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2,237 results on '"Berdel, Wolfgang E"'

3. Prognostic impact of CEBPA mutational subgroups in adult AML

Author

Georgi, Julia-Annabell, Stasik, Sebastian, Kramer, Michael, Meggendorfer, Manja, Röllig, Christoph, Haferlach, Torsten, Valk, Peter, Linch, David, Herold, Tobias, Duployez, Nicolas, Taube, Franziska, Middeke, Jan Moritz, Platzbecker, Uwe, Serve, Hubert, Baldus, Claudia D., Muller-Tidow, Carsten, Haferlach, Claudia, Koch, Sarah, Berdel, Wolfgang E., Woermann, Bernhard J., Krug, Utz, Braess, Jan, Hiddemann, Wolfgang, Spiekermann, Karsten, Boertjes, Emma L., Hills, Robert K., Burnett, Alan, Ehninger, Gerhard, Metzeler, Klaus, Rothenberg-Thurley, Maja, Dufour, Annika, Dombret, Hervé, Pautas, Cecile, Preudhomme, Claude, Fenwarth, Laurene, Bornhäuser, Martin, Gale, Rosemary, and Thiede, Christian

Published
2024
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4. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, Wendelin, Knut, Middeke, Jan Moritz, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Krause, Stefan W, Klein, Stefan A, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Kriege, Oliver, Berdel, Wolfgang E, Ehninger, Gerhard, and Schmidt, Alexander H

Published
2024
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5. Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)

Author

Ozga, Michael, Nicolet, Deedra, Mrózek, Krzysztof, Yilmaz, Ayse S., Kohlschmidt, Jessica, Larkin, Karilyn T., Blachly, James S., Oakes, Christopher C., Buss, Jill, Walker, Christopher J., Orwick, Shelley, Jurinovic, Vindi, Rothenberg-Thurley, Maja, Dufour, Annika, Schneider, Stephanie, Sauerland, Maria Cristina, Görlich, Dennis, Krug, Utz, Berdel, Wolfgang E., Woermann, Bernhard J., Hiddemann, Wolfgang, Braess, Jan, Subklewe, Marion, Spiekermann, Karsten, Carroll, Andrew J., Blum, William G., Powell, Bayard L., Kolitz, Jonathan E., Moore, Joseph O., Mayer, Robert J., Larson, Richard A., Uy, Geoffrey L., Stock, Wendy, Metzeler, Klaus H., Grimes, H. Leighton, Byrd, John C., Salomonis, Nathan, Herold, Tobias, Mims, Alice S., and Eisfeld, Ann-Kathrin

Published
2024
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6. Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia

Author

Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Petzold, Andreas, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Oelschlägel, Uta, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Dahl, Andreas, Schetelig, Johannes, Bornhäuser, Martin, Middeke, Jan Moritz, and Thiede, Christian

Published
2023
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7. Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia – implications for the European LeukemiaNet risk classification

Author

Eckardt, Jan-Niklas, Bill, Marius, Rausch, Christian, Metzeler, Klaus, Spiekermann, Karsten, Stasik, Sebastian, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Krug, Utz, Wörmann, Bernhard, Hiddemann, Wolfgang, Görlich, Dennis, Sauerland, Cristina, Steffen, Björn, Einsele, Hermann, Neubauer, Andreas, Burchert, Andreas, Schäfer-Eckart, Kerstin, Berdel, Wolfgang E., Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Hanoun, Maher, Kaufmann, Martin, Fransecky, Lars, Braess, Jan, Ruhnke, Leo, Schetelig, Johannes, Middeke, Jan Moritz, Serve, Hubert, Baldus, Claudia D., Platzbecker, Uwe, Müller-Tidow, Carsten, Bornhäuser, Martin, Herold, Tobias, Thiede, Christian, and Röllig, Christoph

Published
2023
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8. CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

Author

Altvater, Bianca, Kailayangiri, Sareetha, Spurny, Christian, Flügge, Maike, Meltzer, Jutta, Greune, Lea, Urban, Katja, Schwöppe, Christian, Brand, Caroline, Schliemann, Christoph, Hintelmann, Heike, Harrach, Saliha, Hartmann, Wolfgang, Abken, Hinrich, Kuehle, Johannes, Schambach, Axel, Görlich, Dennis, Berdel, Wolfgang E., and Rossig, Claudia

Published
2023
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9. UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome

Author

Georgi, Julia-Annabell, Stasik, Sebastian, Eckardt, Jan-Niklas, Zukunft, Sven, Hartwig, Marita, Röllig, Christoph, Middeke, Jan Moritz, Oelschlägel, Uta, Krug, Utz, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Kroschinsky, Frank, and Thiede, Christian

Published
2023
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10. Unsupervised meta-clustering identifies risk clusters in acute myeloid leukemia based on clinical and genetic profiles

Author

Eckardt, Jan-Niklas, Röllig, Christoph, Metzeler, Klaus, Heisig, Peter, Stasik, Sebastian, Georgi, Julia-Annabell, Kroschinsky, Frank, Stölzel, Friedrich, Platzbecker, Uwe, Spiekermann, Karsten, Krug, Utz, Braess, Jan, Görlich, Dennis, Sauerland, Cristina, Woermann, Bernhard, Herold, Tobias, Hiddemann, Wolfgang, Müller-Tidow, Carsten, Serve, Hubert, Baldus, Claudia D., Schäfer-Eckart, Kerstin, Kaufmann, Martin, Krause, Stefan W., Hänel, Mathias, Berdel, Wolfgang E., Schliemann, Christoph, Mayer, Jiri, Hanoun, Maher, Schetelig, Johannes, Wendt, Karsten, Bornhäuser, Martin, Thiede, Christian, and Middeke, Jan Moritz

Published
2023
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11. Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome

Author

Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Cerqueira, Tiago, Kroschinsky, Frank, Berdel, Wolfgang E., Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Siepmann, Timo, Bornhäuser, Martin, Middeke, Jan Moritz, and Thiede, Christian

Published
2023
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12. Targeted siRNA nanocarrier: a platform technology for cancer treatment

Author

Bäumer, Nicole, Tiemann, Jessica, Scheller, Annika, Meyer, Theresa, Wittmann, Lisa, Suburu, Matias Ezequiel Gutierrez, Greune, Lilo, Peipp, Matthias, Kellmann, Neele, Gumnior, Annika, Brand, Caroline, Hartmann, Wolfgang, Rossig, Claudia, Müller-Tidow, Carsten, Neri, Dario, Strassert, Cristian A, Rüter, Christian, Dersch, Petra, Lenz, Georg, Koeffler, H Phillip, Berdel, Wolfgang E, and Bäumer, Sebastian

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Medical Biotechnology, Oncology and Carcinogenesis, Rare Diseases, Lung Cancer, Genetics, Biotechnology, Lung, Nanotechnology, Cancer, Bioengineering, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, Male, Oncogene Proteins, Fusion, Protamines, Proto-Oncogene Protein c-fli-1, RNA, Small Interfering, RNA-Binding Protein EWS, Technology, Xenograft Model Antitumor Assays, Clinical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

The small arginine-rich protein protamine condenses complete genomic DNA into the sperm head. Here, we applied its high RNA binding capacity for spontaneous electrostatic assembly of therapeutic nanoparticles decorated with tumour-cell-specific antibodies for efficiently targeting siRNA. Fluorescence microscopy and DLS measurements of these nanocarriers revealed the formation of a vesicular architecture that requires presence of antibody-protamine, defined excess of free SMCC-protamine, and anionic siRNA to form. Only these complex nanoparticles were efficient in the treatment of non-small-cell lung cancer (NSCLC) xenograft models, when the oncogene KRAS was targeted via EGFR-mediated delivery. To show general applicability, we used the modular platform for IGF1R-positive Ewing sarcomas. Anti-IGR1R-antibodies were integrated into an antibody-protamine nanoparticle with an siRNA specifically against the oncogenic translocation product EWS/FLI1. Using these nanoparticles, EWS/FLI1 knockdown blocked in vitro and in vivo growth of Ewing sarcoma cells. We conclude that these antibody-protamine-siRNA nanocarriers provide a novel platform technology to specifically target different cell types and yet undruggable targets in cancer therapy by RNAi.

Published
2022

15. Different treatment strategies versus a common standard arm (CSA) in patients with newly diagnosed AML over the age of 60 years: a randomized German inter-group study

Author

Niederwieser, Dietger, Lang, Thomas, Krahl, Rainer, Heinicke, Thomas, Maschmeyer, Georg, Al-Ali, Haifa Kathrin, Schwind, Sebastian, Jentzsch, Madlen, Cross, Michael, Kahl, Christoph, Wolf, Hans-Heinrich, Sayer, Herbert, Schulze, Antje, Dreger, Peter, Hegenbart, Ute, Krämer, Alwin, Junghanss, Christian, Mügge, Lars-Olof, Hähling, Detlev, Hirt, Carsten, Späth, Christian, Peter, Norma, Opitz, Bernhard, Florschütz, Axel, Reifenrath, Kolja, Zojer, Niklas, Scholl, Sebastian, Pönisch, Wolfram, Heyn, Simone, Vucinic, Vladan, Hochhaus, Andreas, Aul, Carlo, Giagounidis, Aristoteles, Balleisen, Leopold, Oldenkott, Bernd, Staib, Peter, Kiehl, Michael, Schütte, Wolfgang, Naumann, Ralph, Eimermacher, Hartmut, Dörken, Bernd, Sauerland, Cristina, Lengfelder, Eva, Hiddemann, Wolfgang, Wörmann, Bernhard, Müller-Tidow, Carsten, Serve, Hubert, Schliemann, Christoph, Hehlmann, Rüdiger, Berdel, Wolfgang E., Pfirrmann, Markus, Krug, Utz, and Hoffmann, Verena S.

Published
2023
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16. Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Author

Frank, Daria, Patnana, Pradeep Kumar, Vorwerk, Jan, Mao, Lianghao, Gopal, Lavanya Mokada, Jung, Noelle, Hennig, Thorben, Ruhnke, Leo, Frenz, Joris Maximillian, Kuppusamy, Maithreyan, Autry, Robert, Wei, Lanying, Sun, Kaiyan, Mohammed Ahmed, Helal Mohammed, Künstner, Axel, Busch, Hauke, Müller, Heiko, Hutter, Stephan, Hoermann, Gregor, Liu, Longlong, Xie, Xiaoqing, Al-Matary, Yahya, Nimmagadda, Subbaiah Chary, Cano, Fiorella Charles, Heuser, Michael, Thol, Felicitas, Göhring, Gudrun, Steinemann, Doris, Thomale, Jürgen, Leitner, Theo, Fischer, Anja, Rad, Roland, Röllig, Christoph, Altmann, Heidi, Kunadt, Desiree, Berdel, Wolfgang E., Hüve, Jana, Neumann, Felix, Klingauf, Jürgen, Calderon, Virginie, Opalka, Bertram, Dührsen, Ulrich, Rosenbauer, Frank, Dugas, Martin, Varghese, Julian, Reinhardt, Hans Christian, von Bubnoff, Nikolas, Möröy, Tarik, Lenz, Georg, Batcha, Aarif M. N., Giorgi, Marianna, Selvam, Murugan, Wang, Eunice, McWeeney, Shannon K., Tyner, Jeffrey W., Stölzel, Friedrich, Mann, Matthias, Jayavelu, Ashok Kumar, and Khandanpour, Cyrus

Published
2023
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17. A randomized phase 2 trial of nintedanib and low-dose cytarabine in elderly patients with acute myeloid leukemia ineligible for intensive chemotherapy

Author

Berdel, Andrew F., Koch, Raphael, Gerss, Joachim, Hentrich, Marcus, Peceny, Rudolf, Bartscht, Tobias, Steffen, Björn, Bischoff, Marina, Spiekermann, Karsten, Angenendt, Linus, Mikesch, Jan-Henrik, Kewitz, Tobias, Butterfass-Bahloul, Trude, Serve, Hubert, Lenz, Georg, Berdel, Wolfgang E., Krug, Utz, and Schliemann, Christoph

Published
2023
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18. Using stroma-anchoring cytokines to augment ADCC: a phase 1 trial of F16IL2 and BI 836858 for posttransplant AML relapse

Author

Berdel, Andrew F., Ruhnke, Leo, Angenendt, Linus, Wermke, Martin, Röllig, Christoph, Mikesch, Jan-Henrik, Scheller, Annika, Hemmerle, Teresa, Matasci, Mattia, Wethmar, Klaus, Kessler, Torsten, Gerwing, Mirjam, Hescheler, Daniel, Schäfers, Michael, Hartmann, Wolfgang, Altvater, Bianca, Rossig, Claudia, Bornhäuser, Martin, Lenz, Georg, Stelljes, Matthias, Rueter, Bjoern, Neri, Dario, Berdel, Wolfgang E., and Schliemann, Christoph

Published
2022
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19. Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation

Author

Kunadt, Desiree, Stasik, Sebastian, Metzeler, Klaus H., Röllig, Christoph, Schliemann, Christoph, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Scholl, Sebastian, Hilgendorf, Inken, Brümmendorf, Tim H., Jost, Edgar, Steffen, Björn, Bug, Gesine, Einsele, Hermann, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Krause, Stefan W., Hänel, Mathias, Hanoun, Maher, Kaufmann, Martin, Wörmann, Bernhard, Kramer, Michael, Sockel, Katja, Egger-Heidrich, Katharina, Herold, Tobias, Ehninger, Gerhard, Burchert, Andreas, Platzbecker, Uwe, Berdel, Wolfgang E., Müller-Tidow, Carsten, Hiddemann, Wolfgang, Serve, Hubert, Stelljes, Matthias, Baldus, Claudia D., Neubauer, Andreas, Schetelig, Johannes, Thiede, Christian, Bornhäuser, Martin, Middeke, Jan M., and Stölzel, Friedrich

Published
2022
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20. Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations

Author

Eckardt, Jan-Niklas, Stölzel, Friedrich, Kunadt, Desiree, Röllig, Christoph, Stasik, Sebastian, Wagenführ, Lisa, Jöhrens, Korinna, Kuithan, Friederike, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Kroschinsky, Frank, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Bornhäuser, Martin, Thiede, Christian, and Middeke, Jan Moritz

Published
2022
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21. Electrostatic anti-CD33-antibody–protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia

Author

Bäumer, Nicole, Scheller, Annika, Wittmann, Lisa, Faust, Andreas, Apel, Mara, Nimmagadda, Subbaiah Chary, Geyer, Christiane, Grunert, Katharina, Kellmann, Neele, Peipp, Matthias, Kailayangiri, Sareetha, Gutierrez Suburu, Matias Ezequiel, Strassert, Cristian A., Schenk, Mathias, Greune, Lilo, Rüter, Christian, Dersch, Petra, Hartmann, Wolfgang, Rossig, Claudia, Neri, Dario, Müller-Tidow, Carsten, Schwöppe, Christian, Schliemann, Christoph, Khandanpour, Cyrus, Lenz, Georg, Berdel, Wolfgang E., and Bäumer, Sebastian

Published
2022
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22. Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study

Author

Middeke, Jan M., Metzeler, Klaus H., Röllig, Christoph, Krämer, Michael, Eckardt, Jan-Niklas, Stasik, Sebastian, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Kaufmann, Martin, Kunadt, Desiree, Wörmann, Bernhard, Sockel, Katja, von Bonin, Malte, Herold, Tobias, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Baldus, Claudia D., Ehninger, Gerhard, Schetelig, Johannes, Hiddemann, Wolfgang, Bornhäuser, Martin, Stölzel, Friedrich, and Thiede, Christian

Published
2022
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23. CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome

Author

Taube, Franziska, Georgi, Julia Annabell, Kramer, Michael, Stasik, Sebastian, Middeke, Jan Moritz, Röllig, Christoph, Krug, Utz, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Petzold, Andreas, Mulet-Lazaro, Roger, Valk, Peter J.M., Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Herold, Sylvia, Stölzel, Friedrich, Sockel, Katja, von Bonin, Malte, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, and Thiede, Christian

Published
2022
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25. A clinically applicable gene expression–based score predicts resistance to induction treatment in acute myeloid leukemia

Author

Moser, Christian, Jurinovic, Vindi, Sagebiel-Kohler, Sabine, Ksienzyk, Bianka, Batcha, Aarif M.N., Dufour, Annika, Schneider, Stephanie, Rothenberg-Thurley, Maja, Sauerland, Cristina M., Görlich, Dennis, Berdel, Wolfgang E., Krug, Utz, Mansmann, Ulrich, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten, Greif, Philipp A., Vosberg, Sebastian, Metzeler, Klaus H., Kumbrink, Jörg, and Herold, Tobias

Published
2021
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26. Friday leukemia—a structural phenomenon

Author

Rausch, Christian, primary, Arnreich, Chiara, additional, Rothenberg-Thurley, Maja, additional, Dufour, Annika, additional, Schneider, Stephanie, additional, Gittinger, Hanna, additional, Bücklein, Veit, additional, Subklewe, Marion, additional, Sauerland, Cristina, additional, Görlich, Dennis, additional, Krug, Utz, additional, Berdel, Wolfgang E., additional, Wörmann, Bernhard J., additional, Hiddemann, Wolfgang, additional, Braess, Jan, additional, von Bergwelt-Baildon, Michael, additional, Spiekermann, Karsten, additional, Metzeler, Klaus H., additional, and Herold, Tobias, additional

Published
2024
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27. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Stelljes, Matthias, Middeke, Jan Moritz, Bug, Gesine, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Schmid, Christoph, Krause, Stefan W, Bethge, Wolfgang, Jost, Edgar, Platzbecker, Uwe, Klein, Stefan A, Schubert, Jörg, Niederland, Judith, Kaufmann, Martin, Schäfer-Eckart, Kerstin, Schaich, Markus, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Röllig, Christoph, Alakel, Nael, Steffen, Björn, Hauptrock, Beate, Schliemann, Christoph, Sockel, Katja, Lang, Fabian, Kriege, Oliver, Schaffrath, Judith, Reicherts, Christian, Berdel, Wolfgang E, Serve, Hubert, Ehninger, Gerhard, Schmidt, Alexander H, Bornhäuser, Martin, Mikesch, Jan-Henrik, Schetelig, Johannes, Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, and Wendelin, Knut

Abstract

Whether high-dose cytarabine-based salvage chemotherapy, administered to induce complete remission in patients with poor responsive or relapsed acute myeloid leukaemia scheduled for allogeneic haematopoietic stem-cell transplantation (HSCT) after intensive conditioning confers a survival advantage, is unclear.

Published
2024
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28. Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia

Author

Stasik, Sebastian, Eckardt, Jan-Niklas, Kramer, Michael, Röllig, Christoph, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan, Herbst, Regina, Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Rácil, Zdenek, Platzbecker, Uwe, Berdel, Wolfgang E., Mayer, Jiri, Serve, Hubert, Müller-Tidow, Carsten, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Middeke, Jan M., and Thiede, Christian

Published
2021
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31. Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response

Author

Scheller, Marina, Ludwig, Anne Kathrin, Göllner, Stefanie, Rohde, Christian, Krämer, Stephen, Stäble, Sina, Janssen, Maike, Müller, James-Arne, He, Lixiazi, Bäumer, Nicole, Arnold, Christian, Gerß, Joachim, Schönung, Maximilian, Thiede, Christian, Niederwieser, Christian, Niederwieser, Dietger, Serve, Hubert, Berdel, Wolfgang E., Thiem, Ulrich, Hemmerling, Inga, Leuschner, Florian, Plass, Christoph, Schlesner, Matthias, Zaugg, Judith, Milsom, Michael D., Trumpp, Andreas, Pabst, Caroline, Lipka, Daniel B., and Müller-Tidow, Carsten

Published
2021
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33. Prognostic impact of CEBPA mutational subgroups in adult AML

Author

Georgi, Julia Annabell, Stasik, Sebastian, Kramer, Michael, Meggendorfer, Manja, Röllig, Christoph, Haferlach, Torsten, Valk, Peter, Linch, David, Herold, Tobias, Duployez, Nicolas, Taube, Franziska, Middeke, Jan Moritz, Platzbecker, Uwe, Serve, Hubert, Baldus, Claudia D., Muller-Tidow, Carsten, Haferlach, Claudia, Koch, Sarah, Berdel, Wolfgang E., Woermann, Bernhard J., Krug, Utz, Braess, Jan, Hiddemann, Wolfgang, Spiekermann, Karsten, Boertjes, Emma L., Hills, Robert K., Burnett, Alan, Ehninger, Gerhard, Metzeler, Klaus, Rothenberg-Thurley, Maja, Dufour, Annika, Dombret, Hervé, Pautas, Cecile, Preudhomme, Claude, Fenwarth, Laurene, Bornhäuser, Martin, Gale, Rosemary, Thiede, Christian, Georgi, Julia Annabell, Stasik, Sebastian, Kramer, Michael, Meggendorfer, Manja, Röllig, Christoph, Haferlach, Torsten, Valk, Peter, Linch, David, Herold, Tobias, Duployez, Nicolas, Taube, Franziska, Middeke, Jan Moritz, Platzbecker, Uwe, Serve, Hubert, Baldus, Claudia D., Muller-Tidow, Carsten, Haferlach, Claudia, Koch, Sarah, Berdel, Wolfgang E., Woermann, Bernhard J., Krug, Utz, Braess, Jan, Hiddemann, Wolfgang, Spiekermann, Karsten, Boertjes, Emma L., Hills, Robert K., Burnett, Alan, Ehninger, Gerhard, Metzeler, Klaus, Rothenberg-Thurley, Maja, Dufour, Annika, Dombret, Hervé, Pautas, Cecile, Preudhomme, Claude, Fenwarth, Laurene, Bornhäuser, Martin, Gale, Rosemary, and Thiede, Christian

Abstract

Despite recent refinements in the diagnostic and prognostic assessment of CEBPA mutations in AML, several questions remain open, i.e. implications of different types of basic region leucin zipper (bZIP) mutations, the role of co-mutations and the allelic state. Using pooled primary data analysis on 1010 CEBPA-mutant adult AML patients, a comparison was performed taking into account the type of mutation (bZIP: either typical in-frame insertion/deletion (InDel) mutations (bZIP InDel), frameshift InDel or nonsense mutations inducing translational stop (bZIP STOP) or single base-pair missense alterations (bZIP ms), and transcription activation domain (TAD) mutations) and the allelic state (single (smCEBPA) vs. double mutant (dmCEBPA)). Only bZIP InDel patients had significantly higher rates of complete remission and longer relapse free and overall survival (OS) compared with all other CEBPA-mutant subgroups. Moreover, co-mutations in bZIP InDel patients (e.g. GATA2, FLT3, WT1 as well as ELN2022 adverse risk aberrations) had no independent impact on OS, whereas in non-bZIP InDel patients, grouping according to ELN2022 recommendations added significant prognostic information. In conclusion, these results demonstrate bZIP InDel mutations to be the major independent determinant of outcome in CEBPA-mutant AML, thereby refining current classifications according to WHO (including all dmCEBPA and smCEBPA bZIP) as well as ELN2022 and ICC recommendations (including CEBPA bZIP ms). (Figure presented.)

Published
2024

34. Deep learning predicts therapy-relevant genetics in acute myeloid leukemia from Pappenheim-stained bone marrow smears

Author

Kockwelp, Jacqueline, primary, Thiele, Sebastian, additional, Bartsch, Jannis, additional, Haalck, Lars, additional, Gromoll, Jörg, additional, Schlatt, Stefan, additional, Exeler, Rita, additional, Bleckmann, Annalen, additional, Lenz, Georg, additional, Wolf, Sebastian, additional, Steffen, Björn, additional, Berdel, Wolfgang E., additional, Schliemann, Christoph, additional, Risse, Benjamin, additional, and Angenendt, Linus, additional

Published
2023
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35. Sex-associated differences in frequencies and prognostic impact of recurrent genetic alterations in adult acute myeloid leukemia (Alliance, AMLCG)

Author

Ozga, Michael, primary, Nicolet, Deedra, additional, Mrózek, Krzysztof, additional, Yilmaz, Ayse S., additional, Kohlschmidt, Jessica, additional, Larkin, Karilyn T., additional, Blachly, James S., additional, Oakes, Christopher C., additional, Buss, Jill, additional, Walker, Christopher J., additional, Orwick, Shelley, additional, Jurinovic, Vindi, additional, Rothenberg-Thurley, Maja, additional, Dufour, Annika, additional, Schneider, Stephanie, additional, Sauerland, Maria Cristina, additional, Görlich, Dennis, additional, Krug, Utz, additional, Berdel, Wolfgang E., additional, Woermann, Bernhard J., additional, Hiddemann, Wolfgang, additional, Braess, Jan, additional, Subklewe, Marion, additional, Spiekermann, Karsten, additional, Carroll, Andrew J., additional, Blum, William G., additional, Powell, Bayard L., additional, Kolitz, Jonathan E., additional, Moore, Joseph O., additional, Mayer, Robert J., additional, Larson, Richard A., additional, Uy, Geoffrey L., additional, Stock, Wendy, additional, Metzeler, Klaus H., additional, Grimes, H. Leighton, additional, Byrd, John C., additional, Salomonis, Nathan, additional, Herold, Tobias, additional, Mims, Alice S., additional, and Eisfeld, Ann-Kathrin, additional

Published
2023
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36. Prevalence and clinical impact of CD56 and T‐cell marker expression in acute myeloid leukaemia: A single‐centre retrospective analysis

Author

Shaforostova, Inna, primary, Call, Simon, additional, Evers, Georg, additional, Reicherts, Christian, additional, Angenendt, Linus, additional, Stelljes, Matthias, additional, Berdel, Wolfgang E., additional, Pohlmann, Alexander, additional, Mikesch, Jan‐Henrik, additional, Rosenbauer, Frank, additional, Lenz, Georg, additional, Schliemann, Christoph, additional, and Wethmar, Klaus, additional

Published
2023
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37. Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia

Author

Herold, Tobias, Rothenberg-Thurley, Maja, Grunwald, Victoria V., Janke, Hanna, Goerlich, Dennis, Sauerland, Maria C., Konstandin, Nikola P., Dufour, Annika, Schneider, Stephanie, Neusser, Michaela, Ksienzyk, Bianka, Greif, Philipp A., Subklewe, Marion, Faldum, Andreas, Bohlander, Stefan K., Braess, Jan, Wörmann, Bernhard, Krug, Utz, Berdel, Wolfgang E., Hiddemann, Wolfgang, Spiekermann, Karsten, and Metzeler, Klaus H.

Published
2020
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38. Author Correction: Loss-of-function uORF mutations in human malignancies

Author

Schulz, Julia, Mah, Nancy, Neuenschwander, Martin, Kischka, Tabea, Ratei, Richard, Schlag, Peter M., Castaños-Vélez, Esmeralda, Fichtner, Iduna, Tunn, Per-Ulf, Denkert, Carsten, Klaas, Oliver, Berdel, Wolfgang E., von Kries, Jens P., Makalowski, Wojciech, Andrade-Navarro, Miguel A., Leutz, Achim, and Wethmar, Klaus

Published
2021
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40. Clinical presentation and differential splicing of SRSF2, U2AF1 and SF3B1 mutations in patients with acute myeloid leukemia

Author

Bamopoulos, Stefanos A., Batcha, Aarif M. N., Jurinovic, Vindi, Rothenberg-Thurley, Maja, Janke, Hanna, Ksienzyk, Bianka, Philippou-Massier, Julia, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Schneider, Stephanie, Konstandin, Nikola, Sauerland, Maria Cristina, Görlich, Dennis, Berdel, Wolfgang E., Woermann, Bernhard J., Bohlander, Stefan K., Canzar, Stefan, Mansmann, Ulrich, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten, Metzeler, Klaus H., and Herold, Tobias

Published
2020
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41. Monitoring minimal residual/relapsing disease after allogeneic haematopoietic stem cell transplantation in adult patients with acute lymphoblastic leukaemia

Author

Wethmar, Klaus, Matern, Svenja, Eßeling, Eva, Angenendt, Linus, Pfeifer, Heike, Brüggemann, Monika, Stelmach, Patrick, Call, Simon, Albring, Jörn C., Mikesch, Jan-Henrik, Reicherts, Christian, Groth, Christoph, Schliemann, Christoph, Berdel, Wolfgang E., Lenz, Georg, and Stelljes, Matthias

Published
2020
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42. The clinical mutatome of core binding factor leukemia

Author

Opatz, Sabrina, Bamopoulos, Stefanos A., Metzeler, Klaus H., Herold, Tobias, Ksienzyk, Bianka, Bräundl, Kathrin, Tschuri, Sebastian, Vosberg, Sebastian, Konstandin, Nikola P., Wang, Christine, Hartmann, Luise, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Schneider, Stephanie, Thiede, Christian, Middeke, Jan Moritz, Stölzel, Friedrich, Röllig, Christoph, Schetelig, Johannes, Ehninger, Gerhard, Krämer, Alwin, Braess, Jan, Görlich, Dennis, Sauerland, Maria Cristina, Berdel, Wolfgang E., Wörmann, Bernhard J., Hiddemann, Wolfgang, Spiekermann, Karsten, Bohlander, Stefan K., and Greif, Philipp A.

Published
2020
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43. The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia

Author

Angenendt, Linus, Bormann, Eike, Pabst, Caroline, Alla, Vijay, Görlich, Dennis, Braun, Leonie, Dohlich, Kim, Schwöppe, Christian, Bohlander, Stefan K., Arteaga, Maria Francisca, Wethmar, Klaus, Hartmann, Wolfgang, Angenendt, Adrian, Kessler, Torsten, Mesters, Rolf M., Stelljes, Matthias, Rothenberg-Thurley, Maja, Spiekermann, Karsten, Hébert, Josée, Sauvageau, Guy, Valk, Peter J. M., Löwenberg, Bob, Serve, Hubert, Müller-Tidow, Carsten, Lenz, Georg, Wörmann, Bernhard J., Sauerland, M. Christina, Hiddemann, Wolfgang, Berdel, Wolfgang E., Krug, Utz, Metzeler, Klaus H., Mikesch, Jan-Henrik, Herold, Tobias, and Schliemann, Christoph

Published
2019
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45. Germline variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Author

Frank, Daria, primary, Patnana, Pradeep Kumar, additional, Vorwerk, Jan, additional, Mao, Lianghao, additional, Mokada Gopal, Lavanya, additional, Jung, Noelle, additional, Hennig, Thorben, additional, Ruhnke, Leo, additional, Frenz, Joris Maximillian, additional, Kuppusamy, Maithreyan, additional, Autry, Robert J, additional, Wei, Lanying, additional, Sun, Kaiyan, additional, Ahmed, Helal, additional, Künstner, Axel, additional, Busch, Hauke, additional, Müller, Heiko, additional, Hutter, Stephan, additional, Hoermann, Gregor, additional, Liu, Longlong, additional, Xie, Xiaoqing, additional, Al-Matary, Yahya, additional, Nimmagadda, Subbaiah Chary, additional, Charles Cano, Fiorella, additional, Heuser, Michael, additional, Thol, Felicitas R., additional, Göhring, Gudrun, additional, Steinemann, Doris, additional, Thomale, Jürgen, additional, Leitner, Theo, additional, Fischer, Anja, additional, Rad, Roland, additional, Röllig, Christoph, additional, Altmann, Heidi, additional, Kunadt, Desiree, additional, Berdel, Wolfgang E., additional, Hüve, Jana, additional, Neumann, Felix, additional, Klingauf, Jürgen, additional, Calderon, Virginie, additional, Opalka, Bertram, additional, Dührsen, Ulrich, additional, Rosenbauer, Frank, additional, Dugas, Martin, additional, Varghese, Julian, additional, Reinhardt, H. Christian H., additional, von Bubnoff, Nikolas, additional, Möröy, Tarik, additional, Lenz, Georg, additional, Batcha, Aarif M.N., additional, Giorgi, Marianna, additional, Selvam, Murugan, additional, Wang, Eunice S., additional, McWeeney, Shannon K., additional, Tyner, Jeffrey W., additional, Stölzel, Friedrich, additional, Mann, Matthias, additional, Jayavelu, Ashok Kumar, additional, and Khandanpour, Cyrus, additional

Published
2023
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46. P446: COMPREHENSIVE CHARACTERIZATION OF DIFFERENTIAL GENE EXPRESSION AND ISOFORM USAGE IN SPLICING FACTOR-MUTATED ACUTE MYELOID LEUKEMIA USING LONG-READ SEQUENCING

Author

Thieme, Susanne, primary, Graf, Alexander, additional, Krebs, Stefan, additional, Blum, Helmut, additional, Solovey, Maria, additional, Ziemann, Frank, additional, Christ, Jonathan, additional, Rothenberg-Thurley, Maja, additional, Dufour, Annika, additional, Schneider, Stephanie, additional, Cristina Sauerland, Maria, additional, Görlich, Dennis, additional, Krug, Utz, additional, Berdel, Wolfgang E., additional, Wörmann, Bernhard, additional, Hiddemann, Wolfgang, additional, Braess, Jan, additional, Spiekermann, Karsten, additional, Metzeler, Klaus, additional, Mannsmann, Ulrich, additional, and Herold, Tobias, additional

Published
2023
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47. P434: MYELODYSPLASIA-RELATED MUTATIONS IN THE NEW ELN CLASSIFICATION: DOES CLONAL SIZE PLAY A ROLE?

Author

Rausch, Christian, primary, Rothenberg-Thurley, Maja, additional, Dufour, Annika, additional, Schneider, Stephanie, additional, Gittinger, Hanna, additional, Sauerland, Cristina, additional, Görlich, Dennis, additional, Krug, Utz, additional, Berdel, Wolfgang E., additional, Woermann, Bernhard J., additional, Hiddemann, Wolfgang, additional, Braess, Jan, additional, von Bergwelt-Baildon, Michael, additional, Spiekermann, Karsten, additional, Herold, Tobias, additional, and Metzeler, Klaus H., additional

Published
2023
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48. P457: COMPLEX CARYOTYPE IS AN INDEPENDENT RISK FACTOR IN TP53-MUTATED AML

Author

Rausch, Christian, primary, Rothenberg-Thurley, Maja, additional, Dufour, Annika, additional, Schneider, Stephanie, additional, Gittinger, Hanna, additional, Sauerland, Cristina, additional, Görlich, Dennis, additional, Krug, Utz, additional, Berdel, Wolfgang E., additional, Woermann, Bernhard E., additional, Hiddemann, Wolfgang, additional, Braess, Jan, additional, von Bergwelt-Baildon, Michael, additional, Spiekermann, Karsten, additional, Herold, Tobias, additional, and Metzeler, Klaus H., additional

Published
2023
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49. Long-term efficacy of reduced-intensity versus myeloablative conditioning before allogeneic haemopoietic cell transplantation in patients with acute myeloid leukaemia in first complete remission: retrospective follow-up of an open-label, randomised phase 3 trial

Author

Fasslrinner, Frederick, Schetelig, Johannes, Burchert, Andreas, Kramer, Michael, Trenschel, Rudolf, Hegenbart, Ute, Stadler, Michael, Schäfer-Eckart, Kerstin, Bätzel, Michael, Eich, Hans, Stuschke, Martin, Engenhart-Cabillic, Rita, Krause, Mechthild, Dreger, Peter, Neubauer, Andreas, Ehninger, Gerhard, Beelen, Dietrich, Berdel, Wolfgang E, Siepmann, Timo, Stelljes, Matthias, and Bornhäuser, Martin

Published
2018
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