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4. Clinical and FDG-PET/CT correlates in patients with polymyalgia rheumatica

Author

Camellino, D., Francesco Paparo, Morbelli, S. D., Pesce, G., Bauckneht, M., Bagnasco, M., Cutolo, M., Sambuceti, G., and Cimmino, M. A.

Subjects
Aged, 80 and over, Giant Cell Arteritis, Immunology, Middle Aged, Rheumatology, Fluorodeoxyglucose F18, Polymyalgia Rheumatica, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Humans, Immunology and Allergy, Female, Radiopharmaceuticals, Aged
Abstract

We aimed to evaluate joint and vessel uptake in patients with polymyalgia rheumatica (PMR) by FDG-PET and correlate it with clinical findings.Consecutive PMR patients, without clinical signs of giant cell arteritis, underwent a standardised clinical examination and FDG-PET/CT. Controls were consecutive subjects undergoing FDG-PET for the suspicion of neoplasm not confirmed by the examination. Uptake was evaluated by a qualitative visual score, using the liver uptake as reference and by the semi-quantitative mean standardised uptake value (SUV) and target-to-background ratio (TBR) methods.Eighty-four patients and 84 controls (55 women, median age 73 years, range 50-92 years in both groups) were studied. Sixteen patients were taking glucocorticoids (GC). PMR patients showed a higher articular uptake than controls. GC-treated patients showed uptake lower than GC-naïve patients, but still higher than controls. PMR patients showed a higher vascular uptake than controls in all districts except in the carotid arteries, when evaluated by the visual score. Conversely, the semi-quantitative approach yielded no significant differences. Forty-two patients (50%) showed PET evidence of large-vessel vasculitis (LVV), defined as uptake ≥ than that of the liver, and 11.9% showed LVV with vascular uptake higher than that of the liver. The correlation between clinical findings and uptake was scarce. Neither clinical nor laboratory findings could predict the presence of LVV.Patients with PMR show a typical joint pattern at FDG-PET. There are no clinical or laboratory predictors of LVV. Imaging appears to be the only tool to assess LVV in these patients.

Published
2022

6. Evidence for charge-based mimicry in anti dsDNA antibody generation

Author

Bruschi, M, Angeletti, A, Kajana, X, Moroni, G, Sinico, R, Fredi, M, Vaglio, A, Cavagna, L, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Negrini, S, Bui, F, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Verrina, E, Franceschini, F, Ravelli, A, Prunotto, M, Meroni, P, Ghiggeri, G, Bruschi, Maurizio, Angeletti, Andrea, Kajana, Xhuliana, Moroni, Gabriella, Sinico, Renato Alberto, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe Alvise, Esposito, Pasquale, Negrini, Simone, Bui, Federica, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Verrina, Enrico, Franceschini, Franco, Ravelli, Angelo, Prunotto, Marco, Meroni, Pier Luigi, Ghiggeri, Gian Marco, Bruschi, M, Angeletti, A, Kajana, X, Moroni, G, Sinico, R, Fredi, M, Vaglio, A, Cavagna, L, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Negrini, S, Bui, F, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Verrina, E, Franceschini, F, Ravelli, A, Prunotto, M, Meroni, P, Ghiggeri, G, Bruschi, Maurizio, Angeletti, Andrea, Kajana, Xhuliana, Moroni, Gabriella, Sinico, Renato Alberto, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe Alvise, Esposito, Pasquale, Negrini, Simone, Bui, Federica, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Verrina, Enrico, Franceschini, Franco, Ravelli, Angelo, Prunotto, Marco, Meroni, Pier Luigi, and Ghiggeri, Gian Marco

Abstract

Mechanisms for the generation of anti-dsDNA autoantibodies are still not completely elucidated. One theory states that dsDNA interacts for mimicry with antibodies raised versus other antigens but molecular features for mimicry are unknown. Here we show that, at physiological acid-base balance, anti-Annexin A1 binds IgG2 dsDNA in a competitive and dose-dependent way with Annexin A1 and that the competition between the two molecules is null at pH 9. On the other hand, these findings also show that dsDNA and Annexin A1 interact with their respective antibodies on a strictly pH-dependent basis: in both cases, the binding was minimal at pH 4 and maximal at pH9-10. The anionic charge of dsDNA is mainly conferred by the numerous phosphatidic residues. The epitope binding site of Annexin A1 for anti-Annexin A1 IgG2 was here characterized as a string of 34 amino acids at the NH2 terminus, 10 of which are anionic. Circulating levels of anti-dsDNA and anti-Annexin A1 IgG2 antibodies were strongly correlated in patients with systemic lupus erythematosus (n 496) and lupus nephritis (n 425) stratified for age, sex, etc. These results show that dsDNA competes with Annexin A1 for the binding with anti-Annexin A1 IgG2 on a dose and charged mediated base, being able to display an inhibition up to 75%. This study provides the first demonstration that dsDNA may interact with antibodies raised versus other anionic molecules (anti-Annexin A1 IgG2) because of charge mimicry and this interaction may contribute to anti-dsDNA antibodies generation.

Published
2022

7. Rationale and Mechanisms of Cancer Chemoprevention

Author

De Flora, S., Bennicelli, C., Bagnasco, M., Schlag, P. M., editor, Senn, H.-J., editor, Diehl, V., editor, Parkin, D. M., editor, Rajewsky, M. F., editor, Rubens, R., editor, Wannenmacher, M., editor, Senn, Hans-Jörg, editor, Costa, Alberto, editor, and Jordan, V. Craig, editor

Published
1999
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9. Neutrophil Extracellular Traps (NETs) profiles in patients with incident SLE and lupus nephritis

Author

Bruschi, M, Bonanni, A, Petretto, A, Vaglio, A, Pratesi, F, Santucci, L, Migliorini, P, Bertelli, R, Galetti, M, Belletti, S, Cavagna, L, Moroni, G, Franceschini, F, Fredi, M, Pazzola, G, Allegri, L, Sinico, Ra, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, Ga, Ramoino, P, Bianchini, P, Puppo, F, Pupo, F, Negrini, S, Mattana, F, Emmi, G, Garibotto, G, Santoro, D, Scolari, F, Ravelli, A, Tincani, A, Cravedi, P, Volpi, S, Candiano, G, Ghiggeri, Gm, Bruschi, M, Bonanni, A, Petretto, A, Vaglio, A, Pratesi, F, Santucci, L, Migliorini, P, Bertelli, R, Galetti, M, Belletti, S, Cavagna, L, Moroni, G, Franceschini, F, Fredi, M, Pazzola, G, Allegri, L, Sinico, R, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Ramoino, P, Bianchini, P, Puppo, F, Pupo, F, Negrini, S, Mattana, F, Emmi, G, Garibotto, G, Santoro, D, Scolari, F, Ravelli, A, Tincani, A, Cravedi, P, Volpi, S, Candiano, G, and Ghiggeri, G

Subjects
lupus nephritis, Systemic Lupus Erythematosus (SLE), Neutrophil Extracellular Traps (NETs)
Abstract

Objective. Neutrophil extracellular traps (NET) expose modified antigens for autoantibodies in vasculitis. Little is known about levels and removal pathways of NET in systemic lupus erythematosus (SLE), especially in lupus nephritis (LN). We determined circulating levels and defined NET removal in large subsets of patients with incident SLE (iSLE), some of whom had new-onset nephritis. Methods. Serum levels of NET (ELISA), DNase1/DNase1L3 (ELISA), and DNase activity (functional assay) were determined in 216 patients with iSLE [103 had incident LN (iLN)], in 50 patients with other primary glomerulonephritis, and in healthy controls. Ex vivo NET production by neutrophils purified from a random selection of patients was quantified as elastase/DNA release and by immunofluorescence techniques. Results. Serum NET levels were very high in iSLE/iLN compared to all groups of controls and correlated with anti-dsDNA, C3-C4, and proteinuria; iLN had the highest levels. DNase activity was decreased in iLN compared to SLE (20% had one-half DNase activity) despite similar serum levels of DNase1/DNase1L3. In these cases, pretreatment of serum with protein A restored DNase efficiency; 1 patient was homozygous for a c.289_290delAC variant of DNASE1L3. Ex vivo NET production by neutrophils purified from LN, SLE, and normal controls was similar in all cases. Conclusion. Patients with iLN have increased circulating NET and reduced DNase activity, the latter being explained by the presence of inhibitory substances in circulation and/or by rare DNase1L3 mutations. Accumulation of NET derives from a multifactorial mechanism, and is associated and may contribute to disease severity in SLE, in particular to renal lesions. (Clinical trial registration: The Zeus study was registered at ClinicalTrials.gov, study number NCT02403115).

Published
2020

13. Serum IgG2 antibody multi-composition in systemic lupus erythematosus and in lupus nephritis (Part 2): prospective study

Author

Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, Ghiggeri, Gian Marco, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Objectives: Circulating anti-ENO1 and anti-H2A IgG2 have been identified as specific signatures of LN in a cross-over approach. We sought to show whether the same antibodies identify selected population of patients with LN with potentially different clinical outcomes. Methods: Here we report the prospective analysis over 36 months of circulating IgG2 levels in patients with newly diagnosed LN (n=91) and SLE (n=31) and in other patients with SLE recruited within 2 years from diagnosis (n=99). Anti-podocyte (ENO1), anti-nucleosome (DNA, histone 2 A, histone 3) and anti-circulating proteins (C1q, AnnexinA1-ANXA1) IgG2 antibodies were determined by home-made techniques. Results: LN patients were the main focus of the study. Anti-ENO1, anti-H2A and anti-ANXA1 IgG2 decreased in parallel to proteinuria and normalized within 12 months in the majority of patients while anti-dsDNA IgG2 remained high over the 36 months. Anti-ENO1 and anti-H2A had the highest association with proteinuria (Heat Map) and identified the highest number of patients with high proteinuria (68% and 71% respectively) and/or with reduced estimated glomerula filtration rate (eGFR) (58% for both antibodies) compared with 23% and 17% of anti-dsDNA (agreement analysis). Anti-ENO1 positive LN patients had higher proteinuria than negative patients at T0 and presented the maximal decrement within 12 months. Conclusions: Anti-ENO1, anti-H2A and anti-ANXA1 antibodies were associated with high proteinuria in LN patients and Anti-ENO1 also presented the maximal reduction within 12 months that paralleled the decrease of proteinuria. Anti-dsDNA were not associated with renal outcome parameters. New IgG2 antibody signatures should be utilized as tracers of personalized therapies in LN. Trial registration: The Zeus study was registered at https://clinicaltrials.gov (study number: NCT02403115).

Published
2021

14. Second wave antibodies in autoimmune renal diseases: The case of lupus nephritis

Author

Angeletti, A, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Ravelli, A, Ghiggeri, G, Angeletti, Andrea, Bruschi, Maurizio, Moroni, Gabriela, Sinico, Renato, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Ravelli, Angelo, Ghiggeri, Gian Marco, Angeletti, A, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Ravelli, A, Ghiggeri, G, Angeletti, Andrea, Bruschi, Maurizio, Moroni, Gabriela, Sinico, Renato, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Clinical Trial registry name and registration number: Zeus study, NCT02403115

Published
2021

15. Serum IgG2 antibody multicomposition in systemic lupus erythematosus and lupus nephritis (Part 1): cross-sectional analysis

Author

Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Volpi, S, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela&nbsp, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello&nbsp, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Mosca, Marta, Tincani, Angela&nbsp, Candiano, Giovanni, Prunotto, Marco, Volpi, Stefano, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, Ghiggeri, Gian Marco, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Volpi, S, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela&nbsp, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello&nbsp, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Mosca, Marta, Tincani, Angela&nbsp, Candiano, Giovanni, Prunotto, Marco, Volpi, Stefano, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Objectives: Serum anti-dsDNA and anti-nucleosome IgGs have been proposed as signatures for SLE and LN in limited numbers of patients. We sought to show higher sensitivity and specificity of the same antibodies with the IgG2 isotype and included IgG2 antibodies vs specific intracellular antigens in the analysis. Methods: A total of 1052 SLE patients with (n = 479) and without (n = 573) LN, recruited at different times from the beginning of symptoms, were included in the study. Patients with primary APS (PAPS, n = 24), RA (RA, n = 24) and UCTD (UCTD, n = 96) were analysed for comparison. Anti-nucleosome (dsDNA, Histone2A, Histone3), anti-intracellular antigens (ENO1), anti-annexin A1 and anti-C1q IgG2 were determined by non-commercial techniques. Results: The presence in the serum of the IgG2 panel was highly discriminatory for SLE/LN vs healthy subjects. Serum levels of anti-dsDNA and anti-C1q IgG2 were more sensitive than those of IgGs (Farr radioimmunoassay/commercial assays) in identifying SLE patients at low-medium increments. Of more importance, serum positivity for anti-ENO1 and anti-H2A IgG2 discriminated between LN and SLE (ROC T0-12 months), and high levels at T0-1 month were detected in 63% and 67%, respectively, of LN, vs 3% and 3%, respectively, of SLE patients; serum positivity for each of these was correlated with high SLEDAI values. Minor differences existed between LN/SLE and the other rheumatologic conditions. Conclusion: Nephritogenic IgG2 antibodies represent a specific signature of SLE/LN, with a few overlaps with other rheumatologic conditions. High levels of anti-ENO1 and anti-H2A IgG2 correlated with SLE activity indexes and were discriminatory between SLE patients limited to the renal complication and other SLE patients. Trial registration: The Zeus study was registered at https://clinicaltrials.gov, NCT02403115.

Published
2021

18. Progress in the integrated simulation of thermal-hydraulic operation of the ITER magnet system

Author

Bagnasco, M., Bessette, D., Bottura, L., Marinucci, C., and Rosso, C.

Subjects
Superconducting magnets -- Thermal properties, Superconducting magnets -- Design and construction, Technical institutes -- Management, Company business management, Business, Electronics, Electronics and electrical industries, International Thermonuclear Experimental Reactor -- Management
Published
2010

19. Methods, accuracy and reliability of ITER conductor tests in SULTAN

Author

Bruzzone, P., Stepanov, B., Wesche, R., Ilyin, Y., Herzog, R., Calvi, M., Bagnasco, M., and Cau, F.

Subjects
Electrical conduits -- Design and construction, Nuclear reactors -- Design and construction, Nuclear reactors -- Testing, Superconducting magnets -- Quality management, Superconducting magnets -- Thermal properties, Business, Electronics, Electronics and electrical industries
Published
2009

23. Inter-strand resistance in the termination of ITER conductors

Author

Cau, F., Bagnasco, M., Bruzzone, P., Calvi, M., and Roth, F.

Subjects
Niobium -- Electric properties, Niobium -- Thermal properties, Nuclear reactors -- Design and construction, Tin alloys -- Electric properties, Tin alloys -- Thermal properties, Superconductivity -- Analysis, Business, Electronics, Electronics and electrical industries
Abstract

The current redistribution phenomenon is studied at CRPP by using an experimental investigation on a [Nb.sub.3]Sn CICC termination. The results have ruled out the speculations about the impact of current re-distribution effects on the voltage-current and voltage-temperature characteristics in short length conductor test.

Published
2008

24. Two results of two European ITER TF conductor samples in SULTAN

Author

Bruzzone, P., Bagnasco, M., Calvi, M., Cau, F., Ciazynski, D., della Corte, A., Di Zenobio, A., Muzzi, L., Nijhuis, A., Salpietro, E., Richard, L.. Savoldi, Turtu, S., Vostner, A., Wesche, R., and Zanino, R.

Subjects
Magnetic fields -- Analysis, Nuclear reactors -- Design and construction, Superconducting magnets -- Evaluation, Business, Electronics, Electronics and electrical industries
Abstract

Two European ITER toroidal field (TF) prototype samples are prepared, assembled and tested in SULTAN. The ITER specifications are fulfilled by both samples, with outstanding results for the conductor with longer twist pitches.

Published
2008

25. Re-test of the TFAS1 sample with solder filled extremities

Author

Stepanov, B., Bruzzone, P., Wesche, R., Bagnasco, M., Vogel, M., Ciazynski, D., and Martovetsky, N.N.

Subjects
Electric currents -- Evaluation, Magnetic fields -- Analysis, Superconductors -- Evaluation, Business, Electronics, Electronics and electrical industries
Abstract

The extremely delicate solder filling process of the explosion bonded termination is developed and performed at CRPP. The studies have confirmed the good quality of the solder filling after the destructive test of all the terminations.

Published
2008

26. Development of a react & wind conductor for the ITER toroidal field coils

Author

Bruzzone, P., Bagnasco, M., Cau, F., Stepanov, B., and Wesche, R.

Subjects
Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Magnetic fields -- Analysis, Niobium -- Magnetic properties, Niobium -- Electric properties, Nuclear reactors -- Design and construction, Superconducting magnets -- Usage, Business, Electronics, Electronics and electrical industries
Abstract

The 48 kA react and wind toroidal field (TF) conductor developed at CRPP has shown no degradation even without solder filling of the cable. The advantages of a react and wind conductor option for the ITER TF coils, heat treatment, electrical insulation, structural reinforcement and overall cost saving potential are discussed.

Published
2008

27. Preparatory work to host the EDIPO test facility at CRPP

Author

Calvi, M., Bagnasco, M., Bruzzone, P., Cau, F., Herzog, R., Marinucci, C., Stepanov, B., Vogel, M., and Wesche, R.

Subjects
Colliders (Nuclear physics) -- Testing, Dipole moments -- Analysis, Research institutes -- Buildings and facilities, Superconducting magnets -- Design and construction, Business, Electronics, Electronics and electrical industries
Abstract

The preparatory work ongoing at CRPP to integrate the EFDA dipole (EDIPO) test facility is discussed. The preparatory work has included the design and procurement of many items as well as the final assembly and commissioning of the facility.

Published
2008

28. Winding configurations studies for the EFDA dipole test facility EDIPO

Author

Portone, A., Bruzzone, P., Calvi, M., Bagnasco, M., and Cau, F.

Subjects
Dipole moments -- Analysis, Niobium -- Magnetic properties, Niobium -- Electric properties, Nuclear fusion -- Analysis, Metals -- Quenching, Metals -- Analysis, Tin alloys -- Magnetic properties, Tin alloys -- Electric properties, Business, Electronics, Electronics and electrical industries
Abstract

Two planar coil windings are studied in order to produce a required level of vertical field inside a rectangular shaped bore. Their performances are compared with the reference the EFDA dipole (EDIPO) configuration, which is based on different cost indexes and different winding engineering current densities.

Published
2008

30. Serum IgG2 antibody multi composition in systemic lupus erythematosus and in lupus nephritis

Author

Bruschi, M, Moroni, G, Sinico, Ra, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, Ga, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, and Ghiggeri, Gm.

Published
2020

31. Test results of two ITER TF conductor short samples using high current density [Nb.sub.3]Sn strand

Author

Bruzzone, P., Bagnasco, M., Ciazynski, D., della Corte, A., Di Zenobio, A., Herzog, R., Ilyin, Y., Lacroix, B., Muzzi, L., Nijhuis, A., Renard, B., Salpietro, E., Richard, L.S., Stepanov, B., Turtu, S., Vostner, A., Wesche, R., Zani, L., and Zanino, R.

Subjects
Niobium -- Electric properties, Electrical cables -- Electric properties, Superconductors -- Electric properties, Business, Electronics, Electronics and electrical industries
Abstract

Two conductor short samples were tested for examining the use of high current [Nb.sub.3]Sn strands in International Thermonuclear Experimental Reactor (ITER) cable-in-conduit conductors (CICC). Findings revealed the strong degradation of the CICC performance in comparison to the strand for all conductors.

Published
2007

32. Predictive analysis of the ITER Poloidal Field Conductor Insert (PFCI) test program

Author

Zanino, R., Astrov, M., Bagnasco, M., Baker, W., Bellina, F., Ciazynski, D., Egorov, S., Kim, K., Kvitkovic, J.L., Lacroix, B., Martovetsky, N., Mitchell, N., Muzzi, L., Nunoya, Y., Okuno, K., Polak, M., Ribani, P.L., Salpietro, E., Richard, L. Savoldi, Sborchia, C., Takahashi, Y., Weng, P., Wesche, R., Zani, L., and Zapretilina, E.

Subjects
Superconducting magnets -- Electric properties, Fusion reactors -- Design and construction, Electric coils -- Electric properties, Electric coils -- Magnetic properties, Business, Electronics, Electronics and electrical industries
Abstract

The predictive analysis of the International Thermonuclear Experimental Reactor (ITER) Poloidal Field Conductor Insert (PFCI) test program is presented. PFCI is the first insert coil based on NbTi and is aimed at bridging the extrapolation gap between its full-size short sample and the ITER Poloidal Field (PF) coils.

Published
2007

34. T(Sub cs) tests and performance assessment of the ITER toroidal field model coil (phase II)

Author

Zanino, R., Fillunger, H., Komarek, P., Nijhuis, A., Taylor, D.M.J., Ulbricht, A., Fietz, W.H., Dittrich, G., Bagnasco, M., Heller, R., Hampshire, D.P., Mitchell, N., Mertovetsky, N., Marchese, V., Maix, R., Langhans, O., Richard, Savoldi L., Salpietro, E., Suesser, M., Ricci, M., Raff, S., Zahn, G., Wuechner, F., and Vostner, A.

Subjects
Electric coils -- Properties, High temperature superconductors -- Mechanical properties, Business, Electronics, Electronics and electrical industries
Abstract

The tests of the Toroidal Field Model Coil (TFMC) are completed in the TOSKA facility of Forschungszentrun Karlsruhe. The TFMC isolated strand is characterized at different applied uniaxial strain, and preliminary results indicate a stronger reduction of carrying capacity compared to the extrapolation from summers scaling used in the analysis.

Published
2004

39. Recommendations for the Use of Tryptase in the Diagnosis of Anaphylaxis and Clonal Mastcell Disorders

Author

Platzgummer, S., primary, Bizzaro, N., additional, Bilò, M.B., additional, Pravettoni, V., additional, Cecchi, L., additional, Sargentini, V., additional, Caponi, L., additional, Visentini, D., additional, Brusca, I., additional, Pesce, G., additional, Bagnasco, M., additional, Antico, A., additional, Montera, M.C., additional, Quercia, O., additional, Musarra, A., additional, Bonazza, L., additional, Borrelli, P., additional, Cortellini, G., additional, Polillo, B.R., additional, Valenti, G., additional, Zedda, M.T., additional, Asero, R., additional, and Villalta, D., additional

Published
2020
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42. The ITER toroidal field model coil project

Author

Ulbricht, A., Duchateau, J.L., Fietz, W.H., Ciazynski, D., Fillunger, H., Fink, S., Heller, R., Maix, R., Nicollet, S., Raff, S., Ricci, M., Salpietro, E., Zahn, G., Zanino, R., Bagnasco, M., Besette, D., Bobrov, E., Bonicelli, T., Bruzzone, P., Darweschsad, M.S., Decool, P., Dolgetta, N., della Corte, A., Formisano, A., Grünhagen, A., Hertout, P., Herz, W., Huguet, M., Hurd, F., Ilyin, Yu., Komarek, P., Libeyre, P., Marchese, V., Marinucci, C., Martinez, A., Martone, R., Martovetsky, N., Michael, P., Mitchell, N., Nijhuis, A., Nöther, G., Nunoya, Y., Polak, M., Portone, A., Savoldi Richard, L., Spadoni, M., Süßer, M., Turtú, S., Vostner, A., Takahashi, Y., Wüchner, F., and Zani, L.

Published
2005
Full Text
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