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Background: Mood disorders and strokes are often comorbid, and their health toll worldwide is huge. This study characterizes prognostic and causal roles of mood disorders in stroke. Methods: We tested if genetic susceptibilities for mood disorders were associated with all strokes, ischemic strokes in the Malmö Diet and Cancer cohort (24 631 individuals with a median follow-up of 21.3 (interquartile range: 16.6–23.2) years. We further examined the causal effects for mood disorders on all strokes and ischemic strokes using summary statistics from large genome-wide association studies of mood disorders (up to 609 424 individuals, Psychiatric Genomics Consortium), all strokes and ischemic strokes (up to 446 696 individuals, MEGASTROKE Consortium). Results: Among 24 366 stroke-free participants at baseline, 2632 individuals developed strokes, 2172 of them ischemic, during follow-up. After properly adjusting for well-known risk factors, participants in the highest quintile of polygenic risk scores for mood disorders had 1.45× (95% CI, 1.21–1.74) higher risk of strokes and 1.44× (95% CI, 1.18–1.76) higher risk of ischemic strokes compared with the lowest quintile in women. Mendelian randomization analyses suggested that mood disorders had a causal effect on strokes (odds ratio, 1.07 [95% CI, 1.03–1.11]) and ischemic strokes (odds ratio, 1.09 [95% CI, 1.04–1.13]). Conclusions: Our results suggest a causal role of mood disorders in the risk of stroke. High-risk women could be identified early in life using polygenic risk scores to ultimately prevent mood disorders and strokes.

Severe alpha-1-antitrypsin deficiency (AATD), phenotype PiZZ, was associated with venous thromboembolism (VTE) in a case-control study.This study aimed to determine the genetic variation in the SERPINA1 gene and a possible thrombotic risk of these variants in a population-based cohort study.The coding sequence of SERPINA1 was analyzed for the Z (rs28929474), S (rs17580), and other qualifying variants in 28,794 subjects without previous VTE (born 1923-1950, 60% women), who participated in the Malmö Diet and Cancer study (1991-1996). Individuals were followed from baseline until the first event of VTE, death, or 2018.Resequencing the coding sequence of SERPINA1 identified 84 variants in the total study population, 21 synonymous, 62 missense, and 1 loss-of-function variant. Kaplan-Meier analysis showed that homozygosity for the Z allele increased the risk of VTE whereas heterozygosity showed no effect. The S (rs17580) variant was not associated with VTE. Thirty-one rare variants were qualifying and included in collapsing analysis using the following selection criteria, loss of function, in frame deletion or non-benign (PolyPhen-2) missense variants with minor allele frequency (MAF)0.1%. Combining the rare qualifying variants with the Z variant showed that carrying two alleles (ZZ or compound heterozygotes) showed increased risk. Cox regression analysis revealed an adjusted hazard ratio of 4.5 (95% confidence interval 2.0-10.0) for combinations of the Z variant and rare qualifying variants. One other variant (rs141620200; MAF = 0.002) showed an increased risk of VTE.The SERPINA1 ZZ genotype and compound heterozygotes for severe AATD are rare but associated with VTE in a population-based Swedish study.

Parasitic diseases are considered to be one of the most prevalent pathologies worldwide. They are characterized as one of the most critical sanitary problems in cattle, causing a decrease in the productive capacity of parasitized animals, which translates into economic losses. Intestinal parasitism in cattle is caused by protozoa and helminths, and its manifestation is generally multi-etiological. Clinical signs in gastrointestinal parasitism may vary depending on parasite load, parasite species, and host immunity. This research aimed to determine the prevalence of the main parasitic families affecting cattle in the central province of the department of Boyacá. A cross-sectional study with simple random sampling was carried out, where 716 fecal samples were taken and processed using a modified Ritchie technique. An overall prevalence of 95,6% was determined, and the most prevalent families were Trichostrongylidae, Eimeriidae, Taeniidae, and Trichuridae. The age showed no significant statistical association with most of the parasitic families, except for the Strongyloididae family. The breeds showed a correlation with the Trichostrongylidae, Eimeriidae, Strongylidae, Chabertiidae, and Taeniidae families. The results show the high prevalence of GIP (gastrointestinal parasites) in cattle of the central province of the department of Boyacá. Resumen Las enfermedades parasitarias son consideradas como una de las patologías más prevalentes alrededor del mundo. Se caracterizan por ser uno de los problemas sanitarios de mayor importancia en los bovinos, causando una disminución en la capacidad productiva de los animales parasitados, lo cual se traduce en pérdidas económicas. El parasitismo gastrointestinal en bovinos es causado por protozoos y helmintos, y generalmente su presentación es multietiológica. Los signos clínicos en el parasitismo gastrointestinal pueden variar dependiendo de la carga parasitaria, la especie parasitaria y la inmunidad del huésped. El objetivo de esta investigación fue determinar la prevalencia de las principales familias parasitarias que afectan a los bovinos de la provincia central del departamento de Boyacá. Se realizó un estudio de corte transversal con muestreo aleatorio simple, en el cual se tomaron 716 muestras de materia fecal que fueron procesadas mediante la técnica de Ritchie modificada. Se determinó una prevalencia general de 95,6 %, en donde las familias más prevalentes fueron Trichostrongylidae, Eimeriidae, Taeniidae y Trichuridae. La edad no presentó asociación estadística significativa con la mayoría de las familias parasitarias, a excepción de la familia Strongyloididae. La raza mostró asociación con las familias Trichostrongylidae, Eimeriidae, Strongylidae, Chabertiidae y Taeniidae. Los resultados muestran una alta prevalencia de PGI (parásitos gastrointestinales) en la provincia central de Boyacá. Resumo As doenças parasitárias são consideradas uma das patologias mais prevalentes em todo o mundo, caracterizam-se por ser um dos mais importantes problemas de saúde dos bovinos, apresentando uma diminuição da capacidade produtiva dos animais parasitados, que se traduzem em perdas econômicas. O parasitismo gastrointestinal em bovinos é causado por protozoários e helmintos e sua apresentação é geralmente multe etiológica. Os sinais clínicos no parasitismo gastrointestinal podem variar dependendo da carga do parasita, da espécie parasitária e da imunidade do hospedeiro. O objetivo desta pesquisa foi determinar a prevalência das principais famílias de parasitas que afetam o gado na província Central do departamento de Boyacá. Foi realizado um estudo transversal com amostragem aleatória simples, no qual 716 amostras de fezes foram retiradas e processadas pela técnica de Ritchie modificada. Foi determinada uma prevalência geral de 95,6%, onde as famílias mais prevalentes foram Trichostrongylidae, Eimeriidae, Taeniidae e Trichuridae. A idade não apresentou associação estatística significativa com a maioria das famílias de parasitas, com exceção da família Strongyloididae. A raça apresentou associação com as famílias Trichostrongylidae, Eimeriidae, Strongylidae, Chabertiidae e Taeniidae. Os resultados mostram uma alta prevalência de IGP na província central de Boyacá.

Sarilumab is a human monoclonal antibody against interleukin (IL)-6Rα that has been approved for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) and an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs). Mild liver function test abnormalities have been observed in patients treated with sarilumab. We describe a genome-wide association study of bilirubin elevations in RA patients treated with sarilumab. Array genotyping and exome sequencing were performed on DNA samples from 1075 patients. Variants in the UGT1A1 gene were strongly associated with maximum bilirubin elevations in sarilumab-treated patients (rs4148325; p = 2.88 × 10−41) but were not associated with aminotransferase elevations. No other independent loci showed evidence of association with bilirubin elevations after sarilumab treatment. These findings suggest that most bilirubin increases during sarilumab treatment are related to genetic variation in UGT1A1 rather than underlying liver injury.

Drilling in Colombian foothills have been a big challenge since BP drilled on this area in 1987, currently operating by Ecopetrol S.A foothill implementing innovative well design and new technologies. This basin has been characterized by its complex geological conditions, structure full of faults and high stresses that make drilling operation a big challenge. New well construction engineering based on thorough offset wells and NPT events analysis in addition to the implementation of lessons learned from previous wells in the area, combined with state-of-the-art rotary steerable system have changed the way of drilling in Colombian foothills field overcoming all the challenges faced in the past. To achieve this success, the following approach was followed: Concatenate well profile to balance dogleg severity to minimize tortuosity to allow running the casing smoothlyInnovative well design to achieve exploration objectives in Cupiagua XD45, a well drilled by Ecopetrol S.A. in 2022.BHA optimization including state-of-the-art rotary steerable system to enhance the drilling performance.Transient finite element simulation for 12 ¼" × 14 ¾" section to determine optimum rotary steerable BHA and underreamer cutting structure configuration to achieve smooth drilling condition and borehole quality. This integrated approach allowed to: Optimize well trajectory design process achieving lower and concatenated dogleg severities driven by formation dips bedding to avoid wellbore instability problemsOptimum BHA design and stabilization to minimize stuck probability and assure an optimal BHA dynamic while drilling the wellMinimize borehole tortuosity using last generation of RSS system to achieve smooth borehole quality enhancing tripping, drilling, and running the surface casing and intermediate liner, improve drilling, tripping and casing run performance.Simulation and technical analysis to choose the proper bit profile and design correct underreamer’s cutters to run on 12 ¼" × 14 ¾" section to deliver good wellbore quality and allow smooth 11 ¾" × 11 7/8" liner. This new well construction engineering approach represent an effective solution to overcome Andean foothill challenges achieving optimum borehole quality and improving drilling performance in complex drilling environment by incorporating state-of-the-art RSS

Background Cardiometabolic diseases are highly comorbid, but their relationship with female‐specific or overwhelmingly female‐predominant health conditions (breast cancer, endometriosis, pregnancy complications) is understudied. This study aimed to estimate the cross‐trait genetic overlap and influence of genetic burden of cardiometabolic traits on health conditions unique to women. Methods and Results Using electronic health record data from 71 008 ancestrally diverse women, we examined relationships between 23 obstetrical/gynecological conditions and 4 cardiometabolic phenotypes (body mass index, coronary artery disease, type 2 diabetes, and hypertension) by performing 4 analyses: (1) cross‐trait genetic correlation analyses to compare genetic architecture, (2) polygenic risk score–based association tests to characterize shared genetic effects on disease risk, (3) Mendelian randomization for significant associations to assess cross‐trait causal relationships, and (4) chronology analyses to visualize the timeline of events unique to groups of women with high and low genetic burden for cardiometabolic traits and highlight the disease prevalence in risk groups by age. We observed 27 significant associations between cardiometabolic polygenic scores and obstetrical/gynecological conditions (body mass index and endometrial cancer, body mass index and polycystic ovarian syndrome, type 2 diabetes and gestational diabetes, type 2 diabetes and polycystic ovarian syndrome). Mendelian randomization analysis provided additional evidence of independent causal effects. We also identified an inverse association between coronary artery disease and breast cancer. High cardiometabolic polygenic scores were associated with early development of polycystic ovarian syndrome and gestational hypertension. Conclusions We conclude that polygenic susceptibility to cardiometabolic traits is associated with elevated risk of certain female‐specific health conditions.

El objetivo general de la presente investigación fue analizar la constitucionalidad de los derechos humanos en Ecuador. Desde el paradigma cuantitativo, se manejó para este tipo de estudio, documentos, textos legales, investigaciones científicas mediante la recolección, selección y análisis de los mismos. El diseño bibliográfico-documental se apoyó en los procesos lógicos y mentales. Se consideró el análisis de contenido de la información recopilada, lo que permitió la formulación de resultados. Además, se apoyó en el análisis, analítico–sintético, consistió en descomponer mentalmente el sistema estudiado en varios elementos para poder llegar a la obtención de nuevos conocimientos. Se concluye, sobre la importancia jurídica y social del derecho constitucional relacionado a la protección de los derechos humanos en el Ecuador y más allá de sus fronteras, gracias a los convenios firmados con los organismos internacionales, como garantista el Estado ha propiciado normas protectoras.

Following current trends, the global chemical industry is set to become the largest consumer of fossil fuels. Among energy intensive industries, the chemical industry is one of the most challenging...

Active façade systems incorporating solar thermal collectors currently offer very promising energetic solutions. From among the available systems, a simple solution is the unglazed heat collector for potential integration in low-temperature applications. However, when adopting system definitions, the modification of some design parameters and their impact has to be fully understood. In this study, the case of an unglazed collector integrated into a sandwich panel is assessed and a specific analysis is performed for a proper assessment of the influence of key design parameters. Based on that case study of the real built system, a CFD model is developed and validated and a parametric assessment is then performed, by altering the configurations of both the panel and the hydraulic circuit. In this way, the potential of each measure to harness solar energy can be evaluated and each parameter with its different level of impact can be highlighted, to identify those of higher relevance. A characterization of the real solution completes the study, by providing the efficiency curves and the total energy collected during the experimental campaign. The maximum estimate of the efficiency of a 6 m2 façade was within a range between 0.47 and 0.34 and the heat loss factor was between 4.8 and 7.5. The case study exercises reveal the real energy efficiency and solar production patterns. There was also an opportunity to consider significant improvements to increase the output of the active façade. The main conclusions concerned the different criteria that improved the definition of the system and greater comprehension of alternative designs that may be integrated in the underlying concept. The authors are grateful to the Basque Government for fundingthis research through projects IT781-13 and IT1314-19 and to allthose involved in the different stages for their guidance andinvaluable help.The authors would also like to thank all those companies andresearchers participating in the BASSE project for their stronginvolvement during that research. Results from BASSE project haveinspired present research. The BASSE project received funding fromthe European Union, RFCS Program, Research Fund for Coal and Steel project Building Active Steel Skin (BASSE, Grant Agreement noRFSR-CT-2013-00026)

Background: Bovine leptospirosis is a zoonotic, infectious, and cosmopolitan disease of worldwide distribution, caused by the spirochete Leptospira spp., which has been diagnosed in humans; domestic mammals, such as dogs, sheep, goats, swine, horses and cattle; and wild animals. It is considered a significant cause of economic losses in livestock because it causes infertility, abortion and reduced milk production. Aim: To establish the prevalence and the main risk factors associated with Leptospira spp. in cattle in the municipality of Sotaquirá, Colombia. Methods: An observational, descriptive, cross-sectional study with simple random sampling was carried out. 1,000 cattle of Ayrshire, Holstein, Jersey, Normande, Zebu, and crossbreeds were sampled. Blood samples were taken by coccygeal venipuncture and processed by microscopic agglutination technique; animals were considered positive when titers were ≥1:100. The data obtained were processed with the statistical program EpiInfo®. Results: A general apparent prevalence (AP) of 16% (160/1,000) was established, where the crossbreeds (20.5% AP), the 2–4 years age group (17% AP), and the serovars Leptospira interrogans serogroup Pomona (5.1%) and L. interrogans serogroup Sjroe serovar Hardjo (3.4%) presented the highest seropositivity. The variables barnyard, artificial insemination, and use of certified semen were identified as protective factors against the disease, while diarrhea was considered a risk factor. Conclusion: The prevalence in this study is within the range of those reported at the national level; however, it is essential to establish plans to control and prevent the disease.

Around the world, rental housing is frequently seen as secondary to home ownership; yet it plays a crucial role in many countries. In particular, rental housing in urban informal neighbourhoods has a critical but consistently overlooked role in housing the most vulnerable households in the Global South. If better policy and practice are to be pursued, there is a need for improved data on rental housing in urban informal settlements, and in particular, better understanding of ‘the lived experiences of the poor’. This paper responds to these empirical gaps in debates on informality and rental housing with qualitative research on residents’ experiences of informal rented housing in two Colombian cities, Bogotá and Cali. The paper frames informal rental housing as an essential option for diverse low-income households for whom ownership is not accessible or attractive. In this way, it also contributes to policy and theoretical debates calling for a better understanding of the dynamics, possibilities and potential of informal housing.

Background and Aim: Infectious bovine rhinotracheitis (IBR) is an infectious disease widely distributed globally and is considered the main cause of various reproductive and respiratory tract diseases in cattle and buffaloes. This study aimed to estimate seroprevalence and determine risk factors associated with the presentation of IBR in the municipality of Sotaquirá, Boyacá (Colombia). Materials and Methods: A descriptive cross-sectional study with simple random sampling was performed, and the sample size was 1,000 cattle. Blood samples were obtained by coccygeal venipuncture and processed through indirect enzyme-linked immunosorbent assay using the Synbiotics® kit (Zoetis, New Jersey, USA) with a sensitivity and specificity of 96% and 98%, respectively. Data were processed using the statistical program EpiInfo® (Centers for Disease Control and Prevention; Atlanta, Georgia). Results: A high seroprevalence of 57.5% was established. Seroprevalence was the highest in cattle >4 years of age (65.0% apparent seroprevalence[AS]; 67% true seroprevalence [TS]) and in the Holstein breed (65.5% AS; 67.8% TS). The breed and age of the animals were significantly associated with each other. The Holstein breed, age group >4 years, uncertified semen, and fetal death were established as risk factors for IBR. In comparison, the age groups of

The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world1. Here we describe the release of exome-sequence data for the first 49,960 study participants, revealing approximately 4 million coding variants (of which around 98.6% have a frequency of less than 1%). The data include 198,269 autosomal predicted loss-of-function (LOF) variants, a more than 14-fold increase compared to the imputed sequence. Nearly all genes (more than 97%) had at least one carrier with a LOF variant, and most genes (more than 69%) had at least ten carriers with a LOF variant. We illustrate the power of characterizing LOF variants in this population through association analyses across 1,730 phenotypes. In addition to replicating established associations, we found novel LOF variants with large effects on disease traits, including PIEZO1 on varicose veins, COL6A1 on corneal resistance, MEPE on bone density, and IQGAP2 and GMPR on blood cell traits. We further demonstrate the value of exome sequencing by surveying the prevalence of pathogenic variants of clinical importance, and show that 2% of this population has a medically actionable variant. Furthermore, we characterize the penetrance of cancer in carriers of pathogenic BRCA1 and BRCA2 variants. Exome sequences from the first 49,960 participants highlight the promise of genome sequencing in large population-based studies and are now accessible to the scientific community., Exome sequences from the first 49,960 participants in the UK Biobank highlight the promise of genome sequencing in large population-based studies and are now accessible to the scientific community.

La enseñanza del Inglés como Lengua Extranjera (ILE) es un área de amplio crecimiento en República Dominicana. En este contexto, la figura del docente de ILE es preponderante. Este artículo tiene el objetivo de identificar dos aspectos clave en el campo profesional de la enseñanza: Diseño Instruccional (DI) y Desarrollo Profesional Docente (DPD). En primer lugar, se analiza la percepción de estos docentes concerniente a la secuencia o estructura del proceso de enseñanza-aprendizaje. En segundo lugar, se estudia qué consideran los maestros como DPD. Para recolectar datos relevantes, fue utilizada la encuesta como instrumento de investigación a través de un formulario de Google Forms (n=79). Los resultados de este estudio plantean una presencia predominante de enfoques tradicionales en la enseñanza del ILE que no refleja la corriente posmétodo actual, y una idea turbia con respecto a lo que realmente supone el desarrollo profesional docente, altamente limitada a programas de formación y promoción laboral. Al final del estudio, se discuten las implicaciones de estos resultados y recomendaciones para docentes en servicio.

"The present study aims to analyse migratory grief, coping (focusing on the problem, negative self-focus, positive reappraisal, open emotional expression, avoidance, search for social support, and religion), and psychological distress of people according to their main reasons for migrating. The sample consisted of 454 participants (48.7% men and 51.3% women) aged between 18 and 74 years (M = 35.48; SD = 11.06). The methodology used was quantitative and non-experimental design. The Migratory Grief Assessment Questionnaire, the Coping with Stress Questionnaire, and the Kessler Psychological Distress Scale K10 were used. The results indicate a significant and positive relationship between migratory grief, the passive coping styles, and psychological distress, as well as a negative relationship between migratory grief and the strategy focused on the problem. In addition, students are the group with the least migratory grief compared to groups who migrated for economic reasons, insecurity (wars, violence, threats), and sexual orientation. In addition, people fleeing because of security reasons are the ones who use less the strategy of seeking social support compared to the group of people studying. People migrating for economic reasons use religion more as a coping strategy compared to the groups motivated by sexual orientation and educational background. Regarding psychological distress, people who flee because of their sexual orientation have higher levels of psychological distress compared to those who have migrated for economic and academic reasons. The relevant and significant findings related to the variables investigated are discussed."

Casing rotation is a mechanical aid that improves fluids displacement efficiency and helps achieve zonal isolation. A Colombian oil company faced its biggest challenge to successfully place cement across zones with washouts, rate restrictions, and difficult mud removal. This paper describes the deployment of a rotating cement head for cementing services on a land operation in Colombia, Ecopetrol S.A. has supported and leveraged the deployment of this technology since 2018. The Casing Running Tool (CRT) Adapter provided an enhanced system to reduce stuck pipe risks and decrease rig up time. The main solution selected to enhance results was implementing casing rotation; nevertheless, execution had to be completed safely and efficiently. Top-drive cement heads are commonly used in offshore operations. In Colombia, the use of a top-drive cement head was targeted as a safe solution to rotate intermediate and production casings in land operations. This method would allow for rig up, pressure test, and execution of the cement job (including rotation throughout the entirety of the job) without having to break connections or shutdown operations. The main component of the system is the cement head itself, but it was necessary to also incorporate a triple water bushing that serves to connect the cement head with casing and cementing plugs for the specified casing size. The system was enhanced by incorporating an adapter that allows connecting the assembly directly to CRT. This configuration enabled us to complete cementing without any connection make-ups during job, which reduced personnel risk and saved any flat time. During the installation process in prior operations, it was necessary to disconnect and rack back the casing running tool and then connect the cement head to the top drive. In some cases, the overall time to perform these actions was about 1 hour and 30 minutes. On certain wells this additional time could increase the risk of stuck pipe and prevent our ability to rotate the casing during cementing. The system has been improved by adding a CRT adapter that joins the cement head to the top drive without disconnecting the CRT. This new system helps mitigate stuck pipe risks by reducing connection time to as little as 10 minutes while safely enabling casing rotation to improve cement isolation. This configuration enables casing rotation during cementing in wells with high torque requirements and stuck pipe risks while improving annular cement placement. The system makes the operation safer and more efficient.

Background Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle‐aged and older adults. Methods and Results Factor V Leiden, prothrombin G20210A and protein‐coding variants in the PROC (protein C), PROS1 (protein S), and SERPINC1 (antithrombin) anticoagulant genes were determined in 29 387 subjects (born 1923–1950, 60% women) who participated in the Malmö Diet and Cancer study (1991–1996). The Human Gene Mutation Database was used to define 68 disease‐causing mutations. Patients were followed up from baseline until the first event of venous thromboembolism (VTE), death, or Dec 31, 2018. Carriership (n=908, 3.1%) for disease‐causing mutations in the PROC , PROS1 , and SERPINC1 genes was associated with incident VTE: Hazard ratio (HR) was 1.6 (95% CI, 1.3–1.9). Variants not in Human Gene Mutation Database were not linked to VTE (HR, 1.1; 95% CI, 0.8–1.5). Heterozygosity for rs6025 and rs1799963 was associated with incident VTE: HR, 1.8 (95% CI, 1.6–2.0) and HR, 1.6 (95% CI, 1.3–2.0), respectively. The HR for carrying 1 classical thrombophilia variant was 1.7 (95% CI, 1.6–1.9). HR was 3.9 (95% CI, 3.1–5.0) for carriers of ≥2 thrombophilia variants. Conclusions The 5 classic thrombophilias are associated with a dose‐graded risk of VTE in middle‐aged and older adults. Disease‐causing variants in the PROC , PROS1 , and SERPINC1 genes were more common than the rs1799963 variant but the conferred genetic risk was comparable with the rs6025 and rs1799963 variants.

The aim of this paper is for the production of oils processed in refineries to come from the pyrolysis of real waste from the high plastic content rejected by the recycling industry of the Basque Country (Spain). Concretely, the rejected waste streams were collected from (1) a light packaging waste sorting plant, (2) the paper recycling industry, and (3) a waste treatment plant of electrical and electronic equipment (WEEE). The influence of pre-treatments (mechanical separation operations) and temperature on the yield and quality of the liquid fraction were evaluated. In order to study the pre-treatment effect, the samples were pyrolyzed at 460 °C for 1 h. As pre-treatments concentrate on the suitable fraction for pyrolysis and reduce the undesirable materials (metals, PVC, PET, inorganics, cellulosic materials), they improve the yield to liquid products and considerably reduce the halogen content. The sample with the highest polyolefin content achieved the highest liquid yield (70.6 wt.% at 460 °C) and the lowest chlorine content (160 ppm) among the investigated samples and, therefore, was the most suitable liquid to use as refinery feedstock. The effect of temperature on the pyrolysis of this sample was studied in the range of 430–490 °C. As the temperature increased the liquid yield increased and solid yield decreased, indicating that the conversion was maximized. At 490 °C, the pyrolysis oil with the highest calorific value (44.3 MJ kg−1) and paraffinic content (65% area), the lowest chlorine content (128 ppm) and more than 50 wt.% of diesel was obtained. This research was funded by the Basque Government through the project with reference KK-2020/00107 (ELKARTEK program) and through the support of the SUPREN group (GIC10/31, GIC15/13, S-PE13UN126 (SAI13/190)).

[EN] Waste generation is one of the greatest problems of present times, and the recycling of carbon fibre reinforced composites one big challenge to face. Currently, no resin valorisation is done in thermal fibre recycling methods. However, when pyrolysis is used, additional valuable compounds (syngas or H2-rich gas) could be obtained by upgrading the generated vapours and gases. This work presents the thermodynamic and kinetic multi-reaction modelling of the pyrolysis vapours and gases upgrading process in Aspen Plus software. These models forecast the theoretical and in-between scenario of a thermal upgrading process of an experimentally characterised vapours and gases stream (a blend of thirty-five compounds). Indeed, the influence of temperature (500°C-1200°C) and pressure (DeltaP=0, 1 and 2bar) operating parameters are analysed in the outlet composition, residence time and possible reaction mechanisms occurring. Validation of the kinetic model has been done comparing predicted outlet composition with experimental data (at 700°C and 900°C with DeltaP=0bar) for H2 (g), CO (g), CO2 (g), CH4 (g), H2O (v) and C (s). Kinetic and experimental results show the same tendency with temperature, validating the model for further research. Good kinetic fit is obtained for H2 (g) (absolute error: 0.5wt% at constant temperature and 0.3wt% at variable temperature) and H2O (v) shows the highest error at variable T (8.8wt%). Both simulation and experimental results evolve towards simpler, less toxic and higher generation of hydrogen-rich gas with increasing operating temperature and pressure. The authors want to thank the Ministry of Science and Innovation of Spain (Ref. PID2019-110770RB-I00) and the Basque Government (Ref. KK-2020/00107, ELKARTEK program) for the funding to carry out the investigation. The authors also thank the financing granted to the “Sustainable Process Engineering” research group for the 2016–2021 period (Basque Government, Ref. IT993-16) and are grateful to Iñaki Múgica from Su Medioambiente (SUMA Soluciones Medioambientales, S.L.) for the technical support provided.