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Copyright of Fudan University Journal of Medical Sciences is the property of Fudan University Journal of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the clinical characteristics of severe coronary stenosis (SCS) and the relationship between serum uric acid level and the risk of SCS in non-gout patients with type 2 diabetes mellitus (T2DM) and hypertension. To explore the appropriate intervention point for asymptomatic hyperuricemia (HUA) patients with multiple cardiovascular high-risk factors. Methods From Jan 2015 to Dec 2020, 1 417 non-gout patients with T2DM and hypertension who were hospitalized in Zhongshan Hospital, Fudan University and completed coronary computed tomography angiography (CTA) wereretrospectively enrolled. The characteristics of SCS patients and the relationship between serum uric acid level and the prevalence of SCS were analyzed. Results Patients with SCS had higher male proportions, smoking prevalence, systolic blood pressure, and older age. Serum uric acid, glycosylated hemoglobin, triglycerides, low-density cholesterol, erythrocyte sedimentation rate, C-reactive protein, homocysteine acid, and peripheral white blood cell count were all higher. However, there were no significant differences in BMI, fasting blood glucose, and diastolic blood pressure compared with patients without SCS. After adjusting for factors such as age, gender, BMI, systolic blood pressure, glycosylated hemoglobin, triglyceride, low-density cholesterol, and smoking history, the prevalence of SCS was significantly increased when serum uric acid≥430 μmol/L (OR=1.586, P=0.039). The level of serum uric acid was positively correlated with traditional cardiovascular risk factors such as BMI, triacylglycerol and homocysteine. Conclusion Elevated serum uric acid level is associated with increased risk of SCS in non-gout patients with T2DM and hypertension. The control of serum uric acid level in asymptomatic HUA patients need to be stratified according to risk factors, and patients with multiple high-risk factors may require intervention earlier than the current Chinese guidelines recommend (480 μmol/L). More prospective studies are needed to establish the benefits of uric acid-lowering interventions. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical efficacy and safety of Bixie Fenqing Pills combined with allopurinol in the treatment of hyperuricemia in patients with gout. Methods Seventy-two patients with gout were randomly divided into experimental group(n=36)and control group(n=36)for a total course of 12 weeks. The initialdose of allopurinol in both groups was 100 mg/day in the first week，and was adjusted to 200 mg/day from the second week. The experimental group and the control group took Bixie Fenqing Pills and placebo，simultaneously and respectively(9 g/time，twice a day). Results After 12 weeks of treatment，serum uric acid levels were <6.0 mg/dL in 3 and 10 patients in the control and experimental group，respectively.The standard-reaching rate of the experimental group was higher than that of the control group.There were no significant difference in adverse events，major adverse events，serious adverse events， and adverse reactions between the two groups. Conclusion Bixie Fenqing Pills improved the standardreaching rate of allopurinol in uric acid lowering therapy and showed good safety. [ABSTRACT FROM AUTHOR]

Copyright of Fudan University Journal of Medical Sciences is the property of Fudan University Journal of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)