Search

Abstract Defect-engineered and even amorphous two-dimensional (2D) materials have recently gained interest due to properties that differ from their pristine counterparts. Since these properties are highly sensitive to the exact atomic structure, it is crucial to be able to characterize them at atomic resolution over large areas. This is only possible when the imaging process is automated to reduce the time spent on manual imaging, which at the same time reduces the observer bias in selecting the imaged areas. Since the necessary datasets include at least hundreds if not thousands of images, the analysis process similarly needs to be automated. Here, we introduce disorder into graphene and monolayer hexagonal boron nitride (hBN) using low-energy argon ion irradiation, and characterize the resulting disordered structures using automated scanning transmission electron microscopy annular dark field imaging combined with convolutional neural network-based analysis techniques. We show that disorder manifests in these materials in a markedly different way, where graphene accommodates vacancy-type defects by transforming hexagonal carbon rings into other polygonal shapes, whereas in hBN the disorder is observed simply as vacant lattice sites with very little rearrangement of the remaining atoms. Correspondingly, in the case of graphene, the highest introduced disorder leads to an amorphous membrane, whereas in hBN, the highly defective lattice contains a large number of vacancies and small pores with no indication of amorphisation. Overall, our study demonstrates that combining automated imaging and image analysis is a powerful way to characterize the structure of disordered and amorphous 2D materials, while also illustrating some of the remaining shortcomings with this methodology.

Tungsten (W) samples containing 0, 1, 3, and 5 at.% rhenium (Re) were irradiated by 20 MeV W ions to 0.5 dpa at 290 K and to 0.3 dpa at 1350 K. An additional set of samples was irradiated to 0.5 dpa at 290 K and then annealed at 1350 K. The irradiated samples were exposed to a deuterium (D) plasma at 370 K. D concentration profiles in the samples were measured using D(He3,p)α nuclear reaction analysis. The D binding states in the defects were analysed using thermal desorption spectroscopy (TDS). In the case of irradiation at 290 K, the trapped D concentration monotonically increases with increasing Re concentration: in W-5%Re it is 17% higher than in pure W. On the contrary, for irradiation at 1350 K the trapped D concentration monotonically decreases with increasing Re concentration: in W-5%Re it is 50 times smaller than in pure W. In the case of annealing at 1350 K of the samples irradiated at 290 K, the Re presence yields only up to three times reduction of trapped D concentration compared with pure W. TDS shows that the nature of D trapping sites is different for the irradiations at 290 K and 1350 K. We attribute the reduced D trapping in W-Re alloys irradiated at 1350 K to the reduction of cavity growth caused by the presence of Re.

Boronisation was first used for wall conditioning in W7-X during the OP 1.2b operational period, which was characterized by the use of the fine-grain graphite Test Divertor Unit (TDU) and inertial cooling only. After this period, deposited layers were observed on all inner surfaces. Deposited layers were analyzed on 21 inner wall tiles using ion beam analysis methods, the deposited layers consisted mostly of boron with additional carbon and oxygen. During the operational period OP 2.1 with an actively water cooled divertor made of carbon fiber reinforced carbon, different materials were exposed during two individual boronisations using the multi-purpose manipulator. Deposited boronisation layers on the samples were analyzed using nuclear reaction analysis. The deposited layer thicknesses showed some variation depending on substrate material and surface roughness, but a systematic dependence on material and/or roughness was not observed. Under the typical boronisation conditions at W7-X, one A × h (Ampere times hour) of boronisation results in a boronisation layer with a thickness of about 30 ± 15 × 1015 B-atoms/cm2 (about 3 ± 1.5 nm) at the position of the multi-purpose manipulator. The oxygen gettering capacity of the layers is up to 0.5 – 0.9O/B.

Oceanic transports shape the global climate, but the evaluation and validation of this key quantity based on reanalysis and model data are complicated by the distortion of the used curvilinear ocean model grids towards their displaced north poles. Combined with the large number of different grid types, this has made the exact calculation of oceanic transports a challenging and time-consuming task. Use of data interpolated to standard latitude/longitude grids is not an option, since transports computed from interpolated velocity fields are not mass-consistent. We present two methods for transport calculations on grids with variously shifted north poles, different orientations, and different Arakawa partitions. The first method calculates net transports through arbitrary sections using line integrals, while the second method generates cross sections of the vertical–horizontal planes of these sections using vector projection algorithms. Apart from the input data on the original model grids, the user only needs to specify the start and endpoints of the required section to get the net transports (for the first method) and their cross sections (for the second method). Integration of the cross sections along their depth and horizontal extent yields net transports in very good quantitative agreement with the line integration method. This allows us to calculate oceanic fluxes through almost arbitrary sections to compare them with observed oceanic volume and energy transports at available sections, such as the RAPID array or at Fram Strait and other Arctic gateways, or to compare them amongst reanalyses and to model integrations from the Coupled Model Intercomparison Projects (CMIPs). We implemented our methods in a Python package called StraitFlux. This paper represents its scientific documentation and demonstrates its application on outputs of multiple CMIP6 models and several ocean reanalyses. We also analyze the robustness and computational performance of the tools, as well as the uncertainties in the results. The package is available on GitHub and Zenodo and can be installed using pypi.

IntroductionTraditionally, internal tooth bleaching was performed using sodium perborate slurries. These are banned in some areas for potential carcinogenic effects. More recently, highly concentrated hydrogen peroxide gels have been used, which may cause dentin degradation. Consequently, the search for ideal internal tooth bleaching agents is still on. This study compared pure ROS-releasing granules regarding their liberation of oxidizing species, pH induction, bleaching of blood-stained dentin, and effects on mechanical dentin properties.Materials and methodsThe ROS-releasing granules under investigation were sodium perborate, carbamide peroxide, and sodium percarbonate in aqueous suspension (4:3, wt/wt). The bleaching efficacy of these suspensions was compared in blood-stained human dentin (n = 6) ex vivo. In addition, effects on mechanical dentin integrity were tested using bovine dentin beams (n = 9) exposed to a 3-point bending test (ISO 4049) after immersion in test suspensions or control solutions (35% H2O2 and physiological saline) for 1 week.ResultsGranules release between 21.5% and 35.2% (wt/wt) of H2O2 equivalent. The sodium-containing granules (perborate and percarbonate) caused an alkaline pH of 10.3 and 10.6, respectively. The carbamide peroxide suspension was acidic (pH 3.9), as was the 35% H2O2 solution used as a control (pH 2.2). All the suspensions bleached the blood-stained dentin, albeit with a lesser overall effect by sodium percarbonate (one-way ANOVA and Tukey's HSD, p

A 13C tracer experiment was carried out to investigate impurity transport and migration in the stellarator Wendelstein 7-X (W7-X). About 4.0 × 1022 molecules of 13C marked methane were injected through the divertor gas injection system during plasma operation. After the experiment, the divertor target elements were extracted to be analyzed by post-mortem methods. In particular, the results of the Nuclear Reaction Analysis are presented, and the 13C balance and predominating contributors to migration are discussed.A two-dimensional 13C deposition pattern on 12C graphite modules was obtained with over 6000 single measurements. The post-mortem analysis results extrapolations show a high local deposition of around 25% of the 13C within a 5 cm radius around the injection holes embedded in a graphite target module of one of the ten divertor units. Additionally, a striation is detected in the toroidal direction along the outer strike line and the net carbon deposition zone along the intersecting magnetic island containing about 23% of the 13C within the same divertor unit where injections were made. The residual 52% of 13C are globally migrated across the machine. In total, ∼ 90% of the injected 13C could be extrapolated by post-mortem analysis. Thus, the 13C balance is closed. The distribution indicates a non-negligible amount of global transport and the strong influence of the magnetic topology on migration. In contrast to the strike line pathway, the transport along the magnetic island only takes place counterclockwise in toroidal direction. These results are used to provide benchmark data for ERO2.0 impurity tracing simulations and to be a reference for impurity migration processes in a stellarator.

As Internet of Things (IoT) devices proliferate, sustainable methods for powering them are becoming indispensable. The wireless provision of power enables battery-free operation and is crucial for complying with weight and size restrictions. For the energy harvesting (EH) components of these devices to be small, a high operating frequency is necessary. In conjunction with a large transmit antenna, the receivers may be located in the radiating near-field (Fresnel) region, e.g., in indoor scenarios. In this paper, we propose a wireless power transfer (WPT) system ensuring reliable supply of power to an arbitrary number of mobile, low-power, and single-antenna receivers, whose locations in a three-dimensional cuboid room are unknown. A max-min optimisation problem is formulated to determine the optimal transmit power distribution. We show that, in general, the optimal transmit power distribution’s support has a lower dimensionality than its domain and thus, the employment of a continuous aperture antenna, utilised in Holographic MIMO (HMIMO), is unnecessary in the context of the considered WPT problem. Indeed, deploying a discrete transmit antenna architecture, i.e., a transmit antenna array, is sufficient and our proposed solution provides the optimal transmit antenna deployment and power allocation. Moreover, for a one-dimensional transmit antenna architecture, a finite number of transmit antennas is proven to be optimal. The proposed optimal solution is validated through computer simulations. Our simulation results indicate that the optimal transmit antenna architecture requires a finite number of transmit antennas and depends on the geometry of the environment and the dimensionality of the transmit antenna array. The robustness of the solution, which is obtained under the assumption that a line-of-sight (LoS) link exists between the transmitter and receiver, is assessed in an isotropic scattering environment containing a strong LoS component.

This work aims to investigate the temporal stability and reliability of trends in air–sea heat fluxes from ERA5 forecasts over the North Atlantic basin for the period 1950–2019. Driving forces of the trends are investigated using analyzed state quantities from ERA5. Estimating trends from reanalysis data can be challenging as changes in the observing system may introduce temporal inconsistencies. To this end, the impact of analysis increments is discussed. For individual sub-regions in the North Atlantic basin, parametrization formulas for latent and sensible heat fluxes are linearized to quantitatively attribute trends to long-term changes in wind speed, moisture, and temperature. Our results suggest good temporal stability and reliability of air–sea heat fluxes from ERA5 forecasts on sub-basin scales and below. Regional averages show that trends are largely driven by changes in the skin temperature and atmospheric advection (e.g., of warmer or drier air masses). The influence of modes of climate variability, such as the North Atlantic Oscillation (NAO) and Atlantic Multidecadal Oscillation, on the patterns found is discussed as well. Results indicate a significant impact on trends in the Irminger and Labrador seas associated with more positive NAO phases during the past 4 decades. Finally, we use basin-wide trends of air–sea heat fluxes in combination with an observational ocean heat content estimate to provide an energy-budget-based trend estimate of the Atlantic Meridional Overturning Circulation (AMOC). A decrease in area-averaged air–sea heat fluxes in the North Atlantic basin suggests a decline in the AMOC over the study period. However, basin-wide flux trends are deemed partially artificial, as indicated by temporally varying moisture increments. Thus, the exact magnitude of change is uncertain, but its sign appears robust and adds complementary evidence that the AMOC has weakened over the past 70 years.

The transport of heat and freshwater from the Pacific Ocean to the Indian Ocean via the Indonesian seas is commonly referred to as the Indonesian Throughflow (ITF). The interaction between the ITF and large-scale phenomena occurring from intraseasonal to decadal timescales reflects its connection to the global ocean and the climate system, indicating the need for monitoring the ITF region. In situ observations in this region are highly valuable, but they are temporally and spatially insufficient for near-real-time monitoring. Ocean reanalyses have the potential to serve as near-real-time monitoring tools and to extend time series backward in time, yet a comprehensive quality assessment of their realism in this region with challenging bathymetry has been lacking so far. We focus on oceanic transports diagnosed from the Copernicus Marine Service (CMEMS) Global Reanalysis Ensemble Product (GREP) and the higher-resolution product GLORYS12V1, totaling six reanalysis products. They are validated against in situ observations taken from two different monitoring programs, namely International Nusantara Stratification and Transport (INSTANT 2004–2006) and Monitoring the Indonesian Throughflow (MITF 2006–2011 and 2013–2017), resulting in a total time series of about 11.5 years in the major inflow passage of the Makassar Strait and shorter sampled time series in the Lombok Strait, the Ombai Strait, and the Timor Passage. Results show that there is reasonable agreement between reanalysis-based transports and observations in terms of means, seasonal cycles, and variability, although some shortcomings stand out. The lower-resolution products do not represent the spatial structure of the flow accurately. They also tend to underestimate the integrated net flow in the narrower straits of Lombok and Ombai, an aspect that is improved in GLORYS12V1. Reanalyses tend to underestimate the effect of seasonal Kelvin waves on the transports, which leads to errors in the mean seasonal cycle. Interannual variations of reanalyzed transports agree well with observations, but uncertainties are much larger on sub-annual variability. Finally, as an application of physically consistent and observationally constrained fields provided by ocean reanalyses, we study the impact of the vertically varying pressure gradient on the vertical structure of the ITF to better understand an apparent two-layer regime of the flow.

ABSTRACTAntibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs and into the membrane of poxvirus. The protein of interest is correctly folded and expressed in the cell-derived viral membrane and does not require any detergents or refolding before downstream use. The poxvirus is selective in which proteins are incorporated into the viral membrane, making the antigen poxvirus an antigenically cleaner target for in vitro panning. Antigen-expressing virus can be readily purified at scale and used for antibody selection using any in vitro display platform.

The Earth climate system is out of energy balance, and heat has accumulated continuously over the past decades, warming the ocean, the land, the cryosphere, and the atmosphere. According to the Sixth Assessment Report by Working Group I of the Intergovernmental Panel on Climate Change, this planetary warming over multiple decades is human-driven and results in unprecedented and committed changes to the Earth system, with adverse impacts for ecosystems and human systems. The Earth heat inventory provides a measure of the Earth energy imbalance (EEI) and allows for quantifying how much heat has accumulated in the Earth system, as well as where the heat is stored. Here we show that the Earth system has continued to accumulate heat, with 381±61 ZJ accumulated from 1971 to 2020. This is equivalent to a heating rate (i.e., the EEI) of 0.48±0.1 W m−2. The majority, about 89 %, of this heat is stored in the ocean, followed by about 6 % on land, 1 % in the atmosphere, and about 4 % available for melting the cryosphere. Over the most recent period (2006–2020), the EEI amounts to 0.76±0.2 W m−2. The Earth energy imbalance is the most fundamental global climate indicator that the scientific community and the public can use as the measure of how well the world is doing in the task of bringing anthropogenic climate change under control. Moreover, this indicator is highly complementary to other established ones like global mean surface temperature as it represents a robust measure of the rate of climate change and its future commitment. We call for an implementation of the Earth energy imbalance into the Paris Agreement's Global Stocktake based on best available science. The Earth heat inventory in this study, updated from von Schuckmann et al. (2020), is underpinned by worldwide multidisciplinary collaboration and demonstrates the critical importance of concerted international efforts for climate change monitoring and community-based recommendations and we also call for urgently needed actions for enabling continuity, archiving, rescuing, and calibrating efforts to assure improved and long-term monitoring capacity of the global climate observing system. The data for the Earth heat inventory are publicly available, and more details are provided in Table 4.

Abstract Factors driving freshwater salinization syndrome (FSS) influence the severity of impacts and chances for recovery. We hypothesize that spread of FSS across ecosystems is a function of interactions among five state factors: human activities, geology, flowpaths, climate, and time. (1) Human activities drive pulsed or chronic inputs of salt ions and mobilization of chemical contaminants. (2) Geology drives rates of erosion, weathering, ion exchange, and acidification‐alkalinization. (3) Flowpaths drive salinization and contaminant mobilization along hydrologic cycles. (4) Climate drives rising water temperatures, salt stress, and evaporative concentration of ions and saltwater intrusion. (5) Time influences consequences, thresholds, and potentials for ecosystem recovery. We hypothesize that state factors advance FSS in distinct stages, which eventually contribute to failures in systems‐level functions (supporting drinking water, crops, biodiversity, infrastructure, etc.). We present future research directions for protecting freshwaters at risk based on five state factors and stages from diagnosis to prognosis to cure.

We developed a high-quality global integrated water vapour (IWV) dataset from 12 552 ground-based global positioning system (GPS) stations in 2020. It consists of 5 min GPS IWV estimates with a total number of 1 093 591 492 data points. The completeness rates of the IWV estimates are higher than 95 % at 7253 (58 %) stations. The dataset is an enhanced version of the existing operational GPS IWV dataset provided by the Nevada Geodetic Laboratory (NGL). The enhancement is reached by employing accurate meteorological information from the fifth generation of European ReAnalysis (ERA5) for the GPS IWV retrieval with a significantly higher spatiotemporal resolution. A dedicated data screening algorithm is also implemented. The GPS IWV dataset has a good agreement with in situ radiosonde observations at 182 collocated stations worldwide. The IWV biases are within ±3.0 kg m−2 with a mean absolute bias (MAB) value of 0.69 kg m−2. The standard deviations (SD) of IWV differences are no larger than 3.4 kg m−2. In addition, the enhanced IWV product shows substantial improvements compared to NGL's operational version, and it is thus recommended for high-accuracy applications, such as research of extreme weather events and diurnal variations of IWV and intercomparisons with other IWV retrieval techniques. Taking the radiosonde-derived IWV as reference, the MAB and SD of IWV differences are reduced by 19.5 % and 6.2 % on average, respectively. The number of unrealistic negative GPS IWV estimates is also substantially reduced by 92.4 % owing to the accurate zenith hydrostatic delay (ZHD) derived by ERA5. The dataset is available at https://doi.org/10.5281/zenodo.6973528 (Yuan et al., 2022).

Recent results emphasize the supportive effects of adipose-derived multipotent stem/progenitor cells (ADSPCs) in peripheral nerve recovery. Cultivation under hypoxia is considered to enhance the release of the regenerative potential of ADSPCs. This study aimed to examine whether peripheral nerve regeneration in a rat model of autologous sciatic nerve graft benefits from an additional custom-made fibrin conduit seeded with hypoxic pre-conditioned (2% oxygen for 72 hours) autologous ADSPCs (n = 9). This treatment mode was compared with three others: fibrin conduit seeded with ADSPCs cultivated under normoxic conditions (n = 9); non-cell-carrying conduit (n = 9); and nerve autograft only (n = 9). A 16-week follow-up included functional testing (sciatic functional index and static sciatic index) as well as postmortem muscle mass analyses and morphometric nerve evaluations (histology, g-ratio, axon density, and diameter). At 8 weeks, the hypoxic pre-conditioned group achieved significantly higher sciatic functional index/static sciatic index scores than the other three groups, indicating faster functional regeneration. Furthermore, histologic evaluation showed significantly increased axon outgrowth/branching, axon density, remyelination, and a reduced relative connective tissue area. Hypoxic pre-conditioned ADSPCs seeded in fibrin conduits are a promising adjunct to current nerve autografts. Further studies are needed to understand the underlying cellular mechanism and to investigate a potential application in clinical practice.

For each of the three JET ILW campaigns a few special marker tiles were placed in the divertor. Amongst the W-coated CFC tiles are tiles coated with a ∼ 3 µm layer of Mo with a ∼ 4 µm topcoat of W and tiles with just a ∼ 4 µm layer of Mo to measure erosion and re-deposition.During ILW1 just one Mo marker tile was included in the inner divertor band of Tiles 3. After ILW1 the Mo marker was removed for analysis and inter alia two W-coated Tiles 4 to check for re-deposited Mo. About 7% of the Mo removed from the Tile 3 Mo marker was found on band 4 tiles.A fresh Mo marker Tile 3 was inserted in for ILW2 + 3 plus a Mo marker Tile 4 for ILW2 (after which it was removed for analysis). Tile 4 removed after ILW3 was measured for Mo re-deposition. The Mo deposition pattern on Tile 4 with a regular W topcoat was quite different to that after ILW1, with much more Mo located towards the corner of the divertor.

Freshwater Salinization Syndrome (FSS) refers to groups of biological, physical, and chemical impacts which commonly occur together in response to salinization. FSS can be assessed by the mobilization of chemical mixtures, termed “chemical cocktails”, in watersheds. Currently, we do not know if salinization and mobilization of chemical cocktails along streams can be mitigated or reversed using restoration and conservation strategies. We investigated 1) the formation of chemical cocktails temporally and spatially along streams experiencing different levels of restoration and riparian forest conservation and 2) the potential for attenuation of chemical cocktails and salt ions along flowpaths through conservation and restoration areas. We monitored high-frequency temporal and longitudinal changes in streamwater chemistry in response to different pollution events (i.e., road salt, stormwater runoff, wastewater effluent, and baseflow conditions) and several types of watershed management or conservation efforts in six urban watersheds in the Chesapeake Bay watershed. Principal component analysis (PCA) indicates that chemical cocktails which formed along flowpaths (i.e., permanent reaches of a stream) varied due to pollution events. In response to winter road salt applications, the chemical cocktails were enriched in salts and metals (e.g., Na+, Mn, and Cu). During most baseflow and stormflow conditions, chemical cocktails were less enriched in salt ions and trace metals. Downstream attenuation of salt ions occurred during baseflow and stormflow conditions along flowpaths through regional parks, stream-floodplain restorations, and a national park. Conversely, chemical mixtures of salt ions and metals, which formed in response to multiple road salt applications or prolonged road salt exposure, did not show patterns of rapid attenuation downstream. Multiple linear regression was used to investigate variables that influence changes in chemical cocktails along flowpaths. Attenuation and dilution of salt ions and chemical cocktails along stream flowpaths was significantly related to riparian forest buffer width, types of salt pollution, and distance downstream. Although salt ions and chemical cocktails can be attenuated and diluted in response to conservation and restoration efforts at lower concentration ranges, there can be limitations in attenuation during road salt events, particularly if storm drains bypass riparian buffers.

There are challenges in monitoring and managing water quality due to spatial and temporal heterogeneity in contaminant sources, transport, and transformations. We demonstrate the importance of longitudinal stream synoptic (LSS) monitoring, which can track combinations of water quality parameters along flowpaths across space and time. Specifically, we analyze longitudinal patterns of chemical mixtures of carbon, nutrients, greenhouse gasses, salts, and metals concentrations along 10 flowpaths draining 1,765 km2 of the Chesapeake Bay region. These 10 longitudinal stream flowpaths are drained by watersheds experiencing either urban degradation, forest and wetland conservation, or stream and floodplain restoration. Along the 10 longitudinal stream flowpaths, we monitored over 300 total sampling sites along a combined stream length of 337 km. Synoptic monitoring along longitudinal flowpaths revealed: (1) increasing, decreasing, piecewise, or no trends and transitions in water quality with increasing distance downstream, which provide insights into water quality processes along flowpaths; (2) longitudinal trends and transitions in water quality along flowpaths can be quantified and compared using simple linear and non-linear statistical relationships with distance downstream and/or land use/land cover attributes, (3) attenuation and transformation of chemical cocktails along flowpaths depend on: spatial scales, pollution sources, and transitions in land use and management, hydrology, and restoration. We compared our LSS patterns with others from the global literature to synthesize a typology of longitudinal water quality trends and transitions in streams and rivers based on hydrological, biological, and geochemical processes. Applications of LSS monitoring along flowpaths from our results and the literature reveal: (1) if there are shifts in pollution sources, trends, and transitions along flowpaths, (2) which pollution sources can spread further downstream to sensitive receiving waters such as drinking water supplies and coastal zones, and (3) if transitions in land use, conservation, management, or restoration can attenuate downstream transport of pollution sources. Our typology of longitudinal water quality responses along flowpaths combines many observations across suites of chemicals that can follow predictable patterns based on watershed characteristics. Our typology of longitudinal water quality responses also provides a foundation for future studies, watershed assessments, evaluating watershed management and stream restoration, and comparing watershed responses to non-point and point pollution sources along streams and rivers. LSS monitoring, which integrates both spatial and temporal dimensions and considers multiple contaminants together (a chemical cocktail approach), can be a comprehensive strategy for tracking sources, fate, and transport of pollutants along stream flowpaths and making comparisons of water quality patterns across different watersheds and regions.

Experiments on ASDEX Upgrade (AUG) in 2021 and 2022 have addressed a number of critical issues for ITER and EU DEMO. A major objective of the AUG programme is to shed light on the underlying physics of confinement, stability, and plasma exhaust in order to allow reliable extrapolation of results obtained on present day machines to these reactor-grade devices. Concerning pedestal physics, the mitigation of edge localised modes (ELMs) using resonant magnetic perturbations (RMPs) was found to be consistent with a reduction of the linear peeling-ballooning stability threshold due to the helical deformation of the plasma. Conversely, ELM suppression by RMPs is ascribed to an increased pedestal transport that keeps the plasma away from this boundary. Candidates for this increased transport are locally enhanced turbulence and a locked magnetic island in the pedestal. The enhanced D-alpha (EDA) and quasi-continuous exhaust (QCE) regimes have been established as promising ELM-free scenarios. Here, the pressure gradient at the foot of the H-mode pedestal is reduced by a quasi-coherent mode, consistent with violation of the high-n ballooning mode stability limit there. This is suggestive that the EDA and QCE regimes have a common underlying physics origin. In the area of transport physics, full radius models for both L- and H-modes have been developed. These models predict energy confinement in AUG better than the commonly used global scaling laws, representing a large step towards the goal of predictive capability. A new momentum transport analysis framework has been developed that provides access to the intrinsic torque in the plasma core. In the field of exhaust, the X-Point Radiator (XPR), a cold and dense plasma region on closed flux surfaces close to the X-point, was described by an analytical model that provides an understanding of its formation as well as its stability, i.e., the conditions under which it transitions into a deleterious MARFE with the potential to result in a disruptive termination. With the XPR close to the divertor target, a new detached divertor concept, the compact radiative divertor, was developed. Here, the exhaust power is radiated before reaching the target, allowing close proximity of the X-point to the target. No limitations by the shallow field line angle due to the large flux expansion were observed, and sufficient compression of neutral density was demonstrated. With respect to the pumping of non-recycling impurities, the divertor enrichment was found to mainly depend on the ionisation energy of the impurity under consideration. In the area of MHD physics, analysis of the hot plasma core motion in sawtooth crashes showed good agreement with nonlinear 2-fluid simulations. This indicates that the fast reconnection observed in these events is adequately described including the pressure gradient and the electron inertia in the parallel Ohm’s law. Concerning disruption physics, a shattered pellet injection system was installed in collaboration with the ITER International Organisation. Thanks to the ability to vary the shard size distribution independently of the injection velocity, as well as its impurity admixture, it was possible to tailor the current quench rate, which is an important requirement for future large devices such as ITER. Progress was also made modelling the force reduction of VDEs induced by massive gas injection on AUG. The H-mode density limit was characterised in terms of safe operational space with a newly developed active feedback control method that allowed the stability boundary to be probed several times within a single discharge without inducing a disruptive termination. Regarding integrated operation scenarios, the role of density peaking in the confinement of the ITER baseline scenario (high plasma current) was clarified. The usual energy confinement scaling ITER98( p,y ) does not capture this effect, but the more recent H20 scaling does, highlighting again the importance of developing adequate physics based models. Advanced tokamak scenarios, aiming at large non-inductive current fraction due to non-standard profiles of the safety factor in combination with high normalised plasma pressure were studied with a focus on their access conditions. A method to guide the approach of the targeted safety factor profiles was developed, and the conditions for achieving good confinement were clarified. Based on this, two types of advanced scenarios (‘hybrid’ and ‘elevated’ q -profile) were established on AUG and characterised concerning their plasma performance.

After a long device enhancement phase, scientific operation resumed in 2022. The main new device components are the water cooling of all plasma facing components and the new water-cooled high heat flux divertor units. Water cooling allowed for the first long-pulse operation campaign. A maximum discharge length of 8 min was achieved with a total heating energy of 1.3 GJ. Safe divertor operation was demonstrated in attached and detached mode. Stable detachment is readily achieved in some magnetic configurations but requires impurity seeding in configurations with small magnetic pitch angle within the edge islands. Progress was made in the characterization of transport mechanisms across edge magnetic islands: Measurement of the potential distribution and flow pattern reveals that the islands are associated with a strong poloidal drift, which leads to rapid convection of energy and particles from the last closed flux surface into the scrape-off layer. Using the upgraded plasma heating systems, advanced heating scenarios were developed, which provide improved energy confinement comparable to the scenario, in which the record triple product for stellarators was achieved in the previous operation campaign. However, a magnetic configuration-dependent critical heating power limit of the electron cyclotron resonance heating was observed. Exceeding the respective power limit leads to a degradation of the confinement.

In 2021 JET exploited its unique capabilities to operate with T and D–T fuel with an ITER-like Be/W wall (JET-ILW). This second major JET D–T campaign (DTE2), after DTE1 in 1997, represented the culmination of a series of JET enhancements—new fusion diagnostics, new T injection capabilities, refurbishment of the T plant, increased auxiliary heating, in-vessel calibration of 14 MeV neutron yield monitors—as well as significant advances in plasma theory and modelling in the fusion community. DTE2 was complemented by a sequence of isotope physics campaigns encompassing operation in pure tritium at high T-NBI power. Carefully conducted for safe operation with tritium, the new T and D–T experiments used 1 kg of T (vs 100 g in DTE1), yielding the most fusion reactor relevant D–T plasmas to date and expanding our understanding of isotopes and D–T mixture physics. Furthermore, since the JET T and DTE2 campaigns occurred almost 25 years after the last major D–T tokamak experiment, it was also a strategic goal of the European fusion programme to refresh operational experience of a nuclear tokamak to prepare staff for ITER operation. The key physics results of the JET T and DTE2 experiments, carried out within the EUROfusion JET1 work package, are reported in this paper. Progress in the technological exploitation of JET D–T operations, development and validation of nuclear codes, neutronic tools and techniques for ITER operations carried out by EUROfusion (started within the Horizon 2020 Framework Programme and continuing under the Horizon Europe FP) are reported in (Litaudon et al Nucl. Fusion accepted), while JET experience on T and D–T operations is presented in (King et al Nucl. Fusion submitted).

The mission of WEST (tungsten-W Environment in Steady-state Tokamak) is to explore long pulse operation in a full tungsten (W) environment for preparing next-step fusion devices (ITER and DEMO) with a focus on testing the ITER actively cooled W divertor in tokamak conditions. Following the successful completion of phase 1 (2016-2021), phase 2 started in December 2022 with the lower divertor made entirely of actively cooled ITER-grade tungsten mono-blocks. A boronization prior the first plasma attempt allowed for a smooth startup with the new divertor. Despite the reduced operating window due to tungsten, rapid progress has been made in long pulse operation, resulting in discharges with a pulse length of 100 s and an injected energy of around 300 MJ per discharge. Plasma startup studies were carried out with equatorial boron nitride limiters to compare them with tungsten limiters, while Ion Cyclotron Resonance Heating assisted startup was attempted. High fluence operation in attached regime, which was the main thrust of the first campaigns, already showed the progressive build up of deposits and appearance of dust, impacting the plasma operation as the plasma fluence increased. In total, the cumulated injected energy during the first campaigns reached 43 GJ and the cumulated plasma time exceeded 5 h. Demonstration of controlled X-Point Radiator regime is also reported, opening a promising route for investigating plasma exhaust and plasma-wall interaction issues in more detached regime. This paper summarises the lessons learned from the manufacturing and the first operation of the ITER-grade divertor, describing the progress achieved in optimising operation in a full W environment with a focus on long pulse operation and plasma wall interaction.

Freshwater Salinization Syndrome (FSS) refers to the suite of physical, biological, and chemical impacts of salt ions on the degradation of natural, engineered, and social systems. Impacts of FSS on mobilization of chemical cocktails has been documented in streams and groundwater, but little research has focused on the effects of FSS on stormwater best management practices (BMPs) such as: constructed wetlands, bioswales, ponds, and bioretention. However emerging research suggests that stormwater BMPs may be both sources and sinks of contaminants, shifting seasonally with road salt applications. We conducted lab experiments to investigate this premise; replicate water and soil samples were collected from four distinct stormwater feature types (bioretention, bioswale, constructed wetlands and retention ponds) and were used in salt incubation experiments conducted under six different salinities with three different salts (NaCl, CaCl2, and MgCl2). Increased salt concentrations had profound effects on major and trace element mobilization, with all three salts showing significant positive relationships across nearly all elements analyzed. Across all sites, mean salt retention was 34%, 28%, and 26% for Na+, Mg2+ and Ca2+ respectively, and there were significant differences among stormwater BMPs. Salt type showed preferential mobilization of certain elements. NaCl mobilized Cu, a potent toxicant to aquatic biota, at rates over an order of magnitude greater than both CaCl2 and MgCl2. Stormwater BMP type also had a significant effect on elemental mobilization, with ponds mobilizing significantly more Mn than other sites. However, salt concentration and salt type consistently had significant effects on mean concentrations of elements mobilized across all stormwater BMPs (p < 0.05), suggesting that processes such as ion exchange mobilize metals mobilize metals and salt ions regardless of BMP type. Our results suggest that decisions regarding the amounts and types of salts used as deicers can have significant effects on reducing contaminant mobilization to freshwater ecosystems.

The net carbon erosion rate at the divertor strike line of W7-X was determined experimentally during the operational phases OP 1.2a and OP 1.2b [M. Mayer et al. Phys. Scr. T171 (2020) 014035; M. Mayer et al., Nuclear Fusion 62 (2022) 126049]. OP 1.2a was characterized by high concentrations of oxygen and a very high net carbon erosion rate. The oxygen concentration decreased by 1–2 orders of magnitude in OP 1.2b due to boronizations, and the experimentally observed erosion rate decreased by a factor of 5–6. The carbon erosion rate at the W7-X divertor is calculated using an analytical erosion model taking physical and chemical erosion by hydrogen, carbon and oxygen impact into account. Experimentally determined plasma parameters from several discharges and experimental surface roughnesses were used for the simulations. The calculated erosion rates for the selected discharges are in reasonable agreement with the experimental values. According to the calculations, during OP 1.2a carbon erosion at the strike line was dominated by chemical erosion by oxygen. The decrease of the oxygen impurity concentration in OP 1.2b decreased the carbon erosion rate by a factor of about five, which is in good agreement with the experimental values. During OP 1.2b carbon erosion was dominated by sputtering by incident hydrogen and carbon ions. The surface morphology has a profound influence on the net carbon erosion rate and develops during a campaign by erosion/deposition phenomena. Plasma-exposed surfaces get smoother with plasma exposure time, which can result in an increase of the erosion yield.

Studying the ageing of tungsten monoblocks, their erosion and their fuel inventory is the priority of the WEST post-mortem analyses programme. Actively-cooled ITER-like plasma-facing units (PFUs) and special W-coated marker lower divertor tiles were retrieved from the WEST divertor after the C3 and C4 experimental campaigns to perform ex-situ analyses. The erosion/deposition pattern on the divertor was determined. The deposition is found mainly on the inner side which is covered by layered deposits that increase in thickness in the radial direction from a few hundreds of nm to a maximum of >10 µm. The deposits are mainly composed of W, O, C, B and D coming from transport of W in the vacuum chamber, oxidized layers and boronizations. Traces of Cu, Fe, Mo, Cr, Ag were also detected. A maximum deposition rate of about 1.4 nm/s was estimated while a minimum campaign-averaged net erosion rate of 0.1 nm/s was measured for the erosion markers at the strike line areas. No assessment of the erosion could be done for the W monoblocks due to a lack of diagnostics. However, the W monoblock edges clearly show traces of damage (melting, cracks) when exposed to the parallel heat flux due to relative misalignment of ITER-like PFUs during assembly. Optical hot spots were also evidenced, confirming the numerical simulations, although their impact on the operation and the lifetime of the components was limited.

Bone conduction is a promising haptic feedback modality for upper-limb prosthesis users, however, its potential and characteristics as a non-invasive feedback modality have not been thoroughly investigated. This study aimed to establish the temporal and spatial characteristics of non-invasive bone conduction as a sensory feedback interface for upper-limb prostheses. Psychometric human-subject experiments were conducted on three bony landmarks of the elbow, with a vibrotactile transducer affixed to each to provide the stimulus. The study characterized the temporal domain by testing perception threshold and resolution in amplitude and frequency. The spatial domain was evaluated by assessing the ability of subjects to detect the number of simultaneous active stimulation sites. The experiment was conducted with ten able-bodied subjects and compared to two subjects with trans-radial amputation. The psychometric evaluation of the proposed non-invasive bone conduction feedback showed results comparable to invasive methods. The experimental results demonstrated similar amplitude and frequency resolution of the interface for all three stimulation sites for both able-bodied subjects and subjects with trans-radial amputation, highlighting its potential as a non-invasive feedback modality for upper-limb prostheses.

This study analyses river discharge into the Arctic Ocean using state-of-the-art reanalyses such as the fifth-generation European Reanalysis (ERA5) and the reanalysis component from the Global Flood Awareness System (GloFAS). GloFAS, in its operational version 2.1, combines the land surface model (Hydrology Tiled European Centre for Medium-Range Weather Forecasts – ECMWF – Scheme for Surface Exchanges over Land, HTESSEL) from ECMWF’s ERA5 with a hydrological and channel routing model (LISFLOOD). Furthermore, we analyse GloFAS' most recent version 3.1, which is not coupled to HTESSEL but uses the full configuration of LISFLOOD. Seasonal cycles as well as annual runoff trends are analysed for the major Arctic watersheds – Yenisei, Ob, Lena, and Mackenzie – where reanalysis-based runoff can be compared to available observed river discharge records. Furthermore, we calculate river discharge over the whole pan-Arctic region and, by combination with atmospheric inputs, storage changes from the Gravity Recovery and Climate Experiment (GRACE) and oceanic volume transports from ocean reanalyses, we assess closure of the non-steric water volume budget. Finally, we provide best estimates for every budget equation term using a variational adjustment scheme. Runoff from ERA5 and GloFAS v2.1 features pronounced declining trends induced by two temporal inhomogeneities in ERA5's data assimilation system, and seasonal river discharge peaks are underestimated by up to 50 % compared to observations. The new GloFAS v3.1 product exhibits distinct improvements and performs best in terms of seasonality and long-term means; however, in contrast to gauge observations, it also features declining runoff trends. Calculating runoff indirectly through the divergence of moisture flux is the only reanalysis-based estimate that is able to reproduce the river discharge increases measured by gauge observations (pan-Arctic increase of 2 % per decade). In addition, we examine Greenlandic discharge, which contributes about 10 % of the total pan-Arctic discharge and features strong increases mainly due to glacial melting. The variational adjustment yields reliable estimates of the volume budget terms on an annual scale, requiring only moderate adjustments of less than 3 % for each individual term. Approximately 6583±84 km3 of freshwater leaves the Arctic Ocean per year through its boundaries. About two-thirds of this is contributed by runoff from the surrounding land areas to the Arctic Ocean (4379±25 km3 yr−1), and about one-third is supplied by the atmosphere. However, on a seasonal scale budget residuals of some calendar months were too large to be eliminated within the a priori spreads of the individual terms. This suggests that systematical errors are present in the reanalyses and ocean reanalysis data sets, which are not considered in our uncertainty estimation.

Background: Phase 2 trial endpoints that can be utilized in high-risk biochemical recurrence (BCR) after prostatectomy as a way of more rapidly identifying treatments for phase 3 trials are urgently needed. The efficacy of abiraterone acetate plus prednisone (AAP) in BCR is unknown. Objective: To compare the rates of complete biochemical responses after testosterone recovery after 8 mo of AAP and degarelix, a gonadotropin-releasing hormone antagonist, alone or in combination. Design, setting, and participants: Patients with BCR (prostate-specific antigen [PSA] ≥1.0 ng/ml, PSA doubling time ≤9 mo, no metastases on standard imaging, and testosterone ≥150 ng/dl) after prostatectomy (with or without prior radiotherapy) were included in this study. Intervention: Patients were randomized to AAP (arm 1), AAP with degarelix (arm 2), or degarelix (arm 3) for 8 mo, and monitored for 18 mo. Outcome measurements and statistical analysis: The primary endpoint was undetectable PSA with testosterone >150 ng/dl at 18 mo. Secondary endpoints were undetectable PSA at 8 mo and time to testosterone recovery. Results and limitations: For the 122 patients enrolled, no difference was found between treatments for the primary endpoint (arm 1: 5.1% [95% confidence interval {CI}: 1–17%], arm 2: 17.1% [95% CI: 7–32%], arm 3: 11.9% [95% CI: 4–26%]; arm 1 vs 2, p = 0.93; arm 2 vs 3, p = 0.36). AAP therapy showed the shortest median time to testosterone recovery (36.0 wk [95% CI: 35.9–36.1]) relative to degarelix (52.9 wk [95% CI: 49.0–56.0], p < 0.001). Rates of undetectable PSA at 8 mo differed between AAP with degarelix and degarelix alone (p = 0.04), but not between AAP alone and degarelix alone (p = 0.12). Limitations of this study include a lack of long-term follow-up. Conclusions: Rates of undetectable PSA levels with testosterone recovery were similar between arms, suggesting that increased androgen suppression with AAP and androgen deprivation therapy (ADT) is unlikely to eradicate recurrent disease compared with ADT alone. Patient summary: We evaluated the use of abiraterone acetate plus prednisone (AAP) and androgen deprivation therapy (ADT), AAP alone, or ADT alone in men with biochemically recurrent, nonmetastatic prostate cancer. While more men who received the combination had an undetectable prostate-specific antigen (PSA) level at 8 mo on treatment, once men came off treatment and testosterone level rose, there was no difference in the rates of undetectable PSA levels. This suggests that the combination is not able to eradicate disease any better than ADT alone.

A more critical evaluation of the actions of autonomous vehicles in comparison to those of human drivers in accident scenarios may complicate the introduction of autonomous vehicles into daily traffic. In two experiments, we tested whether the evaluation of actions in road-accident scenarios differs as a function of whether the actions were performed by human drivers or autonomous vehicles. Participants judged how morally adequate they found the actions of a non-anthropomorphized autonomous vehicle (Experiments 1 and 2), an anthropomorphized autonomous vehicle (Experiment 2), and a human driver (Experiments 1 and 2) in otherwise identical road-accident scenarios. The more lives were spared, the better the action was evaluated irrespective of the agent. However, regardless of the specific action that was chosen, the actions of the human driver were always considered more morally justifiable than the corresponding actions of the autonomous vehicle. The differences in the moral evaluations between the human driver and the autonomous vehicle were reduced, albeit not completely eliminated, when the autonomous vehicle was anthropomorphized (Experiment 2). Anthropomorphizing autonomous vehicles may thus influence the processes underlying moral judgments about the actions of autonomous vehicles such that the actions of anthropomorphized autonomous vehicles appear closer in moral justifiability to the actions of humans. The observed differences in the moral evaluation of the actions of human drivers and autonomous vehicles could cause a more critical public response to accidents involving autonomous vehicles compared to those involving human drivers which might be reduced by anthropomorphizing the autonomous vehicles.

In recent years, there has been an increasing interest in electrically conductive hydrogels for a wide range of biomedical applications, like tissue engineering or biosensors. In this study, we present a cost-effective conductive hydrogel based on alginate and graphene nanoplatelets for extrusion-based bioprinters. The hydrogel is prepared under ambient conditions avoiding high temperatures detrimental for cell culture environments. Investigation of the hydrogel revealed a conductivity of up to 7.5 S/cm, depending on the ratio of platelets. Furthermore, in vitro tests with human embyronic kidney cells - as an example cell type - showed good adhesion of the cells to the surface of the conductive hydrogel. Electrochemical measurements revealed a low electrode impedance which is desirable for the extracellular recording, but also low electrode capacitance, which is unfavorable for electrical stimulation purposes. Therefore, future experiments with the graphene nanoplatelets-based hydrogels will focus on electrodes for biosensors and extracellular recordings of neurons or cardiac myocytes.

Measuring the reduction of in vitro bioaccessible (IVBA) Pb from the addition of phosphate amendments has been researched for more than 20 years. A range of effects have been observed from increases in IVBA Pb to almost 100% reduction. This study determined the mean change in IVBA Pb as a fraction of total Pb (AC) and relative to the IVBA Pb of the control soil (RC) with a random effects meta-analysis. Forty-four studies that investigated the ability of inorganic phosphate amendments to reduce IVBA Pb were identified through 5 databases. These studies were split into 3 groups: primary, secondary, and EPA Method 1340 based on selection criteria, with the primary group being utilized for subgroup analysis and meta-regression. The mean AC was approximately -12% and mean RC was approximately -25% for the primary and secondary groups. For the EPA Method 1340 group, the mean AC was -5% and mean RC was -8%. The results of subgroup analysis identified the phosphorous amendment applied and contamination source as having a significant effect on the AC and RC. Soluble amendments reduce bioaccessible Pb more than insoluble amendments and phosphoric acid is more effective than other phosphate amendments. Urban Pb contamination associated with legacy Pb-paint and tetraethyl Pb from gasoline showed lower reductions than other sources such as shooting ranges and smelting operations. Meta-regression identified high IVBA Pb in the control, low incubated soil pH, and high total Pb with the greater reductions in AC and RC. In order to facilitate comparisons across future remediation research, a set of minimum reported data should be included in published studies and researchers should use standardized in vitro bioaccessibility methods developed for P-treated soils. Additionally, a shared data repository should be created for soil remediation research to enhance available soil property information and better identify unique materials.

Teratomas are the most common type of germ cell tumours in childhood. Although head and neck teratomas are rare, they carry a high risk of airway obstruction. We report a case of a teenage pregnancy who delivered a male infant at 36 weeks via emergency caesarean section. She attended antenatal care, with no significant prenatal or family history and antenatal ultrasound was not performed. The infant was born with a large cervicofacial teratoma and required resuscitation with bag and mask ventilation at birth with Apgar scores of 6 and 7 at 1 and 5 min respectively. He required intubation to maintain patency of the airway, during which he was noted to have erythematous vocal cords and difficult visualization due to external pressure exerted by the mass on the airway. Complete excision of the mass was performed successfully by a multi-disciplinary team of ear nose and throat and pediatric surgeons after delineating the mass with MRI scan. Infant was discharged home with a tracheostomy tube after a prolonged hospital stay. Intervention soon after birth and a multi-disciplinary approach was critical for survival of this patient.

Abstract Background During the COVID-19 pandemic, billions of people have to change their behaviours to slow down the spreading of the virus. Protective measures include self-isolation, social (physical) distancing and compliance with personal hygiene rules, particularly regular and thorough hand washing. Prevalence estimates for the compliance with the COVID-19 measures are often based on direct self-reports. However, during a health crisis there is strong public pressure to comply with health and safety regulations so that people’s responding in direct self-reports may be seriously compromised by social desirability. Methods In an online survey, an indirect questioning technique was used to test whether the prevalence of hygiene practices may be lower than in conventional surveys when confidentiality of responding is guaranteed. The Extended Crosswise Model is an indirect questioning technique that guarantees the confidentiality of responding. To the degree that direct self-reports are biased by social desirability, prevalence estimates of hygiene practices such as thorough hand washing based on the Extended Crosswise Model should be lower than those based on direct self-reports. Results We analysed data of 1434 participants. In the direct questioning group 94.5% of the participants claimed to practice proper hand hygiene; in the indirect questioning group a significantly lower estimate of only 78.1% was observed. Conclusions These results indicate that estimates of the degree of commitment to measures designed to counter the spread of the disease may be significantly inflated by social desirability in direct self-reports. Indirect questioning techniques with higher levels of confidentiality seem helpful in obtaining more realistic estimates of the degree to which people follow the recommended personal hygiene measures. More realistic estimates of compliance can help to inform and to adjust public information campaigns on COVID-19 hygiene recommendations.

Nowadays many seasonal forecasting centres provide dynamical predictions of sea ice. While initializing sea ice by assimilating sea ice concentration (SIC) is common, constraining initial conditions of sea ice thickness (SIT) is only in its early stages. Here, we make use of the availability of Arctic-wide winter SIT observations covering 2011–2016 to constrain SIT in the ECMWF (European Centre for Medium-Range Weather Forecasts) ocean–sea-ice analysis system with the aim of improving the initial conditions of the coupled forecasts. The impact of the improved initialization on the predictive skill of pan-Arctic sea ice for lead times of up to 7 months is investigated in a low-resolution analogue of the currently operational ECMWF seasonal forecasting system SEAS5. By using winter SIT information merged from CS2 and SMOS (CS2SMOS: CryoSat-2 Soil Moisture and Ocean Salinity), substantial changes in sea ice volume and thickness are found in the ocean–sea-ice analysis, including damping of the overly strong seasonal cycle of sea ice volume. Compared with the reference experiment, which does not use SIT information, forecasts initialized using SIT data show a reduction of the excess sea ice bias and an overall reduction of seasonal sea ice area forecast errors of up to 5 % at lead months 2 to 5. Change in biases is the main forecast impact. Using the integrated ice edge error (IIEE) metric, we find significant improvement of up to 28 % in the September sea ice edge forecast started in April. However, sea ice forecasts for September started in spring still exhibit a positive sea ice bias, which points to a melting that is too slow in the forecast model. A slight degradation in skill is found in the early freezing season sea ice forecasts initialized in July and August, which is related to degraded initial conditions during these months. Both ocean reanalyses, with and without SIT constraint, show strong melting in the middle of the melt season compared to the forecasts. This excessive melting related to positive net surface radiation biases in the atmospheric flux forcing of the ocean reanalyses remains and consequently degrades analysed summer SIC. The impact of thickness initialization is also visible in the sea surface and near-surface temperature forecasts. While positive forecast impact is seen in near-surface temperature forecasts of early freezing season (September–October–November) initialized in May (when the sea ice initial conditions have been observationally constrained in the preceding winter months), negative impact is seen for the same season when initialized in the month of August when the sea ice initial conditions are degraded. We conclude that the strong thinning by CS2SMOS initialization mitigates or enhances seasonally dependent forecast model errors in sea ice and near-surface temperatures in all seasons. The results indicate that the memory of SIT in the spring initial conditions lasts into autumn, influencing forecasts of the peak summer melt and early freezing seasons. Our results demonstrate the usefulness of new sea ice observational products in both data assimilation and forecasting systems, and they strongly suggest that better initialization of SIT is crucial for improving seasonal sea ice forecasts.

Human-induced atmospheric composition changes cause a radiative imbalance at the top of the atmosphere which is driving global warming. This Earth energy imbalance (EEI) is the most critical number defining the prospects for continued global warming and climate change. Understanding the heat gain of the Earth system – and particularly how much and where the heat is distributed – is fundamental to understanding how this affects warming ocean, atmosphere and land; rising surface temperature; sea level; and loss of grounded and floating ice, which are fundamental concerns for society. This study is a Global Climate Observing System (GCOS) concerted international effort to update the Earth heat inventory and presents an updated assessment of ocean warming estimates as well as new and updated estimates of heat gain in the atmosphere, cryosphere and land over the period 1960–2018. The study obtains a consistent long-term Earth system heat gain over the period 1971–2018, with a total heat gain of 358±37 ZJ, which is equivalent to a global heating rate of 0.47±0.1 W m−2. Over the period 1971–2018 (2010–2018), the majority of heat gain is reported for the global ocean with 89 % (90 %), with 52 % for both periods in the upper 700 m depth, 28 % (30 %) for the 700–2000 m depth layer and 9 % (8 %) below 2000 m depth. Heat gain over land amounts to 6 % (5 %) over these periods, 4 % (3 %) is available for the melting of grounded and floating ice, and 1 % (2 %) is available for atmospheric warming. Our results also show that EEI is not only continuing, but also increasing: the EEI amounts to 0.87±0.12 W m−2 during 2010–2018. Stabilization of climate, the goal of the universally agreed United Nations Framework Convention on Climate Change (UNFCCC) in 1992 and the Paris Agreement in 2015, requires that EEI be reduced to approximately zero to achieve Earth's system quasi-equilibrium. The amount of CO2 in the atmosphere would need to be reduced from 410 to 353 ppm to increase heat radiation to space by 0.87 W m−2, bringing Earth back towards energy balance. This simple number, EEI, is the most fundamental metric that the scientific community and public must be aware of as the measure of how well the world is doing in the task of bringing climate change under control, and we call for an implementation of the EEI into the global stocktake based on best available science. Continued quantification and reduced uncertainties in the Earth heat inventory can be best achieved through the maintenance of the current global climate observing system, its extension into areas of gaps in the sampling, and the establishment of an international framework for concerted multidisciplinary research of the Earth heat inventory as presented in this study. This Earth heat inventory is published at the German Climate Computing Centre (DKRZ, https://www.dkrz.de/, last access: 7 August 2020) under the DOI https://doi.org/10.26050/WDCC/GCOS_EHI_EXP_v2 (von Schuckmann et al., 2020).

Renal cell carcinoma (RCC) metastases to the testicle are an extremely rare clinical entity. Here, we describe the case of a man with metastatic RCC who developed a new testicular mass. Pathologic analysis after surgical removal of this testicle confirmed the diagnosis of metastatic RCC. This report highlights the unique diagnostic and therapeutic challenges associated with such a disease process.

BackgroundTraining in the Helping Babies Breathe (HBB) Program has been associated with a reduction in early neonatal mortality rate (ENMR), the neonatal mortality rate (NMR), and fresh stillbirth rate (FSBR) in low- and middle-income countries (LMICs). This program was implemented in five different healthcare facilities in the Oliver Reginald Tambo (ORT) District, South Africa from September 2015 to December 2020.ObjectiveTo determine and compare the FSBR, ENMR, and NMR between 2015 before initiation of the program (baseline) and subsequent years up to 2020 following the implementation of facility-based training of HBB in five hospitals in ORT District.MethodsRecords of perinatal statistics from January 2015 to December 2020 were reviewed to calculate FSBR, ENMR, and NMR. Data were collected from the five healthcare facilities which included two district hospitals (Hospital A&B), two regional hospitals (Hospital C&D), and one tertiary hospital (Hospital E). Comparisons were made between pre- (2015) and post- (2016–2020) HBB implementation periods. Differences in changes over time were also assessed using linear regression analysis.ResultsThere were 19,275 births in 2015, increasing to 22,192 in 2020 with the majority (55.3%) of births occurring in regional hospitals. There were significant reductions in ENMR (OR−0.78, 95% CI 0.70–0.87) and NMR (OR−0.81, 95% CI 0.73–0.90), but not in FSBR, in the five hospitals combined when comparing the two time periods. Significant reduction was also noted in trends over time in ENMR (r2 = 0.45, p = 0.001) and NMR (r2 = 0.23, p = 0.026), but not in FSBR (r2 = 0.0, p = 0.984) with all hospitals combined. In looking at individual hospitals, Hospital A (r2 = 0.61, p < 0.001) and Hospital E (r2 = 0.19, p = 0.048) showed a significant reduction in ENMR over time, but there were no significant changes in all mortality rates for Hospitals B, C, and D, and for the district or regional hospitals combined.ConclusionThere was an overall reduction of 22% and 19% in ENMR and NMR, respectively, from pre- to post-HBB implementation periods, although there were variations from year to year over the 5-year period and, across hospitals. These differences suggest that there were other factors that affected the perinatal/neonatal outcomes in the hospital sites in addition to the implementation of training in HBB.

A number of 35 samples cored from JET divertor tiles exposed to JET plasmas in ILW1 (ITER Like Wall – first campaign), ILW2, ILW1 + ILW2 and ILW3 campaigns were analyzed using the Glow Discharge Optical Emission Spectrometry (GDOES) technique. The depth profiles of the elements contained in the surface layer of the tiles (W, Mo, Be, C, O and D) have been quantitatively determined up to a depth of 30–60 μm.The upper zone of Tile 3 (the lower vertical zone of the inner divertor) seems to be an erosion zone as it was demonstrated with a Mo marker layer in the ILW1 campaign. By increasing the input energy in the following campaigns this erosion did not increase, but it almost disappeared, probably due to significant amounts of Be that were transported from the main chamber and deposited on that area. The Be concentration increased in the upper zone of Tile3 in ILW2 and ILW3 by a factor of about 5 in comparison with the ILW1 campaign. It looks like the Be layer protects the tile surface from erosion.Depending on the amount of Be deposited on specific areas of the W-coated CFC (Carbon Fiber Composite) tiles, two mechanisms of D retention were identified. If the peak concentration of Be is less than ∼4.5 at.% D is mainly trapped into the defects of the W/Mo structure including W/Mo and Mo/C interfaces. When the peak concentration of Be exceeds ∼4.5 at.%, D is mainly retained in the Be deposits. The GDOES results were correlated with SEM analyses performed on the GDOES crater flanks and with the TDS (Thermal Desorption Spectroscopy), results obtained with the same samples after GDOES analyses. They are in good agreement with the corresponding results obtained by other authors using NRA (Nuclear Reaction Analysis), SIMS (Secondary Ion Mass Spectrometry) and TDS.

Ion–molecule reactions between the neutral ethyl- (EF), isopropyl- (IF), t-butyl- (TF) and phenyl formate (PF) and proton-bound water clusters W2H+ and W3H+ (W = H2O) showed that the major reaction product is water loss from the initial encounter complex, followed ultimately by the formation of the protonated formate. Collision-induced dissociation breakdown curves of the formate–water complexes were obtained as a function of collision energy and modeled to extract relative activation energies for the observed channels. Density functional theory calculations (B3LYP/6-311+G(d,p)) of the water loss reactions were consistent with reactions having no reverse energy barrier in each case. Overall, the results indicate that the interaction of formates with atmospheric water can form stable encounter complexes that will dissociate by sequential water loss to form protonated formates.