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2,654 results on '"BALZARINI, J."'

38. Abstracts of oral presentations

Author

Boulieu, R., Lenoir, A., Mornex, J. F., Bohman, C., Balzarini, J., Wigerinck, P., Van Aerschot, A., Herdewijn, P., De Clercq, Erik, Brosh, S., Zoref-Shani, E., Sperling, O., Danziger, E., Sidi, Y., Bromberg, Y., Burgemeister, Renate, Rötzer, Elke, Gutensohn, Wolf, Connolly, G. P., Harrison, P. J., Diasio, R. B., Lu, Z., Zhang, R., Gresser, U., Gutensohn, W., Resta, R., Thompson, L. F., Javaux, F., Vincent, M. F., Van den Berghe, G., Kamilli, I., Rauch, R., Hahn, D., Keuzenkamp-Jansen, C. W., De Abreu, R. A., Bökkerink, J. P. M., vd Heijden, M. A. H., Löffler, M., Becker, C., Wegerie, E., Marcussen, M., Overgaard-Hansen, K., Klenow, H., Marinaki, A. M., Harley, E. H., McBride, M. B., Simmonds, H. A., Moro, F., Cameron, J. S., Ogg, C. S., Williams, D. G., Rigden, S., Haycock, G., Miranda, M. E., Puig, J. G., Mateos, F. A., Vázquez, J. O., van Haperen, V. W. T. Ruiz, Veerman, G., Vermorken, J. B., Peters, G. J., van der Wilt, C. L., Noordhuis, P., Smid, K., Pinedo, H. M., Salerno, C., Lomonte, A., Giardini, O., Crifo, C., Smolenski, R. T., Yacoub, M. H., Seymour, A. M. -L., Stegmann, A. P. A., Honders, M. W., Willemze, R., Landegent, J. E., Stet, E. H., Vogels-Mentink, G. M., Lambooy, L. H. J., Trijbels, J. M. F., Torres, R. J., Tozzi, M. G., Pesi, R., Turriani, M., Allegrini, S., Camici, M., Ipata, P. L., van den Berg, A. A., Meinsma, J. R., van Lenthe, H., van Gennip, A. H., van Kuilenburg, A. B. P., Abeling, N. G. G. M., Bakker, H. D., Slingerland, R. J., Van den Bergh, F., and Sabina, R. L.

Published
1993
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42. Suppression of the breakthrough of human immunodeficiency virus type I (HIV-1) in cell culture by thiocarboxonilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives)

Author

Balzarini, J., Perez-Perez, M.-J., Velazquez, S., San-Felix, A., Camarasa, M.-J., Clerco, E. de, and Karlsson, A.

Subjects
HIV (Viruses) -- Research, Reverse transcriptase -- Research, HIV infection -- Research, Science and technology
Abstract

Synthesis of thiophene and furane revealed five structurally-related analogues of oxathiin carboxanilide derivative NSC 615985. Testing of the sensitivity of the strains to various test compounds indicated that they are potent inhibitors of HIV-1 replication and HIV-1 reverse transcription. PCR analysis and sequencing of the strains revealed that these compounds are active against mutant HIV-1 strains at specific amino acid configurations. The addition of bis(heteroaryl)piperazine, a specific reverse transcriptase inhibitor, increased resistance of strains against infection.

Published
1995

49. Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific (2', 5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5'-(4'-amino-1',2'-oxathiole-2', 2'-dioxide))-beta-D-pentofuranosyl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors

Author

Balzarini, J., Karlsson, A., Vandamme, A.-M., Perez-Perez, M.-J., Zhang, H., Vrang, L., Oberg, B., Backbro, K., Unge, T., San-Felix, A., Velazquez, S., Camarasa, M.-J., and Clercq, E. De

Subjects
HIV (Viruses) -- Research, Nucleoside analogs -- Observations, Mutagenesis -- Research, Science and technology
Abstract

Human immunodeficiency virus type 1 (HIV-1) is highly inhibited by the newly discovered class of necleoside analogues. The nucleoside analogues target the nonsubstrate binding site of HIV-1 reverse transcriptase (RT). The nucleotide analogues called TSAO are experimented upon to determine the resistivity of the HIV-1. The HIV-1 strains, which resist the TSAO nucleoside derivatives, are sensitive to the other HIV-1 specific nucleoside derivatives. Rapid degradation occurs in the HIV-1 RT, where the Glu-138 to Lys substitution was introduced by the site directed mutagenesis. However, stability was noticed in the HIV-1 Rt having the Glu-138 to Lys substitution.

Published
1993

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