1. Serum Creatinine and Occurrence and Severity of Coronary Artery Disease
- Author
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Babak Bagheri, Najme Radmard, Atena Faghani-Makrani, and Mehdi Rasouli
- Subjects
Adult ,Male ,030213 general clinical medicine ,medicine.medical_specialty ,Renal function ,Coronary Disease ,Iran ,030204 cardiovascular system & hematology ,Kidney ,Coronary artery ,Severity of Illness Index ,Gastroenterology ,Coronary artery disease ,03 medical and health sciences ,chemistry.chemical_compound ,Sex Factors ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,Prevalence ,medicine ,Humans ,Urea ,Aged ,Original Paper ,Creatinine ,Apolipoprotein A-I ,business.industry ,Cholesterol, HDL ,General Medicine ,Odds ratio ,Middle Aged ,Lipid ,medicine.disease ,Uric Acid ,medicine.anatomical_structure ,chemistry ,Case-Control Studies ,Hypertension ,Potassium ,Uric acid ,Population study ,Female ,business ,Biomarkers - Abstract
Introduction: The risk for cardiovascular disease is increased in all stages of the impairment of renal function. It is proposed that serum creatinine is a marker of diabetes and coronary artery disease (CAD) as well as the kidney function. Aim: to study the association of serum creatinine with the likelihood and severity of CAD. The study population consisted of 262 males and 266 females who were classified as CAD cases and controls according to the results of coronary angiography. Results: Patients with CAD compared with the controls had increased levels of serum urea and creatinine. Serum creatinine showed significant positive correlation with male sex, hypertension and negative correlation with total- and HDL-cholesterol and apoAI. Serum urea, uric acid and potassium were the major determinants of creatinine. All hematological parameters were strong negative correlates of creatinine. None of markers of inflammation had significant correlation with creatinine. Creatinine was associated significantly with the prevalence [odds ratio of 1.79 (1.47-2.20), p
- Published
- 2019
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