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8. Biological and Environmental Research Exascale Requirements Review. An Office of Science review sponsored jointly by Advanced Scientific Computing Research and Biological and Environmental Research, March 28-31, 2016, Rockville, Maryland

Author

Arkin, Adam, Bader, David C, Coffey, Richard, Antypas, Katie, Bard, Deborah, Dart, Eli, Dosanjh, Sudip, Gerber, Richard, Hack, James, Monga, Inder, Papka, Michael E, Riley, Katherine, Rotman, Lauren, Straatsma, Tjerk, Wells, Jack, Aluru, Srinivas, Andersen, Amity, Aprá, Edoardo, Azad, Ariful, Bates, Susan, Blaby, Ian, Blaby-Haas, Crysten, Bonneau, Rich, Bowen, Ben, Bradford, Mark A, Brodie, Eoin, Brown, James Ben, Buluc, Aydin, Bernholdt, David, Bylaska, Eric, Calvin, Kate, Cannon, Bill, Chen, Xingyuan, Cheng, Xiaolin, Cheung, Margaret, Chowdhary, Kenny, Colella, Phillip, Collins, Bill, Compo, Gil, Crowley, Mike, Debusschere, Bert, D’Imperio, Nicholas, Dror, Ron, Egan, Rob, Evans, Katherine, Friedberg, Iddo, Fyke, Jeremy, Gao, Zheng, Georganas, Evangelos, Giraldo, Frank, Gnanakaran, Gnana, Govind, Niri, Grandy, Stuart, Gustafson, Bill, Hammond, Glenn, Hargrove, William, Heroux, Michael, Hoffman, Forrest, Hofmeyr, Steven, Hunke, Elizabeth, Jackson, Charles, Jacob, Rob, Jacobson, Dan, Jacobson, Matt, Jain, Chirag, Johansen, Hans, Johnson, Jeff, Jones, Andy, Jones, Phil, Kalyanaraman, Ananth, Kang, Senghwa, King, Eric, Koanantakool, Penporn, Kollias, Pavlos, Kopera, Michal, Kotamarthi, Rao, Kowalski, Karol, Kumar, Jitendra, Kyrpides, Nikos, Leung, Ruby, Li, Xiaolin, Lin, Wuyin, Link, Robert, Liu, Yangang, Loew, Leslie, Luke, Edward, Ma, Hsi-Yen, Mahadevan, Radhakrishnan, Maranas, Costas, Martin, Daniel, Maslowski, Wieslaw, McCue, Lee Ann, McInnes, Lois Curfman, Mills, Richard, Molins Rafa, Sergi, Morozov, Dmitriy, Mostafavi, Sara, Moulton, David J, Mourao, Zenaida, and Najm, Habib

Published
2022

10. Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome

Author

Vadivel, Chella Krishna, Willerslev-Olsen, Andreas, Namini, Martin R. J., Zeng, Ziao, Yan, Lang, Danielsen, Maria, Gluud, Maria, Pallesen, Emil M. H., Wojewoda, Karolina, Osmancevic, Amra, Hedebo, Signe, Chang, Yun-Tsan, Lindahl, Lise M., Koralov, Sergei B., Geskin, Larisa J., Bates, Susan E., Iversen, Lars, Litman, Thomas, Bech, Rikke, Wobser, Marion, Guenova, Emmanuella, Kamstrup, Maria R., Ødum, Niels, and Buus, Terkild B.

Published
2024
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11. Malodour classification with low-cost flexible electronics

Author

Ozer, Emre, Kufel, Jedrzej, Biggs, John, Rana, Anjit, Rodriguez, Francisco J., Lee-Clark, Thomas, Sou, Antony, Ramsdale, Catherine, White, Scott, Garlapati, Suresh Kumar, Valliappan, Palaniappan, Rahmanudin, Aiman, Komanduri, Venuskrishnan, Saez, Glenn Sunley, Gollu, Sankara, Brown, Gavin, Dudek, Piotr, Persaud, Krishna C., Turner, Michael L., Murray, Stephanie, Bates, Susan, Treloar, Robert, Newby, Brian, and Ford, Jane

Published
2023
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14. Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Akce, Mehmet, Ales Diaz, Inmaculada, Alves, Gustavo, Anand, Sumitra, Arslan, Cagatay, Asselah, Jamil, Assenat, Eric, Aubin, Francine, Bai, Li-Yuan, Bai, Yuxian, Barajas, Olga, Bates, Susan, Begbie, Stephen, Ben-Aharon, Irit, Beri, Nina, Berres, Marie-Luise, Blanc, Jean-Frederic, Borbath, Ivan, Bordonaro, Robert, Bouattour, Mohamed, Brandi, Giovanni, Burgoyne, Adam, Butthongkomvong, Kritiya, Camandaroba, Marcos, Cao, Ke, Carballido, Marcela, Chan, Stephan Lam, Chen, Jen-Shi, Chen, Ming-Huang, Chen, Xiaoming, Cheng, Ashley, Chiu, Tai-Jan, Choi, Hye Jin, Chon, Hong Jae, Collignon, Joelle, Cubillo Gracian, Antonio, Davis, Sarah, de Carvalho, Ricardo Saraiva, de Groot, D.J.A., Demols, Anne, De Vos, Judith, Diab, Maria, Easaw, Jacob, Eatock, Martin, Edeline, Julien, Elias, Rawad, Eskens, Fredericus, Falcone, Alfredo, Fernandez, Plinio, Finn, Richard, Franke, Fabio, Furukawa, Masayuki, Furuse, Junji, Gbolahan, Olumide, Geboes, Karen, Geneser, Keri-Lee, Geng, Zhimin, Geva, Ravit, Gillmore, Roopinder, Goetze, Thorsten, Gou, Hongfeng, Grasselli, Julieta, Gu, Shanzhi, Gumus, Mahmut, Haj Mohammad, Nadia, Hao, Chunyi, Harputluoglu, Hakan, Hatoum, Hassan, Heinemann, Volker, Ho, Wang Kwong, Hsu, Chiun, Hubert, Ayala, Hwang, Juneul, Inanc, Mevlude, Iseas, Soledad, Jeyasingam, Vaishnavi, Jimenez Fonseca, Paula, Joubert, Warren, Juengsamarn, Jitlada, Kaen, Diego, Kanai, Masashi, Kasper-Virchow, Stefan, Kazemi, Ghazaleh, Kelleher, Fergal, Kelley, Robin, Kim, Jin Won, Kim, Jong Gwang, Kinupe Abrahao, Ana Beatriz, Klumpen, Heinz, Kochenderfer, Mark, Kose, Fatih, Lam, Ho Ching, Lee, Choong-kun, Lee, Hyun Woo, Lee, Margaret, Lee, Myung Ah, Lee, Wai Man Sarah, Le Sourd, Samuel, Li, Dongliang, Li, Wei, Liang, Houjie, Liang, Tingbo, Lim, Chun Sen, Lingerfelt, Brian, Lopez, Charles, Low, John, Macarulla Mercade, Teresa, Malka, David, Mao, Yimin, Masi, Gianluca, McCune, Steven, McDermott, Ray, McWhirter, Elaine, Mendez, Guillermo, Milella, Michele, Mizuno, Nobumasa, Mizutani, Tomonori, Moniz, Camila, Morales, Luisa, Munoz Martin, Andres Jesús, Nervi, Bruno, Ngamphaiboon, Nuttapong, Oh, Sang Cheul, Oksuzoglu, Berna, Outlaw, Darryl, Ozaka, Masato, Ozguroglu, Mustafa, Ozyilkan, Ozgur, Painemal, Claudio, Pan, Yueyin, Park, Joon Oh, Pelzer, Uwe, Peng, Chuang, Petorin, Caroline, Pezet, Denis, Power, Derek, Qin, Shukui, Ren, Zhenggang, Roohullah, Aflah, Ryu, Hyewon, Salman, Pamela, Sasaki, Mitsuhito, Sasidharan, Rita, Satoh, Taroh, Schulze, Kornelius, Scott-Brown, Martin, Segovia, Ruben, Seufferlein, Thomas, Siena, Salvatore, Sinapi, Isabelle, Smolenschi, Cristina, Song, Tianqiang, Sookprasert, Aumkhae, Soparattanapaisarn, Nopadol, Starling, Naureen, Stein, Stacey, Stemmer, Salomon, Su, Haichuan, Sugimoto, Rie, Suksombooncharoen, Thatthan, Tam, Vincent, Tan, Ai Lian, Tan, Chih Kiang, Tanasanvimon, Suebpong, Tonini, Giuseppe, Tortora, Giampaolo, Tsuji, Akihito, Ueno, Makoto, Uribe, Rodrigo, Venerito, Marino, Verdaguer Mata, Helena, Verslype, Chris, Victorino, Ana Paula, Vogel, Arndt, Wade, James, Waldschmidt, Dirk Thomas, Wang, Lu, Wan Isahk, Wan Zamaniah, Wasan, Harpeet, Weschenfelder, Rui, Wong, Chun Yin, Wong, Yoke Fui, Yalcin, Suayib, Yanez Weber, Patricio, Yang, Xuezhong, Yasui, Hisateru, Yau, Thomas, Yazici, Ozan, Yen, Chia-Jui, Ying, Jieer, Yoo, Changhoon, Yu, Wenchang, Zhao, Haitao, Kelley, Robin Kate, Finn, Richard S, Klümpen, Heinz-Josef, Chan, Stephen L, Valle, Juan W, Yu, Li, Malhotra, Usha, and Siegel, Abby B

Published
2023
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15. Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

Author

Van Cutsem, Eric, Tempero, Margaret A, Sigal, Darren, Oh, Do-Youn, Fazio, Nicola, Macarulla, Teresa, Hitre, Erika, Hammel, Pascal, Hendifar, Andrew E, Bates, Susan E, Li, Chung-Pin, Hingorani, Sunil R, de la Fouchardiere, Christelle, Kasi, Anup, Heinemann, Volker, Maraveyas, Anthony, Bahary, Nathan, Layos, Laura, Sahai, Vaibhav, Zheng, Lei, Lacy, Jill, Park, Joon Oh, Portales, Fabienne, Oberstein, Paul, Wu, Wilson, Chondros, Dimitrios, and Bullock, Andrea J

Subjects
Clinical Research, Rare Diseases, Clinical Trials and Supportive Activities, Pancreatic Cancer, Digestive Diseases, Cancer, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Albumins, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Pancreatic Ductal, Deoxycytidine, Disease Progression, Double-Blind Method, Fatigue, Female, Humans, Hyaluronic Acid, Hyaluronoglucosaminidase, Hyponatremia, Male, Middle Aged, Paclitaxel, Pancreatic Neoplasms, Progression-Free Survival, Response Evaluation Criteria in Solid Tumors, Spasm, Survival Rate, HALO 109-301 Investigators, Gemcitabine, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeTo evaluate the efficacy and safety of pegvorhyaluronidase alfa (PEGPH20) plus nab-paclitaxel/gemcitabine (AG) in patients with hyaluronan-high metastatic pancreatic ductal adenocarcinoma (PDA).Patients and methodsHALO 109-301 was a phase III, randomized, double-blind, placebo-controlled study. Patients ≥ 18 years of age with untreated, metastatic, hyaluronan-high PDA were randomly assigned 2:1 to PEGPH20 plus AG or placebo plus AG. Treatment was administered intravenously in 4-week cycles (3 weeks on, 1 week off) until progression or intolerable adverse events: PEGPH20 3.0 µg/kg twice per week for cycle 1 and once per week thereafter; nab-paclitaxel 125 mg/m2 once per week; and gemcitabine 1,000 mg/m2 once per week. The primary end point was overall survival (OS); secondary end points included progression-free survival (PFS), objective response rate (ORR), and safety. Response was independently assessed per RECIST v1.1.ResultsAt data cutoff, 494 patients were randomly assigned, with 492 (327 for PEGPH20 and 165 for placebo) included in intention-to-treat analyses. Baseline characteristics were balanced for PEGPH20 plus AG versus placebo plus AG. There were 330 deaths, with a median OS of 11.2 months for PEGPH20 plus AG versus 11.5 months for placebo plus AG (hazard ratio [HR], 1.00; 95% CI, 0.80 to 1.27; P = .97); median PFS was 7.1 months versus 7.1 months (HR, 0.97 [95% CI, 0.75 to 1.26]); ORR was 47% versus 36% (ORR ratio, 1.29 [95% CI, 1.03 to 1.63]). Grade ≥ 3 adverse events with a ≥ 2% higher rate with PEGPH20 plus AG than with placebo plus AG included fatigue (16.0% v 9.6%), muscle spasms (6.5% v 0.6%), and hyponatremia (8.0% v 3.8%).ConclusionThe addition of PEGPH20 to AG increased the ORR but did not improve OS or PFS. The safety profile of PEGPH20 plus AG was consistent with that found in previous studies. These results do not support additional development of PEGPH20 in metastatic PDA.

Published
2020

17. Supplemental Table S5 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Author

Robey, Robert W., primary, Fitzsimmons, Christina M., primary, Guiblet, Wilfried M., primary, Frye, William J.E., primary, González Dalmasy, José M., primary, Wang, Li, primary, Russell, Drake A., primary, Huff, Lyn M., primary, Perciaccante, Andrew J., primary, Ali-Rahmani, Fatima, primary, Lipsey, Crystal C., primary, Wade, Heidi M., primary, Mitchell, Allison V., primary, Maligireddy, Siddhardha S., primary, Terrero, David, primary, Butcher, Donna, primary, Edmondson, Elijah F., primary, Jenkins, Lisa M., primary, Nikitina, Tatiana, primary, Zhurkin, Victor B., primary, Tiwari, Amit K., primary, Piscopio, Anthony D., primary, Totah, Rheem A., primary, Bates, Susan E., primary, Arda, H. Efsun, primary, Gottesman, Michael M., primary, and Batista, Pedro J., primary

Published
2024
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18. Figure S3 from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Author

Robey, Robert W., primary, Fitzsimmons, Christina M., primary, Guiblet, Wilfried M., primary, Frye, William J.E., primary, González Dalmasy, José M., primary, Wang, Li, primary, Russell, Drake A., primary, Huff, Lyn M., primary, Perciaccante, Andrew J., primary, Ali-Rahmani, Fatima, primary, Lipsey, Crystal C., primary, Wade, Heidi M., primary, Mitchell, Allison V., primary, Maligireddy, Siddhardha S., primary, Terrero, David, primary, Butcher, Donna, primary, Edmondson, Elijah F., primary, Jenkins, Lisa M., primary, Nikitina, Tatiana, primary, Zhurkin, Victor B., primary, Tiwari, Amit K., primary, Piscopio, Anthony D., primary, Totah, Rheem A., primary, Bates, Susan E., primary, Arda, H. Efsun, primary, Gottesman, Michael M., primary, and Batista, Pedro J., primary

Published
2024
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19. Data from The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Author

Robey, Robert W., primary, Fitzsimmons, Christina M., primary, Guiblet, Wilfried M., primary, Frye, William J.E., primary, González Dalmasy, José M., primary, Wang, Li, primary, Russell, Drake A., primary, Huff, Lyn M., primary, Perciaccante, Andrew J., primary, Ali-Rahmani, Fatima, primary, Lipsey, Crystal C., primary, Wade, Heidi M., primary, Mitchell, Allison V., primary, Maligireddy, Siddhardha S., primary, Terrero, David, primary, Butcher, Donna, primary, Edmondson, Elijah F., primary, Jenkins, Lisa M., primary, Nikitina, Tatiana, primary, Zhurkin, Victor B., primary, Tiwari, Amit K., primary, Piscopio, Anthony D., primary, Totah, Rheem A., primary, Bates, Susan E., primary, Arda, H. Efsun, primary, Gottesman, Michael M., primary, and Batista, Pedro J., primary

Published
2024
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20. The Impact of Noise in Early Childhood Settings: A New Zealand Perspective

Author

Bates, Susan, Page, Wyatt, and Stover, Sue

Abstract

Excessive noise levels in early childhood centres have a direct impact on the learning of young children, as well as on the wellbeing of teachers. Psycho-acoustic studies show that noise is a key factor contributing to elevated adult stress levels and annoyance, leading to lower levels of adult sensitivity to children's needs and fewer direct interactions with them. Longer term, local and international research indicates correlations between excessive noise in early childhood education (ECE) centres and health problems, such as to hearing loss, voice strain, obesity, diabetes, and cardiac conditions. Noise as a chaos factor in early childhood settings undermines wellbeing of both adults and children. Because noise negatively impacts on quality relationship and communication, children's language development is also impacted. Yet noise within New Zealand early childhood settings is under-researched, under-regulated, and under-monitored. Drawing on local and international research and on a survey of New Zealand early childhood teachers, this article recommends regulating for the creation of quieter environments for the benefit of teachers and learners, the adults and children in early childhood settings.

Published
2021
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22. Contribution of neoadjuvant chemotherapy and radiation therapy (intensity-modulated radiation therapy with concurrent chemotherapy versus stereotactic body radiation therapy alone) on tumor volume regression in patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma: A single institution experience.

Author

Jamison, Jacob K., primary, Cho, Hope, additional, May, Michael S., additional, Luk, Lyndon, additional, Flusberg, Milana, additional, Kobi, Mariya, additional, Beylergil, Volkan, additional, Skorohodova, Ksenia, additional, Raufi, Alexander G, additional, Horowitz, David Paul, additional, Kluger, Michael D., additional, Pan, Samuel M, additional, Kachnic, Lisa A., additional, Schrope, Beth, additional, Bates, Susan Elaine, additional, White, Ruth Aroon, additional, Moy, Ryan H., additional, Wu, Linda, additional, Chabot, John A., additional, and Manji, Gulam Abbas, additional

Published
2024
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23. Abstract PR05: CheMo4METPANC: Combination Chemotherapy (gemcitabine and nab-paclitaxel), chemokine (C-X-C) Motif receptor 4 inhibitor (motixafortide), and immune checkpoint blockade (cemiplimab) in METastatic treatment-naïve PANCreatic adenocarcinoma

Author

Manji, Gulam A., primary, May, Michael, additional, Chalabi, Morteza Hajkarim, additional, Pellicciotta, Ilenia, additional, Sta Ana, Sarah I., additional, Sender, Naomi, additional, Pan, Samuel S., additional, Ross, Isabelle V., additional, Olive, Kenneth P., additional, Wang, Shikun, additional, Izar, Benjamin, additional, White, Ruth A., additional, Bates, Susan E., additional, and Raufi, Alexander G., additional

Published
2024
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25. A simple approach to determining the efficacy of antiperspirants using paper-based colorimetric paper sensors: SweatSENSE

Author

Hand, Rachel A., primary, Efstathiou, Spyridon, additional, Wemyss, Alan M., additional, Grypioti, Maria, additional, Kirby, Gavin, additional, Barlow, Tammie, additional, Cullen Tinley, Emmett, additional, Ford, Jane, additional, Jamieson, Andy, additional, Reynolds, Janette, additional, Miller, Jean, additional, Bates, Susan, additional, Khoshdel, Ezat, additional, and Haddleton, David M., additional

Published
2024
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27. Dapper doll.

Author

BATES, SUSAN and CLAIRE

Published
2024

30. Assessing the Eventual Publication of Clinical Trial Abstracts Submitted to a Large Annual Oncology Meeting

Author

Massey, Paul R, Wang, Ruibin, Prasad, Vinay, Bates, Susan E, and Fojo, Tito

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Clinical Research, Clinical Trials and Supportive Activities, Antineoplastic Agents, Clinical Trials as Topic, Humans, Medical Oncology, Neoplasms, Publications, Publishing, Societies, Medical, Oncology clinical trials, ClinicalTrials.gov, Publication rates, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundDespite the ethical imperative to publish clinical trials when human subjects are involved, such data frequently remain unpublished. The objectives were to tabulate the rate and ascertain factors associated with eventual publication of clinical trial results reported as abstracts in the Proceedings of the American Society of Clinical Oncology (American Society of Clinical Oncology).Materials and methodsAbstracts describing clinical trials for patients with breast, lung, colorectal, ovarian, and prostate cancer from 2009 to 2011 were identified by using a comprehensive online database (http://meetinglibrary.asco.org/abstracts). Abstracts included reported results of a treatment or intervention assessed in a discrete, prospective clinical trial. Publication status at 4-6 years was determined by using a standardized search of PubMed. Primary outcomes were the rate of publication for abstracts of randomized and nonrandomized clinical trials. Secondary outcomes included factors influencing the publication of results.ResultsA total of 1,075 abstracts describing 378 randomized and 697 nonrandomized clinical trials were evaluated. Across all years, 75% of randomized and 54% of nonrandomized trials were published, with an overall publication rate of 61%. Sample size was a statistically significant predictor of publication for both randomized and nonrandomized trials (odds ratio [OR] per increase of 100 participants = 1.23 [1.11-1.36], p < .001; and 1.64 [1.15-2.34], p = .006, respectively). Among randomized studies, an industry coauthor or involvement of a cooperative group increased the likelihood of publication (OR 2.37, p = .013; and 2.21, p = .01, respectively). Among nonrandomized studies, phase II trials were more likely to be published than phase I (p < .001). Use of an experimental agent was not a predictor of publication in randomized (OR 0.76 [0.38-1.52]; p = .441) or nonrandomized trials (OR 0.89 [0.61-1.29]; p = .532).ConclusionThis is the largest reported study examining why oncology trials are not published. The data show that 4-6 years after appearing as abstracts, 39% of oncology clinical trials remain unpublished. Larger sample size and advanced trial phase were associated with eventual publication; among randomized trials, an industry-affiliated author or a cooperative group increased likelihood of publication. Unfortunately, we found that, despite widespread recognition of the problem and the creation of central data repositories, timely publishing of oncology clinical trials results remains unsatisfactory.

Published
2016

31. The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Author

Robey, Robert W., primary, Fitzsimmons, Christina M., additional, Guiblet, Wilfried M., additional, Frye, William J.E., additional, González Dalmasy, José M., additional, Wang, Li, additional, Russell, Drake A., additional, Huff, Lyn M., additional, Perciaccante, Andrew J., additional, Ali-Rahmani, Fatima, additional, Lipsey, Crystal C., additional, Wade, Heidi M., additional, Mitchell, Allison V., additional, Maligireddy, Siddhardha S., additional, Terrero, David, additional, Butcher, Donna, additional, Edmondson, Elijah F., additional, Jenkins, Lisa M., additional, Nikitina, Tatiana, additional, Zhurkin, Victor B., additional, Tiwari, Amit K., additional, Piscopio, Anthony D., additional, Totah, Rheem A., additional, Bates, Susan E., additional, Arda, H. Efsun, additional, Gottesman, Michael M., additional, and Batista, Pedro J., additional

Published
2023
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35. Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Author

Giddings, Emily L., Champagne, Devin P., Wu, Meng-Han, Laffin, Joshua M., Thornton, Tina M., Valenca-Pereira, Felipe, Culp-Hill, Rachel, Fortner, Karen A., Romero, Natalia, East, James, Cao, Phoebe, Arias-Pulido, Hugo, Sidhu, Karatatiwant S., Silverstrim, Brian, Kam, Yoonseok, Kelley, Shana, Pereira, Mark, Bates, Susan E., Bunn, Janice Y., Fiering, Steven N., Matthews, Dwight E., Robey, Robert W., Stich, Domink, D’Alessandro, Angelo, and Rincon, Mercedes

Published
2021
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36. Contributors

Author

Agyemang, Amma F., primary, Alsop, Kathryn, additional, Au-Yeung, George, additional, Bates, Susan, additional, Bowtell, David D., additional, Christie, Elizabeth L., additional, Cole, Christopher B., additional, Connolly, Denise C., additional, Craig, Amaranta D., additional, deFazio, Anna, additional, Fereday, Sian, additional, Fojo, Antonio, additional, Freimund, Alison E., additional, Friedlander, Michael, additional, Gao, Bo, additional, Harnett, Paul R., additional, Hoang, Therese, additional, House, Carrie D., additional, Mapagu, Cristina, additional, Moore, Kathleen N., additional, Moujaber, Tania, additional, Odunsi, Kunle O., additional, Peri, Suraj, additional, Pishas, Kathleen, additional, Richardson, Debra L., additional, Sodi, Valerie L., additional, Soragni, Alice, additional, Trivedi, Meghna S., additional, Washington, Christina R., additional, and Waters, Jennifer A., additional

Published
2021
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38. Early Childhood Teacher Health and Wellbeing: Rights, Risks, and Implications

Author

Bates, Susan

Abstract

All workers in New Zealand can expect to have their rights to health implemented in their workplaces. For early childhood teachers, health risks extend to the children they care for, as well as their own offspring. Teachers and carers in daycare and kindergarten are exposed to a range of diseases and sustain various injuries through work practices and environments. Pregnant teachers and those with pre-existing medical conditions are at particular risk of environmental factors such as infection, heavy and repetitive lifting, excessive noise, and poor air quality. Early childhood teachers are also at risk of mental-health problems due to the emotional nature of their work, a high workload and stress levels, poor regulations, and from bullying. Workplace bullying causes both physical and psychological damage, often chronic and long-lasting, which must impact on the quality of crucial relationships with young children.

Published
2018
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39. Assessment of PSA responses and changes in the rate of tumor growth (g-rate)with immune checkpoint inhibitors in US Veterans with prostate cancer

Author

Leuva, Harshraj, Moran, George, Jamaleddine, Nader, Meseha, Mina, Zhou, Mengxi, Im, Yunju, Rosenberg, Ta-Chueh Melody, Park, Yeun-Hee Anna, Luhrs, Carol, Bates, Susan E., and Faiena, Izak

Abstract

We examined data from US Veterans with prostate cancer (PC) to assess disease response to immune checkpoint inhibitors (ICI) as monotherapy or combined with abiraterone or enzalutamide to assess ICI efficacy in the real-world. We queried the VA corporate data warehouse (CDW) to identify Veterans with a diagnosis of PC who received ICI for any malignancy and had ≥1 PSA measurement while receiving ICI. To evaluate ICI monotherapy, we restricted analysis to Veterans who had not received LHRH agonists/antagonists, PC-directed medical therapy, or radiation/extirpative surgery of the bladder/prostate within and preceding the duration of ICI administration. For ICI combination analysis, we identified Veterans who received abiraterone or enzalutamide for PC while on ICI. We calculated rates of tumor (PSA) growth (g-rates), comparing them to a 1:2 matched reference cohort. We identified 787 Veterans with PC and ≥1 PSA measurement while receiving an ICI. Median duration of ICI therapy was 155 days. 223 Veterans received ICI monotherapy, with only 17(8%) having a reduction in PSA (median decline = 43%). 12 (5%) had PSA declines >30% (PSA30) which included 6 (3%) who had PSA reductions greater than 50% (PSA50). Median g-rates for ICI plus abiraterone (n = 20) or enzalutamide (n = 31) were 0.000689/d−1and 0.002819/d−1, respectively, and were statistically insignificant compared to g-rates of matched cohorts receiving abiraterone (g = 0.000925/d−1, P = 0.73) or enzalutamide (g = 0.001929/d−1, P = 0.58) alone. Our data align with clinical trial data in PC, demonstrating limited benefit from ICI monotherapy and predicting no survival benefit from simultaneous abiraterone or enzalutamide with an ICI using g-rate.

Published
2024
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44. The influence of complementary practices and spirituality on British design, 1930-2005

Author

North-Bates, Susan T., Cowdell, Theo, Rust, Chris, and Cunliffe-Charlesworth, Hilary

Subjects
745.209410904
Abstract

This thesis investigates the nature and role of spiritually-influenced approaches to design in Britain in the period 1930-2005. The role of spiritual factors in design is considered as a complement to the predominance of the Modernist rationalist-functionalist discourse prevalent in much twentieth century design history writing and theories of design. Non-rational and spiritual facets of Modernism in this period are also examined. The influence of 'alternative' lifestyles, the New Age movement, ecology, holism, complementary and alternative medical practices, and spirituality on design is presented as a complementary paradigm to the predominance of Modernism. The origins and development of these influences are explored in relation to design and material culture. In order to reveal a body of relevant exemplars, the particular areas selected for detailed examination are the domestic environment, gardens and landscape design, and the influence of Complementary and Alternative Medicine on the design of therapeutic environments. This material, arising from practices of consumption as well as those of designing, challenges some of the established methods of design history and to deal with this, insights from the academic disciplines of Archaeology and Pagan Studies, relating to Shamanic concepts of the object, are explored as useful adjuncts to Postmodernism and other approaches in theorising complementary and alternative design practices. The research demonstrates that during the period under consideration, what was once considered outlandish has now become part of the mainstream and has affected contemporary design practice, material culture and consumption. The pluralism of contemporary design ideologies and methods presents a complement to, and a transformation of the Modernist hegemony in design practice and writing. This study contributes to a more complete historical picture of British design in the twentieth century and indicates that the predominance of a Modernist interpretation of design and its history is both insufficient and inadequate to understand the rich texture and complexity of the design history of this period.

Published
2007

46. Assessment of PSA responses and changes in the rate of tumor growth (g-rate) with immune checkpoint inhibitors in US Veterans with prostate cancer

Author

Leuva, Harshraj, primary, Moran, George, additional, Jammaleddine, Nader, additional, Maseeha, Mina, additional, Zhou, Mengxi, additional, Im, Yunju, additional, Rosenberg, Ta-Chueh, additional, Luhrs, Carol, additional, Bates, Susan, additional, Park, Yeun-Hee, additional, Fojo, Tito, additional, and Faiena, Izak, additional

Published
2023
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47. Abstract CT084: Targeted intra-arterial gemcitabine vs. continuation of IV gemcitabine plus nab-paclitaxel following Induction with sequential IV gemcitabine plus nab-paclitaxel and radiotherapy for unresectable locally advanced pancreatic cancer (TIGeR-PaC) - phase III trial interim analysis

Author

Pishvaian, Michael, primary, Zureikat, Amer, additional, Lopez, Charles, additional, Meredith, Kenneth, additional, Zervos, Emmanuel, additional, Hatoum, Hassan, additional, Chung, Ki, additional, Berg, Daniel J., additional, Ucar, Antonio, additional, Gandhi, Ripal, additional, Nazemzadeh, Reza, additional, Nainesh, Parikh, additional, Novelli, Paula, additional, Kouri, Brian, additional, Laing, Christopher, additional, Boone, Brian, additional, Johnson, Thor, additional, Bates, Susan, additional, Goodman, Karyn, additional, and Agah, Ramtin, additional

Published
2023
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50. Data from R-Loop–Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin

Author

Safari, Maryam, primary, Litman, Thomas, primary, Robey, Robert W., primary, Aguilera, Andrés, primary, Chakraborty, Arup R., primary, Reinhold, William C., primary, Basseville, Agnes, primary, Petrukhin, Lubov, primary, Scotto, Luigi, primary, O'Connor, Owen A., primary, Pommier, Yves, primary, Fojo, Antonio T., primary, and Bates, Susan E., primary

Published
2023
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