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Your search keyword '"A Almarghalani D"' showing total 3 results
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3 results on '"A Almarghalani D"'

1. Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice

Author

Amit Sharma, Mehta S, Youssef Sari, Jorge A. Masso-Silva, Al-Kolla R, Crotty Alexander Le, Brand C, Deepti Gunge, Min Kwang Byun, Zahoor A. Shah, Josephine Pham, A. Moshensky, Park K, Hasan Alhaddad, Sedtavut Nilaad, John Shin, Samantha Perera, Joan Heller Brown, Jahan A, Soumita Das, Ira Advani, Hoyoung Moon, and Almarghalani D

Subjects
Chemokine, Lung, Inhalation, biology, Heart disease, business.industry, Inflammation, Lung injury, medicine.disease, HMGB1, medicine.anatomical_structure, Immunology, medicine, biology.protein, medicine.symptom, business, Neuroinflammation
Abstract

While health effects of conventional tobacco are well defined, data on vaping devices, including the most popular e-cigarette JUUL, are less established. Prior acute e-cigarette studies demonstrated inflammatory and cardiopulmonary physiology changes while chronic studies demonstrated extra-pulmonary effects, including neurotransmitter alterations in reward pathways. In this study we investigated effects of chronic flavored JUUL aerosol inhalation on inflammatory markers in brain, lung, heart, and colon. JUUL induced upregulation of cytokine and chemokine gene expression and increased HMGB1 and RAGE in the nucleus accumbens. Inflammatory gene expression increased in colon, and cardiopulmonary inflammatory responses to acute lung injury with lipopolysaccharide were exacerbated in the heart. Flavor-dependent changes in several responses were also observed. Our findings raise concerns regarding long-term risks of e-cigarette use as neuroinflammation may contribute to behavioral changes and mood disorders, while gut inflammation has been tied to poor systemic health and cardiac inflammation to development of heart disease.One Sentence SummaryChronic, daily inhalation of pod-based e-cigarette aerosols alters the inflammatory state across multiple organ systems in mice.

Published
2021

2. Multi-Organ Inflammatory Effects by the Chronic Use of the Pod-Based Electronic Cigarette JUULTMin Mice

Author

Masso Silva, J.A., primary, Moshensky, A., additional, Brand, C., additional, Alhaddad, H., additional, Shin, J., additional, Almarghalani, D., additional, Advani, I.N., additional, Gunge, D., additional, Mehta, S., additional, Jahan, A., additional, Nilaad, S., additional, Pham, J., additional, Perera, S., additional, Park, K., additional, Al Kolla, R., additional, Das, S., additional, Byun, M., additional, Shah, Z., additional, Sari, Y., additional, Heller Brown, J., additional, and Crotty Alexander, L.E., additional

Published
2021
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3. The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents.

Author

Alzweiri M, S Alsegiani A, Karaj E, A Almarghalani D, Tabaza Y, A Shah Z, and Tillekeratne LMV

Subjects
Alzheimer Disease metabolism, Animals, Biological Products chemical synthesis, Biological Products chemistry, Cell Survival drug effects, Cholinesterase Inhibitors chemistry, Dose-Response Relationship, Drug, Lysergic Acid chemical synthesis, Lysergic Acid chemistry, Molecular Structure, Neuroprotective Agents chemical synthesis, Neuroprotective Agents chemistry, PC12 Cells, Rats, Structure-Activity Relationship, Acetylcholinesterase metabolism, Alzheimer Disease drug therapy, Biological Products pharmacology, Cholinesterase Inhibitors pharmacology, Lysergic Acid pharmacology, Neuroprotective Agents pharmacology
Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder, projected to be the second leading cause of mortality by 2040. AD is characterized by a progressive impairment of memory leading to dementia and loss of ability to carry out daily functions. In addition to the deficiency of acetylcholine release in synapse, there are other mechanisms explaining the etiology of the disease. The most disputing ones are associated with the accumulation of damaged proteins β-amyloid (Aβ) and hyperphosphorylated tau outside and inside neurons, respectively. Lysergic acid derivatives have been shown to possess promising anti-Alzheimer effect. Moreover, lysergic acid structure encompasses the general structural requirements for acetylcholinesterase inhibition. In this study, sixteen analogues, derived from lysergic acid structure, were synthesized. Heck and Mannich reactions were carried out to 4-bromo indole nucleus to generate potentially active analogues. Some of them were subsequently cyclized by nitromethane and zinc reduction procedures. Some of these compounds showed neuroprotective and anti-inflammatory effects stronger than the currently used anti-Alzheimer drug; donepezil. Some of the synthesized com-pounds showed a noticeable acetylcholinesterase inhibition. Twelve molecular targets attributed with AD etiology were tested versus the synthesized compounds by in silico modeling. Docking scores of modeling were plotted against in vitro activity of the compounds. The one afforded the strongest positive correlation was ULK-1 which has a significant role in autophagy., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
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