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The presence of adults, nymphs, and oothecae of the African giant mantis Sphodromantis viridis Forsskål is for the first time recorded on the island of Tenerife, the largest and most populated of the Canary archipelago, an autonomous Spanish community in the Atlantic Ocean. The discovery took place in a popular water park rich in non-native plants in the municipality of Costa Adeje. It is possible that anthropogenic movements, particularly the massive movement of tourists and goods that continually cross this small archipelago, aided the dispersal to the area of this mantis, which for some years has also been expanding in many areas of the Mediterranean basin. A hypothesis on the ecological impact and the possible invasiveness of this extremely adaptable species is discussed and supported by the large number of sightings of oothecae and specimens that are, fortunately, still confined within the west coast of the island.

The Parkinson's Disease (PD) is a chronic neurodegenerative condition characterized by motor symptoms such as tremors, rigidity, and bradykinesia, which can significantly impact various aspects of daily life. Among these aspects, pain is a prominent element. Despite the widespread use of therapies aimed at improving symptoms and quality of life, effective pain management is essential to enhance the quality of life of individuals affected by this disease. However, a detailed understanding of the factors associated with pain in PD is still evolving. In this study, we examined the disability caused by pain and the pain experienced by PD patients using two validated questionnaires, namely the Parkinson's Disease Questionnaire (PDQ) and the King's Parkinson's Disease Pain Questionnaire (KPPQ). Customized questions were also included to further explore the pain experience and management strategies adopted by PD patients. Through statistical analysis, we explored the relationships between questionnaire scores, socio-demographic data, and other relevant variables. Additionally, generative Artificial Intelligence (AI) was employed to gain a deeper understanding of patient responses. The results indicate the extent and impact of pain in PD and provide valuable insights for more targeted and personalized management. This study lays the foundation for future research and the development of interventions aimed at improving the quality of life for individuals affected by this condition.

Abstract Objective Exercise may be physically and psychologically important for people with ALS, especially in the earlier stages of the disease, and, as a consequence, current ALS clinical management includes individualized rehabilitation as part of multidisciplinary care because. However, while recent studies focused on which type of exercise is more indicated to ALS patients, there is no evidence at which frequency training sessions should be performed. Methods We performed an assessor blinded randomized clinical trial to investigate the superiority of two different frequencies of exercise on rate of progression in ALS. We enrolled 65 patients in two groups: intensive exercise regimen (IER, five sessions/week) versus usual exercise regimen (UER, two sessions/week). The primary aim was to assess if IER decreased disease progression, measured through Amyotrophic Lateral Sclerosis Functional Rating Scale‐Revised, with respect to UER. Secondary aims included assessment of adverse events, tracheostomy‐free survival, motor and respiratory functions, fatigue, quality of life and caregiver burden. Treatment regimen consisted for both groups of the same kind of exercise including aerobic training, endurance training, stretching or assisted active mobilization, differing for frequency of intervention. Results No significant changes in disease progression were found in patients under IER versus UER. At the end of the study, there were no significant differences between the two groups in survival, respiratory function, time to supporting procedures, and quality of life. Adverse events, fatigue, and caregiver burden were not different between the two treatment regimens. Conclusions Despite some limitations, our trial demonstrated that high‐frequency physical exercise was not superior to UER on ALSFRS‐R scores, motor and respiratory functions, survival, fatigue, and quality of life of ALS patients.

Abstract Objective To compare the incidence and clinical features of individuals presenting in emergency rooms (ER) with facial palsy during the Italian COVID‐19 outbreak and in the same period of 2019. Methods We retrospectively reviewed the medical records for all accesses to the six ER in the province of Reggio Emilia, Italy, during the first phase of the COVID‐19 pandemic (27 February‐3 May 2020) to identify all cases of diagnosed facial palsy. Clinical information was retrieved for each patient and compared with that of facial palsy cases presenting in 2019. Result Between 27 February and 3 May 2020, 38 patients presented to provincial ERs for facial palsy; in 2019, there were 22 cases, for an incidence rate ratio of 1.73 (95% CI 1.02–2.92) for the 2020 cohort. Of the 2020 cohort, eight patients (21%) presented with active or recent symptoms consistent with COVID‐19 infection, compared with 2 (9%) in 2019 (p = .299); one was tested and resulted positive for SARS‐CoV‐2. Moreover, patients were younger (−11 years, p = .037) than those of the previous year and manifested a longer lag (+1.1 days, p = .001) between symptoms onset and ER presentation. Conclusion We observed a higher occurrence of facial palsy during the COVID‐19 outbreak compared to the same period of the previous year; 21% of patients presenting with facial palsy had active or recent symptoms consistent with SARS‐CoV‐2 infection, suggesting an excess risk of facial palsy during or after COVID‐19. These patients searched for medical attention later, probably because of the fear of contracting COVID‐19 during assistance.

It is well known that venules equipped with valves play a critical role in regulating blood flow. Essentially they are peristaltic pumps that increase the efficiency of venous blood return to the heart, thanks to the presence of valves preventing backflow. Inspired by two recent papers, we have modeled the venule as a vessel with valves placed at its ends and walls animated by radial oscillations that are independent of heart pulsation and respiratory rhythm. Differently from the previous papers, the present model takes into account the valves inertia allowing, for progressive closing/opening stages. The numerical simulations produce a pressure pulse and a velocity profile which agree almost perfectly with the experimental data of Dongaonkar et al., eliminating the discrepancies found in Farina et al., arising from the hypothesis that valves act instantaneously.

We investigated whether the C9orf72 repeat expansion is associated with specific clinical features, comorbidities, and prognosis in patients with amyotrophic lateral sclerosis (ALS). A cohort of 1417 ALS patients, diagnosed between January 1, 2009 and December 31, 2013 by 13 Italian ALS Referral Centers, was screened for the C9orf72 repeat expansion, and the analyses were performed comparing patients carrying this expansion (ALS-C9Pos) to those negative for this and other explored ALS-related mutations (ALS without genetic mutations, ALSwoGM). Compared to the ALSwoGM group, ALS-C9Pos patients (n = 84) were younger at disease onset, at the first clinical observation and at diagnosis (p < 0.001). After correcting for these differences, we found that ALS-C9Pos patients had higher odds of bulbar onset, diagnosis of frontotemporal dementia (FTD) and family history of ALS, FTD, and Alzheimer's disease and had lower odds of spinal onset, non-invasive ventilation, hypertension and psychiatric diseases than ALSwoGM patients. Among these variables, those related to shorter survival time were: bulbar onset, presence of FTD, hypertension, psychiatric disease, and family history of ALS (p < 0.05). Cox proportional hazards regression multivariate analysis suggested that carrying the C9orf72 repeat expansion was an independent factor negatively impacting on survival time in men (HR 1.58, 95% CI 1.07–2.33, p = 0.021), but not in women (p > 0.05) as well as in the whole sample (p > 0.05). When compared to ALSwoGM, ALS-C9Pos showed an earlier disease onset, no significant diagnostic delay and a higher odds of bulbar onset, FTD and family history of ALS and dementia. Moreover, male sex drove the negative effect of expanded variant on survival, confirming the hypothesis that sex is likely to be a crucial factor in the biology of C9orf72-related disease.

Blood rheology is a challenging subject owing to the fact that blood is a mixture of a fluid (plasma) and of cells, among which red blood cells make about 50% of the total volume. It is precisely this circumstance that originates the peculiar behavior of blood flow in small vessels (i.e., roughly speaking, vessel with a diameter less than half a millimeter). In this class we find arterioles, venules, and capillaries. The phenomena taking place in microcirculation are very important in supporting life. Everybody knows the importance of blood filtration in kidneys, but other phenomena, of not less importance, are known only to a small class of physicians. Overviewing such subjects reveals the fascinating complexity of microcirculation.

In this paper, we study the stationary configurations of a vapor-dominated geothermal system. We propose a general mathematical model, which turns out to be a free boundary problem, and we focus on the stationary solutions. The analysis, developed considering the data of the geothermal field in Larderello, Tuscany (Italy), shows that steady-stable states may exist both when the re-injection takes place in depth and when the natural recharge is distributed both in the area occupied by vapor and in the one occupied by liquid.

This study addresses two targets: first, the relationship between performance measurement and the focusing of fund investment strategies on local risk factors; second, the behavioral considerations which fall under this topic, in particular with regard to fund managers’ overconfidence. Brazil, Russia, India and China were supposed to represent a force of new demand growth and spending power, but the recent financial crisis in China (July and August 2015) and the former problems in the Russian economy, also caused by an embargo by other countries, have contributed to a shift which has occurred more quickly than expected. In this context, weak active management strategies, handicapped by behavioral biases, will be more evident and will cause more harm to the industry. Connections between these biases and the performance of funds are identified with the managers in charge, who are not only misguided by strong beliefs, but also take big bets on risky assets without producing significant alphas. To investigate the relationship between local bias and activism, we compare stock picking skills of local managers, the managing of domestic funds and non-local managers; therefore, we assume that local information can be exploited by a local manager with an active management strategy. It is also true that overconfident managers might be too focused on the specific stocks for which they believe to possess superior information. The results show that BRIC local managers are not closely tied to replication strategies of domestic indices and do not produce significant domestic alphas.