Weckel, Neurosciences sensorielles et cognitives (NSC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
medicine.medical_specialty ,Neurology ,Vestibular disorders ,Concordance ,Dizziness ,Unmet needs ,03 medical and health sciences ,0302 clinical medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,Medical physics ,030212 general & internal medicine ,ComputingMilieux_MISCELLANEOUS ,Neuroradiology ,Vestibular system ,Modalities ,business.industry ,Magnetic Resonance Imaging ,3. Good health ,Fully developed ,Vestibular Diseases ,Vertigo ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Vestibule, Labyrinth ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Vertigo and dizziness are a frequent reason for medical consultation. However, diagnostic and therapeutic management is sometimes limited, and clinicians are faced with many unmet needs. The purpose of this study was to identify and prioritize these needs.A questionnaire methodology was used to determine the need for innovation in vestibular disorder management. The questionnaire was sent to 19 teams in French-speaking ENT centers. We measured the concordance of the panel of experts on 56 questions related to the different vestibular pathologies encountered and the desired modalities of innovations.Thirteen questions were identified as priorities. The needs expressed by the experts had better knowledge of the pathophysiological mechanisms of the main diseases encountered and the development of new treatment modalities. Particular attention was paid to inner ear imaging techniques and the development of specific electrophysiology techniques.Some of the anticipated innovations are already under development, such as new inner ear fluid imaging techniques (hydrops visualization using MRI) or in situ treatments (transtympanic dexamethasone or gentamicin injections). Others, such as new electrophysiological techniques, are still not fully developed CONCLUSION: This study provides a snapshot of the needs of the medical profession in vestibular disorder management. It highlights a real concern of the attending personnel, as well as a critical need to optimize the means of diagnosing and treating patients with vestibular disorders.
- Published
- 2020
22. Prognostics Factors of Cochlear Implant in Adults: How Can We Improve Poorer Performers?
- Author
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Chris James and Bernard Fraysse
- Subjects
medicine.medical_specialty ,business.industry ,Cochlear implant ,medicine.medical_treatment ,InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL ,medicine ,Prognostics ,Audiology ,business ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Published
- 2020
23. Early Sentence Recognition in Adult Cochlear Implant Users
- Author
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Marie-Laurence Laborde, Olivier Deguine, Bernard Escudé, Bernard Fraysse, Charles-Edouard Molinier, Benoit Lepage, Chadlia Karoui, Christopher J. James, Marjorie Tartayre, Mathieu Marx, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'oto-rhino-laryngologie et d'oto-neurologie, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Speech perception ,medicine.medical_treatment ,Signal-To-Noise Ratio ,Audiology ,Severity of Illness Index ,01 natural sciences ,Autoimmune Diseases ,Young Adult ,03 medical and health sciences ,Speech and Hearing ,Imaging, Three-Dimensional ,0302 clinical medicine ,Statistical significance ,Cochlear implant ,0103 physical sciences ,Linear regression ,otorhinolaryngologic diseases ,Humans ,Medicine ,Hearing Loss ,030223 otorhinolaryngology ,010301 acoustics ,Aged ,Aged, 80 and over ,business.industry ,[SCCO.NEUR]Cognitive science/Neuroscience ,Cone-Beam Computed Tomography ,Middle Aged ,Cochlear Implantation ,Otitis Media ,Noise ,Treatment Outcome ,Otorhinolaryngology ,Signal-to-noise ratio (imaging) ,Ear, Inner ,QUIET ,Chronic Disease ,Linear Models ,Speech Perception ,Female ,Analysis of variance ,business ,Tomography, Spiral Computed - Abstract
Normal-hearing subjects listening to acoustic simulations of cochlear implants (CI) can obtain sentence recognition scores near 100% in quiet and in 10 dB signal-to-noise ratio (SNR) noise with acute exposure. However, average sentence recognition scores for real CI listeners are generally lower, even after months of experience, and there is a high degree of heterogeneity. Our aim was to identify the relative importance and strength of factors that prevent CI listeners from achieving early, 1-mo scores as high as those for normal-hearing-listener acoustic simulations.Sentence recognition scores (100 words/list, 65 dB SPL) using CI alone were collected for all adult unilateral CI listeners implanted in our center over a 5-yr period. Sentence recognition scores in quiet and in 10 dB SNR 8-talker babble, collected from 1 to 12 mo, were reduced to a single dependent variable, the "initial" score, via logarithmic regression. "Initial" scores equated to an improved estimate of 1-mo scores, and integrated the time to rise above zero score for poorer performing subjects. Demographic, device, and medical data were collected for 118 subjects who met standard CI candidacy criteria. Computed tomography of the electrode array allowing determination of the insertion depth as an angle, and the presence or absence of scala dislocation was available for 96 subjects. Predictive factors for initial scores were selected using stepwise multiple linear regression. The relative importance of predictive factors was estimated as partial r with a low bias method, and statistical significance tested with type II analysis of variance.The etiologies chronic otitis and autoimmune disease were associated with lower, widely variable sentence recognition scores in the long-term. More than 60% of CI listeners scored50/100 in quiet at 1 mo. Congenital hearing loss was associated with significantly lower initial scores in quiet (r 0.23, p0.001), as was longer duration of hearing loss (r 0.12, p0.001, -0.76 pts per year). Initial scores were negatively correlated with insertion depth (r 0.09, p0.001, -0.1 pts per degree), with the highest initial scores being obtained for insertion depths of 300° to 400°. A much greater proportion of scala dislocations was found for perimodiolar arrays compared with straight arrays. Scores were negatively correlated with the proportion of the active electrode array found in scala vestibuli for Nucleus perimodiolar devices (r 0.14, p0.01, coefficient -25). Similar overall results were obtained for sentence recognition scores in noise (+10 dB SNR). The intercept value for the obtained regression functions indicated that CI listeners with the least limiting factors generally scored ~95/100 in quiet and ~90/100 in noise. In addition, CI listeners with insertion angles as low as 315° to 360° could obtain sentence recognition scores80/100 even at 1 day after activation. Insertion depths of 360° were estimated to produce frequency-place mismatches of about one octave upward shift.Patient-related factors etiology and duration of deafness together explained ~40% of the variance in early sentence recognition scores, and electrode position factors ~20%. CI listeners with insertion depths of about one turn obtained the highest early sentence recognition scores in quiet and in noise, and these were comparable with those reported in the literature for normal-hearing subjects listening to 8 to 12 channel vocoder simulations. Differences between device brands were largely explained by differences in insertion depths. This indicates that physiological frequency-place mismatches of about one octave are rapidly accommodated by CI users for understanding sentences, between 1 day to 1 mo postactivation, and that channel efficiency may be significantly poorer for more deeply positioned electrode contacts.
- Published
- 2018
24. Cochlear implantation as a treatment for single-sided deafness and asymmetric hearing loss: a randomized controlled evaluation of cost-utility
- Author
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Olivier Deguine, Laurent Molinier, Nadège Costa, Mathieu Marx, Benoit Lepage, Bernard Fraysse, and Soumia Taoui
- Subjects
Single-sided deafness ,Sound localization ,medicine.medical_specialty ,medicine.medical_treatment ,Asymmetric hearing loss ,Audiology ,Binaural hearing ,law.invention ,Study Protocol ,Tinnitus ,03 medical and health sciences ,0302 clinical medicine ,Bone conduction ,Randomized controlled trial ,Quality of life ,law ,Cochlear implant ,otorhinolaryngologic diseases ,Medicine ,030223 otorhinolaryngology ,Cost-utility ,business.industry ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,medicine.symptom ,business - Abstract
Single-sided deafness (SSD) and asymmetric hearing loss (AHL) have recently been proposed as a new indication for cochlear implantation. There is still no recommended treatment for these hearing deficits, and most options considered rely on the transfer of sound from the poor ear to the better ear, using Contralateral Routing of the Signal (CROS) hearing aids or bone conduction (BC) devices. In contrast, cochlear implantation allows the poor ear to be stimulated and binaural hearing abilities to be partially restored. Indeed, most recently published studies have reported an improvement in the spatial localisation of an incoming sound and better speech recognition in noisy environments after cochlear implantation in SSD/AHL subjects. It also provides consistent relief of tinnitus when associated. These encouraging hearing outcomes raise the question of the cost-utility of this expensive treatment in an extended indication. The final endpoint of this national multicentre study is to determine the incremental cost-utility ratio (ICUR) of cochlear implantation in comparison to the current standard of care in France through simple observation, using a randomised controlled trial. Firstly, the study comprises a prospective and descriptive part, where 150 SSD/AHL subjects try CROS hearing aids and a BC device for three weeks each. Secondly, the choice is made between CROS hearing aids, BC implanted device and cochlear implantation. Hearing outcomes and quality of life measurements are described after 6 months for the subjects who chose CROS, BC or declined any option. The subjects who opt for cochlear implantation are randomised between one group where the cochlear implant is inserted without delay and one group of simple initial observation. Hearing outcomes and quality of life measurements are compared after 6 months. The present study was designed to assess the efficiency of cochlear implantation in SSD/AHL. A favourable cost-utility ratio in this extended indication would strengthen the promising clinical results and justify a reimbursement by the health insurance. The efficiency of other options (CROS, BC) will also be described. This research has been registered in ClinicalTrials.gov ( http://www.clinicaltrials.gov/ ), the 29th July 2014 under the n°NCT02204618.
- Published
- 2019
25. Management of parotid duct injury secondary to cow horn in a developing country
- Author
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Bernard Fraysse, Hady Tall, Charles Edouard Molinier, El Hadj Malick Diop, and Ahmed Alshamsi
- Subjects
Parotid duct ,medicine.medical_specialty ,Injuries ,business.industry ,Anatomical structures ,Case Report ,030206 dentistry ,Cheek ,Surgery ,Physical trauma ,stomatognathic diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Medicine ,Cow horn ,Clinical case ,Oral mucosa ,business ,Duct (anatomy) - Abstract
Stensen duct injury has been reported in the medical literature following penetrating injuries of the cheek or by exeresis of tumors of the cheek or of the oral mucosa. This type of physical trauma often arises from injuries as a result being assaulted (e.g. with knife) or from road accidents. The complexity of the damage to the anatomical structures and the causative agent sometimes makes the diagnosis difficult. We report on a clinical case of managemenent Stensen duct injury secondary of goring by a cow horn.
- Published
- 2017
26. Arterial embolization with Onyx of head and neck paragangliomas
- Author
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Bernard Fraysse, Philippe Tall, Elie Serrano, Olivier Deguine, Victor Cuvinciuc, Caterina Michelozzi, Fabrice Bonneville, Christophe Cognard, and Anne Christine Januel
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Biocompatible Materials ,Radiosurgery ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Preoperative Care ,medicine ,Humans ,Dimethyl Sulfoxide ,Embolization ,Aged ,Retrospective Studies ,Paraganglioma, Extra-Adrenal ,Palsy ,medicine.diagnostic_test ,business.industry ,Arterial Embolization ,General Medicine ,Middle Aged ,Embolization, Therapeutic ,Surgery ,Radiation therapy ,Skull ,Dissection ,Treatment Outcome ,medicine.anatomical_structure ,Head and Neck Neoplasms ,Angiography ,Female ,Polyvinyls ,Neurology (clinical) ,Radiology ,business ,030217 neurology & neurosurgery - Abstract
ObjectTo report the morbidity and long term results in the treatment of paragangliomas by transarterial embolization with ethylene vinyl alcohol (Onyx), either as preoperative or palliative treatment.MethodsBetween September 2005 and 2012, 18 jugulotympanic, 7 vagal, and 4 carotid body paragangliomas (CBPs) underwent Onyx embolization, accordingly to our head and neck multidisciplinary team's decision. CBPs were embolized preoperatively. Jugulotympanic and vagal paragangliomas underwent surgery when feasible, otherwise palliative embolization was carried out alone, or in combination with radiotherapy or tympanic surgery in the case of skull base or tympanic extension. Treatment results, and clinical and MRI follow-up data were recorded.ResultsIn all cases, devascularization of at least 60% of the initial tumor blush was obtained; 6 patients underwent two embolizations. Post-embolization, 8 patients presented with cranial nerve palsy, with partial or complete regression at follow-up (mean 31 months, range 3–86 months), except for 2 vagal and 1 hypoglossal palsy. 10 patients were embolized preoperatively; 70% were cured after surgery and 30% showed residual tumor. 19 patients received palliative embolization, of whom 5 underwent radiotherapy and 3 received tympanic surgery post-embolization. Long term follow-up of palliative embolization resulted in tumor volume stability (75%) or extension in intracranial or tympanic compartments. Onyx embolization of CBPs resulted in more difficult surgical dissection in 2 of 4 cases.ConclusionsOnyx embolization is a valuable alternative to surgery in the treatment of jugulotympanic and vagal paragangliomas; tympanic surgery or radiosurgery of the skull base should be considered in selected cases. Preoperative Onyx embolization of CBPs is not recommended.
- Published
- 2015
27. Increased audiovisual integration in cochlear-implanted deaf patients: independent components analysis of longitudinal positron emission tomography data
- Author
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Jean-François Démonet, Bernard Fraysse, Olivier Deguine, Kuzma Strelnikov, Sebastien Lagleyre, Pascal Barone, Julien Rouger, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Service d'Oto-Rhino-Laryngologie et d'otoneurochirurgie, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Fédération des Centres Mémoire de Ressource et de Recherche du Sud de la France [CHU Toulouse] (F-CMRR-SF), and Centre hospitalier universitaire de Toulouse - CHU Toulouse-Hôpital La Grave-Casselardit [Toulouse]
- Subjects
Adult ,Male ,medicine.medical_specialty ,Visual perception ,Brain activity and meditation ,medicine.medical_treatment ,Deafness ,Audiology ,050105 experimental psychology ,Temporal lobe ,03 medical and health sciences ,0302 clinical medicine ,Neuroimaging ,Cochlear implant ,otorhinolaryngologic diseases ,medicine ,Humans ,0501 psychology and cognitive sciences ,Aged ,Visual Cortex ,Aged, 80 and over ,Temporal cortex ,medicine.diagnostic_test ,[SCCO.NEUR]Cognitive science/Neuroscience ,General Neuroscience ,05 social sciences ,Middle Aged ,Temporal Lobe ,Cochlear Implants ,Visual cortex ,medicine.anatomical_structure ,Positron emission tomography ,Case-Control Studies ,Positron-Emission Tomography ,Auditory Perception ,Visual Perception ,Female ,Psychology ,030217 neurology & neurosurgery - Abstract
It has been demonstrated in earlier studies that patients with a cochlear implant have increased abilities for audio-visual integration because the crude information transmitted by the cochlear implant requires the persistent use of the complementary speech information from the visual channel. The brain network for these abilities needs to be clarified. We used an independent components analysis (ICA) of the activation (H2(15)O) positron emission tomography data to explore occipito-temporal brain activity in post-lingually deaf patients with unilaterally implanted cochlear implants at several months post-implantation (T1), shortly after implantation (T0) and in normal hearing controls. In between-group analysis, patients at T1 had greater blood flow in the left middle temporal cortex as compared with T0 and normal hearing controls. In within-group analysis, patients at T0 had a task-related ICA component in the visual cortex, and patients at T1 had one task-related ICA component in the left middle temporal cortex and the other in the visual cortex. The time courses of temporal and visual activities during the positron emission tomography examination at T1 were highly correlated, meaning that synchronized integrative activity occurred. The greater involvement of the visual cortex and its close coupling with the temporal cortex at T1 confirm the importance of audio-visual integration in more experienced cochlear implant subjects at the cortical level.
- Published
- 2015
28. Quality of Life and Auditory Performance in Adults with Asymmetric Hearing Loss
- Author
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Olivier Deguine, Pascal Barone, Nicolas Vannson, Kuzma Strelnikov, Christopher J. James, Mathieu Marx, Bernard Fraysse, Service d'oto-rhino-laryngologie et d'oto-neurologie, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Cochlear France, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and CHU Toulouse [Toulouse]
- Subjects
Adult ,Male ,Sound localization ,medicine.medical_specialty ,Speech perception ,Physiology ,Hearing loss ,Health Status ,Signal-To-Noise Ratio ,Audiology ,Hearing Loss, Unilateral ,Dichotic Listening Tests ,Young Adult ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Quality of life ,otorhinolaryngologic diseases ,medicine ,Humans ,10. No inequality ,030223 otorhinolaryngology ,Aged ,medicine.diagnostic_test ,Dichotic listening ,[SCCO.NEUR]Cognitive science/Neuroscience ,Middle Aged ,Sensory Systems ,Noise ,Otorhinolaryngology ,Signal-to-noise ratio (imaging) ,Case-Control Studies ,Quality of Life ,Speech Perception ,Female ,Audiometry ,medicine.symptom ,Audiometry, Speech ,Psychology ,030217 neurology & neurosurgery - Abstract
We evaluated the relationship between binaural hearing deficits and quality of life. The study included 49 adults with asymmetric hearing loss (AHL), and 11 adult normal-hearing listeners (NHL) served as controls. Speech reception thresholds (SRT) were assessed with the French Matrix Test. Quality of life was evaluated with the Speech, Spatial and Qualities of Hearing Scale (SSQ) and the Glasgow Health Status Inventory. Speech recognition in noise was significantly poorer for AHL subjects [-0.12 dB signal-to-noise ratio (SNR) in dichotic (with speech presented to the poorer ear and noise to the better ear), -1.72 dB in diotic and -6.84 dB in reverse-dichotic conditions] compared to NHL (-4.98 dB in diotic and -9.58 dB in dichotic conditions). Scores for quality-of-life questionnaires were significantly below norms. Significant correlations were found between the SRT for the dichotic condition and the SSQ total score (r = -0.38, p = 0.01), and pure-tone average thresholds for both groups.
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- 2015
29. Speech-in-noise perception in unilateral hearing loss: Relation to pure-tone thresholds and brainstem plasticity
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Pascal Barone, Christopher J. James, Kuzma Strelnikov, Olivier Deguine, Bernard Fraysse, Nicolas Vannson, Boris Lescure, M. Marx, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Purpan [Toulouse], and CHU Toulouse [Toulouse]
- Subjects
Sound localization ,Adult ,Male ,medicine.medical_specialty ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Audiology ,Monaural ,Functional Laterality ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,030223 otorhinolaryngology ,Hearing Loss ,Aged ,Vestibular system ,Neuronal Plasticity ,medicine.diagnostic_test ,Dichotic listening ,[SCCO.NEUR]Cognitive science/Neuroscience ,Auditory Threshold ,Middle Aged ,medicine.disease ,Noise ,Acoustic Stimulation ,Speech Perception ,Audiometry, Pure-Tone ,Female ,Pure tone audiometry ,Unilateral hearing loss ,Psychology ,Binaural recording ,030217 neurology & neurosurgery ,Brain Stem - Abstract
We investigated speech recognition in noise in subjects with mild to profound levels of unilateral hearing loss. Thirty-five adults were evaluated using an adaptive signal-to-noise ratio (SNR50) sentence recognition threshold test in three spatial configurations. The results revealed a significant correlation between pure-tone average audiometric thresholds in the poorer ear and SNR thresholds in the two conditions where speech and noise were spatially separated: dichotic - with speech presented to the poorer ear and reverse dichotic - with speech presented to the better ear. This first result suggested that standard pure-tone air-conduction thresholds can be a reliable predictor of speech recognition in noise for binaural conditions. However, a subgroup of 14 subjects was found to have poorer-than-expected speech recognition scores, especially in the reverse dichotic listening condition. In this subgroup 9 subjects had been diagnosed with vestibular schwannoma at stage III or IV likely affecting the lower brainstem function. These subjects showed SNR thresholds in the reverse dichotic condition on average 4dB poorer (higher) than for the other 21 normally-performing subjects. For the 7 of 9 subjects whose vestibular schwannoma was removed, the deficit was no longer apparent on average 5 months following the surgical procedure. These results suggest that following unilateral hearing loss the capacity to use monaural spectral information is supported by the lower brainstem.
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- 2017
30. Orchestrations instrumentales pour l’appropriation d’artefacts professionnels
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Bernard Fraysse, Guillaume Gillet, and Hélène Veyrac
- Abstract
Cet article aborde l’activite d’enseignement dans une approche instrumentale. Il s’agit d’analyser la pratique de deux enseignants dans un environnement constitue par de nombreux artefacts. Le champ disciplinaire retenu se refere aux Sciences de l’ingenieur dans le cas d’une formation professionnelle en Sciences et Techniques des Agroequipements (STA). Cette situation d’enseignement-apprentissage est marquee par des prescriptions faibles voire explicitement discretionnaires, si bien qu’elle est mediatisee par un ensemble d’instruments heterogenes, propre a chaque enseignant. Alors se pose la question de caracteriser ces pratiques pour lesquelles le langage ne constituerait pas le seul instrument professionnel de l’enseignant. Comment les enseignants agissent ? Pourquoi ? Quels sont les variabilites inter-individuelles d’une activite multi-instrumentee ? A la suite des travaux de Rabardel, Pastre, Trouche, Bourmaud, nous avons defini, construit et experimente un outil methodologique que nous appelons « l’orchestration d’un systeme d’instruments ». Cet instrument de mesure de l’activite constitue un indicateur de la strategie didactique effectivement mobilisee par l’enseignant. Il permet d’acceder a la signification de l’acte global d’enseignement en regard de la proposition instrumentale soumise aux eleves. La variabilite et inter-individuelle et les similitudes constatees par un des indicateurs de l'activite sont discutees.
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- 2013
31. Cochlear Implantation Feasibility in Rhesus Macaque Monkey
- Author
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Pascal Girard, Olivier Deguine, Bernard Fraysse, Pascal Barone, Bernard Escudé, Mathieu Marx, Service d'oto-rhino-laryngologie et d'oto-neurologie, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Cone beam computed tomography ,medicine.medical_treatment ,Macaque ,03 medical and health sciences ,0302 clinical medicine ,biology.animal ,Cochlear implant ,otorhinolaryngologic diseases ,medicine ,Electrode array ,Animals ,Humans ,Inner ear ,030223 otorhinolaryngology ,Cochlear implantation ,Electrodes ,Cochlea ,biology ,business.industry ,Temporal Bone ,Anatomy ,biology.organism_classification ,Cochlear Implantation ,Macaca mulatta ,Sensory Systems ,Rhesus macaque ,Cochlear Implants ,medicine.anatomical_structure ,Otorhinolaryngology ,Feasibility Studies ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,sense organs ,Neurology (clinical) ,Tomography, X-Ray Computed ,business ,030217 neurology & neurosurgery - Abstract
Background: Large animal models of implantable hearing devices are needed to assess innovative technologies before using them in humans. The rhesus macaque has cognitive abilities close to humans and has been used in the past but with noncommercial implants or no detailed radiologic descriptions of the surgical procedures. The aim of this study was to evaluate the feasibility of cochlear implantation in this animal model. Methods: We present detailed radiologic data (CT scan and Cone beam computed tomography) from 7 heads of rhesus macaque monkeys coming from autopsy materials. Several comparative measurements were performed with 10 human temporal bones to emphasize similarities and differences between the macaque and the human inner ear. The radiologic analyses helped planning the surgical approach for cochlear implant insertion in the macaque. Results: We managed to perform one full (720 degrees) and 3 partial insertions (190Y330 degrees) of cochlear implants in 4 rhesus macaque cochleae, documented by cone beam computed tomography reconstructions. We confirm that the procedure is facilitated in this animal because the cochlea dimensions are close to humans. However, marked differences in the orientation of the external auditory canal and the basal turn must be taken into account. We suggest that the removal of the inferior wall of tympanal bone provides the optimal axis for electrode array insertion. Conclusion: The rhesus macaque monkey is a valid and closeto-human animal model for cochlear implants insertion. Because this species is widely used in both behavioral and physiologic studies, we expect that functional implants can be coupled with electrophysiologic recordings to study the mechanisms of auditory compensation. Key Words: Animal modelVCochlear implantVCochlea sizeVTemporal bone anatomy. Otol Neurotol 34:e76Ye81, 2013.
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- 2013
32. Crossmodal interactions during non-linguistic auditory processing in cochlear-implanted deaf patients
- Author
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Olivier Deguine, Mathieu Marx, Bernard Fraysse, Pascal Belin, Laure Chambaudie, Kuzma Strelnikov, Pascal Barone, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and BELIN, Pascal
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,genetic structures ,Cognitive Neuroscience ,Experimental and Cognitive Psychology ,Speech comprehension ,Audiology ,050105 experimental psychology ,Young Adult ,03 medical and health sciences ,Nonverbal communication ,0302 clinical medicine ,deafness ,medicine ,otorhinolaryngologic diseases ,Humans ,0501 psychology and cognitive sciences ,Cochlear implantation ,Aged ,audiovisual ,Aged, 80 and over ,Communication ,Social communication ,Modality (human–computer interaction) ,Crossmodal ,business.industry ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.NEUR] Cognitive science/Neuroscience ,05 social sciences ,face ,voice ,Middle Aged ,Speech processing ,cochlear implantation ,Cochlear Implants ,Persons With Hearing Impairments ,Neuropsychology and Physiological Psychology ,Acoustic Stimulation ,Categorization ,Auditory Perception ,Visual Perception ,Female ,business ,Psychology ,Photic Stimulation ,030217 neurology & neurosurgery - Abstract
International audience; Due to signal distortion, speech comprehension in cochlear-implanted (CI) patients relies strongly on visual information, a compensatory strategy supported by important cortical crossmodal reorganisations. Though crossmodal interactions are evident for speech processing, it is unclear whether a visual influence is observed in CI patients during non-linguistic visual-auditory processing, such as face-voice interactions, which are important in social communication. We analyse and compare visual-auditory interactions in CI patients and normal-hearing subjects (NHS) at equivalent auditory performance levels. Proficient CI patients and NHS performed a voice-gender categorisation in the visual-auditory modality from a morphing-generated voice continuum between male and female speakers, while ignoring the presentation of a male or female visual face. Our data show that during the face-voice interaction, CI deaf patients are strongly influenced by visual information when performing an auditory gender categorization task, in spite of maximum recovery of auditory speech. No such effect is observed in NHS, even in situations of CI simulation. Our hypothesis is that the functional crossmodal reorganisation that occurs in deafness could influence nonverbal processing, such as face-voice interaction; this is important for patient internal supramodal representation.
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- 2016
33. Comparison of three types of French speech-in-noise tests: A multi-center study
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Jan Wouters, Matthieu Del Rio, Birger Kollmeier, Bruno Frachet, Sofie Jansen, René Dauman, Kirsten C. Wagener, Astrid Van Wieringen, Bernard Fraysse, Christopher J. James, Emilie Vormès, and Heleen Luts
- Subjects
Adult ,Male ,Linguistics and Language ,medicine.medical_specialty ,Normative study ,Screening test ,Audiology ,Intelligibility (communication) ,Language and Linguistics ,Speech in noise ,Young Adult ,Speech and Hearing ,Belgium ,Discriminative model ,otorhinolaryngologic diseases ,medicine ,Humans ,Speech reception ,Language ,Speech Reception Threshold Test ,Reproducibility of Results ,Middle Aged ,Multi center study ,Linear Models ,Speech Discrimination Tests ,Female ,France ,Noise ,Psychology ,Sentence - Abstract
OBJECTIVE: To compare results on the everyday sentence test 'FIST', the new closed-set sentence test 'FrMatrix', and the digit triplet screening test 'FrDigit3'. DESIGN: First, the FrMatrix was developed and normative values were obtained. Subsequently, speech reception thresholds (SRTs) for the three types of tests were gathered at four study centers representing different geographic regions in Belgium and France. STUDY SAMPLE: Fifty-seven normal-hearing listeners took part in the normative study of the FrMatrix, and 118 subjects, with a wide range of hearing thresholds, participated in the comparative study. RESULTS: Homogenizing the individual words of the FrMatrix with regard to their intelligibility resulted in a reference SRT of -6.0 (±0.6) dB SNR and slope at the SRT of 14.0 %/dB. The within-subject variability was only 0.4 dB. Comparison of the three tests showed high correlations between the SRTs mutually (>0.81). The FrMatrix had the highest discriminative power, both in stationary and in fluctuating noise. For all three tests, differences across the participating study centers were small and not significant. CONCLUSIONS: The FIST, the FrMatrix, and the FrDigit3 provide similar results and reliably evaluate speech recognition performance in noise both in normal-hearing and hearing-impaired listeners. ispartof: International Journal of Audiology vol:51 issue:3 pages:164-173 ispartof: location:England status: published
- Published
- 2011
34. Données morphologiques de la tomographie volumique à faisceau conique Cone Beam du rocher. Comparaison aux données de la tomedensitométrie hélicoïdale multibarettes
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Bernard Escudé, M. Marx, Benoit Lepage, M. Dahmani-Causse, Bernard Fraysse, and Olivier Deguine
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Otorhinolaryngology ,Surgery - Abstract
Resume Introduction Le scanner a haute resolution du rocher est indispensable dans le diagnostic et le suivi des pathologies du rocher. Sur le plan morphologique, le scanner est l’examen de reference. La necessite d’un suivi a long terme expose les patients a une dose d’irradiation cumulee. Or la limitation de l’exposition des patients aux rayonnements ionisants preoccupe de plus en plus les pouvoirs publics. Le Cone Beam presente pour principal avantage une reduction significative des doses d’irradiation. L’objectif principal de l’etude est d’evaluer la concordance morphologique entre l’imagerie Cone Beam et scanner mesuree sur 20 criteres anatomiques correspondant aux zones d’interet etudiees en pratique clinique. Les objectifs secondaires concernent, d’une part, la comparaison qualitative des deux techniques dans l’evaluation de l’etrier et de la region platinaire et la mesure de l’epaisseur de la platine et, d’autre part, la comparaison dosimetrique. Materiel et Methodes Il s’agit d’une etude anatomique experimentale sur 12 rochers de cadavres humains frais, non traites, dont l’histoire clinique est inconnue. Chaque rocher beneficie d’un scanner et d’un Cone Beam. Resultats Il n’y a pas de difference significative dans l’evaluation morphologique du rocher entre les deux techniques. L’exploration de l’etrier, de l’articulation incudostapedienne, de l’articulation vestibuloplatinaire anterieure et de la platine est qualitativement plus precise avec le Cone Beam et la mesure de l’epaisseur platinaire moins surestimee qu’avec le scanner. Cone Beam est 22 fois moins irradiant que le scanner dans les conditions de l’etude. Conclusion Le Cone Beam permet une evaluation morphologique du rocher fiable, grâce a une resolution spatiale meilleure que celle du scanner, avec une reduction significative des doses d’irradiation.
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- 2011
35. Development and evaluation of the modiolar research array – multi-centre collaborative study in human temporal bones
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Charles G. Wright, Frank Risi, J. Thomas Roland, Thomas Lenarz, Mathieu Marx, Michael Tykocinski, Antje Aschendorff, Bernard Fraysse, James F. Patrick, Roland Lazsig, Peter S. Roland, Robert Briggs, Bruce J. Gantz, and Timo Stöver
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Models, Anatomic ,Microsurgery ,medicine.medical_specialty ,Computer science ,Electrode ,medicine.medical_treatment ,Temporal bone ,Cochleostomy ,Prosthesis Design ,Round window ,Speech and Hearing ,Hearing ,Cochlear implant ,medicine ,Electrode array ,Humans ,Cooperative Behavior ,Multi centre ,Hearing Loss ,Intraoperative Complications ,Cochlear implantation ,Device Removal ,Perimodiolar ,Articles ,Cochlear Implantation ,Electrodes, Implanted ,Surgery ,Stylet ,Cochlear Implants ,medicine.anatomical_structure ,Round Window, Ear ,Otorhinolaryngology ,Feasibility Studies ,Hearing preservation ,Biomedical engineering - Abstract
Objective Multi-centre collaborative study to develop and refine the design of a prototype thin perimodiolar cochlear implant electrode array and to assess feasibility for use in human subjects. Study Design Multi-centre temporal bone insertion studies. Materials and Methods The modiolar research array (MRA) is a thin pre-curved electrode that is held straight for initial insertion with an external sheath rather than an internal stylet. Between November 2006 and February 2009, six iterations of electrode design were studied in 21 separate insertion studies in which 140 electrode insertions were performed in 85 human temporal bones by 12 surgeons. These studies aimed at addressing four fundamental questions related to the electrode concept, being: (1) Could a sheath result in additional intra-cochlear trauma? (2) Could a sheath accommodate variations in cochlea size and anatomies? (3) Could a sheath be inserted via the round window? and (4) Could a sheath be safely removed once the electrode had been inserted? These questions were investigated within these studies using a number of evaluation techniques, including X-ray and microfluoroscopy, acrylic fixation and temporal bone histologic sectioning, temporal bone microdissection of cochlear structures with electrode visualization, rotational tomography, and insertion force analysis. Results Frequent examples of electrode rotation and tip fold-over were demonstrated with the initial designs. This was typically caused by excessive curvature of the electrode tip, and also difficulty in handling of the electrode and sheath. The degree of tip curvature was progressively relaxed in subsequent versions with a corresponding reduction in the frequency of tip fold-over. Modifications to the sheath facilitated electrode insertion and sheath removal. Insertion studies with the final MRA design demonstrated minimal trauma, excellent perimodiolar placement, and very small electrode dimensions within scala tympani. Force measurements in temporal bones demonstrated negligible force on cochlear structures with angular insertion depths of between 390 and 450°. Conclusion The MRA is a novel, very thin perimodiolar prototype electrode array that has been developed using a systematic collaborative approach. The different evaluation techniques employed by the investigators contributed to the early identification of issues and generation of solutions. Regarding the four fundamental questions related to the electrode concept, the studies demonstrated that (1) the sheath did not result in additional intra-cochlear trauma; (2) the sheath could accommodate variations in cochlea size and anatomies; (3) the sheath was more successfully inserted via a cochleostomy than via the round window; and (4) the sheath could be safely removed once the electrode had been inserted.
- Published
- 2011
36. Evolution of crossmodal reorganization of the voice area in cochlear-implanted deaf patients
- Author
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Jean-François Démonet, Julien Rouger, Bernard Fraysse, Olivier Deguine, Sebastien Lagleyre, Pascal Barone, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Service d'oto-rhino-laryngologie et d'oto-neurologie, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Imagerie cérébrale et handicaps neurologiques (ICHN), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Speech perception ,Hearing loss ,medicine.medical_treatment ,Lipreading ,Sensory system ,Deafness ,Audiology ,03 medical and health sciences ,0302 clinical medicine ,Cochlear implant ,otorhinolaryngologic diseases ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,speechreading ,Research Articles ,030304 developmental biology ,Aged, 80 and over ,Temporal cortex ,Speechreading ,crossmodal compensation ,Brain Mapping ,0303 health sciences ,Neuronal Plasticity ,Radiological and Ultrasound Technology ,Crossmodal ,multisensory integration ,cochlear implant ,Brain ,Multisensory integration ,Middle Aged ,Cochlear Implants ,Neurology ,voice area ,Positron-Emission Tomography ,Speech Perception ,Visual Perception ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,Neurology (clinical) ,Anatomy ,medicine.symptom ,Psychology ,Photic Stimulation ,030217 neurology & neurosurgery - Abstract
International audience; Psychophysical and neuroimaging studies in both animal and human subjects have clearly demonstrated that cortical plasticity following sensory deprivation leads to a brain functional reorganization that favors the spared modalities. In postlingually deaf patients, the use of a cochlear implant (CI) allows a recovery of the auditory function, which will probably counteract the cortical crossmodal reorganization induced by hearing loss. To study the dynamics of such reversed crossmodal plasticity, we designed a longitudinal neuroimaging study involving the follow-up of 10 postlingually deaf adult CI users engaged in a visual speechreading task. While speechreading activates Broca's area in normally hearing subjects (NHS), the activity level elicited in this region in CI patients is abnormally low and increases progressively with post-implantation time. Furthermore, speechreading in CI patients induces abnormal crossmodal activations in right anterior regions of the superior temporal cortex normally devoted to processing human voice stimuli (temporal voice-sensitive areas-TVA). These abnormal activity levels diminish with post-implantation time and tend towards the levels observed in NHS. First, our study revealed that the neuroplasticity after cochlear implantation involves not only auditory but also visual and audiovisual speech processing networks. Second, our results suggest that during deafness, the functional links between cortical regions specialized in face and voice processing are reallocated to support speech-related visual processing through cross-modal reorganization. Such reorganization allows a more efficient audiovisual integration of speech after cochlear implantation. These compensatory sensory strategies are later completed by the progressive restoration of the visuo-audio-motor speech processing loop, including Broca's area. Hum Brain Mapp, 2011. © 2011 Wiley-Liss, Inc.
- Published
- 2011
37. Voice discrimination in cochlear-implanted deaf subjects
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Pascal Belin, Christopher J. James, Bernard Fraysse, Pascal Barone, Julien Rouger, Zoé Massida, Olivier Deguine, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Voice Neurocognition Laboratory, University of Glasgow, Service d'Oto-Rhino-Laryngologie et d'otoneurochirurgie, Hôpital Purpan [Toulouse], and CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Speech perception ,Dissociation (neuropsychology) ,Neuroprosthetics ,Hearing loss ,media_common.quotation_subject ,Deafness ,Audiology ,Paralanguage ,03 medical and health sciences ,0302 clinical medicine ,Perception ,Reaction Time ,otorhinolaryngologic diseases ,medicine ,Humans ,030223 otorhinolaryngology ,10. No inequality ,Human voice ,Aged ,media_common ,Aged, 80 and over ,Crossmodal ,Brain ,Linguistics ,Acoustics ,Middle Aged ,Cochlear Implantation ,Sensory Systems ,Cochlear Implants ,Speech Perception ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery - Abstract
International audience; The human voice is important for social communication because voices carry speech and other information such as a person's physical characteristics and affective state. Further restricted temporal cortical regions are specifically involved in voice processing. In cochlear-implanted deaf patients, the processor alters the spectral cues which are crucial for the perception of the paralinguistic information of human voices. The aim of this study was to assess the abilities of voice discrimination in cochlear-implant (CI) users and in normal-hearing subjects (NHS) using a CI simulation (vocoder). In NHS the performance in voice discrimination decreased when reducing the spectral information by decreasing the number of channels of the vocoder. In CI patients with different delays after implantation we observed a strong impairment in voice discrimination at time of activation of the neuroprosthesis. No significant improvement can be detected in patients after two years of experience of the implant while they have reached a higher level of recovery of speech perception, suggesting a dissociation in the dynamic of functional recuperation of speech and voice processing. In addition to the lack of spectral cues due to the implant processor, we hypothesized that the origin of such deficit could derive from a crossmodal reorganization of the temporal voice areas in CI patients.
- Published
- 2011
38. Cardiovascular and Thromboembolic Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss: A Case-Control Study
- Author
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Gabriel Baron, Bernard Fraysse, Bernard Meyer, Camille Bodenez, Fannie Defay, Olivier Sterkers, N. Ameziane, Dominique de Prost, Isabelle Mosnier, Evelyne Ferrary, Pierre Bertholon, Alain Robier, and Alain Stepanian
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Male ,Pediatrics ,medicine.medical_specialty ,genetic structures ,Physiology ,Hearing loss ,Hearing Loss, Sensorineural ,Blood Pressure ,Audiology ,Statistics, Nonparametric ,Speech and Hearing ,Risk Factors ,Odds Ratio ,otorhinolaryngologic diseases ,Humans ,Medicine ,Genetic Testing ,Risk factor ,medicine.diagnostic_test ,business.industry ,Vascular disease ,Smoking ,Case-control study ,Factor V ,Odds ratio ,Hearing Loss, Sudden ,medicine.disease ,Thrombosis ,Sensory Systems ,Otorhinolaryngology ,Embolism ,Cardiovascular Diseases ,Case-Control Studies ,Audiometry, Pure-Tone ,Female ,Prothrombin ,medicine.symptom ,Audiometry ,business - Abstract
Objective: The pathogenesis of idiopathic sudden sensorineural hearing loss (ISSHL) remains unknown, but vascular involvement is one of the main hypotheses. The main objective of this study was to investigate the association between ISSHL and cardiovascular and thromboembolic risk factors. Study Design: Multicentric case-control study. Methods: Ninety-six Caucasian patients with ISSHL and 179 sex- and age-matched controls were included. Patients were evaluated on the day of the inclusion and 1 week, 3 weeks and 3 months later. Clinical information concerning personal and familial cardiovascular and thromboembolic risk factors and concerning the ISSHL was collected. Blood samples were collected for genetic analysis of factor V Leiden and G20210A polymorphism in the factor II gene. The severity of the hearing loss was classified as mild (21–40 dB), moderate (41–70 dB), severe (71–90 dB) and profound or total (>90 dB). Hearing improvement was calculated as a relative improvement of hearing thresholds using the contralateral ear as baseline. Results: Systolic blood pressure was higher in patients (130 ± 1.7 mm Hg) than in controls (124 ± 1.1 mm Hg, p = 0.003). The personal/familial history of cardiovascular events was also more prevalent in patients (p = 0.023 and p = 0.014, respectively), whereas no difference was found in the prevalence of personal cardiovascular risk factors (hypertension, diabetes mellitus, hyperlipidemia, smoking habits). There was no correlation between the audiogram type, the hearing outcome and the presence of cardiovascular risk factors. No significant difference was observed in the personal/familial history or in the presence of thromboembolic risk factors. The prothrombin and factor V mutations were uncommon in both patients and controls. The final hearing threshold was only correlated with the severity of the initial hearing loss (p < 0.001), but not influenced by the presence of vertigo, audiogram type, time elapsed from onset of ISSHL to hospitalization or failure of a previous oral therapy. Hearing stabilization was obtained at 21 days in 92% of patients. Conclusion: These results support the theory of vascular involvement as the etiology of some cases of ISSHL. The sole predictive factor of poor final hearing is the severity of the initial hearing loss.
- Published
- 2010
39. The development of sentence recognition in noise by cochlear implant users
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Marjorie Tartayre, Marie-Laurence Laborde, Olivier Deguine, Chadlia Karoui, Mathieu Marx, Christopher J. James, and Bernard Fraysse
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medicine.medical_specialty ,Acoustics and Ultrasonics ,medicine.medical_treatment ,Sigmoid function ,Audiology ,Sentence recognition ,Term (time) ,Noise ,Arts and Humanities (miscellaneous) ,Cochlear implant ,QUIET ,medicine ,Active listening ,Psychology - Abstract
We previously established that under certain physiological conditions the sentence recognition scores in noise of cochlear implant (CI) users one month after activation are similar to those for normal listeners listening to 10–12 channel acoustic (vocoder) simulations (James et al., CIAP, Lake Tahoe, July 2017). We further analysed sentence recognition scores in noise over time in order to determine whether short term, 1-month scores predict long-term outcomes for sentence recognition in noise. Long-term sentence-in-noise data for fixed-SNR-level testing (10, 5, 2.5, 0 dB) were reduced to SNR50 values using a validated analytic sigmoid fit. Data were analysed for 106 adult CI users. 12-month SNR50s were highly correlated with 1-month sentence recognition scores in quiet and 10 dB SNR (r2 = 0.29 and r2 = 0.22, both p 80% correct score in quiet) was generally associate...
- Published
- 2018
40. Does Brain Activity at Rest Reflect Adaptive Strategies? Evidence from Speech Processing after Cochlear Implantation
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Olivier Deguine, Julien Rouger, Kuzma Strelnikov, Sebastien Lagleyre, Jean-François Démonet, Bernard Fraysse, Pascal Barone, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Imagerie cérébrale et handicaps neurologiques (ICHN), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oto-Rhino-Laryngologie et d'otoneurochirurgie, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Cognitive Neuroscience, and RS: FPN CN I
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Male ,CROSS-MODAL PLASTICITY ,Brain activity and meditation ,medicine.medical_treatment ,Statistics as Topic ,LANGUAGE ,Deafness ,Audiology ,Vocabulary ,0302 clinical medicine ,CONNECTIVITY ,Cochlear implant ,Aged, 80 and over ,Temporal cortex ,Brain Mapping ,0303 health sciences ,Brain ,Middle Aged ,Adaptation, Physiological ,Cochlear Implantation ,Cerebral blood flow ,Cerebrovascular Circulation ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,Psychology ,Adult ,medicine.medical_specialty ,Rest ,Cognitive Neuroscience ,Auditory area ,Sensory system ,ORGANIZATION ,Auditory cortex ,CONGENITALLY BLIND ,Temporal lobe ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,rest condition ,otorhinolaryngologic diseases ,medicine ,audiovisual integration ,Humans ,Speech ,VISUAL-CORTEX ,Aged ,030304 developmental biology ,cochlear implant ,Recognition, Psychology ,REPRESENTATIONS ,CORTICAL ACTIVATION ,Acoustic Stimulation ,brain plasticity ,Neuroscience ,Photic Stimulation ,030217 neurology & neurosurgery ,AUDITORY-CORTEX - Abstract
International audience; In functional neuroimaging studies, task-related activity refers to the signal difference between the stimulation and rest conditions. We asked whether long-term changes in the sensory environment may affect brain activity at rest. To answer this question, we compared regional cerebral blood flow between a group of normally hearing controls and a group of cochlear-implanted (CI) deaf patients. Here we present evidence that long-term alteration of auditory experience, such as profound deafness followed by partial auditory recuperation through cochlear implantation, leads to functional cortical reorganizations at rest. Without any visual or auditory stimulation, CI subjects showed changes of cerebral blood flow in the visual, auditory cortex, Broca area, and in the posterior temporal cortex with an increment of activity in these areas from the time of activation of the implant to less than a year after the implantation.
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- 2009
41. Quels indicateurs de développement professionnel en formation technologique supérieure ?
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Bernard Fraysse, Raquel Becerril Ortega, and Ecole Nationale de Formation Agronomique de Toulouse (ENFA)
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formation continue ,activities ,professionnalisation ,ComputingMilieux_THECOMPUTINGPROFESSION ,[SHS.EDU]Humanities and Social Sciences/Education ,graduate studies in technology ,formation initiale ,activités ,[SHS]Humanities and Social Sciences ,professional context ,ComputingMilieux_COMPUTERSANDEDUCATION ,professional training ,lcsh:L ,ComputingMilieux_MISCELLANEOUS ,lcsh:Education - Abstract
Ce travail porte sur le développement professionnel dans un contexte de formation technologique supérieure. La réflexion théorique proposée permet de problématiser cette recherche en présentant l’activité professionnelle comme une source de développement de compétences, et en proposant l’analyse de l’activité dans une situation de formation comme voie d’exploration de développement professionnel. Le dispositif méthodologique prend appui sur la construction a posteriori d’un indicateur de développement professionnel et de deux variables qui lui sont associées. Les résultats montrent ainsi des différences dans la gestion de la coactivité entre l’enseignant et les apprenants en relation aux situations génératrices de développement professionnel présentes dans la formation. Enfin, quelques perspectives sont annoncées, en relation avec le contexte institutionnel de la formation initiale, permettant d’élargir la réflexion au contexte de la formation continue.The article proposes an indicator which measures the reciprocal relationship between graduate studies in technology and the professional world. The chosen theoretical framework conceives professional activity as a source of professional competence development. The results of the analysis show that there are different ways of managing the classroom coactivity between the teacher and the students which are related to professional development and students’ profile.
- Published
- 2009
42. How Much Residual Hearing Is ‘Useful’ for Music Perception with Cochlear Implants?
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Marie-Laurence Laborde, Fouad El Fata, Bernard Fraysse, and Christopher J. James
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Adult ,medicine.medical_specialty ,Physiology ,Bimodal stimulation ,medicine.medical_treatment ,media_common.quotation_subject ,Audiology ,behavioral disciplines and activities ,Speech and Hearing ,Hearing Aids ,Hearing ,Cochlear implant ,Perception ,otorhinolaryngologic diseases ,medicine ,Humans ,Music recognition ,Psychoacoustics ,Hearing Loss ,Aged ,media_common ,medicine.diagnostic_test ,Pure tone ,Middle Aged ,Combined Modality Therapy ,Electric Stimulation ,Sensory Systems ,Cochlear Implants ,Acoustic Stimulation ,Otorhinolaryngology ,Music perception ,Patient Satisfaction ,Audiometry, Pure-Tone ,sense organs ,Audiometry ,Psychology ,Music ,psychological phenomena and processes - Abstract
Aim: To compare performance on a song recognition task of bilaterally combined electric and acoustic hearing (bimodal stimulation) with electric or acoustic hearing alone. Methods:Subjects were 14 adults with cochlear implants (CI) who continued to use a hearing aid (HA) in one/both ears. Subjects were asked to identify excerpts from 15 popular songs, which were familiar to them, presented in a random order via a single loudspeaker. Presentation conditions were fixed in order: bimodal, CI alone and then HA alone. Musical excerpts were presented in each condition with and then without lyrics. Results:In a subgroup of subjects (n = 8) with better low-frequency residual hearing (thresholds Conclusions:Bimodal stimulation provides better perception of popular music, particularly melody recognition, compared to CI alone when low-frequency residual hearing is better than 85 dB HL.
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- 2009
43. McGurk effects in cochlear-implanted deaf subjects
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Olivier Deguine, Pascal Barone, Bernard Fraysse, Julien Rouger, Centre de recherche cerveau et cognition (CERCO), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'oto-rhino-laryngologie, Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut des sciences du cerveau de Toulouse. (ISCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), RS: FPN CN I, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
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Male ,genetic structures ,medicine.medical_treatment ,Deafness ,Audiology ,0302 clinical medicine ,Cochlear implant ,Neural Pathways ,030223 otorhinolaryngology ,Cerebral Cortex ,Speechreading ,Language Tests ,Neuronal Plasticity ,General Neuroscience ,Middle Aged ,Illusions ,Articulatory feature ,McGurk effect ,Speech Perception ,Visual Perception ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Cues ,medicine.symptom ,Psychology ,psychological phenomena and processes ,Adult ,medicine.medical_specialty ,Speech perception ,Hearing loss ,Sensory system ,03 medical and health sciences ,otorhinolaryngologic diseases ,medicine ,Humans ,Molecular Biology ,Nasality ,Cochlear implantation Audiovisual speech ,Recovery of Function ,Cross-modal reorganization ,Cochlear Implants ,Acoustic Stimulation ,Reading ,Voice ,sense organs ,Neurology (clinical) ,Photic Stimulation ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
International audience; Cochlear implants are neuroprostheses designed to restore speech perception in case of profound bilateral hearing loss. As speech is fundamentally an audiovisual percept, a deficit in processing auditory information might lead to changes in audiovisual integration of speech comprehension. Using vowel-consonant-vowel stimuli under unimodal, audiovisual congruent and audiovisual incongruent (McGurk) conditions, we tested postlingually deaf cochlear-implanted (CI) users and normally hearing (NH) subjects in order to investigate their audiovisual perceptive strategies. Mode/Place-of-articulation perceptive analysis and information transmission analysis of congruent and incongruent percepts indicated a similar sensory specialization for CI users when compared to NH subjects, with voicing and nasality cues transmitted via audition and place cues principally transmitted via vision. NH as well as CI subjects underwent typical McGurk illusory percepts. However, while normally hearing subjects show a well-balanced bimodal integration of incongruent speech, we demonstrated that cochlear implantees present a bias toward a visual-predominant bimodal integration. Our results are complementary to previous studies showing that CI users maintain a high level of speechreading, even after several years of recovery of auditory speech comprehension. Altogether, our results suggest a cross-modal reorganization of speech comprehension in cochlear-implanted patients that might recruit more strongly than in NH the visual and visuo-auditory brain areas involved in speechreading.
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- 2008
44. Un dispositif de formation simulé pour professionnaliser les élèves-ingénieurs
- Author
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Bernard Fraysse
- Subjects
Developmental and Educational Psychology ,Education - Abstract
L’article qui suit presente un dispositif de formation technologique innovant de simulation de machine-outil a commande numerique. Il precise l’interet d’un tel dispositif, les fondamentaux theoriques permettant d’elaborer un modele original a partir de la didactique professionnelle. Ce modele de simulation de l’activite qui articule une dimension didactique et fonctionnelle a une dimension socio-cognitive montre toute sa pertinence, lorsqu’il est developpe en contexte de formation d’eleves-ingenieurs, car il permet de mieux professionnaliser les acteurs. La perspective de simulation d’activite de formation, et de simulation d’activite de travail ouvre des pistes prometteuses en formation technologique superieure en lien avec le monde industriel.
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- 2007
45. Evidence that cochlear-implanted deaf patients are better multisensory integrators
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Sophie Denève, Julien Rouger, Pascal Barone, Sebastien Lagleyre, Olivier Deguine, Bernard Fraysse, Centre de recherche cerveau et cognition (CERCO), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'oto-rhino-laryngologie, Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Groupe de Neurosciences Théoriques, Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Institut des sciences du cerveau de Toulouse. (ISCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
- Subjects
Visual perception ,medicine.medical_treatment ,Lipreading ,Audiology ,MESH: Cochlear Implants ,MESH: Aged, 80 and over ,0302 clinical medicine ,Hearing ,speech comprehension ,Cochlear implant ,MESH: Models, Psychological ,030223 otorhinolaryngology ,Aged, 80 and over ,MESH: Aged ,Speechreading ,MESH: Middle Aged ,Multidisciplinary ,Rehabilitation ,Biological Sciences ,Middle Aged ,MESH: Hearing Impaired Persons ,MESH: Lipreading ,MESH: Speech Discrimination Tests ,Auditory Perception ,Speech Discrimination Tests ,Visual Perception ,MESH: Audiometry, Speech ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Psychology ,Adult ,Auditory perception ,medicine.medical_specialty ,Neuroprosthetics ,Models, Psychological ,MESH: Auditory Perception ,03 medical and health sciences ,deafness ,otorhinolaryngologic diseases ,medicine ,Humans ,Aged ,MESH: Humans ,MESH: Visual Perception ,multisensory integration ,cochlear implant ,Multisensory integration ,MESH: Adult ,Cochlear Implants ,Persons With Hearing Impairments ,Word recognition ,Commentary ,Audiometry, Speech ,030217 neurology & neurosurgery - Abstract
International audience; The cochlear implant (CI) is a neuroprosthesis that allows profoundly deaf patients to recover speech intelligibility. This recovery goes through long-term adaptative processes to build coherent percepts from the coarse information delivered by the implant. Here we analyzed the longitudinal postimplantation evolution of word recognition in a large sample of CI users in unisensory (visual or auditory) and bisensory (visuoauditory) conditions. We found that, despite considerable recovery of auditory performance during the first year postimplantation, CI patients maintain a much higher level of word recognition in speechreading conditions compared with normally hearing subjects, even several years after implantation. Consequently, we show that CI users present higher visuoauditory performance when compared with normally hearing subjects with similar auditory stimuli. This better performance is not only due to greater speechreading performance, but, most importantly, also due to a greater capacity to integrate visual input with the distorted speech signal. Our results suggest that these behavioral changes in CI users might be mediated by a reorganization of the cortical network involved in speech recognition that favors a more specific involvement of visual areas. Furthermore, they provide crucial indications to guide the rehabilitation of CI patients by using visually oriented therapeutic strategies.
- Published
- 2007
46. Asymmetric Hearing Loss 2014
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Bernard Fraysse and M. Marx
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Asymmetric hearing loss ,Audiology ,business - Published
- 2015
47. Categorization of common sounds by cochlear implanted and normal hearing adults
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Benoit Roby, Pascal Barone, Olivier Deguine, Bernard Fraysse, Mathieu Marx, Pascal Gaillard, Edward Collett, Advanced Bionics, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Cognition, Langues, Langage, Ergonomie (CLLE), École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Auditory perception ,Adult ,Male ,Time Factors ,medicine.medical_treatment ,Speech recognition ,media_common.quotation_subject ,Multiple Correspondence Analysis ,Deafness ,Hierarchical clustering ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Free-sorting ,Salience (neuroscience) ,Multiple correspondence analysis ,Cochlear implant ,Perception ,medicine ,Animals ,Cluster Analysis ,Humans ,[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs ,030223 otorhinolaryngology ,media_common ,Aged ,Principal Component Analysis ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,Hearing Tests ,Auditory categorization ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Cognition ,Acoustics ,Middle Aged ,Cochlear Implantation ,Sensory Systems ,Cochlear Implants ,Sound ,Categorization ,Acoustic Stimulation ,Data Interpretation, Statistical ,[SCCO.PSYC]Cognitive science/Psychology ,Auditory Perception ,Voice ,Female ,Psychology ,030217 neurology & neurosurgery - Abstract
International audience; Auditory categorization involves grouping of acoustic events along one or more shared perceptual di- mensions which can relate to both semantic and physical attributes. This process involves both high level cognitive processes (categorization) and low-level perceptual encoding of the acoustic signal, both of which are affected by the use of a cochlear implant (CI) device. The goal of this study was twofold: I) compare the categorization strategies of CI users and normal hearing listeners (NHL) II) investigate if any characteristics of the raw acoustic signal could explain the results. 16 experienced CI users and 20 NHL were tested using a Free-Sorting Task of 16 common sounds divided into 3 predefined categories of environmental, musical and vocal sounds. Multiple Correspondence Analysis (MCA) and Hierarchical Clustering based on Principal Components (HCPC) show that CI users followed a similar categorization strategy to that of NHL and were able to discriminate between the three different types of sounds. However results for CI users were more varied and showed less inter-participant agreement. Acoustic analysis also highlighted the average pitch salience and average autocorrelation peak as being important for the perception and categorization of the sounds. The results therefore show that on a broad level of categorization CI users may not have as many difficulties as previously thought in discriminating certain kinds of sound; however the perception of individual sounds remains challenging.
- Published
- 2015
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48. Improvement of cognitive function after cochlear implantation in elderly patients
- Author
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Bernard Fraysse, Françoise Sterkers-Artieres, Jean Pierre Bebear, Olivier Sterkers, Bernard Meyer, Geneviève Lina-Granade, Isabelle Mosnier, Benoit Godey, Alain Robier, Eric Truy, Philippe Bordure, Michel Mondain, Didier Bouccara, Bruno Frachet, Christine Poncet-Wallet, Mathieu Marx, Service d'oto-rhino-laryngologie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon, Institut Claude Bernard - Physiologie et Pathologie ((IFR_2)), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre de recherche cerveau et cognition (CERCO), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'oto-rhino-laryngologie et d'oto-neurologie, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Neurosciences Sensorielles Comportement Cognition, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Département d'ORL, chirurgie cervico-maxillo-faciale et d'audiophonologie [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre hospitalier universitaire de Nantes (CHU Nantes), Service ORL et chirurgie cervico-faciale [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Service d'ORL et de chirurgie maxillo-faciale [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [APHP], Service ORL [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne, Service ORL, CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences du cerveau de Toulouse. (ISCT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Bretonneau-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service d'ORL et de chirurgie maxillo-faciale [Rennes] = ENT Head and Neck Surgery [Rennes], CHU Pontchaillou [Rennes], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Service ORL, otoneurologie et ORL pédiatrique [CHU Toulouse], Pôle Céphalique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier (INM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Beaujon [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)
- Subjects
Male ,medicine.medical_specialty ,Hearing loss ,medicine.medical_treatment ,Trail Making Test ,Audiology ,Neuropsychological Tests ,Cochlear implant ,medicine ,otorhinolaryngologic diseases ,80 and over ,Verbal fluency test ,Humans ,Prospective Studies ,Longitudinal Studies ,Cognitive decline ,Geriatric Assessment ,Aged ,Aged, 80 and over ,business.industry ,Depression ,Hearing Tests ,Cognition ,Aural rehabilitation ,Cochlear Implantation ,Cognitive test ,Cochlear Implants ,Otorhinolaryngology ,Speech Perception ,Quality of Life ,Surgery ,Female ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,medicine.symptom ,business ,Cognition Disorders - Abstract
International audience; IMPORTANCE: The association between hearing impairment and cognitive decline has been established; however, the effect of cochlear implantation on cognition in profoundly deaf elderly patients is not known. OBJECTIVE: To analyze the relationship between cognitive function and hearing restoration with a cochlear implant in elderly patients. DESIGN, SETTING, AND PARTICIPANTS: Prospective longitudinal study performed in 10 tertiary referral centers between September 1, 2006, and June 30, 2009. The participants included 94 patients aged 65 to 85 years with profound, postlingual hearing loss who were evaluated before, 6 months after, and 12 months after cochlear implantation. INTERVENTIONS: Cochlear implantation and aural rehabilitation program. MAIN OUTCOMES AND MEASURES: Speech perception was measured using disyllabic word recognition tests in quiet and in noise settings. Cognitive function was assessed using a battery of 6 tests evaluating attention, memory, orientation, executive function, mental flexibility, and fluency (Mini-Mental State Examination, 5-word test, clock-drawing test, verbal fluency test, d2 test of attention, and Trail Making test parts A and B). Quality of life and depression were evaluated using the Nijmegen Cochlear Implant Questionnaire and the Geriatric Depression Scale-4. RESULTS: Cochlear implantation led to improvements in speech perception in quiet and in noise (at 6 months: in quiet, 42% score increase [95% CI, 35%-49%; P \textless .001]; in noise, at signal to noise ratio [SNR] +15 dB, 44% [95% CI, 36%-52%, P \textless .001], at SNR +10 dB, 37% [95% CI 30%-44%; P \textless .001], and at SNR +5 dB, 27% [95% CI, 20%-33%; P \textless .001]), quality of life, and Geriatric Depression Scale-4 scores (76% of patients gave responses indicating no depression at 12 months after implantation vs 59% before implantation; P = .02). Before cochlear implantation, 44% of the patients (40 of 91) had abnormal scores on 2 or 3 of 6 cognition tests. One year after implant, 81% of the subgroup (30 of 37) showed improved global cognitive function (no or 1 abnormal test score). Improved mean scores in all cognitive domains were observed as early as 6 months after cochlear implantation. Cognitive performance remained stable in the remaining 19% of the participants (7 of 37). Among patients with the best cognitive performance before implantation (ie, no or 1 abnormal cognitive test score), 24% (12 of 50) displayed a slight decline in cognitive performance. Multivariate analysis to examine the association between cognitive abilities before implantation and the variability in cochlear implant outcomes demonstrated a significant effect only between long-term memory and speech perception in noise at 12 months (SNR +15 dB, P = .01; SNR +10 dB, P \textless .001; and SNR +5 dB, P = .02). CONCLUSIONS AND RELEVANCE: Rehabilitation of hearing communication through cochlear implantation in elderly patients results in improvements in speech perception and cognitive abilities and positively influences their social activity and quality of life. Further research is needed to assess the long-term effect of cochlear implantation on cognitive decline.
- Published
- 2015
49. Neuroradiological Evaluation before Cochlear Implantation in Children
- Author
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Olivier Deguine, Alain Uziel, N. Soulier, Michel Mondain, F. Châ, X Cormary, Alain Bonafe, and Bernard Fraysse
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,Audiology ,business ,Cochlear implantation - Published
- 2015
50. Predictive Factors in Cochlear Implant Surgery
- Author
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Alain Uziel, Michel Mondain, Jean-Pierre Piron, N. Cochard, Olivier Deguine, F. Reuillard-Artieres, and Bernard Fraysse
- Subjects
medicine.medical_specialty ,Cochlear implant surgery ,Text mining ,business.industry ,Medicine ,Audiology ,business - Published
- 2015
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