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针对中国第一个海上风电柔性直流送出工程—江苏如东工程，从系统拓扑方案构建、过电压与绝缘配合、系统功率盈余问题与交流故障穿越技术以及控制保护技术等方面开展了深入研究，构建了轻型紧凑化的海上风电柔性直流系统拓扑方案，取消了海上换流站的启动回路与接地回路等；提出了海陆换流站的避雷器配置方案与参考电压的选取原则，形成了海陆换流站的绝缘配合方案的典型范式；提出了集中式、分布式、混合式直流侧有功功率动态平衡装置的典型拓扑方式，解决了陆上换流站交流侧故障穿越难题；提出了工程的整体控制保护方案，并研究了一种基于电压前馈环节比例谐振控制的有源谐振抑制方法，显著降低了工程的振荡风险。通过工程实际运行，全面验证了所提技术的有效性。

目的 探索同侧非狭窄性颈动脉粥样硬化斑块特征与前循环不明原因栓塞性卒中（embolic stroke of undetermined source，ESUS）的相关性。 方法 回顾性纳入北京市大兴区人民医院神经内科2017年1月-2022年5月连续住院的急性单侧前循环缺血性ESUS患者。采用颈动脉超声评估双侧非狭窄性颈动脉粥样硬化斑块，比较梗死同侧颈动脉与对侧颈动脉斑块的发生率、多发斑块的发生率、不均质回声斑块的比例以及颈动脉斑块厚度等特征的差异。 结果 共纳入101例ESUS患者，平均年龄60.7±14.1岁，男性72例（71.3%）。梗死同侧非狭窄性颈动脉粥样硬化斑块发生率为66.3%（67/101），梗死对侧颈动脉斑块发生率为55.4%（56/101），差异有统计学意义（P=0.028）；梗死同侧颈动脉多发斑块发生率为41.6%（42/101），梗死对侧多发斑块发生率为31.7%（32/101），差异有统计学意义（P=0.019）；梗死同侧不均质回声斑块的发生率高于梗死对侧颈动脉（39.6% vs. 23.8%，P＜0.001）。另外，梗死同侧颈动脉斑块平均厚度大于梗死对侧颈动脉（2.8 mm vs. 2.1 mm，P＜0.001）。 结论 本研究急性ESUS患者中，梗死灶同侧的颈动脉较对侧颈动脉更易出现动脉粥样硬化斑块，且多发斑块、斑块不稳定的比例也更高，斑块平均厚度更大，提示ESUS的发生与非狭窄性颈动脉斑块超声特征有一定的相关性。 Abstract: Objective To investigate the correlation between anterior circulation embolic stroke of undetermined source (ESUS) and ipsilateral non-stenotic carotid plaque. Methods This retrospective study enrolled consecutive patients with anterior circulation ESUS at Department of Neurology of Beijing Daxing District People’s Hospital between January 2017 and May 2022. All the subjects underwent bilateral carotid ultrasonography, to evaluate non-stenotic carotid plaque number, thickness and echotexture. The incidence of non-stenotic carotid plaques, multiple plaques, the percentage of heterogeneous echo, and carotid plaque thickness were analyzed to evaluate the correlation of non-stenotic carotid plaque and anterior circulation ESUS. Results A total of 101 ESUS patients were included, with an average age of 60.7±14.1 years and 72 males (71.3%). The incidence of non-stenotic plaques in infarct ipsilateral carotid artery was higher than that in contralateral carotid artery (66.3% vs. 55.4%, P=0.028). The incidence of multiple non-stenotic plaques in infarct ipsilateral carotid artery was higher than that in contralateral carotid artery (41.6% vs. 31.7%, P=0.019). The percentage of patients with mixed-echo plaques in infarct ipsilateral carotid artery was higher than that in contralateral carotid artery (39.6% vs. 23.8%, P

提出了一种新型的节点域箱形加强式工字形柱弱轴连接的梁端加强与削弱并用的节点形式,对应用该新型节点形式的工字形柱钢框架和箱形柱采用梁端加强与削弱并用节点的钢框架的整体力学性能、经济性进行对比分析,以及在循环荷载作用下两种节点的力学性能、转动能力、延性等进行对比分析。分析结果表明,对于8度抗震区的6层钢框架,采用节点域箱形加强式工字形柱弱轴连接的钢框架在整体力学性能和经济性方面完全优于箱形柱钢框架;在循环荷载作用下,节点域箱形加强式工字形柱弱轴连接的滞回性能、承载力等均与箱形柱连接相当,塑性转角均大于0.03rad,延性系数都大于4.0,均满足规范要求,能完全实现"强节点弱构件"和"强柱弱梁"的设计理念,并具有强节点域的特点。

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In this study, based on the comprehensive evaluation theory of fuzzy membership function, 5-, 10-, 15-, 20-, and 25-year-old Populus cathayana and Populus cathayana+Picea crassifolia forests at the eastern edge of the Gonghe Basin in Qinghai Province were investigated and four indicators that can reflect the basic characteristics of the community, namely, population renewal potential, forest soil fertility, forest productivity, and species diversity, were selected to build an evaluation model for forest community stability. The results indicated that the regeneration potential of the P. cathayana+P. crassifolia forest was higher than that of the P. cathayana forest. Planting P. crassifolia in a 25-year-old P. cathayana forest increased the content of available phosphorus, available potassium in the 0-40 cm soil, and organic matter in the 0-60 cm soil of the forest. Mixed planting enriched the canopy structure, whereas replanting enhanced the biomass of the tree layer. The competitive advantage of trees was greater than that of shrubs. As the forest age increased, the biomass growth rate of the underground part of the tree layer in the P. cathayana+P. crassifolia forest was greater than that of the aboveground part. As the habitat in the forest improved, the underground competition effect of plants increased and allocation of biomass in the underground part increased. The 25-year-old P. cathayana+P. crassifolia forest had the highest species richness as well as diversity index and dominance of the understory herb layer. The stability of the community in different restoration years was the highest in the 25-year-old P. cathayana+P. crassifolia forest, and the evaluation results were consistent with the development of the local P. cathayana forest. Mature P. crassifolia can provide a stable reproductive strategy for positive succession and sustainable development of the community, enabling it to develop a near-natural forest structure. The first generation protection forest built with P. cathayana clone cuttings at the east edge of the Gonghe Basin and similar habitats suggested that replanting of local tree species can improve community stability,achieve natural community development. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the effects of Huachansu capsule combine with synchronous radiotherapy and chemotherapy on serum pain mediators and helper T cell (Th)1, Th2 related cytokines in patients with locally advanced esophageal squamous cell carcinoma. Methods: A total of 80 patients with locally advanced esophageal squamous cell carcinoma in Shuyang Hospital Affiliated to Xuzhou Medical University were selected from February 2018 to February 2020. According to the random number table,the patients were divided into control group(n=40, synchronous radiotherapy and chemotherapy) and study group(n=40, Huachansu capsule combined with synchronous radiotherapy and chemotherapy). The efficacy, pain status [visual analogue pain scale(VAS), 5-hydroxytryptamine(5-HT), prostaglandin E2 (PGE2), substance P (SP)], Th1, Th2 related cytokines and incidence of adverse reactions between the two groups were compared. The Kaplan-Meier product limit method was used to plot the 2-year survival curves of two groups, and the Log Rank test was used to compare the differences in survival data between the two groups. Results: The total clinical effective rate of the study group was higher than that of the control group (P<0.05). The VAS score, 5-HT, PGE2 and SP in the study group after treatment were lower than those in the control group(P<0.05). Th1 related cytokines: interleukin (IL)-2, interferon-γ (INF-γ) and tumor necrosis factor-α(TNF-α) in the study group after treatment were lower than those in the control group(P<0.05). Th2 related cytokines: IL-4, IL-10, and IL-13 were higher than those in the control group (P<0.05). There were no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). The 2-year overall survival(OS) rate of the study group was 57.50%, significantly higher than 45.00% of the control group. The 2-year progression free survival (PFS) rate of the study group was 42.50%, significantly higher than 35.00% of the control group (all P<0.05). Conclusion: Huachansu capsule combine with synchronous radiotherapy and chemotherapy for locally advanced esophageal squamous cell carcinoma patients, further increase in clinical total effective rate, at the same time, it can also reduce the secretion of serum pain mediators, regulate the levels of Th1 and Th2 related cytokines, improved patient survival rate. [ABSTRACT FROM AUTHOR]

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Objective To investigate the attitudes and influencing factors of transplantation-related populations towards kidney xenotransplantation. Methods From June 2022 to January 2023, stratified random sampling was performed from patients awaiting kidney transplantation, patients after kidney transplantation, patients' relatives and medical students. Four hundred subjects were collected from each population and 1600 subjects were investigated using a self-designed questionnaire. Baseline data of the respondents, their attitudes towards kidney xenotransplantation and the reasons of rejecting kidney xenotransplantation were analyzed. The influencing factors of attitudes towards kidney xenotransplantation were also identified. Results A total of 1 493 valid questionnaires were collected, and the questionnaire retrieval rate was 93.31%. About 93.10% of the respondents accepted allogeneic kidney transplantation, and 66.78% had heard of kidney xenotransplantation. Seven hundred and ninety-five respondents suggested that they could accept kidney xenotransplantation "when kidney xenotransplantation and allogeneic kidney transplantation yielded the same results and risks". Six hundred and ninety-eight respondents indicated that they were "unable" or "uncertain" whether they could accept kidney xenotransplantation (χ² =16.409, P=0.001). Among these 698 respondents, the proportion of them who were willing to accept kidney xenotransplantation when they did not meet the conditions of allogeneic kidney transplantation was 10.9%. About 35.8% of respondents were willing to accept kidney xenotransplantation if it yielded less risk and better prognosis compared with allogeneic kidney transplantation. If the time of awaiting kidney xenotransplantation was shorter than that of allogeneic kidney transplantation, 21.2% were willing to accept kidney xenotransplantation. If the cost of kidney xenotransplantation was less than that of allogeneic kidney transplantation, 24.5% of them were willing to accept kidney xenotransplantation. The main reasons of rejecting kidney xenotransplantation included surgical risk and other unknown risks. Multivariate analysis showed that respondents residing in cities and towns for a long period of time, those who accept allogeneic kidney transplantation and those who have heard of kidney xenotransplantation showed more positive attitudes towards kidney xenotransplantation. Conclusions Different transplantation-related populations have different attitudes towards kidney xenotransplantation, and the overall attitudes are positive. Active promotion of kidney xenotransplantation research and carrying out relevant popular science education contribute to improving public attitudes towards the acceptance of kidney xenotransplantation. [ABSTRACT FROM AUTHOR]

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Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear estrogen receptor family, and they are involved in a variety of physiological and pathological processes in the human body and play important roles in cellular metabolism, inflammation, and cancer. At present, there are three known subtypes of PPAR, i.e., α, β/δ, and γ. Studies have shown that PPARs are highly expressed in the liver and are widely involved in various physiological and pathological activities such as liver energy metabolism, oxidative stress, and inflammation, and they are also closely associated with the progression of liver diseases. This article reviews the role of PPAR in common liver diseases such as viral hepatitis, metabolic associated fatty liver disease, cholestatic liver disease, liver fibrosis, and primary liver cancer, and the current status of their application in the treatment of liver diseases. [ABSTRACT FROM AUTHOR]

[Objective] The interaction between fine root distribution and soil environment of middle-aged Picea crassifolia forests was revealed, and the contribution factors of soil nutrients to fine root development under different mingling intensity were clarified in order to provide theoretical basis for the rehabilitation and management of natural forests in Qilian Mountains. Methods] The root samples were collected in F. crassi - folia middle-aged forests with different mingling intensities (0, 0.2, ().4, and ().6) by using soil coring method. The relations between root parameters (fine root biomass density, specific root length, specific root surface area, root surface area density and root length density) and soil properties (soil total nitrogen, total phosphorus, alkali-hydrolyzable nitrogen, available phosphorous, available potassium and organic matter) were analyzed. [Results] The fine root biomass was concentrated in the upper 0一20 cm soil layer, and decreased with soil depth. Values of fine root biomass density, root length density, root surface area density, specific root length, and specific root surface area in the soil layer of ()--20 cm were significantly higher than those in 20一4() cm soil layer(p〈().()5). The fine root morphology indices of each soil layer of F. crassifolia forest were all peaked in the mingling of ().4. Total nitrogen, total phosphorus, available potassium and organic matter in each soil layer decreased with the increase of soil depth, while they peaked at the mingling of ().4. Tn the soil layer of 0一4() cm, there were the positive correlations between indices of fine root biomass fine root biomass density, root length density, root surface area density, specific root length, and specific root surface area and soil properties such as total nitrogen, total phosphorus, a 1 ka 1 i-hydro 1 yzab 1 e nitrogen, avaitable phosphorous, organic matter, available potassium. Conclusion] The change of fine root biomass density is mainly affected by the total nitrogen content, mixed F. crassifolia forest with mingling intensity of ().4 has remarkable fine root contribution and better soil fertility, which is more conducive to the development of community stability benefits. [ABSTRACT FROM AUTHOR]

The community of Picea crassifolia planted in the Populus cathayana forest in Huangshatou, Guinan County at the eastern edge of the Gonghe Basin in Qinghai Province in 2019 was taken as the research object, and the non-replanted vegetation community was compared. The structure, community composition, species diversity, and environmental factors in the forest were compared and analyzed. This was undertaken 5, 10, 15, 20, and 25 years after afforestation in the dune land of the sandy land to analyze the short-term benefit for forest structure and species diversity from replanted in shelter forest in an alpine desert area. This study has also provided a theoretical basis for stability and sustainable development of the local shelter forest. The results have shown that the replanted forest biomass was significantly higher than the non-replanted forest, and that the 25-year-old Populus cathayana-Picea crassifolia mixed forest was the largest biomass. The Shannon-Wiener index for the shrub layer was the highest in the 20-year-old Populus cathayana-Picea crassifolia mixed forest (0.56), and the Simpson index was the highest in 15-year-old Populus cathayana- Picea crassifolia mixed forest (0.73). The Shannon-Wiener and Simpson index for the herb layer were the highest in the 25-year-old Populus cathayana-Picea crassifolia mixed forest (0.93, 0.53). After replanted, the humidity and soil moisture (10, 30 cm) in the forest were higher than those of the non-replanted forest (P>0.05). There were positive correlations between indices for species richness, Shannon-Wiener index, evenness index, Simpson index and average tree height, average diameter at breast height, canopy density, surface (10 cm), and deep (150, 200 cm) soil moisture content (P<0.05). In the future, Qinghai spruce can be replanted in the 25-year-old Populus cathayana forest during management of the protective forest with Populus cathayana as a pioneer tree. The sexual reproduction ability of native tree species can provide a stable reproductive strategy for positive succession of the vegetation community, which is conducive to sustainable and healthy development of the shelter forest. [ABSTRACT FROM AUTHOR]

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Carbon monoxide (CO) is the main component of vehicle exhaust in highway tunnels, which is one of the important parameters for the design of ventilation in road tunnels. It is very necessary to predict the CO concentration accurately and quickly to provide a reference for tunnel ventilation system control and mitigating the concentration of CO timely and to ensure the health and safety of the people in the tunnel. At the same time, it is beneficial to the green and energy-saving operation of the tunnel. Based on the field monitoring data of the road tunnel, random forest (RF) model of CO concentration prediction was established with the four influencing factors, i. e., monitor position, traffic, vehicle speed, wind speed. The model was employed to predict the concentration of CO in a 3 300-long road tunnel and the predictive values were compared with the real values. The results show that the CO concentration prediction model based on Random Forest has good prediction accuracy, which can predict the concentration of CO accurately. The RMSE and R 2 of the testing dataset is 0. 497 4 and 0. 943 7, respectively, which is significantly better than those of the linear regression model and support vector machine (SVM) model. The prediction model can be extended to predict the CO concentration of another tunnel. The RMSE and R 2 of the validation dataset is 0. 909 5 and 0. 729 5, respectively. That is, the CO concentration in the tunnel can be predicted under the condition of known monitor position, traffic, vehicle speed, wind speed. The model provides a reference for tunnel ventilation system control or safety warning. The position of monitor point has the greatest influence on the CO concentration in the tunnel, and the CO gas concentration is the highest at the exit of the tunnel. With the increase of wind speed, the concentration of CO gas in the tunnel gradually decreases. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the impact of METTL3 on EMT and invasion ability in colorectal cancer cells. Methods: TGFβ was used to induce EMT in HCT116 and SW480 cells. Wound scratch assay and Transwell-matrigeal assay were used to evaluate the invasion ability of CRC cells. qPCR was used to measure the expression of target genes. SiRNAs were used to knockdown METTL3 in CRC cells. Results: The healing area in the TGFβ treated cells was larger than control cells P<0.0001, while TGFβ plus METTL3 knockdown groups cells showed smaller healing area than TGFβ treated cells P<0.0001 . Transwell-Matrigeal showed the penetrated cells in the TGFβ treated cells was more than control cells P<0.0001, while TGFβ plus METTL3 knockdown groups cells showed less penetrated cells than TGFβ treated cells P<0.0001 . TGFβ treatment induced EMT, while expression of snail1, ZEB1, VIM and MET- TL3 was up-regulated and CHD1 was down-regulated. TGFβ plus METTL3 knockdown groups cells showed less expression of snail1 and ZEB1 than TGFβ treated cells. Conclusions: METTL3 plays key role in the TGFβ induced EMT. Knockdown of METTL3 can impair TGFβs effect, which provides novel target for blocking metastasis in CRC. [ABSTRACT FROM AUTHOR]

Objective·To explore the potential key genes and the gene expression characteristics of microsatellite instability-high (MSI-H) colorectal cancer (CRC) with metastasis at the transcriptome level, and establish a metastasis prediction gene model. Methods·The transcriptome data of MSI-H CRC patients was obtained from The Cancer Genome Atlas database. The patients were divided into metastatic group (21 patients) and non-metastatic group (42 patients). The differentially expressed genes (DEGs) between the two groups were analyzed by Gene Ontology (GO) and Gene Set Enrichment Analysis (GSEA) to annotate, and cluster DEGs and enrich the signaling pathways. STRING and Cytoscape were used to select the hub genes. Nomogram was drawn based on the selected DEGs. The cross validation of the model was performed by Bootstrap method. Survival analysis was done to explore the influences of each gene in the nomogram on progression-free survival (PFS) of MSI-H CRC. Results·A total of 245 DEGs were obtained from the metastatic group and non-metastatic group, among which 204 genes were up-regulated and 41 genes were down-regulated. GO analysis showed that DEGs were mainly clustered in ion transmembrane transport, chloride transmembrane transport and chloride channel activity in terms of biological process and molecular function. In terms of cellular component, DEGs were mainly clustered in extracellular region and extracellular space. GSEA showed that the neuroactive ligand-receptor interaction and metabolic pathways were enriched in the up-regulated genes. The top 10 hub genes in the protein-protein interaction network of the up-regulated genes were screened by Cytoscape. The metastasis prediction gene model, which was set up based on the top 10 DEGs with the lowest adjusted P value and high physiological relevance to tumor, had certain predictive efficiency [area under curve (AUC)=0.975 for training, AUC=0.920 for validation]. The expression levels of AC078993.1 and IGLJ2 (immunoglobulin lambda joining 2) were significantly negatively correlated with PFS of MSI-H CRC (P=0.011, P=0.005). Conclusion·The changes in ion channels and extracellular environment may have important impacts on metastasis of MSI-H CRC. Neuroactive ligand-receptor interaction and metabolic pathways may be two important signaling pathways for metastasis of MSI-H CRC. A metastasis prediction gene model is established, which can provide reference for the follow-up related clinical researches. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Science Research & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Management & Technology Discussion is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Management & Technology Discussion is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)