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中国古代典籍文献浩如烟海，蕴藏了大量的历史人文知识。以电子化和全文检索为主要方法的古籍数字化开发应用模式已经成为语言文学、历史、哲学等学科的重要基础资源和工具。随着人工智能与大数据技术的发展，数字人文的研究范式不断演进，将传统典籍的文本转换为高度结构化的新型数字人文数据库是一项新的探索，将文本中词汇、人物、地理实体等要素有机组织起来，对于历史现象可视化、历史规律量化具有重大意义。以《史记·列传》为对象，进行古汉语自动分词及词性标注、人工校对以及实体信息人工标注，形成多层次、高质量的数字人文知识库，实现包含古籍词汇、人物、地点等要素的定量分析与可视化检索，挖掘出《史记·列传》人物和地点分布情况、人物关系、人地关系等信息。得出：《史记·列传》共出现人物1 787位、地点1 173个；相比《史记·本纪》和《史记·世家》，《史记·列传》特有人物共1 092位，特有地点共556个。本文研究内容为古籍数字人文知识库的构建提供了新的思路与框架。

为了降低红绿蓝发光二极管（RGB-LED）可见光通信系统解复用过程中滤光造成的光能量损失,设计了一种基于分光解复用法的RGB-LED可见光通信系统。介绍了分光解复用法的原理和结构组成,对比了分光解复用法与常用的滤光解复用法在解复用过程中的光能量损失,由对比结果可知,分光解复用法可降低滤光造成的光能量损失,提高光源的利用率。利用光通信仿真软件对通信系统进行了仿真测试,仿真结果显示,在相同误码率条件下,采用分光解复用法的系统能有效延长信号的传输距离。

【目的】研究雷帕霉素对卵巢癌顺铂耐药细胞系 SKOV3/DDP 的逆转作用并探讨其相关分子机制。 【方法】采用四甲基偶氮唑蓝（MTT）法测定卵巢癌顺铂耐药细胞系SKOV3/DDP的耐药倍数、雷帕霉素对其细胞毒 性及逆转倍数；Western blot法检测雷帕霉素对细胞内Akt/mTOR相关通路蛋白表达的影响。【结果】 ① MTT法检 测出雷帕霉素浓度分别为 25、50、100、500 和 1 000 μg/L 对卵巢癌顺铂耐药细胞系 SKOV3/DDP 的抑制率分别为 4.48%、25.30%、35.86%、67.82%和81.43%。选择抑制率小于5%的最大雷帕霉素浓度即25 μg/L作为逆转浓度；② 卵巢癌顺铂耐药细胞株SKOV3/DDP耐药指数RI为2.21；③ 25 μg/L雷帕霉素对卵巢癌顺铂耐药细胞系SKOV3/DDP 逆转倍数为1.63；④ Western blot结果：加用雷帕霉素后，卵巢癌细胞SKOV3和卵巢癌顺铂耐药细胞SKOV3/DDP的 p-mTOR及其下游的p-p70s6k表达均明显降低。同时，雷帕霉素作用于SKOV3及SKOV3/DDP细胞后，均出现p-Akt 反馈性增高。【结论】雷帕霉素对卵巢癌顺铂耐药细胞系SKOV3/DDP具有耐药逆转作用，其机制可能为通过抑制 Akt/mTOR通路中mTOR及下游相关蛋白表达进而抑制耐药细胞的增殖并促进其凋亡进程。

【目的】检测半乳糖凝集素-3（Gal-3）、B淋巴细胞瘤/白血病蛋白-2（Bcl-2）在上皮性卵巢癌组织中的表达，探 究二者与相关临床病理特征及预后关系，检验它们作为预测预后标记物的可能性。【方法】采用免疫组织化学方法，检测 98例上皮性卵巢癌组织、10例正常卵巢组织中Gal-3和Bcl-2的表达，分析二者与临床病理特征、预后的关系。【结果】98例 上皮性卵巢癌中，Gal-3、Bcl-2均为胞浆表达，Gal-3阳性率为76.5%（75/98），Bcl-2阳性率为51.0%（50/98），正常卵巢上皮不 表达Gal-3、Bcl-2蛋白。Gal-3与Bcl-2相关性无统计学意义。Gal-3表达与病理类型、铂敏感性相关（P = 0.043，P = 0.038）， Bcl-2表达与FIGO分期相关（P = 0.029）。Cox单因素分析显示上皮性卵巢癌Gal-3表达（P = 0.008）、Bcl-2表达（P = 0.021）、 分期（P < 0.001）、铂敏感性（P < 0.001）是影响术后生存的因素，而Cox多因素分析中则只有Gal-3表达（P = 0.014）、铂敏感 性（P = 0.021）、分期（P < 0.001）才是独立预后因素。【结论】Gal-3、Bcl-2可能参与上皮性卵巢癌的发生发展。Gal-3表达与 病理类型、铂敏感性、预后相关，可能成为上皮性卵巢癌预后的独立判定因子。

【目的】探讨JAK/STAT信号转导途径负调控子SHP-1基因启动子区域CpG岛异常甲基化在B细胞淋巴瘤中的意义。【方法】收集存档石蜡包埋组织标本61例(52例B细胞非霍奇金淋巴瘤标本,9例良性增生淋巴结标本),健康人外周血单个核细胞DNA标本15例,用甲基化特异性PCR(methylation-specific PCR,MSP)和非甲基化特异性PCR(unmethylation-specific PCR,un-MSP)检测SHP-1启动子区域CpG岛甲基化状态,MSP、un-MSP和RT-PCR方法分别检测接受或未接受去甲基化处理的Burkitt淋巴瘤细胞系Raji的甲基化状态及mRNA的表达,MTT法检测接受去甲基化干预后细胞生长受抑情况。【结果】SHP-1基因启动子区域在弥漫性大B细胞淋巴瘤和滤泡性淋巴瘤甲基化频率分别为94%及97%,对照组9例淋巴结良性增生标本和15例正常人外周血单个核细胞标本中SHP-1基因启动子区域甲基化频率为0。经去甲基化干预后,Raji细胞SHP-1基因启动子区域呈去甲基化状态,基因恢复表达,细胞生长受到抑制。【结论】SHP-1基因启动子区域启动子区域CpG岛在B细胞淋巴瘤中存在高度甲基化，由其所致的SHP-1基因沉默可能是B细胞淋巴瘤发生的一个重要因素，SHP-1基因的甲基化可作为一个良好的分子诊断标记及可能的治疗靶点。

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