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617 results on '"Adeghate, Ernest"'

6. Obesity: Molecular Mechanisms, Epidemiology, Complications and Pharmacotherapy

Author

Al Jaberi, Saeeda, Cohen, Athena, Saeed, Zulqarnain, Ojha, Shreesh, Singh, Jaipaul, Adeghate, Ernest, Dhalla, Naranjan S., Series Editor, Bolli, Roberto, Editorial Board Member, Goyal, Ramesh, Editorial Board Member, Kartha, Chandrasekharan, Editorial Board Member, Kirshenbaum, Lorrie, Editorial Board Member, Makino, Naoki, Editorial Board Member, Mehta, Jawahar L. L., Editorial Board Member, Ostadal, Bohuslav, Editorial Board Member, Pierce, Grant N., Editorial Board Member, Slezak, Jan, Editorial Board Member, Varro, Andras, Editorial Board Member, Werdan, Karl, Editorial Board Member, Weglicki, William B., Editorial Board Member, Tappia, Paramjit S., editor, and Ramjiawan, Bram, editor

Published
2021
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7. Cellular and Biochemical Mechanisms Driving the Susceptibility of Obese Subjects to Covid-19 Infection

Author

Smail, Manal M., Singh, Jaipaul, Ismail, Abla Mohammed, Cummings, Emanuel, Hanoman, Carlin, Rupee, Sunil, Rupee, Khemraj, Adeghate, Ernest, Dhalla, Naranjan S., Series Editor, Bolli, Roberto, Editorial Board Member, Goyal, Ramesh, Editorial Board Member, Kartha, Chandrasekharan, Editorial Board Member, Kirshenbaum, Lorrie, Editorial Board Member, Makino, Naoki, Editorial Board Member, Mehta, Jawahar L. L., Editorial Board Member, Ostadal, Bohuslav, Editorial Board Member, Pierce, Grant N., Editorial Board Member, Slezak, Jan, Editorial Board Member, Varro, Andras, Editorial Board Member, Werdan, Karl, Editorial Board Member, Weglicki, William B., Editorial Board Member, Tappia, Paramjit S., editor, and Ramjiawan, Bram, editor

Published
2021
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8. Reproductive and fetal toxicity studies of histamine H3 receptor antagonist DL76 used in mice to prevent maximal electroshock-induced seizure

Author

Bastaki, Salim M., primary, Abdulrazzaq, Yousef M., additional, Zidan, Marwan Abdelrahim, additional, Shafiullah, Mohamed, additional, Alaryani, Saif Ghdayer, additional, Alnuaimi, Fatima Awad, additional, Adeghate, Ernest, additional, Mohsin, Sahar, additional, Akour, Amal, additional, Siwek, Agata, additional, Łażewska, Dorota, additional, Kieć-Kononowicz, Katarzyna, additional, and Sadek, Bassem, additional

Published
2024
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11. Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV 1287 on streptozotocin-induced beta cell damage and diabetic complications in rats

Author

Tékus, Valéria, Horváth, Ádám István, Csekő, Kata, Szabadfi, Krisztina, Kovács-Valasek, Andrea, Dányádi, Bese, Deres, László, Halmosi, Róbert, Sághy, Éva, Varga, Zoltán V., Adeghate, Ernest, Kőszegi, Tamás, Mátyus, Péter, Gábriel, Róbert, Ferdinandy, Péter, Pintér, Erika, and Helyes, Zsuzsanna

Published
2021
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12. Adropin Is Expressed in Pancreatic Islet Cells and Reduces Glucagon Release in Diabetes Mellitus.

Author

Ali, Ifrah I., D'Souza, Crystal, Tariq, Saeed, and Adeghate, Ernest A.

Subjects
ANIMAL models of diabetes, IMMUNOELECTRON microscopy, SOMATOSTATIN, DIABETES, GLUCAGON, PANCREAS, ISLANDS of Langerhans
Abstract

Diabetes mellitus affects 537 million adults around the world. Adropin is expressed in different cell types. Our aim was to investigate the cellular localization in the endocrine pancreas and its effect on modulating pancreatic endocrine hormone release in streptozotocin (STZ)-induced diabetic rats. Adropin expression in the pancreas was investigated in normal and diabetic rats using immunohistochemistry and immunoelectron microscopy. Serum levels of insulin, glucagon pancreatic polypeptide (PP), and somatostatin were measured using a Luminex® χMAP (Magpix®) analyzer. Pancreatic endocrine hormone levels in INS-1 832/3 rat insulinoma cells, as well as pancreatic tissue fragments of normal and diabetic rats treated with different concentrations of adropin (10−6, 10−9, and 10−12 M), were measured using ELISA. Adropin was colocalized with cells producing either insulin, glucagon, or PP. Adropin treatment reduced the number of glucagon-secreting alpha cells and suppressed glucagon release from the pancreas. The serum levels of GLP-1 and amylin were significantly increased after treatment with adropin. Our study indicates a potential role of adropin in modulating glucagon secretion in animal models of diabetes mellitus. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Effects of Lipoproteins on Metabolic Health.

Author

Albitar, Obaida, D’Souza, Crystal M., and Adeghate, Ernest A.

Abstract

Lipids are primarily transported in the bloodstream by lipoproteins, which are macromolecules of lipids and conjugated proteins also known as apolipoproteins. The processes of lipoprotein assembly, secretion, transportation, modification, and clearance are crucial components of maintaining a healthy lipid metabolism. Disruption in any of these steps results in pathophysiological abnormalities such as dyslipidemia, obesity, insulin resistance, inflammation, atherosclerosis, peripheral artery disease, and cardiovascular diseases. By studying these genetic mutations, researchers can gain valuable insights into the underlying mechanisms that govern the relationship between protein structure and its physiological role. These lipoproteins, including HDL, LDL, lipoprotein(a), and VLDL, mainly serve the purpose of transporting lipids between tissues and organs. However, studies have provided evidence that apo(a) also possesses protective properties against pathogens. In the future, the field of study will be significantly influenced by the integration of recombinant DNA technology and human site-specific mutagenesis for treating hereditary disorders. Several medications are available for the treatment of dyslipoproteinemia. These include statins, fibrates, ezetimibe, niacin, PCSK9 inhibitors, evinacumab, DPP 4 inhibitors, glucagon-like peptide-1 receptor agonists GLP1RAs, GLP-1, and GIP dual receptor agonists, in addition to SGLT2 inhibitors. This current review article exhibits, for the first time, a comprehensive reflection of the available body of publications concerning the impact of lipoproteins on metabolic well-being across various pathological states. [ABSTRACT FROM AUTHOR]

Published
2024
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21. β-Caryophyllene, a Dietary Phytocannabinoid, Alleviates Diabetic Cardiomyopathy in Mice by Inhibiting Oxidative Stress and Inflammation Activating Cannabinoid Type-2 Receptors

Author

Mamdouh Hashiesh, Hebaallah, primary, Sheikh, Azimullah, additional, Meeran, Mohamed Fizur Nagoor, additional, Saraswathiamma, Dhanya, additional, Jha, Niraj Kumar, additional, Sadek, Bassem, additional, Adeghate, Ernest, additional, Tariq, Saeed, additional, Al Marzooqi, Saeeda, additional, and Ojha, Shreesh, additional

Published
2023
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36. Effects of long-term dehydration and quick rehydration on the camel kidney: pathological changes and modulation of the expression of solute carrier proteins and aquaporins

Author

Damir, Hassan Abu, primary, Ali, Mahmoud, additional, adem, Muna, additional, Amir, Naheed, additional, Tariq, Saeed, additional, Adeghate, Ernest, additional, Greenwood, Michael, additional, Lin, Panjiao, additional, Gillard, Benjamin, additional, Alvira-Iraizoz, Fernando, additional, Murphy, David, additional, and ADEM, ABDU, additional

Published
2022
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43. Adropin's Role in Energy Homeostasis and Metabolic Disorders

Author

Ali, Ifrah Ismail, D'Souza, Crystal, Singh, Jaipaul, Adeghate, Ernest, Ali, Ifrah Ismail, D'Souza, Crystal, Singh, Jaipaul, and Adeghate, Ernest

Abstract

Adropin is a novel 76-amino acid-peptide that is expressed in different tissues and cells including the liver, pancreas, heart and vascular tissues, kidney, milk, serum, plasma and many parts of the brain. Adropin, encoded by the gene, plays a crucial role in energy homeostasis. The literature review indicates that adropin alleviates the degree of insulin resistance by reducing endogenous hepatic glucose production. Adropin improves glucose metabolism by enhancing glucose utilization in mice, including the sensitization of insulin signaling pathways such as Akt phosphorylation and the activation of the glucose transporter 4 receptor. Several studies have also demonstrated that adropin improves cardiac function, cardiac efficiency and coronary blood flow in mice. Adropin can also reduce the levels of serum triglycerides, total cholesterol and low-density lipoprotein cholesterol. In contrast, it increases the level of high-density lipoprotein cholesterol, often referred to as the beneficial cholesterol. Adropin inhibits inflammation by reducing the tissue level of pro-inflammatory cytokines such as tumor necrosis factor alpha and interleukin-6. The protective effect of adropin on the vascular endothelium is through an increase in the expression of endothelial nitric oxide synthase. This article provides an overview of the existing literature about the role of adropin in different pathological conditions.

Published
2022

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