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2,312 results on '"A. Rossi Giovanni"'

1. Extracellular vesicles miR-574-5p and miR-181a-5p as prognostic markers in NSCLC patients treated with nivolumab

Author

Genova, Carlo, Marconi, Silvia, Chiorino, Giovanna, Guana, Francesca, Ostano, Paola, Santamaria, Sara, Rossi, Giovanni, Vanni, Irene, Longo, Luca, Tagliamento, Marco, Zullo, Lodovica, Dal Bello, Maria Giovanna, Dellepiane, Chiara, Alama, Angela, Rijavec, Erika, Ludovini, Vienna, Barletta, Giulia, Passiglia, Francesco, Metro, Giulio, Baglivo, Sara, Chiari, Rita, Rivoltini, Licia, Biello, Federica, Baraibar, Iosune, Gil-Bazo, Ignacio, Novello, Silvia, Grossi, Francesco, and Coco, Simona

Published
2024
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6. Proximal sealing in the aortic arch for inner curve disease using the custom Relay scalloped and fenestrated stent graft

Author

Alberti, Antonino, Buia, Francesco, Di Marco, Luca, Massara, Mafalda, Bonanno, Paolo, Lepidi, Sandro, Berti, Sergio, Sica, Simona, Pratesi, Giovanni, Rossi, Giovanni, Ferraresi, Marco, Lovato, Luigi, Volpe, Pietro, Fadda, Gian Franco, Ferri, Michelangelo, Rizza, Antonio, D'Oria, Mario, Micheli, Raimondo, Tshomba, Yamume, and Tinelli, Giovanni

Published
2024
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7. Outcomes of off-the-shelf preloaded inner branch device for urgent endovascular thoraco-abdominal aortic repair in the ItaliaN Branched Registry of E-nside EnDograft

Author

Antonello, Michele, Piazza, Michele, Squizzato, Francesco, Spezia, Matteo, Grego, Franco, Pratesi, Giovanni, Spinella, Giovanni, Esposito, Davide, Bastianon, Martina, Tshomba, Yamume, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Ferri, Michelangelo, Quaglino, Simone, Gaggiano, Andrea, Vento, Vincenzo, Carbonari, Luciano, Gatta, Emanuele, Lenti, Massimo, Simonte, Gioele, Isernia, Giacomo, Parlani, Giambattista, Piffaretti, Gabriele, Frigatti, Paolo, Scrivere, Paola, Furlan, Federico, Veraldi, Gian Franco, Mezzetto, Luca, Gennai, Stefano, Leone, Nicola, Silingardi, Roberto, Iacono, Gustavo, Turricchia, Giorgio Ubaldo, Angiletta, Domenico, Maione, Massimo, Apostolou, Dimitri, Pulli, Raffaele, Fargion, Aaron, Filippi, Federico, De Angelis, Filippo, Arici, Vittorio, Bozzani, Antonio, Luigi Molinari, Alessandro Carlo, Rossi, Giovanni, Costantini Brancadoro, Emidio, Ferraris, Matteo, Dorrucci, Vittorio, Derone, Graziana, Tolva, Valerio Stefano, Compagnoni, Nicola Monzio, Segramora, Vittorio Maria, Deleo, Gaetano, Bracale, Umberto, Guzzardi, Giuseppe, Ferrer, Ciro, Giudice, Rocco, Sbarigia, Enrico, Cuozzo, Simone, Gattuso, Roberto, Mansour, Wassim, Di Marzo, Luca, Grimaldi, Sabrina, Corona, Mario, Chisci, Emiliano, Mechelagnoli, Stefano, De Donato, Gianmarco, Palasciano, Giancarlo, Pasqui, Edoardo, Candeloro, Laura, Ricci, Carmelo, Neri, Eugenio, Mangialardi, Nicola, Orrico, Matteo, Ronchey, Sonia, Fazzini, Stefano, Ippoliti, Arnaldo, Discalzi, Andrea, Rossato, Denis, Vio, Elias, Galeazzi, Edoardo, Farneti, Fabrizio, Bertoglio, Luca, Volpe, Pietro, Massara, Mafalda, Milite, Domenico, and Xodo, Andrea

Published
2024
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11. Analysis of Hospital Admissions of Neurological Patients in the COVID-19 Era: Comparison Between Hospitals

Author

Montella, Emma, Marino, Marta Rosaria, Giglio, Cristiana, Raiola, Eliana, Russo, Giuseppe, Rossi, Giovanni, Borrelli, Anna, Triassi, Maria, Scala, Arianna, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wen, Shiping, editor, and Yang, Cihui, editor

Published
2023
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12. Impact of COVID-19 in a Surgery Department: Comparison Between Two Italian Hospitals

Author

Trunfio, Teresa Angela, Marino, Marta Rosaria, Giglio, Cristiana, Majolo, Massimo, Longo, Giuseppe, Basso, Morena Anna, Rossi, Giovanni, Borrelli, Anna, Triassi, Maria, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wen, Shiping, editor, and Yang, Cihui, editor

Published
2023
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13. Predictive Algorithms to Study the Hospitalization for Knee Replacement Surgery: A Bicentric Study

Author

Ponsiglione, Alfonso Maria, Marino, Marta Rosaria, Raiola, Eliana, Russo, Giuseppe, Balato, Giovanni, Festa, Enrico, Rossi, Giovanni, Borrelli, Anna, Triassi, Maria, Romano, Maria, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wen, Shiping, editor, and Yang, Cihui, editor

Published
2023
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14. Covid-19: The Effect on Hospitalization Patient of Ophthalmology Department in 'Antonio Cardarelli' Hospital

Author

Montella, Emma, Marino, Marta Rosaria, Raiola, Eliana, Majolo, Massimo, Russo, Giuseppe, Rossi, Giovanni, Borrelli, Anna, Triassi, Maria, Scala, Arianna, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wen, Shiping, editor, and Yang, Cihui, editor

Published
2023
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15. Use of Statistical Analysis to Evaluate How Covid-19 Has Changed the Management of the Neurosurgery Department of the AORN 'A. Cardarelli' in Naples

Author

Scala, Arianna, Marino, Marta Rosaria, Giglio, Cristiana, Raiola, Eliana, Russo, Giuseppe, Basso, Morena Anna, Rossi, Giovanni, Borrelli, Anna, Triassi, Maria, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wen, Shiping, editor, and Yang, Cihui, editor

Published
2023
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16. Modeling LOS After Percutaneous Valvuloplasty: A Bicentric Study

Author

Montella, Emma, Marino, Marta Rosaria, Majolo, Massimo, Raiola, Eliana, Russo, Giuseppe, Longo, Giuseppe, Rossi, Giovanni, Borrelli, Anna, Triassi, Maria, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wen, Shiping, editor, and Yang, Cihui, editor

Published
2023
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17. Multiple Regression Model to Analyze the Length of Stay for Patients Undergoing Laparoscopic Appendectomy: A Bicentric Study

Author

Montella, Emma, Marino, Marta Rosaria, Frangiosa, Alessandro, Mazia, Giuseppe, Majolo, Massimo, Raiola, Eliana, Russo, Giuseppe, Longo, Giuseppe, Rossi, Giovanni, Borrelli, Anna, Triassi, Maria, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wen, Shiping, editor, and Yang, Cihui, editor

Published
2023
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18. Uncomplicated Type B Aortic Dissection: A European Multicentre Cross-Sectional Evaluation

Author

Bashir, Mohamad, Jubouri, Matti, Surkhi, Abdelaziz O., Williams, Ian M., Davidovic, Lazar B., Koncar, Igor, Baltrūnas, Tomas, Kunt, Aysegul, Tanyeli, Ömer, Bayram, Muhammed, Ugur, Murat, Rossi, Giovanni, Stelzmueller, Marie-Elisabeth, Hoksbergen, Arjan W.J., Jongkind, Vincent, Bertoglio, Luca, Zacà, Sergio, Mansour, Wassim, Sirignano, Pasqualino, D'Oria, Mario, Tolva, Valerio Stefano, Van Herzeele, Isabelle, Klincheva, Milka, Atanasov, Zvonka, Bartoli, Stefano, Bellosta, Raffaello, Chisci, Emiliano, Guagliano, Alberto, Teraa, Martin, Ivak, Peter, Recicarova, Sandra, Pellenc, Quentin, Heijmen, Robin, Pfister, Karin, Piffaretti, Gabriele, Hutchings, Hayley, Holland, Gail, Bailey, Damian M., Thielmann, Matthias, and Jakob, Heinz

Published
2024
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19. Front-line liquid biopsy for early molecular assessment and treatment of hospitalized lung cancer patients

Author

Parisi, Francesca, De Luca, Giuseppa, Mosconi, Manuela, Lastraioli, Sonia, Dellepiane, Chiara, Rossi, Giovanni, Puglisi, Silvia, Bennicelli, Elisa, Barletta, Giulia, Zullo, Lodovica, Santamaria, Sara, Mora, Marco, Ballestrero, Alberto, Montecucco, Fabrizio, Bellodi, Andrea, Del Mastro, Lucia, Lambertini, Matteo, Barisione, Emanuela, Cittadini, Giuseppe, Tagliabue, Elena, Spagnolo, Francesco, Tagliamento, Marco, Coco, Simona, Dono, Mariella, and Genova, Carlo

Published
2024
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22. NEUROCISTICERCOSE

Author

ALVES GULHOTE, DANIELA, primary, DE OLIVEIRA, AYME, additional, OLIVA DA FONSECA, JÚLIA, additional, IAFIGLIOLA GOMES, NICOLE, additional, DE LIMA BURNIER, VICTORIA, additional, BISTAFFA VITOR, GABRIELA, additional, SILVEIRA D’ANDRÉA ROSSI, GIOVANNI, additional, PERES, AMANDA, additional, GUERNELLI BATISTA, GIOVANA, additional, DUARTE, ROBERTA, additional, SANTOS DA SILVA, ARTHUR, additional, DE MORAES MANGAS, GABRIEL, additional, LUSTOSA CAMPOS, ENZO, additional, SANTOS DE OLIVEIRA, RICARDO, additional, and FERNANDO MANZOLLI BALLESTERO, MATHEUS, additional

Published
2023
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23. Measurement of Sea Waves

Author

Piscopo, Vincenzo, Rossi, Giovanni Battista, Crenna, Francesco, Gaglione, Salvatore, Scamardella, Antonio, Uttieri, Marco, Zambianchi, Enrico, Cain, Markys G., Series Editor, Rossi, Giovanni Battista, Series Editor, Tesař, Jirí, Series Editor, van Veghel, Marijn, Series Editor, Jhang, Kyung-Young, Series Editor, Daponte, Pasquale, editor, and Piscopo, Vincenzo, editor

Published
2022
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24. Diagnosis of lung cancer following emergency admission: Examining care pathways, clinical outcomes, and advanced NSCLC treatment in an Italian cancer Center

Author

Vallome, Giacomo, Cafaro, Iacopo, Bottini, Annarita, Dellepiane, Chiara, Rossi, Giovanni, Bennicelli, Elisa, Parisi, Francesca, Zullo, Lodovica, Tagliamento, Marco, Ballestrero, Alberto, Barisione, Emanuela, Grazia Piroddi, Ines Maria, Montecucco, Fabrizio, Carbone, Federico, Pronzato, Paolo, Lambertini, Matteo, Spagnolo, Francesco, Barletta, Giulia, Barcellini, Lucrezia, Ferrante, Michele, Nardin, Simone, Coco, Simona, Marconi, Silvia, Zinoli, Linda, Moscatelli, Paolo, Arboscello, Eleonora, Del Mastro, Lucia, Bellodi, Andrea, and Genova, Carlo

Published
2023
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27. Editor's Choice – Early Outcomes of a Novel Off the Shelf Preloaded Inner Branch Endograft for the Treatment of Complex Aortic Pathologies in the ItaliaN Branched Registry of E-nside EnDograft (INBREED)

Author

Forcella, Edoardo, Grego, Franco, Spinella, Giovanni, Di Gregorio, Sara, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Ferri, Michelangelo, Quaglino, Simone, Vento, Vincenzo, Carbonari, Luciano, Lenti, Massimo, Isernia, Giacomo, Parlani, Giambattista, Scrivere, Paola, Furlan, Federico, Mezzetto, Luca, Mastrorilli, Davide, Gennai, Stefano, Leone, Nicola, Iacono, Gustavo, Turricchia, Giorgio Ubaldo, Angiletta, Domenico, Maione, Massimo, Apostolou, Dimitri, Pulli, Raffaele, Fargion, Aaron, Pratesi, Carlo, Filippi, Federico, De Angelis, Filippo, Arici, Vittorio, Bozzani, Antonio, Luigi Molinari, Alessandro Carlo, Rossi, Giovanni, Brancadoro, Emidio Costantini, Ferraris, Matteo, Dorrucci, Vittorio, Derone, Graziana, Tolva, Valerio Stefano, Segramora, Vittorio Maria, Deleo, Gaetano, Bracale, Umberto, Guzzardi, Giuseppe, Ferrer, Ciro, Giudice, Rocco, Sbarigia, Enrico, Cuozzo, Simone, Gattuso, Roberto, Mansour, Wassim, Di Marzo, Luca, Grimaldi, Sabrina, Corona, Mario, Chisci, Emiliano, Mechelagnoli, Stefano, De Donato, Gianmarco, Palasciano, Giancarlo, Pasqui, Edoardo, Candeloro, Laura, Ricci, Carmelo, Neri, Eugenio, Mangialardi, Nicola, Orrico, Matteo, Fazzini, Stefano, Ippoliti, Arnaldo, Discalzi, Andrea, Rossato, Denis, Vio, Elias, Galeazzi, Edoardo, Farneti, Fabrizio, Piazza, Michele, Squizzato, Francesco, Pratesi, Giovanni, Tshomba, Yamume, Gaggiano, Andrea, Gatta, Emanuele, Simonte, Gioele, Piffaretti, Gabriele, Frigatti, Paolo, Veraldi, Gian Franco, Silingardi, Roberto, and Antonello, Michele

Published
2023
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29. An Italian prospective multicenter study on colonoscopy practice and quality: What has changed in the last 10 years

Author

Alvisi, Costanza, Amato, Loretta, Azzurro, Maurizio, Benazzato, Luca, Bianco, Maria Antonia, Biviano, Ivano, Bravi, Ivana, Brunacci, Matteo, Bucci, Cristina, Buonocore, Matteo Rossano, Cadoni, Sergio, Camellini, Lorenzo, Capone, Pietro, Cavallaro, Lucas G., Condino, Giovanna, Crosta, Cristiano, de Bellis, Mario, de Colibus, Patrizia, de Nigris, Francesca, Esposito, Dario, Fiori, Giancarla, Fornasarig, Mara, Fracchia, Mario, Gemme, Carlo, Germanà, Bastianello, Gianni, Elena, Giunta, Mariangela, Guarnieri, Giovanni, Iabichino, Giuseppe, Luigiano, Carmelo, Maiero, Stefania, Marini, Mario, Marone, Pietro, Meucci, Costantino, Morandi, Elisabetta, Mura, Donatella, Nucci, Andrea, Peccianti, Caterina, Praianò, Francesca, Prisco, Antonio, Rastelli, Carlotta, Ravizza, Davide, Rocca, Rodolfo, Rosa, Cesare, Rossi, Giovanni Battista, Sannino, Angela, Testoni, Sabrina, Urban, Flavia, Testoni, Pier Alberto, Notaristefano, Chiara, Soncini, Marco, Hassan, Cesare, Monica, Fabio, Radaelli, Franco, Triossi, Omero, Pasquale, Luigi, Neri, Matteo, Cannizzaro, Renato, and Leandro, Gioacchino

Published
2023
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31. Solutions of partition function-based TU games for cooperative communication networking

Author

Rossi, Giovanni

Subjects
Computer Science - Computer Science and Game Theory
Abstract

In networked communications nodes choose among available actions and benefit from exchanging information through edges, while continuous technological progress fosters system functionings that increasingly often rely on cooperation. Growing attention is being placed on coalition formation, where each node chooses what coalition to join, while the surplus generated by cooperation is an amount of TU (transferable utility) quantified by a real-valued function defined on partitions -or even embedded coalitions- of nodes. A TU-sharing rule is thus essential, as how players are rewarded determines their behavior. This work offers a new option for distributing partition function-based surpluses, dealing with cooperative game theory in terms of both global games and games in partition function form, namely lattice functions, while the sharing rule is a point-valued solution or value. The novelty is grounded on the combinatorial definition of such solutions as lattice functions whose M\"obius inversion lives only on atoms, i.e. on the first level of the lattice. While simply rephrasing the traditional solution concept for standard coalitional games, this leads to distribute the surplus generated by partitions across the edges of the network, as the atoms among partitions are unordered pairs of players. These shares of edges are further divided between nodes, but the corresponding Shapley value is very different from the traditional one and leads to two alternative forms, obtained by focusing either on marginal contributions along maximal chains, or else on the uniform division of Harsanyi dividends. The core is also addressed, and supermodularity is no longer sufficient for its non-emptiness., Comment: 10 pages. arXiv admin note: text overlap with arXiv:0905.4057 by other authors

Published
2018

32. Searching for network modules

Author

Rossi, Giovanni

Subjects
Computer Science - Discrete Mathematics, Computer Science - Social and Information Networks
Abstract

When analyzing complex networks a key target is to uncover their modular structure, which means searching for a family of modules, namely node subsets spanning each a subnetwork more densely connected than the average. This work proposes a novel type of objective function for graph clustering, in the form of a multilinear polynomial whose coefficients are determined by network topology. It may be thought of as a potential function, to be maximized, taking its values on fuzzy clusterings or families of fuzzy subsets of nodes over which every node distributes a unit membership. When suitably parametrized, this potential is shown to attain its maximum when every node concentrates its all unit membership on some module. The output thus is a partition, while the original discrete optimization problem is turned into a continuous version allowing to conceive alternative search strategies. The instance of the problem being a pseudo-Boolean function assigning real-valued cluster scores to node subsets, modularity maximization is employed to exemplify a so-called quadratic form, in that the scores of singletons and pairs also fully determine the scores of larger clusters, while the resulting multilinear polynomial potential function has degree 2. After considering further quadratic instances, different from modularity and obtained by interpreting network topology in alternative manners, a greedy local-search strategy for the continuous framework is analytically compared with an existing greedy agglomerative procedure for the discrete case. Overlapping is finally discussed in terms of multiple runs, i.e. several local searches with different initializations., Comment: 10 pages

Published
2018

33. Multiple Regression Model to Analyze the Length of Stay for Patients Undergoing Laparoscopic Appendectomy: A Bicentric Study

Author

Montella, Emma, primary, Marino, Marta Rosaria, additional, Frangiosa, Alessandro, additional, Mazia, Giuseppe, additional, Majolo, Massimo, additional, Raiola, Eliana, additional, Russo, Giuseppe, additional, Longo, Giuseppe, additional, Rossi, Giovanni, additional, Borrelli, Anna, additional, and Triassi, Maria, additional

Published
2023
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42. The Role of Rituximab in Primary Focal Segmental Glomerular Sclerosis of the Adult

Author

Affatato, Stefania, Caroti, Leonardo, Mancini, Elena, Semeraro, Luca, Siligato, Rossella, Arnaldo Cassia, Matthias, Napodano, Pietro, Calatroni, Marta, Distratis, Cosimo, Campo, Andrea, Tedesco, Martina, Mescia, Federica, Pisani, Isabella, Allinovi, Marco, Casazza, Giovanni, Del Vecchio, Lucia, Santostefano, Marisa, Cirillo, Luigi, Ferrario, Francesca, Esposito, Ciro, Esposito, Pasquale, Santoro, Domenico, Lazzarin, Roberta, Rossi, Giovanni Maria, Fiaccadori, Enrico, Ferrantelli, Angelo, Sinico, Renato Alberto, Cozzolino, Mario, Gallieni, Maurizio, Cirami, Lino, Scolari, Francesco, Vaglio, Augusto, and Alberici, Federico

Published
2022
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45. Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of African animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania.

Author

Richards, Shauna, Pagnossin, Davide, Buyugu, Paul Samson, Manangwa, Oliver, Mramba, Furaha, Sindoya, Emmanuel, Paxton, Edith, Torr, Steve J., Ritchie, Ryan, Rossi, Giovanni E., Anyanwu, Lawrence Nnadozie, Barrett, Michael P., Morrison, Liam J., and Auty, Harriet

Subjects
HIGH performance liquid chromatography, ANIMAL herds, AFRICAN animals, INSECTICIDE application, CATTLE herding
Abstract

African animal trypanosomosis (AAT) in cattle is primarily managed through trypanocide administration and insecticide application. Trypanocides can be used for both treatment and prophylaxis, but failure is often reported; this may occur due to resistance, substandard drugs, or inappropriate administration. This study in Tanzania aims to quantify reasons for trypanocide failure. An observational year-long longitudinal study was conducted in high-risk AAT areas in Serengeti District between June 2021-October 2022. Purposive sampling targeted herds with high utilization of the prophylactic trypanocide isometamidium chloride (ISM). When a farmer administered a trypanocide (ISM, diminazine aceturate, homidium), the project veterinarian assessed administration and treatment outcomes were determined based on PCR results from blood samples. A multivariable mixed model was utilized to evaluate risk factors for prophylaxis failure. Quality analysis was performed on trypanocide samples using High Performance Liquid Chromatography. A total of 630 cattle from 21 farms were monitored for a year-long period. A total of 295 trypanocide administrations were reported, predominantly being ISM (56%) used for prophylaxis (87%). One-third of trypanocide administrations were not given adequately, and many trypanocides were given to animals that tested negative for trypanosome infections by PCR. Failures occurred in 7% (95% CI 3.0–14%) of curative treatments, and 44% (95% CI 35–42%) of prophylactic administrations. The brand of ISM was significantly associated with odds of prophylaxis failure (p = 0.011). On quality analysis, two ISM samples had no detectable ISM isomers, but the remainder of ISM and DA samples (n = 46) fell within the range of acceptable levels. Drug counterfeiting, inadequate use of trypanocides, and resistance are all contributing to trypanocide failure, limiting effective AAT control and with implications for human disease risk. In order to curb trypanocide failure a multi-modal approach to managing the use of trypanocides is required to address all contributing factors. Author summary: African animal trypanosomosis (AAT) in cattle is commonly controlled through the use of medications called trypanocides. However, these interventions often fail to control AAT due to reasons such as drug resistance, poor-quality medicines, or incorrect administration. This study, conducted in Tanzania between December 2019 and October 2022, aimed to understand why trypanocides fail. Researchers focused particularly on cattle herds that used a preventive drug called isometamidium chloride (ISM). During the study, a veterinarian monitored how farmers administered trypanocides like ISM, diminazine aceturate (DA), or homidium, ensuring proper dosage and storage. Blood samples from cattle were tested to check if treatments were effective. The study found that one-third of trypanocide treatments were not given correctly, and many cattle treated with trypanocides were not actually infected. It was determined that 7% of treatments and 44% of preventive doses failed. The type of ISM brand used played a significant role in failure rates, with some brands performing worse than others. Additionally, tests revealed that some ISM samples lacked the active ingredients necessary for effectiveness. The study highlights that counterfeit drugs, improper use, and drug resistance all contribute to the problem, and a more comprehensive strategy is needed to tackle these issues. [ABSTRACT FROM AUTHOR]

Published
2025
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46. New Treatment Regimens, New Drugs, and New Treatment Goals for Lupus Nephritis.

Author

Rossi, Giovanni M. and Vaglio, Augusto

Subjects
*CHRONIC kidney failure, *LUPUS nephritis, *SYSTEMIC lupus erythematosus, *MYCOPHENOLIC acid, *BELIMUMAB
Abstract

Lupus nephritis is one of the most severe manifestations of systemic lupus erythematosus, affecting roughly 40% of all lupus patients. With the introduction of cyclophosphamide and mycophenolate mofetil, outcomes have dramatically improved. However, 10% of patients still progress towards end-stage kidney disease, which carries an elevated mortality rate. In recent years, several novel agents have been approved for use or have shown preliminary evidence of efficacy in lupus nephritis. These agents include belimumab, voclosporin, and obinutuzumab, among others. Efficacy has also been demonstrated in recent trials combining older drugs. However, determining which patients would benefit the most from novel agents or combined drug regimens and whether these drugs might serve as an alternative to current remission-induction drug regimens rather than as add-on therapies remain unresolved issues. In this review, we will explore the current evidence regarding the efficacy of novel agents. [ABSTRACT FROM AUTHOR]

Published
2025
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