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374 results on '"Ayyoub, Maha"'

1. Abstract A076: T-cell exhaustion is an independent predictive biomarker of clinical outcome in high grade serous ovarian cancer regardless of homologous recombination deficiency status

Author

Salvioni, Anna, primary, Del, Mathilde, additional, Michelas, Marie, additional, Vuattoux, Pierre, additional, Scarlata, Clara-Maria, additional, Martinez-Gomez, Carlos, additional, Van Acker, Nathalie, additional, Frenois, François-Xavier, additional, Bataillon, Guillaume, additional, Delord, Jean-Pierre, additional, Martinez, Alejandra, additional, and Ayyoub, Maha, additional

Published
2024
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3. Consensus nomenclature for CD8+ T cell phenotypes in cancer

Author

Apetoh, Lionel, Smyth, Mark J, Drake, Charles G, Abastado, Jean-Pierre, Apte, Ron N, Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H, Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P, Comin-Anduix, Begoña, Coukos, Georges, Dhodapkar, Madhav V, Dranoff, Glenn, Frazer, Ian H, Fridman, Wolf-Hervé, Gabrilovich, Dmitry I, Gilboa, Eli, Gnjatic, Sacha, Jäger, Dirk, Kalinski, Pawel, Kaufman, Howard L, Kiessling, Rolf, Kirkwood, John, Knuth, Alexander, Liblau, Roland, Lotze, Michael T, Lugli, Enrico, Marincola, Francesco, Melero, Ignacio, Melief, Cornelis J, Mempel, Thorsten R, Mittendorf, Elizabeth A, Odun, Kunle, Overwijk, Willem W, Palucka, Anna Karolina, Parmiani, Giorgio, Ribas, Antoni, Romero, Pedro, Schreiber, Robert D, Schuler, Gerold, Srivastava, Pramod K, Tartour, Eric, Valmori, Danila, van der Burg, Sjoerd H, van der Bruggen, Pierre, van den Eynde, Benoît J, Wang, Ena, Zou, Weiping, Whiteside, Theresa L, Speiser, Daniel E, Pardoll, Drew M, Restifo, Nicholas P, and Anderson, Ana C

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, 2.1 Biological and endogenous factors, Aetiology, anergy, anticancer immunity, CD8(+) T cells, cytotoxicity, exhaustion, effector, IFN gamma, senescence, stemness, CD8+ T cells, IFNγ, Oncology and carcinogenesis
Abstract

Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T cells in cancer calls for a more precise definition of the CD8+ T cell immune phenotypes in cancer and the abandonment of the generic terms "pro-tumor" and "antitumor." Based on recent studies investigating the functions of CD8+ T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8+ T cells in cancer.

Published
2015

4. Immune changes in hilar tumor draining lymph nodes following node sparing neoadjuvant chemoradiotherapy of localized cN0 non-small cell lung cancer

Author

Khalifa, Jonathan, primary, Thébault, Noémie, additional, Scarlata, Clara-Maria, additional, Norkowski, Emma, additional, Massabeau, Carole, additional, Brouchet, Laurent, additional, Peries Bataille, Sophie, additional, Casaroli, Christelle, additional, Vaz, Liza, additional, Valle, Carine, additional, Sarot, Emeline, additional, Saint-Laurent, Nathalie, additional, Martin, Etienne, additional, Pages, Pierre-Benoît, additional, Millière, Alice, additional, Mazières, Julien, additional, Cohen-Jonathan Moyal, Elizabeth, additional, Lauzéral-Vizcaïno, Françoise, additional, and Ayyoub, Maha, additional

Published
2023
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5. Data from Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

Author

Balança, Camille-Charlotte, primary, Scarlata, Clara-Maria, primary, Michelas, Marie, primary, Devaud, Christel, primary, Sarradin, Victor, primary, Franchet, Camille, primary, Martinez Gomez, Carlos, primary, Gomez-Roca, Carlos, primary, Tosolini, Marie, primary, Heaugwane, Diana, primary, Lauzéral-Vizcaino, Françoise, primary, Mir-Mesnier, Lucile, primary, Féliu, Virginie, primary, Valle, Carine, primary, Pont, Frédéric, primary, Ferron, Gwénaël, primary, Gladieff, Laurence, primary, Motton, Stéphanie, primary, Tanguy Le Gac, Yann, primary, Dupret-Bories, Agnès, primary, Sarini, Jérôme, primary, Vairel, Benjamin, primary, Illac, Claire, primary, Siegfried-Vergnon, Aurore, primary, Mery, Eliane, primary, Fournié, Jean-Jacques, primary, Vergez, Sébastien, primary, Delord, Jean-Pierre, primary, Rochaix, Philippe, primary, Martinez, Alejandra, primary, and Ayyoub, Maha, primary

Published
2023
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6. Supplementary Figures and Tables from Dual Relief of T-lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies

Author

Balança, Camille-Charlotte, primary, Scarlata, Clara-Maria, primary, Michelas, Marie, primary, Devaud, Christel, primary, Sarradin, Victor, primary, Franchet, Camille, primary, Martinez Gomez, Carlos, primary, Gomez-Roca, Carlos, primary, Tosolini, Marie, primary, Heaugwane, Diana, primary, Lauzéral-Vizcaino, Françoise, primary, Mir-Mesnier, Lucile, primary, Féliu, Virginie, primary, Valle, Carine, primary, Pont, Frédéric, primary, Ferron, Gwénaël, primary, Gladieff, Laurence, primary, Motton, Stéphanie, primary, Tanguy Le Gac, Yann, primary, Dupret-Bories, Agnès, primary, Sarini, Jérôme, primary, Vairel, Benjamin, primary, Illac, Claire, primary, Siegfried-Vergnon, Aurore, primary, Mery, Eliane, primary, Fournié, Jean-Jacques, primary, Vergez, Sébastien, primary, Delord, Jean-Pierre, primary, Rochaix, Philippe, primary, Martinez, Alejandra, primary, and Ayyoub, Maha, primary

Published
2023
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12. Supplementary Figure 1 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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13. Supplementary Methods from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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14. Supplementary Figure 1 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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15. Supplementary Table 1 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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17. Supplementary Figure Legend from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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18. Supplementary Table 2 from Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo

Author

Hamaï, Ahmed, primary, Pignon, Pascale, primary, Raimbaud, Isabelle, primary, Duperrier-Amouriaux, Karine, primary, Senellart, Hélène, primary, Hiret, Sandrine, primary, Douillard, Jean-Yves, primary, Bennouna, Jaafar, primary, Ayyoub, Maha, primary, and Valmori, Danila, primary

Published
2023
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19. Data from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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20. Supplementary Figure Legend from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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21. Supplementary Figure 5 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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22. Supplementary Figure 3 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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23. Data from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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28. Supplementary Figure 4 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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29. Supplementary Figure 6 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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30. Supplementary Figure 1 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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31. Supplementary Figure 5 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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32. Supplementary Table 1 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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34. Supplementary Figure 4 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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35. Supplementary Figure 2 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Author

Romero, Ana I., primary, Chaput, Nathalie, primary, Poirier-Colame, Vichnou, primary, Rusakiewicz, Sylvie, primary, Jacquelot, Nicolas, primary, Chaba, Kariman, primary, Mortier, Erwan, primary, Jacques, Yannick, primary, Caillat-Zucman, Sophie, primary, Flament, Caroline, primary, Caignard, Anne, primary, Messaoudene, Meriem, primary, Aupérin, Anne, primary, Vielh, Philippe, primary, Dessen, Philippe, primary, Porta, Camillo, primary, Mateus, Christine, primary, Ayyoub, Maha, primary, Valmori, Danila, primary, Eggermont, Alexander, primary, Robert, Caroline, primary, and Zitvogel, Laurence, primary

Published
2023
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37. Supplementary Figure 2 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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38. Supplementary Figure 3 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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40. Supplementary Materials, Legends for Figures 1-5 from Efficacy of Levo-1-Methyl Tryptophan and Dextro-1-Methyl Tryptophan in Reversing Indoleamine-2,3-Dioxygenase–Mediated Arrest of T-Cell Proliferation in Human Epithelial Ovarian Cancer

Author

Qian, Feng, primary, Villella, Jeannine, primary, Wallace, Paul K., primary, Mhawech-Fauceglia, Paulette, primary, Tario, Joseph D., primary, Andrews, Christopher, primary, Matsuzaki, Junko, primary, Valmori, Danila, primary, Ayyoub, Maha, primary, Frederick, Peter J., primary, Beck, Amy, primary, Liao, Jianqun, primary, Cheney, Richard, primary, Moysich, Kirsten, primary, Lele, Shashikant, primary, Shrikant, Protul, primary, Old, Lloyd J., primary, and Odunsi, Kunle, primary

Published
2023
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43. Distant antimetastatic effect of enterotropic colon cancer–derived α4β7+CD8+ T cells.

Author

Feliu, Virginie, Gomez-Roca, Carlos, Michelas, Marie, Thébault, Noémie, Lauzéral-Vizcaino, Françoise, Salvioni, Anna, Scandella, Lise, Sarot, Emeline, Valle, Carine, Balança, Camille-Charlotte, Scarlata, Clara-Maria, Delord, Jean-Pierre, Ayyoub, Maha, and Devaud, Christel

Abstract

Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC), metastatic disease remains resistant to immunotherapy by immune checkpoint blockade (ICB). Here, we show, in metastatic CRC preclinical models, that orthotopically implanted primary colon tumors exert a colon-specific antimetastatic effect on distant hepatic lesions. Enterotropic α4β7 integrin–expressing neoantigen-specific CD8 T cells were key components of the antimetastatic effect. Accordingly, the presence of concomitant colon tumors improved control of liver lesions by anti–PD-L1 proof-of-concept immunotherapy and generated protective immune memory, whereas partial depletion of α4β7+ cells abrogated control of metastases. Last, in patients with metastatic CRC, response to ICB was associated with expression of α4β7 integrin in metastases and with circulating α4β7+ CD8 T cells. Our findings identify a systemic cancer immunosurveillance role for gut-primed tumor-specific α4β7+ CD8 T cells. Editor's summary: In patients with metastatic colorectal carcinoma (CRC), immune checkpoint blockade (ICB) therapies have historically had a poor success rate. Using a mouse CRC model featuring orthotopic implantation of tumors in the colon, Feliu et al. found that a subset of these colonic tumors could stimulate the differentiation of CD8+ T cells capable of spontaneously controlling growth of the primary tumor and a concomitant tumor implanted in the liver to model metastatic disease. The critical CD8+ effector cells supporting control of metastatic deposits expressed the gut-homing α4β7 integrin receptor. These findings combined with analysis of T cells from patients with metastatic CRC point to gut-primed α4β7+ T cells as key antitumor effectors that can also mediate systemic immunosurveillance providing immune control of metastatic disease. —Claire Olingy [ABSTRACT FROM AUTHOR]

Published
2023
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46. Circulating Exhausted PD-1+CD39+ Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade

Author

Martinez-Gomez, Carlos, primary, Michelas, Marie, additional, Scarlata, Clara-Maria, additional, Salvioni, Anna, additional, Gomez-Roca, Carlos, additional, Sarradin, Victor, additional, Lauzéral-Vizcaino, Françoise, additional, Féliu, Virginie, additional, Dupret-Bories, Agnès, additional, Ferron, Gwénaël, additional, Sarini, Jérôme, additional, Devaud, Christel, additional, Delord, Jean-Pierre, additional, Balança, Camille-Charlotte, additional, Martinez, Alejandra, additional, and Ayyoub, Maha, additional

Published
2022
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47. Abstract 3203: Cutting edge biomarkers strategy to provide early insights into activity of EVT-801, a novel selective VEGFR-3 inhibitor that targets tumor angiogenesis during the FIH clinical trial

Author

Paillasse, Michael R., primary, Garner, James, additional, Fitzgerald, Michael, additional, Davenne, Lise, additional, Ancey, Pierre-Benoit, additional, Poussereau-Pomie, celine, additional, Esquerre, Michael, additional, Badet, Gaelle, additional, Tuyaret, Joel, additional, Mandron, Marie, additional, Rochaix, Philippe, additional, Ayyoub, Maha, additional, Scarlata, Clara Maria, additional, Ménétrier-Caux, Christine, additional, CAUX, Chrsitophe, additional, Cassier, Philippe, additional, Delord, Jean-Pierre, additional, Roca, Carlos Gomez, additional, and Fons, Pierre, additional

Published
2022
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