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Introduction. The problem of ulcerative skin lesions is urgent due to chronicity, severe course, resistance to basic methods of therapy and a decrease in the quality of life of patients. According to statistics, among skin diseases, ulcerative lesions of various etiologies account for about 11.4–14.7 %. Aim of the study. To assess serum procalcitonin levels in the clinical course of ulcerative skin lesions. Patients and methods. We observed 44 patients with ulcerative skin lesions aged 11 to 57 years. The level of procalcitonin was measured in all patients using immunofluorescence assay. The control group included 23 healthy individuals from the same age group. Results. Among 44 patients with ulcerative skin lesions, 22 were diagnosed with a trophic ulcer, 12 patients with necrotizing ulcerative vasculitis, and 12 with chronic ulcerative pyoderma. In patients with ulcerative skin lesions, there was an increase in the level of procalcitonin by 1.3 times compared with the healthy control group (p>0.05). Serum procalcitonin levels were in a significant direct correlation with the skin level of S. aureus (r=+0.8) and in inverse correlations with skin levels of S. epidermidis (r=–0.9) and S. saprophyticus (r=–0.3). Conclusion. The results obtained indicate that procalcitonin has a significant relationship with opportunistic microorganisms, and even a slight increase in its level may indicate a local invasive process of an infiltrative-inflammatory nature, caused by the bacterial flora.

Introduction. Atopic dermatitis (AD) is a global problem of the 21st century, as the number of people suffering from this disease is steadily increasing, and around the world, about 20% of the population with clinical manifestations of this disease seek medical help. Aim of the study. Evaluation of the clinical course of AD in children in the hot climate of Uzbekistan. Patients and methods. 215 patients with atopic dermatitis aged from 1 to 18 years were under observation. The severity of AD was determined using the SCORAD index. Results. Among 215 patients, the erythematous-squamous form was observed in 63 (29.3%), erythematous-squamous with lichenification — in 47 (21.8%), lichenoid — in 55 (25.6%), exudative — in 34 (15.8%), and pruriginous form of AD — in 16 (7.4%). Most observed patients were adolescents, and the number of boys and girls with AD in this group was similar (49.6% and 50.4%, respectively). In terms of severity, taking into account the SCORAD index, in infancy, most patients had moderate (47.4%) and mild (36.8%) clinical course; in childhood — moderate (56.1%); in adolescence — moderate (40.3%) and severe (33.8%). In infancy, the exudative form was the most prevalent (52.6%). At the age of 2 to 11 years, the erythematous-squamous and lichenoid forms were the most frequently diagnosed (43.8% and 31.6% of cases, respectively). Meanwhile, at the age of 12 to 18 years, the patients were characterized by a different distribution of forms: the erythematous-squamous form with lichenification was observed in 28.1%, the lichenoid form — in 26.6%, and the erythematous-squamous form in 20.8%. Conclusion. In the present study, we assessed the relative frequency of forms of atopic dermatitis in children of different age groups in the hot climate of Uzbekistan.

In recent years, evaluation of autoimmune mechanisms of bullous dermatoses has become relevant. In this connection, the aim of our study was to assess serum levels of IgG autoantibodies (AAB) to single stranded DNA (ss-DNA) and double stranded DNA (ds-DNA) in patients with true acantholytic pemphigus. The present study included 57 patients with acantholytic pemphigus and 18 healthy individuals (control group). Analysis of the results obtained showed that most patients with true pemphigus had an increased level of IgG autoantibodies to ds-DNA (59.6% of cases). At the same time, IgG autoantibodies to ss-DNA were detected in 15.8% of cases. Quantitative evaluation of the serum level of IgG autoantibodies to ds-DNA revealed an increase by 1.6 times in patients with pemphigus as compared to the control group (p