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4. Marital status after colorectal surgery in familial adenomatous polyposis: a nationwide multicenter study in Japan

Author

Fujiyoshi, Kenji, Sudo, Tomoya, Fujita, Fumihiko, Tanihara, Shinichi, Ishida, Hideyuki, Shichijo, Satoki, Chino, Akiko, Nagasaski, Toshiya, Takao, Akinari, Sasaki, Kazuhito, Akagi, Kiwamu, Matsubara, Takaaki, Ueno, Hideki, Hirata, Keiji, Miyakura, Yasuyuki, Ishikawa, Toshiaki, Sunami, Eiji, Takahashi, Yusuke, Yamaguchi, Tatsuro, Tanakaya, Kohji, Tomita, Naohiro, and Ajioka, Yoichi

Published
2024
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5. Risk of metachronous colorectal cancer after surgical resection of index rectal cancer in Lynch syndrome: a multicenter retrospective study in Japan

Author

Chikatani, Kenichi, Ishida, Hideyuki, Mori, Yoshiko, Nakajima, Takeshi, Ueki, Arisa, Akagi, Kiwamu, Takao, Akinari, Yamada, Masayoshi, Taniguchi, Fumitaka, Komori, Koji, Sasaki, Kazuhito, Sudo, Tomoya, Miyakura, Yasuyuki, Chino, Akiko, Yamaguchi, Tatsuro, Tanakaya, Kohji, Tomita, Naohiro, and Ajioka, Yoichi

Published
2024
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8. Colorectal cancer and advanced adenoma characteristics according to causative mismatch repair gene variant in Japanese colorectal surveillance for Lynch syndrome

Author

Chino, Akiko, Tanakaya, Kohji, Nakajima, Takeshi, Akagi, Kiwamu, Takao, Akinari, Yamada, Masayoshi, Ishida, Hideyuki, Komori, Koji, Sasaki, Kazuhito, Miguchi, Masashi, Hirata, Keiji, Sudo, Tomoya, Miyakura, Yasuyuki, Ishikawa, Toshiaki, Yamaguchi, Tatsuro, Tomita, Naohiro, and Ajioka, Yoichi

Published
2024
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10. Clinicopathological features and prognosis of primary small bowel adenocarcinoma: a large multicenter analysis of the JSCCR database in Japan

Author

Yamashita, Ken, Oka, Shiro, Yamada, Takeshi, Mitsui, Keigo, Yamamoto, Hironori, Takahashi, Keiichi, Shiomi, Akio, Hotta, Kinichi, Takeuchi, Yoji, Kuwai, Toshio, Ishida, Fumio, Kudo, Shin-Ei, Saito, Shoichi, Ueno, Masashi, Sunami, Eiji, Yamano, Tomoki, Itabashi, Michio, Ohtsuka, Kazuo, Kinugasa, Yusuke, Matsumoto, Takayuki, Sugai, Tamotsu, Uraoka, Toshio, Kurahara, Koichi, Yamaguchi, Shigeki, Kato, Tomohiro, Okajima, Masazumi, Kashida, Hiroshi, Akagi, Yoshito, Ikematsu, Hiroaki, Ito, Masaaki, Esaki, Motohiro, Kawai, Masaya, Yao, Takashi, Hamada, Madoka, Horimatsu, Takahiro, Koda, Keiji, Fukai, Yasumori, Komori, Koji, Saitoh, Yusuke, Kanemitsu, Yukihide, Takamaru, Hiroyuki, Yamada, Kazutaka, Nozawa, Hiroaki, Takayama, Tetsuji, Togashi, Kazutomo, Shinto, Eiji, Torisu, Takehiro, Toyoshima, Akira, Ohmiya, Naoki, Kato, Takeshi, Otsuji, Eigo, Nagata, Shinji, Hashiguchi, Yojiro, Sugihara, Kenichi, Ajioka, Yoichi, and Tanaka, Shinji

Published
2024
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11. Risk of gastric adenoma and adenocarcinoma in patients with familial adenomatous polyposis in Japan: a nationwide multicenter study

Author

Sasaki, Kazuhito, Kawai, Kazushige, Nozawa, Hiroaki, Ishihara, Soichiro, Ishida, Hideyuki, Ishibashi, Keiichiro, Mori, Yoshiko, Shichijo, Satoki, Tani, Yasuhiro, Takeuchi, Yoji, Chino, Akiko, Takao, Misato, Fujiyoshi, Kenji, Matsubara, Takaaki, Miyakura, Yasuyuki, Taniguchi, Fumitaka, Yamaguchi, Tatsuro, Tanakaya, Kohji, Tomita, Naohiro, and Ajioka, Yoichi

Published
2024
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12. Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan

Author

Miyakura, Yasuyuki, Yamaguchi, Tatsuro, Lefor, Alan Kawarai, Tamaki, Sawako, Takao, Akinari, Takao, Misato, Mori, Yoshiko, Chikatani, Kenichi, Ishida, Hideyuki, Kono, Mitsuhiro, Takeuchi, Yoji, Ishikawa, Hideki, Nagasaki, Toshiya, Sasaki, Kazuhito, Matsubara, Takaaki, Hirata, Keiji, Taniguchi, Fumitaka, Tanakaya, Kohji, Tomita, Naohiro, and Ajioka, Yoichi

Published
2024
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13. Usefulness of genotyping APC gene for individualizing management of patients with familial adenomatous polyposis

Author

Mori, Yoshiko, Ishida, Hideyuki, Chika, Noriyasu, Ito, Tetsuya, Amano, Kunihiko, Chikatani, Kenichi, Takeuchi, Yoji, Kono, Mitsuhiro, Shichijo, Satoki, Chino, Akiko, Nagasaki, Toshiya, Takao, Akinari, Takao, Misato, Nakamori, Sakiko, Sasaki, Kazuhito, Akagi, Kiwamu, Yamaguchi, Tatsuro, Tanakaya, Kohji, Naohiro, Tomita, and Ajioka, Yoichi

Published
2023
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14. Risk of metachronous colorectal cancer after colectomy for first colon cancer in Lynch syndrome: multicenter retrospective study in Japan

Author

Chikatani, Kenichi, Ishida, Hideyuki, Mori, Yoshiko, Nakajima, Takeshi, Ueki, Arisa, Akagi, Kiwamu, Takao, Akinari, Yamada, Masayoshi, Taniguchi, Fumitaka, Komori, Koji, Sasaki, Kazuhito, Sudo, Tomoya, Miyakura, Yasuyuki, Chino, Akiko, Yamaguchi, Tatsuro, Tanakaya, Kohji, Tomita, Naohiro, and Ajioka, Yoichi

Published
2023
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17. Endoscopic Removal of Premalignant Lesions Reduces Long-Term Colorectal Cancer Risk: Results From the Japan Polyp Study

Author

Sano, Yasushi, Hotta, Kinichi, Matsuda, Takahisa, Murakami, Yoshitaka, Fujii, Takahiro, Kudo, Shin-ei, Oda, Yasushi, Ishikawa, Hideki, Saito, Yutaka, Kobayashi, Nozomu, Sekiguchi, Masau, Ikematsu, Hiroaki, Katagiri, Atsushi, Konishi, Kazuo, Takeuchi, Yoji, Iishi, Hiroyasu, Igarashi, Masahiro, Kobayashi, Kiyonori, Sada, Miwa, Osera, Shozo, Shinohara, Tomoaki, Yamaguchi, Yuichiro, Hasuda, Kiwamu, Morishima, Toshitaka, Miyashiro, Isao, Shimoda, Tadakazu, Taniguchi, Hirokazu, Fujimori, Takahiro, Ajioka, Yoichi, and Yoshida, Shigeaki

Published
2024
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18. Impact of Lesion Location on Recurrence After Resection of T1 Colorectal Cancer: Post Hoc Analysis of a Nationwide Multicenter Cohort Study

Author

Sugihara, Kenichi, Saito, Shoichi, Fukunaga, Yusuke, Kawachi, Hiroshi, Takamatsu, Manabu, Kojima, Motohiro, Hotta, Kinichi, Yamada, Masayoshi, Kanemitsu, Yukihide, Saito, Yutaka, Sekine, Shigeki, Tanaka, Shinji, Nagata, Shinji, Nakamura, Takahiro, Yamada, Kazutaka, Konno, Maki, Ishihara, Soichiro, Saitoh, Yusuke, Matsuda, Kenji, Togashi, Kazutomo, Komori, Koji, Ishiguro, Megumi, Kuwai, Toshio, Okuyama, Takashi, Ohuchi, Akihiro, Ohnuma, Shinobu, Sakamoto, Kazuhiro, Sugai, Tamotsu, Katsumata, Kenji, Matsushita, Hiro-o, Yamano, Hiro-o, Nakai, Keisuke, Uraoka, Toshio, Akimoto, Naohiko, Kobayashi, Hirotoshi, Minamide, Tatsunori, Ikematsu, Hiroaki, Kajiwara, Yoshiki, Oka, Shiro, Ajioka, Yoichi, and Ueno, Hideki

Published
2024
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19. How Does Omitting Additional Surgery After Local Excision Affect the Prognostic Outcome of Patients With High-risk T1 Colorectal Cancer?

Author

Ouchi, Akira, Komori, Koji, Masahiro, Tajika, Toriyama, Kazuhiro, Kajiwara, Yoshiki, Oka, Shiro, Fukunaga, Yosuke, Hotta, Kinichi, Ikematsu, Hiroaki, Tsukamoto, Shunsuke, Nagata, Shinji, Yamada, Kazutaka, Konno, Maki, Ishihara, Soichiro, Saitoh, Yusuke, Matsuda, Kenji, Togashi, Kazutomo, Ishiguro, Megumi, Kuwai, Toshio, Okuyama, Takashi, Ohuchi, Akihiro, Ohnuma, Shinobu, Sakamoto, Kazuhiro, Sugai, Tamotsu, Katsumata, Kenji, Matsushita, Hiro-o, Nakai, Keisuke, Uraoka, Toshio, Akimoto, Naohiko, Kobayashi, Hirotoshi, Ajioka, Yoichi, Sugihara, Kenichi, and Ueno, Hideki

Published
2024
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20. Outcomes of Metastatic and Unresectable Small Bowel Adenocarcinoma in Japan According to the Treatment Strategy: A Nationwide Observational Study

Author

Nishikawa, Yoshitaka, Horimatsu, Takahiro, Oka, Shiro, Yamada, Takeshi, Mitsui, Keigo, Yamamoto, Hironori, Takahashi, Keiichi, Shiomi, Akio, Hotta, Kinichi, Takeuchi, Yoji, Kuwai, Toshio, Ishida, Fumio, Kudo, Shin-Ei, Saito, Shoichi, Ueno, Masashi, Sunami, Eiji, Yamano, Tomoki, Itabashi, Michio, Ohtsuka, Kazuo, Kinugasa, Yusuke, Matsumoto, Takayuki, Sugai, Tamotsu, Uraoka, Toshio, Kurahara, Koichi, Yamaguchi, Shigeki, Kato, Tomohiro, Okajima, Masazumi, Kashida, Hiroshi, Fujita, Fumihiko, Ikematsu, Hiroaki, Ito, Masaaki, Esaki, Motohiro, Kawai, Masaya, Yao, Takashi, Hamada, Madoka, Koda, Keiji, Fukai, Yasumori, Komori, Koji, Saitoh, Yusuke, Kanemitsu, Yukihide, Takamaru, Hiroyuki, Yamada, Kazutaka, Nozawa, Hiroaki, Takayama, Tetsuji, Togashi, Kazutomo, Shinto, Eiji, Torisu, Takehiro, Toyoshima, Akira, Ohmiya, Naoki, Kato, Takeshi, Otsuji, Eigo, Nagata, Shinji, Hashiguchi, Yojiro, Sugihara, Kenichi, Ajioka, Yoichi, and Tanaka, Shinji

Published
2024
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21. Clinical features and oncological outcomes of intestinal cancers associated with ulcerative colitis and Crohn’s disease

Author

Noguchi, Tatsuki, Ishihara, Soichiro, Uchino, Motoi, Ikeuchi, Hiroki, Okabayashi, Koji, Futami, Kitaro, Tanaka, Shinji, Ohge, Hiroki, Nagahara, Hisashi, Watanabe, Kazuhiro, Itabashi, Michio, Okamoto, Kinya, Okita, Yoshiki, Mizushima, Tsunekazu, Mizuuchi, Yusuke, Yamada, Kazutaka, Shimada, Yoshifumi, Sato, Yu, Kimura, Hideaki, Takahashi, Kenichi, Hida, Koya, Kinugasa, Yusuke, Okuda, Junji, Daito, Koji, Koyama, Fumikazu, Ueno, Hideki, Yamamoto, Takayuki, Hanai, Tsunekazu, Maemoto, Atsuo, Oba, Koji, Ajioka, Yoichi, and Sugihara, Kenichi

Published
2023
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23. Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study

Author

Kajiwara, Yoshiki, Oka, Shiro, Tanaka, Shinji, Nakamura, Takahiro, Saito, Shoichi, Fukunaga, Yosuke, Takamatsu, Manabu, Kawachi, Hiroshi, Hotta, Kinichi, Ikematsu, Hiroaki, Kojima, Motohiro, Saito, Yutaka, Yamada, Masayoshi, Kanemitsu, Yukihide, Sekine, Shigeki, Nagata, Shinji, Yamada, Kazutaka, Kobayashi, Nozomu, Ishihara, Soichiro, Saitoh, Yusuke, Matsuda, Kenji, Togashi, Kazutomo, Komori, Koji, Ishiguro, Megumi, Kuwai, Toshio, Okuyama, Takashi, Ohuchi, Akihiro, Ohnuma, Shinobu, Sakamoto, Kazuhiro, Sugai, Tamotsu, Katsumata, Kenji, Matsushita, Hiro-o, Yamano, Hiro-o, Eda, Hirotsugu, Uraoka, Toshio, Akimoto, Naohiko, Kobayashi, Hirotoshi, Ajioka, Yoichi, Sugihara, Kenichi, and Ueno, Hideki

Published
2023
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24. Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study

Author

Fujiyoshi, Kenji, Sudo, Tomoya, Fujita, Fumihiko, Chino, Akiko, Akagi, Kiwamu, Takao, Akinari, Yamada, Masayoshi, Tanakaya, Kohji, Ishida, Hideyuki, Komori, Koji, Ishihara, Soichiro, Miguchi, Masashi, Hirata, Keiji, Miyakura, Yasuyuki, Ishikawa, Toshiaki, Yamaguchi, Tatsuro, Tomita, Naohiro, Ajioka, Yoichi, and Sugihara, Kenichi

Published
2022
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25. A review on the current status and definitions of activity indices in inflammatory bowel disease: how to use indices for precise evaluation

Author

Kishi, Masahiro, Hirai, Fumihito, Takatsu, Noritaka, Hisabe, Takashi, Takada, Yasumichi, Beppu, Tsuyoshi, Takeuchi, Ken, Naganuma, Makoto, Ohtsuka, Kazuo, Watanabe, Kenji, Matsumoto, Takayuki, Esaki, Motohiro, Koganei, Kazutaka, Sugita, Akira, Hata, Keisuke, Futami, Kitarou, Ajioka, Yoichi, Tanabe, Hiroshi, Iwashita, Akinori, Shimizu, Hirotaka, Arai, Katsuhiro, Suzuki, Yasuo, and Hisamatsu, Tadakazu

Published
2022
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26. Peritoneal lavage cytology in patients with curative resection for stage II and III colorectal cancer: A multi‐institutional prospective study

Author

Kobayashi, Hirotoshi, primary, Kotake, Kenjiro, additional, Maeda, Kotaro, additional, Suto, Takeshi, additional, Kawasaki, Masayasu, additional, Ueno, Hideki, additional, Komori, Koji, additional, Ozawa, Heita, additional, Koda, Keiji, additional, Ohue, Masayuki, additional, Funahashi, Kimihiko, additional, Takemasa, Ichiro, additional, Ishida, Hideyuki, additional, Kazama, Shinsuke, additional, Shimada, Yoshifumi, additional, Morohashi, Hajime, additional, Kinugasa, Yusuke, additional, Kanemitsu, Yukihide, additional, Ochiai, Hiroki, additional, Ishihara, Soichiro, additional, Itabashi, Michio, additional, Sugihara, Kenichi, additional, and Ajioka, Yoichi, additional

Published
2024
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28. Identification of lateral pelvic nodes without metastasis in patients with rectal cancer treated with preoperative chemoradiotherapy or chemotherapy based on magnetic resonance imaging.

Author

Hoshino, Nobuaki, Fukui, Yudai, Ueno, Kohei, Hida, Koya, Obama, Kazutaka, Sakamoto, Kazuhiro, Kobayashi, Hirotoshi, Itabashi, Michio, Ishihara, Soichiro, Kawai, Kazushige, and Ajioka, Yoichi

Subjects
MAGNETIC resonance imaging, NEOADJUVANT chemotherapy, RECTAL cancer, CANCER patients, RECTUM, THERAPEUTICS
Abstract

Background: Intensive localized therapy is promising for the treatment of rectal cancer. In Japan, chemoradiotherapy (CRT) and neoadjuvant chemotherapy (NAC) are used as preoperative treatments for this disease. Magnetic resonance imaging (MRI) is used to diagnose lateral pelvic node (LPN) metastases, but the changes in LPN findings on MRI following preoperative treatment are unclear. Furthermore, there may be patients in whom LPN dissection can be omitted after CRT/NAC. Methods: Patients who underwent total mesorectal excision with LPN dissection after CRT/NAC at 13 Japanese Society for Cancer of the Colon and Rectum member institutions between 2017 and 2019 were included. Changes in the short diameter of the LPNs after CRT/NAC and the reduction rate were examined. Results: A total of 101 LPNs were examined in 28 patients who received CRT and 228 in 47 patients who received NAC. Comparison of LPNs before and after CRT/NAC showed that most LPNs shrank after CRT but that the size reduction was variable after NAC. Although some LPNs with a short diameter of <5 mm showed residual metastasis, no metastases were observed in LPNs that were <5 mm in short diameter before and after CRT/NAC and did not shrink after treatment. Conclusion: Although the short diameter of LPNs was significantly reduced by both CRT and NAC, even LPNs with a short diameter of <5 mm could have residual metastases. However, dissection may be omitted for LPNs <5 mm in short diameter that do not shrink after preoperative CRT or NAC. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Risk factors and development of machine learning diagnostic models for lateral lymph node metastasis in rectal cancer: multicentre study.

Author

Kasai, Shunsuke, Shiomi, Akio, Shimizu, Hideyuki, Aoba, Monami, Kinugasa, Yusuke, Miura, Takuya, Uehara, Kay, Watanabe, Jun, Kawai, Kazushige, and Ajioka, Yoichi

Subjects
MACHINE learning, LYMPHATIC metastasis, RECEIVER operating characteristic curves, MAGNETIC resonance imaging, LYMPHADENECTOMY
Abstract

Background The diagnostic criteria for lateral lymph node metastasis in rectal cancer have not been established. This research aimed to investigate the risk factors for lateral lymph node metastasis and develop machine learning models combining these risk factors to improve the diagnostic performance of standard imaging. Method This multicentre prospective study included patients who underwent lateral lymph node dissection without preoperative treatment for rectal cancer between 2017 and 2019 in 15 Japanese institutions. First, preoperative clinicopathological factors and magnetic resonance imaging findings were evaluated using multivariable analyses for their correlation with lateral lymph node metastasis. Next, machine learning diagnostic models for lateral lymph node metastasis were developed combining these risk factors. The models were tested in a training set and in an internal validation cohort and their diagnostic performance was tested using receiver operating characteristic curve analyses. Results Of 212 rectal cancers, 122 patients were selected, including 232 lateral pelvic sides, 30 sides of which had pathological lateral lymph node metastasis. Multivariable analysis revealed that poorly differentiated/mucinous adenocarcinoma, extramural vascular invasion, tumour deposit and a short-axis diameter of lateral lymph node ≥ 6.0 mm were independent risk factors for lateral lymph node metastasis. Patients were randomly divided into a training cohort (139 sides) and a test cohort (93 sides) and machine learning models were computed on the basis of a combination of significant features (including: histological type, extramural vascular invasion, tumour deposit, short- and long-axis diameter of lateral lymph node, body mass index, serum carcinoembryonic antigen level, cT, cN, cM, irregular border and mixed signal intensity). The top three models with the highest sensitivity in the training cohort were as follows: support vector machine (sensitivity, 1.000; specificity, 0.773), light gradient boosting machine (sensitivity, 0.950; specificity, 0.918) and ensemble learning (sensitivity, 0.950; specificity, 0.917). The diagnostic performances of these models in the test cohort were as follows: support vector machine (sensitivity, 0.750; specificity, 0.667), light gradient boosting machine (sensitivity, 0.500; specificity, 0.852) and ensemble learning (sensitivity, 0.667; specificity, 0.864). Conclusion Machine learning models combining multiple risk factors can contribute to improving diagnostic performance of lateral lymph node metastasis. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Efficacy of lateral lymph node dissection for local control of rectal cancer: A multicenter study.

Author

Tanaka, Yusuke, Hino, Hitoshi, Shiomi, Akio, Uehara, Kay, Watanabe, Jun, Nishikawa, Takeshi, Ueno, Hideki, Kinugasa, Yusuke, Kawai, Kazushige, and Ajioka, Yoichi

Subjects
LYMPHADENECTOMY, RECTAL cancer, PROPENSITY score matching, LYMPHATIC metastasis, CANCER patients, RECTUM
Abstract

Background: This study aimed to evaluate the efficacy of lateral lymph node dissection (LLND) for rectal cancer by comparing the local control in patients with and without pathological lateral lymph node metastasis (LLNM). Methods: We included 189 patients with rectal cancer who underwent total mesorectal excision and LLND at 13 institutions between 2017 and 2019. Patients with and without pathological LLNM were defined as the pLLNM (+) and (−) groups, respectively. Propensity score‐matching helped to balance the basic characteristics of both groups. The incidences of local recurrence (LR) and lateral lymph node recurrence (LLNR) were compared between the groups. Results: In the entire cohort, 39 of the 189 patients had pathological LLNM. The 3‐year LR and LLNR rates were 18.3% and 4.0% (p = 0.01) and 7.7% and 3.3% (p = 0.22) in the pLLNM (+) and (−) groups, respectively. After propensity score matching, the data from 62 patients were analyzed. No significant differences in LR or LLNR were observed between both groups. The 3‐year LR and LLNR rates were 16.4% and 9.8% (p = 0.46) and 9.7% and 9.8% (p = 0.99) in the pLLNM (+) and (−) groups, respectively. Conclusion: LLND would lead to comparable local control in the pLLNM (+) and (−) groups if the clinicopathological characteristics except for LLNM are similar. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Possible poor prognosis in younger‐onset Crohn's disease‐associated anorectal cancer: A subanalysis of the Nationwide Japanese study.

Author

Okita, Yoshiki, Toiyama, Yuji, Ikeuchi, Hiroki, Uchino, Motoi, Futami, Kitaro, Okamoto, Kinya, Noguchi, Tatsuki, Sugihara, Kenichi, Ishihara, Soichiro, and Ajioka, Yoichi

Subjects
CROHN'S disease, CELIAC disease, INTESTINAL cancer, PROGNOSIS, JAPANESE people, PROGRESSION-free survival
Abstract

Background and aims: Crohn's disease (CD)‐associated intestinal cancers are characterized by their high incidence, particularly at the anorectal site in the Japanese population. Accumulating evidence revealed that younger‐onset sporadic colorectal cancer may exhibit unique biological features. To the best of our knowledge, few previous articles reported clinicopathological features in patients with CD‐associated anorectal cancer (CDAAC). Therefore, we aimed to clarify the relationship between the younger onset of cancer and clinicopathological characteristics and prognosis, and the efficacy of cancer surveillance in patients with CDAAC. Methods: CD patients who had been diagnosed with intestinal cancers from 1983 to 2020 were collected from 39 Japanese institutions in this study. Of 316 patients with CD‐associated intestinal cancers, we analyzed 211 patients with CDAAC. We divided the patients into two groups according to the median age at cancer diagnosis (45 years old). Results: Younger‐onset CDAAC (YO‐CDAAC) patients were significantly more likely to have a poor outcome than those with older‐onset CDAAC (OO‐CDAAC) in terms of both disease‐free survival (DFS) (p = 0.0014) and overall survival (OS) (p = 0.023). Multivariate analysis showed that age under 45 years old at diagnosis of cancer was one of the independent factors for poor DFS and OS (hazard ratios: 2.15, 95% confidence interval: 1.09–4.26, p = 0.028, hazard ratios: 1.95, 95% confidence interval: 1.05–3.60, p = 0.033, respectively). Patients detected via surveillance showed significantly better DFS and OS rates than symptomatic patients in YO‐CDAAC (p = 0.012 and 0.0031, respectively). Conclusions: YO‐CDAAC may have a poorer prognosis compared with OO‐CDAAC. Surveillance could be important to improve cancer prognosis, especially in young CD patients with anorectal disease. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Clinicopathological features of post-colonoscopy colorectal cancer in patients with Japanese Lynch syndrome: A multicentric retrospective observational study.

Author

Takao, Akinari, primary, Iizuka, Toshiro, additional, Takao, Misato, additional, Chino, Akiko, additional, Akagi, Kiwamu, additional, Yamada, Masayoshi, additional, Tanakaya, Kohji, additional, Ishida, Hideyuki, additional, Komori, Koji, additional, Sasaki, Kazuhito, additional, Miguchi, Masashi, additional, Hirata, Keiji, additional, Sudo, Tomoya, additional, Miyakura, Yasuyuki, additional, Ishikawa, Toshiaki, additional, Yamaguchi, Tatsuro, additional, Tomita, Naohiro, additional, and Ajioka, Yoichi, additional

Published
2024
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33. Impact of Lesion Location on Recurrence After Resection of T1 Colorectal Cancer: Post Hoc Analysis of a Nationwide Multicenter Cohort Study

Author

Minamide, Tatsunori, primary, Ikematsu, Hiroaki, additional, Kajiwara, Yoshiki, additional, Oka, Shiro, additional, Ajioka, Yoichi, additional, Ueno, Hideki, additional, Sugihara, Kenichi, additional, Saito, Shoichi, additional, Fukunaga, Yusuke, additional, Kawachi, Hiroshi, additional, Takamatsu, Manabu, additional, Kojima, Motohiro, additional, Hotta, Kinichi, additional, Yamada, Masayoshi, additional, Kanemitsu, Yukihide, additional, Saito, Yutaka, additional, Sekine, Shigeki, additional, Tanaka, Shinji, additional, Nagata, Shinji, additional, Nakamura, Takahiro, additional, Yamada, Kazutaka, additional, Konno, Maki, additional, Ishihara, Soichiro, additional, Saitoh, Yusuke, additional, Matsuda, Kenji, additional, Togashi, Kazutomo, additional, Komori, Koji, additional, Ishiguro, Megumi, additional, Kuwai, Toshio, additional, Okuyama, Takashi, additional, Ohuchi, Akihiro, additional, Ohnuma, Shinobu, additional, Sakamoto, Kazuhiro, additional, Sugai, Tamotsu, additional, Katsumata, Kenji, additional, Matsushita, Hiro-o, additional, Yamano, Hiro-o, additional, Nakai, Keisuke, additional, Uraoka, Toshio, additional, Akimoto, Naohiko, additional, and Kobayashi, Hirotoshi, additional

Published
2024
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34. Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial)

Author

Ueno, Hideki, Ishiguro, Megumi, Nakatani, Eiji, Ishikawa, Toshiaki, Uetake, Hiroyuki, Murotani, Kenta, Matsui, Shigeyuki, Teramukai, Satoshi, Sugai, Tamotsu, Ajioka, Yoichi, Maruo, Hirotoshi, Kotaka, Masahito, Tsujie, Masaki, Munemoto, Yoshinori, Yamaguchi, Takashi, Kuroda, Hisashi, Fukunaga, Mutsumi, Tomita, Naohiro, and Sugihara, Kenichi

Published
2021
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35. Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme

Author

Ohashi, Riuko, Martignoni, Guido, Hartmann, Arndt, Caliò, Anna, Segala, Diego, Stöhr, Christine, Wach, Sven, Erlmeier, Franziska, Weichert, Wilko, Autenrieth, Michael, Schraml, Peter, Rupp, Niels J., Ohe, Chisato, Otsuki, Yoshiro, Kawasaki, Takashi, Kobayashi, Hiroshi, Kobayashi, Kazuhiro, Miyazaki, Tatsuhiko, Shibuya, Hiroyuki, Usuda, Hiroyuki, Umezu, Hajime, Fujishima, Fumiyoshi, Furusato, Bungo, Osakabe, Mitsumasa, Sugai, Tamotsu, Kuroda, Naoto, Tsuzuki, Toyonori, Nagashima, Yoji, Ajioka, Yoichi, and Moch, Holger

Published
2020
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36. Correction to: Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme

Author

Ohashi, Riuko, Martignoni, Guido, Hartmann, Arndt, Caliò, Anna, Segala, Diego, Stöhr, Christine, Wach, Sven, Erlmeier, Franziska, Weichert, Wilko, Autenrieth, Michael, Schraml, Peter, Rupp, Niels J., Ohe, Chisato, Otsuki, Yoshiro, Kawasaki, Takashi, Kobayashi, Hiroshi, Kobayashi, Kazuhiro, Miyazaki, Tatsuhiko, Shibuya, Hiroyuki, Usuda, Hiroyuki, Umezu, Hajime, Fujishima, Fumiyoshi, Furusato, Bungo, Osakabe, Mitsumasa, Sugai, Tamotsu, Kuroda, Naoto, Tsuzuki, Toyonori, Nagashima, Yoji, Ajioka, Yoichi, and Moch, Holger

Published
2020
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37. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer

Author

Hashiguchi, Yojiro, Muro, Kei, Saito, Yutaka, Ito, Yoshinori, Ajioka, Yoichi, Hamaguchi, Tetsuya, Hasegawa, Kiyoshi, Hotta, Kinichi, Ishida, Hideyuki, Ishiguro, Megumi, Ishihara, Soichiro, Kanemitsu, Yukihide, Kinugasa, Yusuke, Murofushi, Keiko, Nakajima, Takako Eguchi, Oka, Shiro, Tanaka, Toshiaki, Taniguchi, Hiroya, Tsuji, Akihito, Uehara, Keisuke, Ueno, Hideki, Yamanaka, Takeharu, Yamazaki, Kentaro, Yoshida, Masahiro, Yoshino, Takayuki, Itabashi, Michio, Sakamaki, Kentaro, Sano, Keiji, Shimada, Yasuhiro, Tanaka, Shinji, Uetake, Hiroyuki, Yamaguchi, Shigeki, Yamaguchi, Naohiko, Kobayashi, Hirotoshi, Matsuda, Keiji, Kotake, Kenjiro, and Sugihara, Kenichi

Published
2020
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38. Clinical features and distribution of the APC variant in duodenal and ampullary polyps in patients with familial adenomatous polyposis: a multicenter retrospective cohort study in Japan

Author

Miyakura, Yasuyuki, primary, Yamaguchi, Tatsuro, additional, Lefor, Alan Kawarai, additional, Tamaki, Sawako, additional, Takao, Akinari, additional, Takao, Misato, additional, Mori, Yoshiko, additional, Chikatani, Kenichi, additional, Ishida, Hideyuki, additional, Kono, Mitsuhiro, additional, Takeuchi, Yoji, additional, Ishikawa, Hideki, additional, Nagasaki, Toshiya, additional, Sasaki, Kazuhito, additional, Matsubara, Takaaki, additional, Hirata, Keiji, additional, Taniguchi, Fumitaka, additional, Tanakaya, Kohji, additional, Tomita, Naohiro, additional, and Ajioka, Yoichi, additional

Published
2023
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40. Local excision versus radical surgery for anal squamous cell carcinoma –a multicenter study in Japan-

Author

Murai, Shin, primary, Nozawa, Hiroaki, additional, Yamada, Kazutaka, additional, Saiki, Yasumitsu, additional, Sasaki, Kazuhito, additional, Murono, Koji, additional, Emoto, Shigenobu, additional, Matsuzaki, Hiroyuki, additional, Yokoyama, Yuichiro, additional, Abe, Shinya, additional, Nagai, Yuzo, additional, Yoshioka, Yuichiro, additional, Shinagawa, Takahide, additional, Sonoda, Hirofumi, additional, Sugihara, Kenichi, additional, Ajioka, Yoichi, additional, and Ishihara, Soichiro, additional

Published
2023
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41. Correction to: Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study

Author

Fujiyoshi, Kenji, Sudo, Tomoya, Fujita, Fumihiko, Chino, Akiko, Akagi, Kiwamu, Takao, Akinari, Yamada, Masayoshi, Tanakaya, Kohji, Ishida, Hideyuki, Komori, Koji, Ishihara, Soichiro, Miguchi, Masashi, Hirata, Keiji, Miyakura, Yasuyuki, Ishikawa, Toshiaki, Yamaguchi, Tatsuro, Tomita, Naohiro, Ajioka, Yoichi, and Sugihara, Kenichi

Published
2022
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42. Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer: Prospective Validation in a Randomized Controlled Study (SACURA Trial)

Author

Ueno, Hideki, Ishiguro, Megumi, Nakatani, Eiji, Ishikawa, Toshiaki, Uetake, Hiroyuki, Matsui, Shigeyuki, Teramukai, Satoshi, Murotani, Kenta, Ajioka, Yoichi, Shimazaki, Hideyuki, Maeda, Atsuyuki, Takuma, Kunio, Yoshida, Takefumi, Kambara, Takeshi, Matsuda, Keiji, Takagane, Akinori, Tomita, Naohiro, and Sugihara, Kenichi

Published
2020
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44. Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis: A multicenter retrospective study in Japan

Author

Kagawa, Hiroyasu, primary, Kinugasa, Yusuke, additional, Yamaguchi, Tomohiro, additional, Ohue, Masayuki, additional, Kawai, Kazushige, additional, Hiro, Junichiro, additional, Shinji, Seiichi, additional, Nozawa, Hiroaki, additional, Hirano, Yasumitsu, additional, Komori, Koji, additional, Takii, Yasumasa, additional, Suto, Takeshi, additional, Tsukamoto, Shunsuke, additional, Akagi, Yoshito, additional, Ozawa, Heita, additional, Toiyama, Yuji, additional, Minami, Kazuhito, additional, Shimizu, Tomoharu, additional, Uehara, Kay, additional, Sakamoto, Kazuhiro, additional, Mori, Keita, additional, Sugihara, Kenichi, additional, and Ajioka, Yoichi, additional

Published
2023
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45. Author response to: Comment on: Correlation between recurrence-free survival and overall survival after upfront surgery for resected colorectal liver metastases

Author

Kataoka, Kozo, primary, Takahashi, Kanae, additional, Takeuchi, Jiro, additional, Ito, Kazuma, additional, Beppu, Naohito, additional, Ceelen, Wim, additional, Kanemitsu, Yukihide, additional, Ajioka, Yoichi, additional, Endo, Itaru, additional, Hasegawa, Kiyoshi, additional, Takahashi, Keiichi, additional, and Ikeda, Masataka, additional

Published
2023
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46. Endoscopic Removal of Premalignant Lesions Reduces Long-Term Colorectal Cancer Risk: Results from the Japan Polyp Study

Author

Sano, Yasushi, primary, Hotta, Kinichi, additional, Matsuda, Takahisa, additional, Murakami, Yoshitaka, additional, Fujii, Takahiro, additional, Kudo, Shin-ei, additional, Oda, Yasushi, additional, Ishikawa, Hideki, additional, Saito, Yutaka, additional, Kobayashi, Nozomu, additional, Sekiguchi, Masau, additional, Ikematsu, Hiroaki, additional, Katagiri, Atsushi, additional, Konishi, Kazuo, additional, Takeuchi, Yoji, additional, Iishi, Hiroyasu, additional, Igarashi, Masahiro, additional, Kobayashi, Kiyonori, additional, Sada, Miwa, additional, Osera, Shozo, additional, Shinohara, Tomoaki, additional, Yamaguchi, Yuichiro, additional, Hasuda, Kiwamu, additional, Morishima, Toshitaka, additional, Miyashiro, Isao, additional, Shimoda, Tadakazu, additional, Taniguchi, Hirokazu, additional, Fujimori, Takahiro, additional, Ajioka, Yoichi, additional, and Yoshida, Shigeaki, additional

Published
2023
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47. Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016

Author

Lugli, Alessandro, Kirsch, Richard, Ajioka, Yoichi, Bosman, Fred, Cathomas, Gieri, Dawson, Heather, El Zimaity, Hala, Fléjou, Jean-François, Hansen, Tine Plato, Hartmann, Arndt, Kakar, Sanjay, Langner, Cord, Nagtegaal, Iris, Puppa, Giacomo, Riddell, Robert, Ristimäki, Ari, Sheahan, Kieran, Smyrk, Thomas, Sugihara, Kenichi, Terris, Benoît, Ueno, Hideki, Vieth, Michael, Zlobec, Inti, and Quirke, Phil

Published
2017
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50. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer

Author

Watanabe, Toshiaki, Muro, Kei, Ajioka, Yoichi, Hashiguchi, Yojiro, Ito, Yoshinori, Saito, Yutaka, Hamaguchi, Tetsuya, Ishida, Hideyuki, Ishiguro, Megumi, Ishihara, Soichiro, Kanemitsu, Yukihide, Kawano, Hiroshi, Kinugasa, Yusuke, Kokudo, Norihiro, Murofushi, Keiko, Nakajima, Takako, Oka, Shiro, Sakai, Yoshiharu, Tsuji, Akihito, Uehara, Keisuke, Ueno, Hideki, Yamazaki, Kentaro, Yoshida, Masahiro, Yoshino, Takayuki, Boku, Narikazu, Fujimori, Takahiro, Itabashi, Michio, Koinuma, Nobuo, Morita, Takayuki, Nishimura, Genichi, Sakata, Yuh, Shimada, Yasuhiro, Takahashi, Keiichi, Tanaka, Shinji, Tsuruta, Osamu, Yamaguchi, Toshiharu, Yamaguchi, Naohiko, Tanaka, Toshiaki, Kotake, Kenjiro, Sugihara, Kenichi, and Japanese Society for Cancer of the Colon and Rectum

Published
2018
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