1,739 results on '"Barney J"'
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2. Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India
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Chaitra Shankar, Karthick Vasudevan, Jobin John Jacob, Stephen Baker, Barney J. Isaac, Ayyan Raj Neeravi, Dhiviya Prabaa Muthuirulandi Sethuvel, Biju George, and Balaji Veeraraghavan
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hypervirulent ,K. pneumoniae ,ST2096 ,hybrid plasmid ,CRISPR-Cas ,multidrug resistance ,Microbiology ,QR1-502 - Abstract
BackgroundHypervirulent variants of Klebsiella pneumoniae (HvKp) were typically associated with a broadly antimicrobial susceptible clone of sequence type (ST) 23 at the time of its emergence. Concerningly, HvKp is now also emerging within multidrug-resistant (MDR) clones, including ST11, ST15, and ST147. MDR-HvKp either carry both the virulence and resistance plasmids or carry a large hybrid plasmid coding for both virulence and resistance determinants. Here, we aimed to genetically characterize a collection of MDR-HvKp ST2096 isolates haboring hybrid plasmids carrying both antimicrobial resistance (AMR) and virulence genes.MethodsNine K. pneumoniae ST2096 isolated over 1 year from the blood sample of hospitalized patients in southern India that were MDR and suspected to be HvKp were selected. All nine isolates were subjected to short-read whole-genome sequencing; a subset (n = 4) was additionally subjected to long-read sequencing to obtain complete genomes for characterization. Mucoviscosity assay was also performed for phenotypic assessment.ResultsAmong the nine isolates, seven were carbapenem-resistant, two of which carried blaNDM-5 on an IncFII plasmid and five carried blaOXA-232 on a ColKP3 plasmid. The organisms were confirmed as HvKp, with characteristic virulence genes (rmpA2, iutA, and iucABCD) carried on a large (~320 kbp) IncFIB–IncHI1B co-integrate. This hybrid plasmid also carried the aadA2, armA, blaOXA-1, msrE, mphE, sul1, and dfrA14 AMR genes in addition to the heavy-metal resistance genes. The hybrid plasmid showed about 60% similarity to the IncHI1B virulence plasmid of K. pneumoniae SGH10 and ~70% sequence identity with the first identified IncHI1B pNDM-MAR plasmid. Notably, the hybrid plasmid carried its type IV-A3 CRISPR-Cas system which harbored spacer regions against traL of IncF plasmids, thereby preventing their acquisition.ConclusionThe convergence of virulence and AMR is clinically concerning in K. pneumoniae. Our data highlight the role of hybrid plasmids carrying both AMR and virulence genes in K. pneumoniae ST2096, suggesting that MDR-HvKp is not confined to selected clones; we highlight the continued emergence of such genotypes across the species. The convergence is occurring globally amidst several clones and is of great concern to public health.
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- 2022
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3. Achieving Human Level Competitive Robot Table Tennis
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D'Ambrosio, David B., Abeyruwan, Saminda, Graesser, Laura, Iscen, Atil, Amor, Heni Ben, Bewley, Alex, Reed, Barney J., Reymann, Krista, Takayama, Leila, Tassa, Yuval, Choromanski, Krzysztof, Coumans, Erwin, Jain, Deepali, Jaitly, Navdeep, Jaques, Natasha, Kataoka, Satoshi, Kuang, Yuheng, Lazic, Nevena, Mahjourian, Reza, Moore, Sherry, Oslund, Kenneth, Shankar, Anish, Sindhwani, Vikas, Vanhoucke, Vincent, Vesom, Grace, Xu, Peng, and Sanketi, Pannag R.
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Computer Science - Robotics - Abstract
Achieving human-level speed and performance on real world tasks is a north star for the robotics research community. This work takes a step towards that goal and presents the first learned robot agent that reaches amateur human-level performance in competitive table tennis. Table tennis is a physically demanding sport which requires human players to undergo years of training to achieve an advanced level of proficiency. In this paper, we contribute (1) a hierarchical and modular policy architecture consisting of (i) low level controllers with their detailed skill descriptors which model the agent's capabilities and help to bridge the sim-to-real gap and (ii) a high level controller that chooses the low level skills, (2) techniques for enabling zero-shot sim-to-real including an iterative approach to defining the task distribution that is grounded in the real-world and defines an automatic curriculum, and (3) real time adaptation to unseen opponents. Policy performance was assessed through 29 robot vs. human matches of which the robot won 45% (13/29). All humans were unseen players and their skill level varied from beginner to tournament level. Whilst the robot lost all matches vs. the most advanced players it won 100% matches vs. beginners and 55% matches vs. intermediate players, demonstrating solidly amateur human-level performance. Videos of the matches can be viewed at https://sites.google.com/view/competitive-robot-table-tennis, Comment: v2, 29 pages, 19 main paper, 10 references + appendix, adding an additional 9 references
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- 2024
4. 4-Coumarate 3-hydroxylase in the lignin biosynthesis pathway is a cytosolic ascorbate peroxidase
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Jaime Barros, Luis Escamilla-Trevino, Luhua Song, Xiaolan Rao, Juan Carlos Serrani-Yarce, Maite Docampo Palacios, Nancy Engle, Feroza K. Choudhury, Timothy J. Tschaplinski, Barney J. Venables, Ron Mittler, and Richard A. Dixon
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Science - Abstract
Lignin biosynthesis in higher plants relies upon a 3-hydroxylation reaction that can occur via shikimate esters of 4-coumarate. Here, Barros et al. define an alternative biosynthetic pathway via cytosolic ascorbate peroxidase that can catalyze direct 3-hydroxylation of 4-coumarate.
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- 2019
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5. AGE OF LATE QUATERNARY MARINE DEPOSITS OF SOUTHERN ITALY DETERMINED BY AMINOSTRATIGRAPHY, FAUNAL CORRELATION, AND URANIUM-SERIES DATING
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PAUL J. HEARTY, LAURA BONFIGLIO, DONATA VIOLANTE, and BARNEY J. SZABO
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Amino acid geochronology ,Pleistocene ,Tyrrhenian ,Sicilia ,Calabria. ,Geology ,QE1-996.5 ,Paleontology ,QE701-760 - Abstract
Numerous studies on the 40 to 60 meter strandline at Capo Milazzo, Sicily, yielded no consensus on its place in the Pleistocene sea level chronology; it has been considered to be Sicilian, mid— Pleistocene Milazzian stage, and also Eutyrrhenian. In light of this controversy, we measured amino acid D—alloisoleucine to L—isoleucine ratios (alle/ile) in shells at Capo Milazzo and at other related marine sites in southern Italy. We calibrated amino acid ratios at Mare Piccolo (Taranto) by uranium—series dating of corals to represent 122 ± 4000 years B.P. Using the calibrated amino acid ratios and paleontologic evidence, we correlated the 40—60 m strandline at Capo Milazzo with last interglacial Eutyrrhenian or isotopic Stage 5 deposits near Reggio Calabria (Ravagnese and Bovetto), Messina (Capo Peloro) and at Mare Piccolo, southern Italy. Assuming a constant uplift rate and an initial sea level of + 6 during stage 5e, we calculated the average uplift rate at Bovetto to be 0.99 m/ 1000 years over the past 125,000 years, The shoreline edge has not been located at Milazzo, Ravagnese and Capo Peloro, so only minimum uplift rates are calculated.
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- 2020
6. A practical guide for assessing respiratory burst and phagocytic cell activity in the fathead minnow, an emerging model for immunotoxicity
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Leah M. Thornton Hampton, Marlo K. Sellin Jeffries, and Barney J. Venables
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Kidney cell extraction ,Phagocytosis ,Respiratory burst ,Cellular immune function ,Fish ,Science - Abstract
Measures of respiratory burst and phagocytic cell activity are frequently utilized to assess cellular immune function in teleosts. Respiratory burst predominately occurs in neutrophils and causes the release of reactive oxygen species to kill pathogens. Phagocytosis is the process by which pathogens are engulfed and destroyed by various immune cells. Though a variety of approaches have been utilized to measure respiratory burst and phagocytic cell activity, assays that rely only on common laboratory equipment (e.g., plate reader) may offer advantages over those that rely on more specialized equipment (e.g., flow cytometer). The goal of the current study was to optimize and validate the use of a colorimetric plate-based respiratory burst and fluorometric plate-based phagocytic cell activity assays for use with kidney cells from the fathead minnow (Pimephales promelas), an emerging immunotoxicity model. In addition, a protocol for the dissection of kidney tissue followed by the extraction of kidney cells, as well as recommendations and resources for future experiments utilizing each of these assays, are provided. • All methods are optimized for use with the fathead minnow or similar teleost species. • Respiratory burst and phagocytic cell activity are measured using a standard plate reader.
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- 2020
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7. Unethical behaviour in Human Resource Management practices in South Africa: Views of Human Resource practitioners
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Barney J. Earsmus
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Human Resource Management ,ethics ,South Africa ,practitioners’ views ,Economic growth, development, planning ,HD72-88 ,Economics as a science ,HB71-74 - Abstract
The study on which this article reports, examined the relationship between the susceptibility of unethical behaviour in human resource (HR) practices (dependent variable) and three independent variables, namely the role of the HR function in institutionalising good business ethics, factors influencing the personal ethical behaviour of HR practitioners, and the commitment to ethical business conduct, exhibited by certain individuals and groups within organisations. A descriptive study was undertaken using an online questionnaire, and 304 HR practitioners in South Africa participated. The results indicated that employee selection, performance management and appraisal, recruitment and advertising were the areas most susceptible to unethical HR practices. The least susceptible HR areas were affirmative action, employment equity plans, employee orientation, employee socialisation, and psychometric testing. The results also showed statistically significant relationships among the independent variables and the dependent variable. Amongst others findings, a statistically significant positive relationship existed between susceptible unethical HR practices when HR practitioners are solely responsible for resolving ethical dilemmas, and a negative relationship when HR is not directly involved with resolving ethical dilemmas. The HR function has an important role and contributes to institutionalising business ethics in organisations.
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- 2018
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8. Constraining nucleon effective masses with flow and stopping observables from the S$\pi$RIT experiment
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Tsang, C. Y., Kurata-Nishimura, M., Tsang, M. B., Lynch, W. G., Zhang, Y. X., Barney, J., Estee, J., Jhang, G., Wang, R., Kaneko, M., Lee, J. W., Isobe, T., Murakami, T., Ahn, D. S., Atar, L., Aumann, T., Baba, H., Boretzky, K., Brzychczyk, J., Cerizza, G., Chiga, N., Fukuda, N., Gasparic, I., Hong, B., Horvat, A., Manfredi, J., McIntosh, A. B., Morfouace, P., Nakamura, T., Nakatsuka, N., Nishimura, S., Otsu, H., Pawlowski, P., Pelczar, K., Rossi, D., Sakurai, H., Santamaria, C., Sato, H., Scheit, H., Shane, R., Shimizu, Y., Simon, H., Snoch, A., Sochocka, A., Sumikama, T., Suzuki, H., Suzuki, D., Takeda, H., Tangwancharoen, S., Törnqvist, H., Togano, Y., Xiao, Z. G., Yennello, S. J., Zhang, Y., and collaboration, S$π$RIT
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Nuclear Experiment ,Nuclear Theory - Abstract
Properties of the nuclear equation of state (EoS) can be probed by measuring the dynamical properties of nucleus-nucleus collisions. In this study, we present the directed flow ($v_1$), elliptic flow ($v_2$) and stopping (VarXZ) measured in fixed target Sn + Sn collisions at 270 AMeV with the S$\pi$RIT Time Projection Chamber. We perform Bayesian analyses in which EoS parameters are varied simultaneously within the Improved Quantum Molecular Dynamics-Skyrme (ImQMD-Sky) transport code to obtain a multivariate correlated constraint. The varied parameters include symmetry energy, $S_0$, and slope of the symmetry energy, $L$, at saturation density, isoscalar effective mass, $m_{s}^*/m_{N}$, isovector effective mass, $m_{v}^{*}/m_{N}$ and the in-medium cross-section enhancement factor $\eta$. We find that the flow and VarXZ observables are sensitive to the splitting of proton and neutron effective masses and the in-medium cross-section. Comparisons of ImQMD-Sky predictions to the S$\pi$RIT data suggest a narrow range of preferred values for $m_{s}^*/m_{N}$, $m_{v}^{*}/m_{N}$ and $\eta$.
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- 2023
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9. Robotic Table Tennis: A Case Study into a High Speed Learning System
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D'Ambrosio, David B., Abelian, Jonathan, Abeyruwan, Saminda, Ahn, Michael, Bewley, Alex, Boyd, Justin, Choromanski, Krzysztof, Cortes, Omar, Coumans, Erwin, Ding, Tianli, Gao, Wenbo, Graesser, Laura, Iscen, Atil, Jaitly, Navdeep, Jain, Deepali, Kangaspunta, Juhana, Kataoka, Satoshi, Kouretas, Gus, Kuang, Yuheng, Lazic, Nevena, Lynch, Corey, Mahjourian, Reza, Moore, Sherry Q., Nguyen, Thinh, Oslund, Ken, Reed, Barney J, Reymann, Krista, Sanketi, Pannag R., Shankar, Anish, Sermanet, Pierre, Sindhwani, Vikas, Singh, Avi, Vanhoucke, Vincent, Vesom, Grace, and Xu, Peng
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Computer Science - Robotics ,Computer Science - Machine Learning - Abstract
We present a deep-dive into a real-world robotic learning system that, in previous work, was shown to be capable of hundreds of table tennis rallies with a human and has the ability to precisely return the ball to desired targets. This system puts together a highly optimized perception subsystem, a high-speed low-latency robot controller, a simulation paradigm that can prevent damage in the real world and also train policies for zero-shot transfer, and automated real world environment resets that enable autonomous training and evaluation on physical robots. We complement a complete system description, including numerous design decisions that are typically not widely disseminated, with a collection of studies that clarify the importance of mitigating various sources of latency, accounting for training and deployment distribution shifts, robustness of the perception system, sensitivity to policy hyper-parameters, and choice of action space. A video demonstrating the components of the system and details of experimental results can be found at https://youtu.be/uFcnWjB42I0., Comment: Published and presented at Robotics: Science and Systems (RSS2023)
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- 2023
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10. Determination of energy-dependent neutron backgrounds using shadow bars
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Paneru, S. N., Brown, K. W., Teh, F. C. E, Zhu, K., Tsang, M. B., DellAquila, D., Chajecki, Z., Lynch, W. G., Sweany, S., Tsang, C. Y., Anthony, A. K., Barney, J., Estee, J., Gasparic, I., Jhang, G., Khanal, O. B., Mandredi, J., Niu, C. Y., Wang, R. S., and Zamora, J. C.
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Physics - Instrumentation and Detectors - Abstract
Understanding the neutron background is essential for determining the neutron yield from nuclear reactions. In the analysis presented here, the shadow bars are placed in front of neutron detectors to determine the energy dependent neutron background fractions. The measurement of neutron spectra with and without shadow bars is important to determine the neutron background more accurately. The neutron background, along with its sources and systematic uncertainties, are explored with a focus on the impact of background models and their dependence on neutron energy., Comment: 7 pages, 10 figures
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- 2022
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11. Isoscaling in central Sn+Sn collisions at 270 MeV/u
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Lee, J. W., Tsang, M. B., Tsang, C. Y., Wang, R., Barney, J., Estee, J., Isobe, T., Kaneko, M., Kurata-Nishimura, M., Lynch, W. G., Murakami, T., Ono, A., Souza, S. R., Ahn, D. S., Atar, L., Aumann, T., Baba, H., Boretzky, K., Brzychczyk, J., Cerizza, G., Chiga, N., Fukuda, N., Gasparic, I., Hong, B., Horvat, A., Ieki, K., Ikeno, N., Inabe, N., Jhang, G., Kim, Y. J., Kobayashi, T., Kondo, Y., Lasko, P., Lee, H. S., Leifels, Y., Łukasik, J., Manfredi, J., McIntosh, A. B., Morfouace, P., Nakamura, T., Nakatsuka, N., Nishimura, S., Otsu, H., Pawłowski, P., Pelczar, K., Rossi, D., Sakurai, H., Santamaria, C., Sato, H., Scheit, H., Shane, R., Shimizu, Y., Simon, H., Snoch, A., Sochocka, A., Sumikama, T., Suzuki, H., Suzuki, D., Takeda, H., Tangwancharoen, S., Togano, Y., Xiao, Z. G., Yennello, S. J., and Zhang, Y.
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Nuclear Experiment ,Nuclear Theory - Abstract
Experimental information on fragment emissions is important in understanding the dynamics of nuclear collisions and in the development of transport model simulating heavy-ion collisions. The composition of complex fragments emitted in the heavy-ion collisions can be explained by statistical models, which assume that thermal equilibrium is achieved at collision energies below 100 MeV/u. Our new experimental data together with theoretical analyses for light particles from Sn+Sn collisions at 270 MeV/u, suggest that the hypothesis of thermal equilibrium breaks down for particles emitted with high transfer momentum. To inspect the system's properties in such limit, the scaling features of the yield ratios of particles from two systems, a neutron-rich system of ${}^{132}\mathrm{Sn}+{}^{124}\mathrm{Sn}$ and a nearly symmetric system of ${}^{108}\mathrm{Sn}+{}^{112}\mathrm{Sn}$, are examined in the framework of the statistical multifragmentation model and the antisymmetrized molecular dynamics model. The isoscaling from low energy particles agree with both models. However the observed breakdown of isoscaling for particles with high transverse momentum cannot be explained by the antisymmetrized molecular dynamics model.
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- 2022
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12. A Scintillation Arc Survey of 22 Pulsars with Low to Moderate Dispersion Measures
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Stinebring, Dan R., Rickett, Barney J., Minter, Anthony H., Hill, Alex S., Jussila, Adam P., Mathis, Lele, McLaughlin, Maura A., Ocker, Stella Koch, and Ransom, Scott M.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
Context: By providing information about the location of scattering material along the line of sight (LoS) to pulsars, scintillation arcs are a powerful tool for exploring the distribution of ionized material in the interstellar medium. Here, we present observations that probe the ionized ISM on scales of $\sim$~0.001 -- 30~au. Aims: We have surveyed pulsars for scintillation arcs in a relatively unbiased sample with DM < 100 pc cm-3. We present multi-frequency observations of 22 low to moderate DM pulsars. Many of the 54 observations were also observed at another frequency within a few days. Methods: For all observations we present dynamic spectra, autocorrelation functions, and secondary spectra. We analyze these data products to obtain scintillation bandwidths, pulse broadening times, and arc curvatures. Results: We detect definite or probable scintillation arcs in 19 of the 22 pulsars and 34 of the 54 observations, showing that scintillation arcs are a prevalent phenomenon. The arcs are better defined in low DM pulsars. We show that well-defined arcs do not directly imply anisotropy of scattering. Only the presence of reverse arclets and a deep valley along the delay axis, which occurs in about 20\% of the pulsars in the sample, indicates substantial anisotropy of scattering. Conclusions: The survey demonstrates substantial patchiness of the ionized ISM on both au size scales transverse to the line of sight and on $\sim$~100~pc scales along it. We see little evidence for distributed scattering along most lines of sight in the survey., Comment: 34 pages, 5 tables, 12 figures. In addition, there are two figure sets, one with 54 .png files in it and one with 22 .png files in it. These are included in the /anc directory
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- 2022
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13. Interstellar Scintillation and Scattering of Micro-arc-second AGN
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David L. Jauncey, Hayley E. Bignall, Lucyna Kedziora-Chudczer, Jun Yi Koay, James E. J. Lovell, Jean-Pierre Macquart, Roopesh Ojha, Tapio Pursimo, Cormac Reynolds, and Barney J. Rickett
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quasars ,variability ,interstellar scattering ,Astronomy ,QB1-991 - Abstract
The discovery of the first quasar 3C 273 led directly to the discovery of their variability at optical and radio wavelengths. We review the radio variability observations, in particular the variability found at frequencies below 1 GHz, as well as those exhibiting intra-day variability (IDV) at cm wavelengths. Observations have shown that IDV arises principally from scintillation caused by scattering in the ionized interstellar medium of our Galaxy. The sensitivity of interstellar scintillation towards source angular sizes has provided a powerful tool for studying the most compact components of radio-loud AGN at microarcsecond and milliarcsecond scale resolution.
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- 2016
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14. Rare variants in ischemic stroke: an exome pilot study.
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John W Cole, O Colin Stine, Xinyue Liu, Abhishek Pratap, Yuching Cheng, Luke J Tallon, Lisa K Sadzewicz, Nicole Dueker, Marcella A Wozniak, Barney J Stern, James F Meschia, Braxton D Mitchell, Steven J Kittner, and Jeffrey R O'Connell
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Medicine ,Science - Abstract
The genetic architecture of ischemic stroke is complex and is likely to include rare or low frequency variants with high penetrance and large effect sizes. Such variants are likely to provide important insights into disease pathogenesis compared to common variants with small effect sizes. Because a significant portion of human functional variation may derive from the protein-coding portion of genes we undertook a pilot study to identify variation across the human exome (i.e., the coding exons across the entire human genome) in 10 ischemic stroke cases. Our efforts focused on evaluating the feasibility and identifying the difficulties in this type of research as it applies to ischemic stroke. The cases included 8 African-Americans and 2 Caucasians selected on the basis of similar stroke subtypes and by implementing a case selection algorithm that emphasized the genetic contribution of stroke risk. Following construction of paired-end sequencing libraries, all predicted human exons in each sample were captured and sequenced. Sequencing generated an average of 25.5 million read pairs (75 bp×2) and 3.8 Gbp per sample. After passing quality filters, screening the exomes against dbSNP demonstrated an average of 2839 novel SNPs among African-Americans and 1105 among Caucasians. In an aggregate analysis, 48 genes were identified to have at least one rare variant across all stroke cases. One gene, CSN3, identified by screening our prior GWAS results in conjunction with our exome results, was found to contain an interesting coding polymorphism as well as containing excess rare variation as compared with the other genes evaluated. In conclusion, while rare coding variants may predispose to the risk of ischemic stroke, this fact has yet to be definitively proven. Our study demonstrates the complexities of such research and highlights that while exome data can be obtained, the optimal analytical methods have yet to be determined.
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- 2012
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15. Beam Particle Identification and Tagging of Incompletely Stripped Heavy Beams with HEIST
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Anthony, A. K., Niu, C. Y., Wang, R. S., Wieske, J., Brown, K. W., Chajecki, Z., Lynch, W. G., Ayyad, Y., Barney, J., Baumann, T., Bazin, D., Beceiro-Novo, S., Boza, J., Chen, J., Cook, K. J., Cortesi, M., Ginter, T., Mittig, W., Pype, A., Smith, M. K., Soto, C., Sumithrarachchi, C., Swaim, J., Sweany, S., Teh, F. C. E., Tsang, M. B., Tsang, C. Y., Watwood, N., and Wuosmaa, A. H.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
A challenge preventing successful inverse kinematics measurements with heavy nuclei that are not fully stripped is identifying and tagging the beam particles. For this purpose, the HEavy ISotope Tagger (HEIST) has been developed. HEIST utilizes two micro-channel plate timing detectors to measure time of flight, a multi-sampling ion chamber to measure energy loss, and a high purity Ge detector to identify isomer decays and calibrate the isotope identification system. HEIST has successfully identified $^{198}$Pb and other nearby nuclei at energies of about 75 MeV/A. In the experiment discussed, a typical cut containing 89\% of all $^{198}$Pb$^{+80}$ in the beam had a purity of 86\%. We examine the issues of charge state contamination. The observed charge state populations of these ions are presented and are moderately well described by the charge state model GLOBAL., Comment: The following article has been submitted to Review of Scientific Instruments
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- 2021
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16. Neurosarcoidosis and Neurologic Complications of Sarcoidosis Treatment
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Voortman, Mareye, Drent, Marjolein, and Stern, Barney J.
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- 2024
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17. Probing the Symmetry Energy with the Spectral Pion Ratio
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Estee, J., Lynch, W. G., Tsang, C. Y., Barney, J., Jhang, G., Tsang, M. B., Wang, R., Kaneko, M., Lee, J. W., Isobe, T., Kurata-Nishimura, M., Murakami, T., Ahn, D. S., Atar, L., Aumann, T., Baba, H., Boretzky, K., Brzychczyk, J., Cerizza, G., Chiga, N., Fukuda, N., Gasparic, I., Hong, B., Horvat, A., Ieki, K., Inabe, N., Kim, Y. J., Kobayashi, T., Kondo, Y., Lasko, P., Lee, H. S., Leifels, Y., Łukasik, J., Manfredi, J., McIntosh, A. B., Morfouace, P., Nakamura, T., Nakatsuka, N., Nishimura, S., Otsu, H., Pawłowski, P., Pelczar, K., Rossi, D., Sakurai, H., Santamaria, C., Sato, H., Scheit, H., Shane, R., Shimizu, Y., Simon, H., Snoch, A., Sochocka, A., Sumikama, T., Suzuki, H., Suzuki, D., Takeda, H., Tangwancharoen, S., Toernqvist, H., Togano, Y., Xiao, Z. G., Yennello, S. J., Zhang, Y., and Cozma, M. D.
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Nuclear Experiment - Abstract
Many neutron star (NS) properties, such as the proton fraction within a NS, reflect the symmetry energy contributions to the Equation of State that dominate when neutron and proton densities differ strongly. To constrain these contributions at supra-saturation densities, we measure the spectra of charged pions produced by colliding rare isotope tin (Sn) beams with isotopically enriched Sn targets. Using ratios of the charged pion spectra measured at high transverse momenta, we deduce the slope of the symmetry energy to be $42 < L < 117$ MeV. This value is slightly lower but consistent with the $L$ values deduced from a recent measurement of the neutron skin thickness of $^{208}$Pb.
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- 2021
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18. Symmetry energy investigation with pion production from Sn+Sn systems
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Jhang, G., Estee, J., Barney, J., Cerizza, G., Kaneko, M., Lee, J. W., Lynch, W. G., Isobe, T., Kurata-Nishimura, M., Murakami, T., Tsang, C. Y ., Tsang, M. B., Wang, R., Ahn, D. S., Atar, L., Aumann, T., Baba, H., Boretzky, K., Brzychczyk, J., Chiga, N., Fukuda, N., Gasparic, I., Hong, B., Horvat, A., Ieki, K., Inabe, N., Kim, Y. J., Kobayashi, T., Kondo, Y., Lasko, P., Lee, H. S., Leifels, Y., Łukasik, J., Manfredi, J., McIntosh, A. B., Morfouace, P., Nakamura, T., Nakatsuka, N., Nishimura, S., Olsen, R., Otsu, H., Pawłowski, P., Pelczar, K., Rossi, D., Sakurai, H., Santamaria, C., Sato, H., Scheit, H., Shane, R., Shimizu, Y., Simon, H., Snoch, A., Sochocka, A., Sosin, Z., Sumikama, T., Suzuki, H., Suzuki, D., Takeda, H., Tangwancharoen, S., Toernqvist, H., Togano, Y., Xiao, Z. G., Yennello, S. J., Yurkon, J., Zhang, Y., Colonna, Maria, Cozma, Dan, Danielewicz, Paweł, Elfner, Hannah, Ikeno, Natsumi, Ko, Che Ming, Mohs, Justin, Oliinychenko, Dmytro, Ono, Akira, Su, Jun, Wang, Yong Jia, Wolter, Hermann, Xu, Jun, Zhang, Ying-Xun, and Zhang, Zhen
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Nuclear Experiment ,Nuclear Theory - Abstract
In the past two decades, pions created in the high density regions of heavy ion collisions have been predicted to be sensitive at high densities to the symmetry energy term in the nuclear equation of state, a property that is key to our understanding of neutron stars. In a new experiment designed to study the symmetry energy, the multiplicities of negatively and positively charged pions have been measured with high accuracy for central $^{132}$Sn+$^{124}$Sn, $^{112}$Sn+$^{124}$Sn, and $^{108}$Sn+$^{112}$Sn collisions at $E/A=270~\mathrm{MeV}$ with the S$\pi$RIT Time Projection Chamber. While the uncertainties of individual pion multiplicities are measured to 4\%, those of the charged pion multiplicity ratios are measured to 2\%. We compare these data to predictions from seven major transport models. The calculations reproduce qualitatively the dependence of the multiplicities and their ratios on the total neutron to proton number in the colliding systems. However, the predictions of the transport models from different codes differ too much to allow extraction of reliable constraints on the symmetry energy from the data. This finding may explain previous contradictory conclusions on symmetry energy constraints obtained from pion data in Au+Au system. These new results call for better understanding of the differences among transport codes, and new observables that are more sensitive to the density dependence of the symmetry energy., Comment: 8 pages, 4 figures, 1 table (accepted for publication in PLB)
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- 2020
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19. The S$\pi$RIT Time Projection Chamber
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Barney, J., Estee, J., Lynch, W. G., Isobe, T., Jhang, G., Kurata-Nishimura, M., McIntosh, A. B., Murakami, T., Shane, R., Tangwancharoen, S., Tsang, M. B., Cerizza, G., Kaneko, M., Lee, J. W., Tsang, C. Y., Wang, R., Anderson, C., Baba, H., Chajecki, Z., Famiano, M., Hodges-Showalter, R., Hong, B., Kobayashi, T., Lasko, P., Łukasik, J., Nakatsuka, N., Olsen, R., Otsu, H., Pawłowski, P., Pelczar, K., Powell, W., Sakurai, H., Santamaria, C., Setiawan, H., Taketani, A., Winkelbauer, J. R., Xiao, Z., Yennello, S. J., Yurkon, J., and Zhang, Y.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The SAMURAI Pion Reconstruction and Ion-Tracker Time Projection Chamber (S$\pi$RIT TPC) was designed to enable measurements of heavy ion collisions with the SAMURAI spectrometer at the RIKEN Radioactive Isotope Beam Factory and provide constraints on the Equation of State of neutron-rich nuclear matter. The S$\pi$RIT TPC has a 50.5 cm drift length and an 86.4 cm $\times$ 134.4 cm pad plane with 12,096 pads that are equipped with the Generic Electronics for TPCs readout electronics. The S$\pi$RIT TPC allows excellent reconstruction of particles and provides isotopic resolution for pions and other light charged particles across a wide range of energy losses and momenta. Details of the S$\pi$RIT TPC are presented, along with discussion of the TPC performance based on cosmic ray and experimental data., Comment: 12 pages, 20 figures
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- 2020
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20. Value-assigned pulse shape discrimination for neutron detectors
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Teh, F. C. E., Lee, J. -W., Zhu, K., Brown, K. W., Chajecki, Z., Lynch, W. G., Tsang, M. B., Anthony, A., Barney, J., Dell'Aquila, D., Estee, J., Hong, B., Jhang, G., Khanal, O. B., Kim, Y. J., Lee, H. S., Lee, J. W., Manfredi, J., Nam, S. H., Niu, C. Y., Park, J. H., Sweany, S., Tsang, C. Y., Wang, R., and Wu, H.
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Physics - Instrumentation and Detectors - Abstract
Using the waveforms from a digital electronic system, an offline analysis technique on pulse shape discrimination (PSD) has been developed to improve the neutron-gamma separation in a bar-shaped NE-213 scintillator that couples to a photomultiplier tube (PMT) at each end. The new improved method, called the ``valued-assigned PSD'' (VPSD), assigns a normalized fitting residual to every waveform as the PSD value. This procedure then facilitates the incorporation of longitudinal position dependence of the scintillator, which further enhances the PSD capability of the detector system. In this paper, we use radiation emitted from an AmBe neutron source to demonstrate that the resulting neutron-gamma identification has been much improved when compared to the traditional technique that uses the geometric mean of light outputs from both PMTs. The new method has also been modified and applied to a recent experiment at the National Superconducting Cyclotron Laboratory (NSCL) that uses an analog electronic system., Comment: 8 pages, 8 figures
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- 2020
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21. Charged particle track reconstruction with S$\pi$RIT Time Projection Chamber
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Lee, J. W., Jhang, G., Cerizza, G., Barney, J., Estee, J., Isobe, T., Kaneko, M., Kurata-Nishimura, M., Lynch, W. G., Murakami, T., Tsang, C. Y., Tsang, M. B., Wang, R., Hong, B., McIntosh, A. B., Sakurai, H., Santamaria, C., Shane, R., Tangwancharoen, S., Yennello, S. J., and Zhang, Y.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
In this paper, we present a software framework, S$\pi$RITROOT, which is capable of track reconstruction and analysis of heavy-ion collision events recorded with the S$\pi$RIT time projection chamber. The track-fitting toolkit GENFIT and the vertex reconstruction toolkit RAVE are applied to a box-type detector system. A pattern recognition algorithm which performs helix track finding and handles overlapping pulses is described. The performance of the software is investigated using experimental data obtained at the Radioactive Isotope Beam Facility (RIBF) at RIKEN. This work focuses on data from $^{132}$Sn + $^{124}$Sn collision events with beam energy of 270 AMeV. Particle identification is established using $\left
$ and magnetic rigidity, with pions, hydrogen isotopes, and helium isotopes., Comment: 10 pages, 17 figures - Published
- 2020
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22. Space Charge Effects in the S$\pi$RIT Time Projection Chamber
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Tsang, C. Y., Estee, J., Wang, R., Barney, J., Jhang, G., Lynch, W. G., Zhang, Z. Q., Cerizza, G., Isobe, T., Kaneko, M., Kurata-Nishimura, M., Lee, J. W., Murakami, T., Tsang, M. B., and collaboration, S$π$RIT
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
Time projection chambers (TPCs) are widely used in nuclear and particle physics. They are particularly useful when measuring reaction products from heavy ion collisions. Most nuclear experiments at low energy are performed in a fixed target configuration, in which the unreacted beam will pass through the detection volume. As the beam intensity increases, the buildup of positive ions created from the ionization of the detector gas by the beam creates the main source of space charge, distorting the nominal electric field of the TPC. This has a profound effect on the accuracy of the measured momenta of the emitted particles. In this paper we will discuss the magnitude of the effects and construct an observable more appropriate for fixed target experiments to study the effects. We also will present an algorithm for correcting the space charge and some of the implications it has on the momentum determination., Comment: 9 pages, 10 figures
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- 2019
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23. Determination of energy-dependent neutron backgrounds using shadow bars
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Paneru, S.N., Brown, K.W., Teh, F.C.E, Zhu, K., Tsang, M.B., Dell’Aquila, D., Chajecki, Z., Lynch, W.G., Sweany, S., Tsang, C.Y., Anthony, A.K., Barney, J., Estee, J., Gasparic, I., Jhang, G., Khanal, O.B., Manfredi, J., Niu, C.Y., Wang, R.S., and Zamora, J.C.
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- 2023
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24. Particle decays of levels in $^{11,12}$N and $^{12}$O investigated with the invariant-mass method
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Webb, T. B., Charity, R. J., Elson, J. M., Hoff, D. E. M, Pruitt, C. D., Sobotka, L. G., Brown, K. W., Barney, J., Cerizza, G., Estee, J., Jhang, G., Lynch, W. G., Manfredi, J., Morfouace, P., Santamaria, C., Sweany, S., Tsang, M. B., Tsang, T., Wang, S. M., Zhang, Y., Zhu, K., Kuvin, S. A., McNeel, D., Smith, J., Wuosmaa, A. H., and Chajecki, Z.
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Nuclear Experiment - Abstract
Particle-decaying states of the light nuclei $^{11,12}$N and $^{12}$O were studied using the invariant-mass method. The decay energies and intrinsic widths of a number of states were measured, and the momentum correlations of three-body decaying states were considered. A second 2$p$-decaying 2$^+$ state of $^{12}$O was observed for the first time, and a higher energy $^{12}$O state was observed in the 4$p$+2$\alpha$ decay channel. This 4$p$+2$\alpha$ channel also contains contributions from fission-like decay paths, including $^6$Be$_{g.s.}$+$^{6}$Be$_{g.s.}$. Analogs to these states in $^{12}$O were found in $^{12}$N in the 2$p$+$^{10}$B and 2$p$+$\alpha$+$^6$Li channels. The momentum correlations for the prompt 2$p$ decay of $^{12}$O$_{g.s.}$ were found to be nearly identical to those of $^{16}$Ne$_{g.s.}$, and the correlations for the new 2$^+$ state were found to be consistent with sequential decay through excited states in $^{11}$N. The momentum correlations for the 2$^+_1$ state in $^{12}$O provide a new value for the $^{11}$N ground-state energy. The states in $^{12}$N/$^{12}$O that belong to the $A$=12 isobaric sextet do not deviate from the quadratic isobaric multiplet mass equation (IMME) form., Comment: 16 pages, 16 figures, 7 tables, tables corrected
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- 2019
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25. Twelve Decades: Probing the Interstellar Medium from kiloparsec to sub-AU scales
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Stinebring, Dan, Chatterjee, Shami, Clark, Susan E., Cordes, James M., Dolch, Timothy, Heiles, Carl, Hill, Alex S., Jones, Megan, Kaspi, Victoria, Lam, Michael T., Lazio, T. J. W., Lewandowska, Natalia, Madison, Dustin R., McLaughlin, Maura A., McClure-Griffiths, Naomi, Palliyaguru, Nipuni, Rickett, Barney J., and Surnis, Mayuresh P.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
After a decade of great progress in understanding gas flow into, out of, and through the Milky Way, we are poised to merge observations with simulations to build a comprehensive picture of the multi-scale magnetized interstellar medium (ISM). These insights will also be crucial to four bold initiatives in the 2020s: detecting nanohertz gravitational waves with pulsar timing arrays (PTAs), decoding fast radio bursts (FRBs), cosmic B-mode detection, and imaging the Milky Way's black hole with the Event Horizon Telescope (EHT)., Comment: 11 page, 6 figures, 47 references. Submitted as an Astro2020 science white paper on March 11, 2019
- Published
- 2019
26. Non-linearity effects on the light-output calibration of light charged particles in CsI(Tl) scintillator crystals
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Dell'Aquila, D., Sweany, S., Brown, K. W., Chajecki, Z., Lynch, W. G., Teh, F. C. E., Tsang, C. -Y., Tsang, M. B., Zhu, K., Anderson, C., Anthony, A., Barlini, S., Barney, J., Camaiani, A., Jhang, G., Crosby, J., Estee, J., Ghazali, M., Guan, F., Khanal, O., Kodali, S., Lombardo, I., Manfredi, J., Morelli, L., Morfouace, P., Niu, C., and Verde, G.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
The light output produced by light ions (Z<=4) in CsI(Tl) crystals is studied over a wide range of detected energies (E<=300 MeV). Energy-light calibration data sets are obtained with the 10 cm crystals in the recently upgraded High-Resolution Array (HiRA10). We use proton recoil data from 40,48Ca + CH2 at 28 MeV/u, 56.6 MeV/u, 39 MeV/u and 139.8 MeV/u and data from a dedicated experiment with direct low-energy beams. We also use the punch through points of p, d, and t particles from 40,48Ca + 58,64Ni, 112,124Sn collisions reactions at 139.8 MeV/u. Non-linearities, arising in particular from Tl doping and light collection efficiency in the CsI crystals, are found to significantly affect the light output and therefore the calibration of the detector response for light charged particles, especially the hydrogen isotopes. A new empirical parametrization of the hydrogen light output, L(E,Z=1,A), is proposed to account for the observed effects. Results are found to be consistent for all 48 CsI(Tl) crystals in a cluster of 12 HiRA10 telescopes.
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- 2019
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27. First observation of unbound $^{11}$O, the mirror of the halo nucleus $^{11}$Li
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Webb, T. B., Wang, S. M., Brown, K. W., Charity, R. J., Elson, J. M., Barney, J., Cerizza, G., Chajecki, Z., Estee, J., Hoff, D. E. M., Kuvin, S. A., Lynch, W. G., Manfredi, J., McNeel, D., Morfouace, P., Nazarewicz, W., Pruitt, C. D., Santamaria, C., Smith, J., Sobotka, L. G., Sweany, S., Tsang, C. Y., Tsang, M. B., Wuosmaa, A. H., Zhang, Y., and Zhu, Z.
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Nuclear Experiment ,Nuclear Theory - Abstract
The structure of the extremely proton-rich nucleus $^{11}_{~8}$O$_3$, the mirror of the two-neutron halo nucleus $^{11}_{~3}$Li$_8$, has been studied experimentally for the first time. Following two-neutron knockout reactions with a $^{13}$O beam, the $^{11}$O decay products were detected after two-proton emission and used to construct an invariant-mass spectrum. A broad peak of width $\sim$3\,MeV was observed. Within the Gamow coupled-channel approach, it was concluded that this peak is a multiplet with contributions from the four-lowest $^{11}$O resonant states: $J^{\pi}$=3/2$^-_1$, 3/2$^-_2$, 5/2$^+_1$, and 5/2$^+_2$. The widths and configurations of these states show strong, non-monotonic dependencies on the depth of the $p$-$^9$C potential. This unusual behavior is due to the presence of a broad threshold resonant state in $^{10}$N, which is an analog of the virtual state in $^{10}$Li in the presence of the Coulomb potential. After optimizing the model to the data, only a moderate isospin asymmetry between ground states of $^{11}$O and $^{11}$Li was found., Comment: 6 pages, three figures
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- 2018
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28. The Frequency Dependence of Scintillation Arc Thickness in Pulsar B1133+16
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Stinebring, Dan R., Rickett, Barney J., and Ocker, Stella Koch
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Astrophysics - Astrophysics of Galaxies - Abstract
Scintillation arcs have become a powerful tool for exploring scattering in the ionized interstellar medium. There is accumulating evidence that the scattering from many pulsars is extremely anisotropic resulting in highly elongated, linear brightness functions. We present a three-frequency (327~MHz, 432~MHz, 1450~MHz) Arecibo study of scintillation arcs from one nearby, bright, high-velocity pulsar, PSR~B1133+16. We show that a one-dimensional (1D), linear brightness function is in good agreement with the data at all three observing frequencies. We use two methods to explore the broadening of the 1D brightness function $B(\theta)$ as a function of frequency: 1) crosscuts of the forward arc at constant delay and 2) a 1D modeling of $B(\theta)$ using a comparison between model and observed secondary spectrum as a goodness-of-fit metric. Both methods show that the half-power width of $B(\theta)$ deviates from the expected dependence $\propto \nu^{-a}$, where $\nu$ is the observing frequency . Our estimates of $a$ have moderately large uncertainties but imply $a \lesssim1.8$, and so are inconsistent with the expected $a = 2.0$ for plasma refraction or $a = 2.2$ for Kolmogorov turbulence. In addition the shape of $B(\theta)$ cuts off more steeply than predicted for Kolmogorov turbulence. Ultimately, we conclude that the underlying physics of the broadening mechanism remains unexplained. Our results place the scattering screen at a distance that is broadly consistent with an origin at the boundary of the Local Bubble., Comment: 10 pages, 4 multi-panel figures (18 separate panels)
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- 2018
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29. On Determining Dead Layer and Detector Thicknesses for a Position-Sensitive Silicon Detector
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Manfredi, J., Lee, Jenny, Lynch, W. G., Niu, C. Y., Tsang, M. B., Anderson, C., Barney, J., Brown, K. W., Chajecki, Z., Chan, K. P., Chen, G., Estee, J., Li, Z., Pruitt, C., Rogers, A. M., Sanetullaev, A., Setiawan, H., Showalter, R., Tsang, C. Y., Winkelbauer, J. R., Xiao, Z., and Xu, Z.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
In this work, two particular properties of the position-sensitive, thick silicon detectors (known as the "E" detectors) in the High Resolution Array (HiRA) are investigated: the thickness of the dead layer on the front of the detector, and the overall thickness of the detector itself. The dead layer thickness for each E detector in HiRA is extracted using a measurement of alpha particles emitted from a $^{212}$Pb pin source placed close to the detector surface. This procedure also allows for energy calibrations of the E detectors, which are otherwise inaccessible for alpha source calibration as each one is sandwiched between two other detectors. The E detector thickness is obtained from a combination of elastically scattered protons and an energy-loss calculation method. Results from these analyses agree with values provided by the manufacturer., Comment: Accepted for publication in Nuclear Instruments and Methods in Physics Research
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- 2018
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30. Persistent organic pollutant exposure and associations with gene expression in northern fur seals (Callorhinus ursinus) from St. Paul Island, Alaska
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Soulen, Brianne K., Divine, Lauren M., Venables, Barney J., and Roberts, Aaron P.
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- 2022
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31. Multiplicity trigger detector for the S[formula omitted]RIT experiment
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Kaneko, M., Murakami, T., Miwa, K., Shiozaki, T., Barney, J., Cerizza, G., Estee, J., Isobe, T., Jhang, G., Kurata-Nishimura, M., Lasko, P., Lee, J.W., Łukasik, J., Lynch, W.G., Nakatsuka, N., Pawłowski, P., Sakurai, H., Santamaria, C., Suzuki, D., Tsang, C.Y., Tsang, M.B., Wang, R., and Zhang, Y.
- Published
- 2022
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32. Pion Production in Rare Isotope Collisions
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Tsang, M. B., Estee, J., Setiawan, H., Lynch, W. G., Barney, J., Chen, M. B., Cerizza, G., Danielewicz, P., Hong, J., Morfouace, P., Shane, R., Tangwancharoen, S., Zhu, K., Isobe, T., Kurata-Nishimura, M., Lukasik, J., Murakami, T., and collaboration, the SπRIT
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Nuclear Theory - Abstract
Pion energy spectra are presented for central collisions of neutron-rich 132Sn+124Sn and neutron-deficient 108Sn+112Sn systems using simulations with Boltzmann-Uehling-Uhlenbeck transport model. These calculations, which incorporate isospin-dependent mean field potentials for relevant baryons and mesons, display a sensitivity to the pion spectra that could allow significant constraints on the density dependence of the symmetry energy and its mean field potential at supra-saturation densities. The predicted sensitivity increases with the isospin asymmetry of the total system and decreases with incident energy.
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- 2016
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33. A Gating Grid Driver for Time Projection Chambers
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Tangwancharoen, S., Lynch, W. G., Barney, J., Estee, J., Shane, R., Tsang, M. B., Zhang, Y., Isobe, T., Kurata-Nishimura, M., Murakami, T., Xiao, Z. G., and Zhang, Y. F.
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Physics - Instrumentation and Detectors - Abstract
A simple but novel driver system has been developed to operate the wire gating grid of a Time Projection Chamber (TPC). This system connects the wires of the gating grid to its driver via low impedance transmission lines. When the gating grid is open, all wires have the same voltage allowing drift electrons, produced by the ionization of the detector gas molecules, to pass through to the anode wires. When the grid is closed, the wires have alternating higher and lower voltages causing the drift electrons to terminate at the more positive wires. Rapid opening of the gating grid with low pickup noise is achieved by quickly shorting the positive and negative wires to attain the average bias potential with N-type and P-type MOSFET switches. The circuit analysis and simulation software SPICE shows that the driver restores the gating grid voltage to 90% of the opening voltage in less than 0.20 $\mu$s. When tested in the experimental environment of a time projection chamber larger termination resistors were chosen so that the driver opens the gating grid in 0.35 $\mu$s. In each case, opening time is basically characterized by the RC constant given by the resistance of the switches and terminating resistors and the capacitance of the gating grid and its transmission line. By adding a second pair of N-type and P-type MOSFET switches, the gating grid is closed by restoring 99% of the original charges to the wires within 3 $\mu$s., Comment: 18 pages, 10 figures, 2 tables. Submitted to Nuclear Instruments & Methods in Physics Resarch A
- Published
- 2016
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34. KATANA - a charge-sensitive triggering system for the S$\pi$RIT experiment
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Lasko, P., Adamczyk, M., Brzychczyk, J., Hirnyk, P., Łukasik, J., Pawłowski, P., Pelczar, K., Snoch, A., Sochocka, A., Sosin, Z., Barney, J., Cerizza, G., Estee, J., Isobe, T., Jhang, G., Kaneko, M., Kurata-Nishimura, M., Lynch, W. G., Murakami, T., Santamaria, C., Tsang, M. B., and Zhang, Y.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
KATANA - the Krakow Array for Triggering with Amplitude discrimiNAtion - has been built and used as a trigger and veto detector for the S$\pi$RIT TPC at RIKEN. Its construction allows operating in magnetic field and providing fast response for ionizing particles, giving the approximate forward multiplicity and charge information. Depending on this information, trigger and veto signals are generated. The article presents performance of the detector and details of its construction. A simple phenomenological parametrization of the number of emitted scintillation photons in plastic scintillator is proposed. The effect of the light output deterioration in the plastic scintillator due to the in-beam irradiation is discussed., Comment: 14 pages, 11 figures
- Published
- 2016
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35. Infliximab for the treatment of CNS sarcoidosis
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Gelfand, Jeffrey M, Bradshaw, Michael J, Stern, Barney J, Clifford, David B, Wang, Yunxia, Cho, Tracey A, Koth, Laura L, Hauser, Stephen L, Dierkhising, Jason, Vu, NgocHanh, Sriram, Subramaniam, Moses, Harold, Bagnato, Francesca, Kaufmann, Jeffrey A, Ammah, Deidre J, Yohannes, Tsion H, Hamblin, Mark J, Venna, Nagagopal, Green, Ari J, and Pawate, Siddharama
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Neurosciences ,Clinical Research ,Biomedical Imaging ,Brain Disorders ,Autoimmune Disease ,Adult ,Aged ,Central Nervous System Diseases ,Female ,Humans ,Immunosuppressive Agents ,Infliximab ,Male ,Middle Aged ,Outcome Assessment ,Health Care ,Sarcoidosis ,Tumor Necrosis Factor-alpha ,Young Adult ,Clinical Sciences ,Cognitive Sciences ,Neurology & Neurosurgery - Abstract
ObjectiveTo describe clinical and imaging responses in neurosarcoidosis to infliximab, a monoclonal antibody against tumor necrosis factor-α.MethodsInvestigators at 6 US centers retrospectively identified patients with CNS sarcoidosis treated with infliximab, including only patients with definite or probable neurosarcoidosis following rigorous exclusion of other causes.ResultsOf 66 patients with CNS sarcoidosis (27 definite, 39 probable) treated with infliximab for a median of 1.5 years, the mean age was 47.5 years at infliximab initiation (SD 11.7, range 24-71 years); 56.1% were female; 62.1% were white, 37.0% African American, and 3% Hispanic. Sarcoidosis was isolated to the CNS in 19.7%. Using infliximab doses ranging from 3 to 7 mg/kg every 4-8 weeks, MRI evidence of a favorable treatment response was observed in 82.1% of patients with imaging follow-up (n = 56), with complete remission of active disease in 51.8% and partial MRI improvement in 30.1%; MRI worsened in 1 patient (1.8%). There was clinical improvement in 77.3% of patients, with complete neurologic recovery in 28.8%, partial improvement in 48.5%, clinical stability in 18.2%, worsening in 3%, and 1 lost to follow-up. In 16 patients in remission when infliximab was discontinued, the disease recurred in 9 (56%), typically in the same neuroanatomic location.ConclusionsMost patients with CNS sarcoidosis treated with infliximab exhibit favorable imaging and clinical treatment responses, including some previously refractory to other immunosuppressive treatments.Classification of evidenceThis study provides Class IV evidence that for patients with CNS sarcoidosis infliximab is associated with favorable imaging and clinical responses.
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- 2017
36. Breaking barriers: holistic assessment of ability to work in patients with sarcoidosis
- Author
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Drent, Marjolein, Russell, Anne-Marie, Saketkoo, Lesley Ann, Spagnolo, Paolo, Veltkamp, Marcel, Wells, Athol U, Goh, Nicole, Holland, Anne, Hochreiter, Johann, Kock, Selene, Verheyen, Karolien, Verbraecken, Johan, Cantin, André, Gillson, Ashley, Hambly, Nathan, Kolb, Martin, Bendstrup, Elisabeth, Leistiko, Anna, Møller, Janne, Kaarteenaho, Riitta, Crestani, Bruno, Israël-Biet, Dominique, Cohen Aubart, Fleur, Nunes, Hilario, Valeyre, Dominique, Bonella, Francesco, Buschulte, Katharina, Costabel, Ulrich, Kortsen, Peter, Kreuter, Michael, Luedike, Peter, Quadder, Bernd, Braune, Renate, Skowasch, Dirk, Antoniou, Katerina, Bouros, Demosthenes, Gogali, Athena, Margaritopoulos, George A., Papakosta, Despoina, Papiris, Spyros A, Manali, Effrosyni D, Tzouvelekis, Argyris, Tzilas, Vasilios, Agrawal, Aditya, Kashyap, Surender, Tyagi, Vijay Narain, Unnati, Desai, Abedini, Atefeh, Phelan, Sean, Bargagli, Elena, Cinetto, Francesco, Confalonieri, Marco, Confalonieri, Paola, Harari, Sergio, Luppi, Fabrizio, Martone, Filippo, Palmieri, Anna, Rottoli, Paola, Salton, Francesco, Scarpa, Ricardo, Tana, Claudio, Tomassetti, Sara, Azuma, Arata, Inui, Naoki, Nakamura, Yutaro, Inoue, Yoshikazu, Tanino, Yoshinori, Muhammad, Noorul Afidza, van Beek, Frouke, den Boer, Lenze, Boomars, Karin, Bresser, Paul, Claessen, Laura, Elfferich, Marjon, Erckens, Roel, van Helmondt, Sanne, Karakaya, Bekir, Grutters, Jan C., Hoitsma, Elske, Illy, Károly, Jansen, Tim L, Kahlmann, Vivienne, Knoet, Chris, Korenromp, Ingrid, Lenssen, Ton, Maassen vd Brinkdrs, Karen, Mager, Johannes Jurgen, Marcellis, Rik, Miedema, Jelle, Möller, Trudeke, Moonen, Linda A.A., Moor, Karen, Mostard, Rémy L.M., Nienhuis, Willemien, Nossent, Esther, Paulus, Michelle, Ponds, Rudolf, Nossent, George, Quanjel, Marian, Rottenberg, Felix, van de Sande, Jonathan S.O., Segers, Ruud, Soechitram, Shalini D., van Staa, AnneLoes, Strookappe, Bert, Swaans, Martin, van den Toorn, Leon, van de Ven, Marjo J.T., Voortman, Mareye, Vorselaars, Adriane Dore Marie, Vente, Lenneke, Wijnen, Petal A., Wijsenbeek, Marlies, De Vries, Jolanda, van Zanten, Arthur, Durheim, Michael, Rasch-Halvorsen, Øystein, Tøndell, Anders, Dubaniewicz, Anna, Piotrowski, Wojciech, Roter, Bartlomiej, Robalo Cordeiro, Carlos, Alfaro, Tiago, Strambu, Irina, Vizel, Alexander, Cano, Rafael, Balcells, Eva, Castillo, Diego, Francesqui, Joel, Mañá, Juan, Molina, Maria, Ojanguren, Inigo, Rodriguez Portal, Jose Antonio, Sellares, Jacobo, Arkema, Elizabeth, Darlington, Pernilla, Eldhagen, Per, Elfström, Katinka, Grunewald, Johan, Kullberg, Susanna, Rivera, Natalia V, Rossides, Marios, Werner, Joanna, Dincer, Irem, Koç, Gülcan, Yucesan, Canan, Ozdemir Kumbasar, Ozlem, Birring, Surinder, Boyd, Jeanette, Casimo, Leo, Huntley, Christopher, Kouranos, Vasileios, Newton, Jaqui, Spencer, Lisa, Spears, Mark, Barreras, Paula, Cozier, Yvette, Crouser, Elliott, Harper, Logan, James, W. Ennis, Maier, Lisa, Liao, Shu-Yi, Morgenthau, Adam, Obi, Ogugua Ndili, Patel, Divya, Rivera, Frank, Rossman, Milton D., Sharp, Michelle, Sharma, Maggie, Schupp, Jonas C., Stern, Barney J., Sweiss, Nadera, Tavee, Jinny, Zank, Daniel, Gumeniuk, Galyna, Gavrysyuk, Volodymyr, and Merenkova, Levgeniia
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- 2024
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37. Neurosarcoidosis and Neurologic Complications of Sarcoidosis Treatment
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Longziekten, Voortman, Mareye, Drent, Marjolein, Stern, Barney J., Longziekten, Voortman, Mareye, Drent, Marjolein, and Stern, Barney J.
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- 2024
38. Calibration of large neutron detection arrays using cosmic rays
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Zhu, K., Tsang, M.B., Dell’Aquila, D., Brown, K.W., Chajecki, Z., Lynch, W.G., Sweany, S., Teh, F.C.E., Tsang, C.Y., Anderson, C., Anthony, A., Barney, J., Crosby, J., Estee, J., Gasparic, I., Jhang, G., Khanal, O.B., Kodali, S., Manfredi, J., Niu, C.Y., and Wang, R.S.
- Published
- 2020
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39. Space charge effects in the S[formula omitted]RIT time projection chamber
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Tsang, C.Y., Estee, J., Wang, R., Barney, J., Jhang, G., Lynch, W.G., Zhang, Z.Q., Cerizza, G., Isobe, T., Kaneko, M., Kurata-Nishimura, M., Lee, J.W., Murakami, T., and Tsang, M.B.
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- 2020
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40. Bias corrections of GOSAT SWIR XCO2 and XCH4 with TCCON data and their evaluation using aircraft measurement data
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Inoue, M, Morino, I, Uchino, O, Nakatsuru, T, Yoshida, Y, Yokota, T, Wunch, D, Wennberg, PO, Roehl, CM, Griffith, DWT, Velazco, VA, Deutscher, NM, Warneke, T, Notholt, J, Robinson, J, Sherlock, V, Hase, F, Blumenstock, T, Rettinger, M, Sussmann, R, Kyrö, E, Kivi, R, Shiomi, K, Kawakami, S, De Mazière, M, Arnold, SG, Feist, DG, Barrow, EA, Barney, J, Dubey, M, Schneider, M, Iraci, LT, Podolske, JR, Hillyard, PW, Machida, T, Sawa, Y, Tsuboi, K, Matsueda, H, Sweeney, C, Tans, PP, Andrews, AE, Biraud, SC, Fukuyama, Y, Pittman, JV, Kort, EA, and Tanaka, T
- Subjects
Meteorology & Atmospheric Sciences ,Atmospheric Sciences - Abstract
We describe a method for removing systematic biases of column-averaged dry air mole fractions of CO2 (XCO2) and CH4 (XCH4) derived from short-wavelength infrared (SWIR) spectra of the Greenhouse gases Observing SATellite (GOSAT). We conduct correlation analyses between the GOSAT biases and simultaneously retrieved auxiliary parameters. We use these correlations to bias correct the GOSAT data, removing these spurious correlations. Data from the Total Carbon Column Observing Network (TCCON) were used as reference values for this regression analysis. To evaluate the effectiveness of this correction method, the tnzuncorrected/corrected GOSAT data were compared to independent XCO2 and XCH4 data derived from aircraft measurements taken for the Comprehensive Observation Network for TRace gases by AIrLiner (CONTRAIL) project, the National Oceanic and Atmospheric Administration (NOAA), the US Department of Energy (DOE), the National Institute for Environmental Studies (NIES), the Japan Meteorological Agency (JMA), the HIAPER Pole-to-Pole observations (HIPPO) program, and the GOSAT validation aircraft observation campaign over Japan. These comparisons demonstrate that the empirically derived bias correction improves the agreement between GOSAT XCO2/XCH4 and the aircraft data. Finally, we present spatial distributions and temporal variations of the derived GOSAT biases.
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- 2016
41. S$\pi$RIT: A time-projection chamber for symmetry-energy studies
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Shane, R., McIntosh, A., Isobe, T., Lynch, W. G., Baba, H., Barney, J., Chajecki, Z., Chartier, M., Estee, J., Famiano, M., Hong, B., Ieki, K., Jhang, G., Lemmon, R., Lu, F., Murakami, T., Nakatsuka, N., Nishimura, M., Olsen, R., Powell, W., Sakurai, H., Taketani, A., Tangwancharoen, S., Tsang, M. B., Usukura, T., Wang, R., Yennello, S. J., and Yurkon, J.
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Physics - Instrumentation and Detectors ,Nuclear Experiment - Abstract
A Time-Projection Chamber (TPC) called the SAMURAI Pion-Reconstruction and Ion-Tracker (S$\pi$RIT) has recently been constructed at Michigan State University as part of an international effort to constrain the symmetry-energy term in the nuclear Equation of State (EoS). The S$\pi$RIT TPC will be used in conjunction with the SAMURAI spectrometer at the Radioactive Isotope Beam Factory (RIBF) at RIKEN to measure yield ratios for pions and other light isospin multiplets produced in central collisions of neutron-rich heavy ions, such as $^{132}$Sn + $^{124}$Sn. The S$\pi$RIT TPC can function both as a TPC detector and as an active target. It has a vertical drift length of 50 cm, parallel to the magnetic field. Gas multiplication is achieved through the use of a multi-wire anode. Image charges are produced in the 12096 pads, and are read out with the recently developed Generic Electronics for TPCs., Comment: 7 pages, 3 figures, 2 tables. Submitted to NIM A Proceedings
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- 2014
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42. Developmental thyroid disruption causes long-term impacts on immune cell function and transcriptional responses to pathogen in a small fish model
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Hampton, Leah M. Thornton, Finch, Miranda G., Martyniuk, Christopher J., Venables, Barney J., and Jeffries, Marlo K. Sellin
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- 2021
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43. The Micro-Arcsecond Scintillation-Induced Variability (MASIV) Survey III. Optical Identifications and New Redshifts
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Pursimo, Tapio, Ojha, Roopesh, Jauncey, David L., Rickett, Barney J., Dutka, Michael S., Koay, Jun Yi, Lovell, James E. J., Bignall, Hayley E., Kedziora-Chudczer, Lucyna, and Macquart, Jean-Pierre
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Intraday variability (IDV) of the radio emission from active galactic nuclei is now known to be predominantly due to interstellar scintillation (ISS). The MASIV (The Micro-Arcsecond Scintillation-Induced Variability) survey of 443 flat spectrum sources revealed that the IDV is related to the radio flux density and redshift. A study of the physical properties of these sources has been severely handicapped by the absence of reliable redshift measurements for many of these objects. This paper presents 79 new redshifts and a critical evaluation of 233 redshifts obtained from the literature. We classify spectroscopic identifications based on emission line properties, finding that 78% of the sources have broad emission lines and are mainly FSRQs. About 16% are weak lined objects, chiefly BL Lacs, and the remaining 6% are narrow line objects. The gross properties (redshift, spectroscopic class) of the MASIV sample are similar to those of other blazar surveys. However, the extreme compactness implied by ISS favors FSRQs and BL Lacs in the MASIV sample as these are the most compact object classes. We confirm that the level of IDV depends on the 5\,GHz flux density for all optical spectral types. We find that BL Lac objects tend to be more variable than broad line quasars. The level of ISS decreases substantially above a redshift of about two. The decrease is found to be generally consistent with ISS expected for beamed emission from a jet that is limited to a fixed maximum brightness temperature in the source rest frame., Comment: Accepted for publication by the Astrophysical Journal
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- 2013
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44. Breaking barriers: holistic assessment of ability to work in patients with sarcoidosis
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Goh, Nicole, Holland, Anne, Hochreiter, Johann, Kock, Selene, Verheyen, Karolien, Verbraecken, Johan, Cantin, André, Gillson, Ashley, Hambly, Nathan, Kolb, Martin, Bendstrup, Elisabeth, Leistiko, Anna, Møller, Janne, Kaarteenaho, Riitta, Crestani, Bruno, Israël-Biet, Dominique, Cohen Aubart, Fleur, Nunes, Hilario, Valeyre, Dominique, Bonella, Francesco, Buschulte, Katharina, Costabel, Ulrich, Kortsen, Peter, Kreuter, Michael, Luedike, Peter, Quadder, Bernd, Braune, Renate, Skowasch, Dirk, Antoniou, Katerina, Bouros, Demosthenes, Gogali, Athena, Margaritopoulos, George A., Papakosta, Despoina, Papiris, Spyros A, Manali, Effrosyni D, Tzouvelekis, Argyris, Tzilas, Vasilios, Agrawal, Aditya, Kashyap, Surender, Tyagi, Vijay Narain, Unnati, Desai, Abedini, Atefeh, Phelan, Sean, Bargagli, Elena, Cinetto, Francesco, Confalonieri, Marco, Confalonieri, Paola, Harari, Sergio, Luppi, Fabrizio, Martone, Filippo, Palmieri, Anna, Rottoli, Paola, Salton, Francesco, Scarpa, Ricardo, Tana, Claudio, Tomassetti, Sara, Azuma, Arata, Inui, Naoki, Nakamura, Yutaro, Inoue, Yoshikazu, Tanino, Yoshinori, Muhammad, Noorul Afidza, van Beek, Frouke, den Boer, Lenze, Boomars, Karin, Bresser, Paul, Claessen, Laura, Elfferich, Marjon, Erckens, Roel, van Helmondt, Sanne, Karakaya, Bekir, Grutters, Jan C., Hoitsma, Elske, Illy, Károly, Jansen, Tim L, Kahlmann, Vivienne, Knoet, Chris, Korenromp, Ingrid, Lenssen, Ton, Maassen vd Brinkdrs, Karen, Mager, Johannes Jurgen, Marcellis, Rik, Miedema, Jelle, Möller, Trudeke, Moonen, Linda A.A., Moor, Karen, Mostard, Rémy L.M., Nienhuis, Willemien, Nossent, Esther, Paulus, Michelle, Ponds, Rudolf, Nossent, George, Quanjel, Marian, Rottenberg, Felix, van de Sande, Jonathan S.O., Segers, Ruud, Soechitram, Shalini D., van Staa, AnneLoes, Strookappe, Bert, Swaans, Martin, van den Toorn, Leon, van de Ven, Marjo J.T., Voortman, Mareye, Vorselaars, Adriane Dore Marie, Vente, Lenneke, Wijnen, Petal A., Wijsenbeek, Marlies, De Vries, Jolanda, van Zanten, Arthur, Durheim, Michael, Rasch-Halvorsen, Øystein, Tøndell, Anders, Dubaniewicz, Anna, Piotrowski, Wojciech, Roter, Bartlomiej, Robalo Cordeiro, Carlos, Alfaro, Tiago, Strambu, Irina, Vizel, Alexander, Cano, Rafael, Balcells, Eva, Castillo, Diego, Francesqui, Joel, Mañá, Juan, Molina, Maria, Ojanguren, Inigo, Rodriguez Portal, Jose Antonio, Sellares, Jacobo, Arkema, Elizabeth, Darlington, Pernilla, Eldhagen, Per, Elfström, Katinka, Grunewald, Johan, Kullberg, Susanna, Rivera, Natalia V, Rossides, Marios, Werner, Joanna, Dincer, Irem, Koç, Gülcan, Yucesan, Canan, Ozdemir Kumbasar, Ozlem, Birring, Surinder, Boyd, Jeanette, Casimo, Leo, Huntley, Christopher, Kouranos, Vasileios, Newton, Jaqui, Spencer, Lisa, Spears, Mark, Barreras, Paula, Cozier, Yvette, Crouser, Elliott, Harper, Logan, James, W. Ennis, Maier, Lisa, Liao, Shu-Yi, Morgenthau, Adam, Obi, Ogugua Ndili, Patel, Divya, Rivera, Frank, Rossman, Milton D., Sharp, Michelle, Sharma, Maggie, Schupp, Jonas C., Stern, Barney J., Sweiss, Nadera, Tavee, Jinny, Zank, Daniel, Gumeniuk, Galyna, Gavrysyuk, Volodymyr, Merenkova, Levgeniia, Drent, Marjolein, Russell, Anne-Marie, Saketkoo, Lesley Ann, Spagnolo, Paolo, Veltkamp, Marcel, and Wells, Athol U
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- 2024
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45. Extending the dynamic range of electronics in a Time Projection Chamber
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Estee, J., Lynch, W.G., Barney, J., Cerizza, G., Jhang, G., Lee, J.W., Wang, R., Isobe, T., Kaneko, M., Kurata-Nishimura, M., Murakami, T., Shane, R., Tangwancharoen, S., Tsang, C.Y., Tsang, M.B., Hong, B., Lasko, P., Łukasik, J., McIntosh, A.B., Pawłowski, P., Pelczar, K., Sakurai, H., Santamaria, C., Suzuki, D., Yennello, S.J., and Zhang, Y.
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- 2019
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46. Contributors
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Abrams, Gary M., primary, Albers, Gregory W., additional, Amans, Matthew R., additional, Aminoff, Michael J., additional, Batla, Amit, additional, Betjemann, John P., additional, Camilleri, Michael, additional, Chen, Robert, additional, Christine, Chadwick W., additional, Coleman, Kyle J., additional, Davies-Jones, G.A.B., additional, DeAngelis, Lisa M., additional, Dhand, Amar, additional, Dillon, William P., additional, Douglas, Vanja C., additional, Fox, Christine, additional, Furman, Joseph M., additional, Gelb, Douglas J., additional, Gladstone, David J., additional, Glynn, Simon M., additional, Goodin, Douglas S., additional, Goodman, Brent P., additional, Greenlee, John E., additional, Guterman, Elan, additional, Halabi, Cathra, additional, Hallett, Mark, additional, Halperin, John J., additional, Harris, Shelby, additional, Hemphill, J. Claude, additional, Hurko, Orest, additional, Irani, Sarosh R., additional, Jo, Jasmin, additional, Josephson, S. Andrew, additional, Kaley, Thomas J., additional, Kim, Anthony S., additional, Ko, Nerissa U., additional, Koshy, Anita A., additional, Kraler, Lironn, additional, Krumholz, Allan, additional, Leonard, John M., additional, Levin, Morris, additional, Manno, Edward M., additional, Mastaglia, Frank L., additional, Maurer, Carine W., additional, McCall, Andrew A., additional, Messing, Robert O., additional, Miravalle, Augusto, additional, Monderer, Renee, additional, Morren, John A., additional, Muccilli, Alexandra D., additional, Muir, Ryan T., additional, Murphy, Olwen C., additional, Nash, Kendall, additional, Ooi, Winnie W., additional, Pal, Pramod K., additional, Panicker, Jalesh N., additional, Parent, Jack M., additional, Peluso, Michael J., additional, Perfect, John R., additional, Peyvandi, Shabnam, additional, Pfeiffer, Ronald F., additional, Phillips, Steven M., additional, Poncelet, Ann Noelle, additional, Prasad, Sashank, additional, Prasad, Shweta, additional, Probasco, John C., additional, Purdy, Kaylynn, additional, Rabinstein, Alejandro A., additional, Ralph, Jeffrey W., additional, Ramachandran, Prashanth S., additional, Roos, Karen L., additional, Rose-Innes, Andrew P., additional, Safarpour, Delaram, additional, Schiff, David, additional, Schipper, Hyman M., additional, Shah, Maulik P., additional, Sharzehi, Kaveh, additional, Shaw, Pamela J., additional, Spudich, Serena, additional, Srinivasan, Jayashri, additional, Stern, Barney J., additional, Sun, Chung-Huan Johnny, additional, Sussman, Jon D., additional, Thorpy, Michael, additional, Verber, Nick S., additional, VoduŠek, David B., additional, Weissenborn, Karin, additional, Williams, Linda S., additional, Wilson, Michael R., additional, and Zochodne, Douglas W., additional
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- 2021
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47. Sarcoidosis of the Nervous System
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Murphy, Olwen C., primary, Krumholz, Allan, additional, and Stern, Barney J., additional
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- 2021
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48. Decisions With Patients and Families Regarding Aducanumab in Alzheimer Disease, With Recommendations for Consent: AAN Position Statement
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Chiong, Winston, Tolchin, Benjamin David, Bonnie, Richard J., Busl, Katharina M., Cruz-Flores, Salvador, Epstein, Leon G., Greene, Ericka P., Illes, Judy, Kirschen, Matthew, Larriviere, Daniel G., Mantri, Sneha, Rubin, Michael A., Stern, Barney J., and Taylor, Lynne P.
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- 2022
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49. Advanced In-Flight Verification and New Detector Materials for Particle Detection as Tested for ESRA ECP
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Kroupa, M., primary, Barney, J. E., additional, Caffrey, M. P., additional, Boyd, K. G., additional, Gula, A. C., additional, Mendel, S. M., additional, Miller, Z. B., additional, and Maldonado, C. A., additional
- Published
- 2023
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50. Neurosarcoidosis and Neurologic Complications of Sarcoidosis Treatment
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Voortman, Mareye, primary, Drent, Marjolein, additional, and Stern, Barney J., additional
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- 2023
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- View/download PDF
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