37 results on '"Örgül, Gökçen"'
Search Results
2. The Role of Afamin and Other Trace Elements in the Prediction of GDM: a Tertiary Center Experience
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Eroğlu, Hasan, Örgül, Gökçen, Tonyalı, Nazan Vanlı, Biriken, Derya, Polat, Naci, Yücel, Aykan, Yazihan, Nuray, and Şahin, Dilek
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- 2021
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3. Economic analysis of prenatal screening strategies for Down syndrome in singleton pregnancies in Turkey
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Ökem, Zeynep Güldem, Örgül, Gökçen, Kasnakoglu, Berna Tari, Çakar, Mehmet, and Beksaç, M.Sinan
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- 2017
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4. Does Second Trimester Maternal Serum Zonulin Level Predict Gestational Diabetes Mellitus?
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Tonyalı, Nazan Vanlı, Arslan, Burak, Sucu, Serap Topkara, Sarsmaz, Kemal, İbanoğlu, Müjde Can, Örgül, Gökçen, Aktemur, Gizem, Yücel, Aykan, and Şahin, Dilek
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GESTATIONAL diabetes ,INTESTINAL barrier function ,ENZYME-linked immunosorbent assay ,INSULIN therapy ,GESTATIONAL age - Abstract
Zonulin, a protein that regulates intestinal permeability, has attracted attention as a potential biomarker for GDM. Therefore, this study aims to investigate whether there are differences in zonulin levels between the GDM group and control groups, especially between those receiving different treatments (diet and insulin). Based on this idea, we included 90 patients with a gestational age between 24 and 28 weeks in our study. While GDM was not detected in 33 of these patients, as a result of OGTT, 57 patients were diagnosed with GDM and these patients were followed throughout their pregnancy. Gestational diabetes was diagnosed by an OGTT performed between 24 and 28 weeks of gestation according to American Diabetes Association (ADA) standards. During follow-up, GDM patients were divided into two groups according to whether they required insulin treatment. Plasma zonulin levels were determined using enzyme-linked immunosorbent assay (ELISA) techniques. The GDM group had significantly higher plasma zonulin levels than the control group (p < 0.005). According to our research, zonulin may be a non-invasive biomarker involved in the etiology of GDM. Large-scale research on this topic is still needed. [ABSTRACT FROM AUTHOR]
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- 2024
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5. CORRELATION BETWEEN VARIOUS ANTHROPOMETRIC AND MUSCULOSKELETAL MEASUREMENTS AND HEMORRHOIDS IN PREGNANCY.
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ÇİNAR, Gamze Nalan, AKBAYRAK, Türkan, GÜLÖREN, Gülbala, ÖZGÜL, Serap, ÜZELPASACI, Esra, BARAN, Emine, GÜRŞEN, Ceren, Beksaç, Kemal, Aydın, Emine, ÖRGÜL, Gökçen, and BEKSAÇ, Mehmet Sinan
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- 2024
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6. Second Trimester Fetal Nasal Bone Length Measurement: A Single Center Study and National Data Review.
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BOZBAY, Nizamettin, AVCI, Fazıl, and ÖRGÜL, Gökçen
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NASAL bone ,SECOND trimester of pregnancy ,PERINATOLOGY ,ULTRASONIC imaging - Abstract
Objective: To evaluate second trimester fetal nasal length measurement results in healthy singleton pregnancies in Turkey. Material and Methods: We analyzed the nasal bone lengths within 19-24 weeks in 661 pregnancies in our hospital. All pregnant women with a single healthy fetus who applied to our perinatology outpatient clinic for detailed obstetric ultrasonography were included in the study. All measurements were performed by the same clinician during routine mid-trimester ultrasound scan. Only the patients who were considered healthy by the examining pediatrician were included in the study. The parents of all fetuses are of Turkish ethnicity. Pearson correlation, regression analysis and P value were calculated between gestational week and nasal bone length. Results: Mean nasal length measurement was 6,21 ± 0,08; 6,66 ± 0,05; 6,88 ±0,05; 7,13 ± 0,08; 7,77 ± 0,11 and 8,33 ± 0,25 mm from 19 to 24 week of pregnancy, respectively. A significant positive correlation was observed between gestational week and nasal bone length. Normal values of nasal bone length measuremens are identified for each gestational weeks acoording to our data and previous 5 studies. Conclusion: In this study, we presented the data of our own center and the results obtained from other studies conducted in our country show significant differences. We are of the opinion that studies conducted by different researchers in different regions remain insufficient to reflect the nomogram of Turkish ethnic origin. For this purpose, multicenter studies are needed to cover the whole society. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Significance of inhibitory maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotype combinations in placenta related obstetric complications
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Dönmez, Hanife Güler, Alnıaçık, Ridvan Goksel, Dalva-Aydemir, Sevim, Çakar, Ayşe Nur, Beksaç, Meral, Örgül, Gökçen, Dalva, Klara, Dönmez, Hanife Güler, Alnıaçık, Ridvan Goksel, Dalva-Aydemir, Sevim, Çakar, Ayşe Nur, Beksaç, Meral, Örgül, Gökçen, and Dalva, Klara
- Abstract
Some maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, such as recurrent miscarriage, fetal growth restriction, preeclampsia, and preterm birth. However, how KIR/KIR ligand genotypes affect these placenta-related obstetric complications has not been fully understood. We aimed to demonstrate the association of maternal KIR-fetal KIR ligand genotype combinations with immunological/metabolic risk factor associated placenta-related obstetric complications. This study consisted of three groups of pregnant women: 1) Miscarriage group (n = 30), 2) Complicated Pregnancy (CP) group (n = 30), and 3) Control group (n = 30). The observed maternal genotype frequencies of all inhibitory and activating KIRs were similar in all groups (p > 0.05). However, inhibitory 2DL3 was quite frequent in the miscarriage group (p = 0.052). There was no difference between groups in terms of centromeric and telomeric maternal haplotypes (p > 0.05). The fetal group 1 HLA-C genotype was frequently detected in the miscarriage and CP groups with rates of 83.3 % and 93.3 % respectively, while the observed frequency was 70 % in the control group. The fetal group 2 HLA-C genotype was the same in all groups. The results demonstrated significantly less fetal group 2 HLA-C homozygosity in the CP groups when compared to the control group (p = 0.020). The fetal HLA-Bw4 genotype was detected more frequently in the miscarriage and CP groups (p = 0.028 and p = 0.001, respectively). The inhibitory KIR/KIR ligand genotype combinations of 2DL3-C1 and 3DL1-Bw4 were more frequent in the miscarriage and CP groups (p = 0.045 and p = 0.002, respectively). Enhanced NK cell inhibition may be one of the mechanisms underlying placenta-related obstetric complications., Hacettepe University Scientific Research Projects Coordination UnitHacettepe University [THD-2017-14660], This study was funded by Hacettepe University Scientific Research Projects Coordination Unit, Project number: THD-2017-14660.
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- 2022
8. Maternal Serum and Umbilical Cord Brain Natriuretic Peptide Levels in Fetuses with Intrauterine Growth Restriction.
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Eroğlu, Hasan, Erdöl, Mehmet Akif, Tonyalı, Nazan Vanlı, Örgül, Gökçen, Biriken, Derya, Yücel, Aykan, Yazihan, Nuray, and Şahin, Dilek
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FETAL growth retardation ,FETAL development ,UMBILICAL cord ,CORD blood ,PREGNANT women ,BRAIN natriuretic factor ,PLACENTAL growth factor - Abstract
Aim: We compared maternal serum and fetal cord blood proBNP levels in healthy pregnancies to those with intrauterine growth restriction (IUGR). Methods: Prospectively, maternal and cord blood samples at childbirth of 40 pregnant women with isolated IUGR and 40 healthy pregnant women were evaluated for ProBNP levels. Results: The mean serum ProBNP level was significantly higher in newborn cord blood with IUGR than in the control group (181.28 ± 145.37 vs. 91.41 ± 49.77 pg/mL, p = <0.01). Mean serum ProBNP level trended higher in women with IUGR compared to the controls, but was not statistically significant (124.21 ± 113.32 vs. 88.73 ± 85.18 pg/mL, p= >0.05). Conclusion: Third trimester mean proBNP in fetal cord blood are increased in IUGR fetuses at term birth compared to pregnancies with normal fetal growth. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Maternal Serum and Umbilical Cord Brain Natriuretic Peptide Levels in Fetuses with Intrauterine Growth Restriction
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Eroğlu, Hasan, primary, Erdöl, Mehmet Akif, additional, Tonyalı, Nazan Vanlı, additional, Örgül, Gökçen, additional, Biriken, Derya, additional, Yücel, Aykan, additional, Yazihan, Nuray, additional, and Şahin, Dilek, additional
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- 2021
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10. Budget impact of incorporating non-invasive prenatal testing in prenatal screening for Down syndrome in Turkey
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Ökem, Zeynep Güldem, Örgül, Gökçen, Çakar, Mehmet, Beksaç, Mehmet Sinan, Tarı Kasnakoğlu, Berna, Ökem, Zeynep Güldem, Örgül, Gökçen, Çakar, Mehmet, Beksaç, Mehmet Sinan, and Tarı Kasnakoğlu, Berna
- Abstract
Objectives: To provide information to the government about the budget impact of implementing non-invasive prenatal testing (NIPT) into prenatal screening strategies to detect Down syndrome (DS) in singleton pregnancies in Turkey; the likely costs or savings associated with NIPT in comparison to the current practice were calculated. Methods: A decision-analytic model was developed to calculate the cost estimates for 1,309,771 women who gave birth in 2016; 84.8% of whom were 35-years-of-age. The superior combined test (CT) among current strategies is compared with contingent NIPT for women 35-years-of-age; and usual practice of amniocentesis (AC) for women ? 35 years-of-age was replaced with universal NIPT. Results: When the market price of NIPT (1,077 PPPUS$) is used, contingent NIPT offered to high-risk women 35-years-of-age adds 34,907,225 PPPUS$; and for women-35 ? years-of-age the universal NIPT leads to 142,785,818 PPPUS$ more cost to the government compared to current strategies. The additional costs with NIPT are partially compensated by the cost-savings due to reduction of the number of invasive tests and procedure related losses (17,826,476 PPPUS$ for women 35-years-of-age and 37,070 PPPUS$ for women ? 35-years-of-age). Results are sensitive to the NIPT costs; with a lower cost of NIPT, a total saving would be 33,116,046 PPPUS$ with new strategies. Conclusions: NIPT might be the choice of prenatal screening strategies if its price is lowered to economically acceptable levels. Until that time, currently accepted protocols seem to be more realistic. On the other hand, decision makers should also consider possible savings and the women's quality of life that can be improved with the new technology.
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- 2020
11. Concerns of Pregnant Women in Prenatal Screening/Diagnosis Practice and Termination of Pregnancy
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Fadıloğlu, Erdem, Tanacan, Atakan, Çakar, Mehmet, Ökem, Zeynep Güldem, Tarı Kasnakoğlu, Berna, Beksaç, Mehmet Sinan, Örgül, Gökçen, Fadıloğlu, Erdem, Tanacan, Atakan, Çakar, Mehmet, Ökem, Zeynep Güldem, Tarı Kasnakoğlu, Berna, Beksaç, Mehmet Sinan, and Örgül, Gökçen
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Objective To investigate the reasons for decision-making and concerns of patients in the field of prenatal screening, invasive prenatal diagnostic testing (IPDT), and termination of pregnancy (TOP). Study Design This questionnaire-based study consisted of 107 pregnant women who were referred for prenatal screening to the Hacettepe University Hospital. The questionnaire given to patients was prepared from scratch since there is no standard set of questions measuring patients' feelings and concerns regarding prenatal screening/diagnosis, IPDT, and TOP. Results Our questionnaire results showed that it is possible to classify decision-making factors into 6 groups: psychological, social, fear, religious/faith, support, and trust. The majority of patients were undecided (48.6%) about IPDT if prenatal screening test results were risky. Only 23.4% of patients were willing to accept IPDT. On the other hand, 55.1% of patients were not willing to undergo TOP if the fetal karyotyping results were abnormal. Religious factors seem to be important in refusing IPDT and TOP. Conclusion Physicians should re-evaluate their practice in the field of prenatal screening and diagnosis in light of the high refusal rates of IPDT and TOP. Understanding factors influencing women's decision-making processes provides insight for service providers to help women at high risk of having foetal anomalies to make better-informed choices.
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- 2020
12. Budget impact of incorporating non-invasive prenatal testing in prenatal screening for Down syndrome in Turkey
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Tarı Kasnakoğlu, Berna, Beksaç, Mehmet Sinan, Çakar, Mehmet, Ökem, Zeynep Güldem, Örgül, Gökçen, Tarı Kasnakoğlu, Berna, Beksaç, Mehmet Sinan, Çakar, Mehmet, Ökem, Zeynep Güldem, and Örgül, Gökçen
- Abstract
Objectives: To provide information to the government about the budget impact of implementing non-invasive prenatal testing (NIPT) into prenatal screening strategies to detect Down syndrome (DS) in singleton pregnancies in Turkey; the likely costs or savings associated with NIPT in comparison to the current practice were calculated. Methods: A decision-analytic model was developed to calculate the cost estimates for 1,309,771 women who gave birth in 2016; 84.8% of whom were 35-years-of-age. The superior combined test (CT) among current strategies is compared with contingent NIPT for women 35-years-of-age; and usual practice of amniocentesis (AC) for women ? 35 years-of-age was replaced with universal NIPT. Results: When the market price of NIPT (1,077 PPPUS$) is used, contingent NIPT offered to high-risk women 35-years-of-age adds 34,907,225 PPPUS$; and for women-35 ? years-of-age the universal NIPT leads to 142,785,818 PPPUS$ more cost to the government compared to current strategies. The additional costs with NIPT are partially compensated by the cost-savings due to reduction of the number of invasive tests and procedure related losses (17,826,476 PPPUS$ for women 35-years-of-age and 37,070 PPPUS$ for women ? 35-years-of-age). Results are sensitive to the NIPT costs; with a lower cost of NIPT, a total saving would be 33,116,046 PPPUS$ with new strategies. Conclusions: NIPT might be the choice of prenatal screening strategies if its price is lowered to economically acceptable levels. Until that time, currently accepted protocols seem to be more realistic. On the other hand, decision makers should also consider possible savings and the women's quality of life that can be improved with the new technology.
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- 2020
13. Tetanus vaccine during pregnancy: data of a tertiary hospital in Turkey
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DAĞDEVİREN, Gülşah, primary, ÖRGÜL, Gökçen, additional, YÜCEL, Aykan, additional, and ŞAHİN, Dilek, additional
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- 2020
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14. Perinatal outcomes of twenty-five human immunodeficiency virus-infected pregnant women: Hacettepe University experience
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İnkaya, Ahmet Çağkan, primary, Örgül, Gökçen, additional, Halis, Nurhayat, additional, Alp, Şehnaz, additional, Kara, Ateş, additional, Özyüncü, Özgür, additional, Yurdakok, Murat, additional, Ünal, Serhat, additional, and Beksaç, M. Sinan, additional
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- 2020
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15. Cord blood delta neutrophil index values of term neonates
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Büyükeren, Melek, primary, Çelik, Hasan Tolga, additional, Portakal, Oytun, additional, Fadıloğlu, Erdem, additional, Örgül, Gökçen, additional, Yiğit, Şule, additional, Beksaç, M. Sinan, additional, and Yurdakök, Murat, additional
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- 2020
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16. Neonatal outcomes of early- and late-onset preeclampsia
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Büyükeren, Melek, primary, Çelik, Hasan Tolga, additional, Örgül, Gökçen, additional, Yiğit, Şule, additional, Beksaç, M. Sinan, additional, and Yurdakök, Murat, additional
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- 2020
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17. Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus
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Dolgun, Anıl, Çakar, Ayşe Nur, Beksaç, Mehmet Sinan, Tanacan, Atakan, Örgül, Gökçen, Gürbüz, Rumeysa Hekimoğlu, Atilla, Pergin, Dolgun, Anıl, Çakar, Ayşe Nur, Beksaç, Mehmet Sinan, Tanacan, Atakan, Örgül, Gökçen, Gürbüz, Rumeysa Hekimoğlu, and Atilla, Pergin
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Objective: To evaluate the impact of type-1 diabetes mellitus (DM) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms on impaired placentation leading to early pregnancy loss. Methods: Miscarriage materials were obtained from eight pregnant women with type-1 DM without MTHFR polymorphism, eight with MTHFR polymorphisms without type-1 DM, and eight controls with neither DM nor MTHFR polymorphisms. Insulin-like growth factor-1 (IGF-1), leukemia inhibitory factor (LIF), and Beclin-1 expression were assessed to evaluate placentation. Results: Cytoplasmic LIF, IGF-1, and Beclin-1 expression were decreased in the superficial and glandular epithelial cells of the decidua in both study groups. LIF expression was increased in interstitial trophoblasts in the MTHFR group. IGF-1 expression was decreased in the decidual cells and interstitial trophoblasts in both study groups, while the decrease in stromal cells was noted only in type-1 DM group. Beclin-1 expression was increased in interstitial and villous trophoblasts in both study groups. Conclusion: The expression of IGF-1, LIF, and Beclin-1 are altered in both the decidua and the trophoblasts in pregnancies of women with type-1 DM and MTHFR polymorphisms, compared to normal pregnancies undergoing (elective) terminations., This study was supported by the Hacettepe University Research fund (Project no: 011D071010122012).
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- 2019
18. Economic analysis of prenatal screening strategies for Down syndrome in singleton pregnancies in Turkey
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Ökem, Zeynep Güldem, Tarı Kasnakoğlu, Berna, Örgül, Gökçen, Cakar, Mehmet, Beksaç, Mehmet Sinan, Ökem, Zeynep Güldem, Tarı Kasnakoğlu, Berna, Örgül, Gökçen, Cakar, Mehmet, and Beksaç, Mehmet Sinan
- Abstract
Objectives: To examine the costs and outcomes of different screening strategies for Down Syndrome (DS) in singleton pregnancies. Study design: A decision-analytic model was developed to compare the costs and the outcomes of different prenatal screening strategies. Five strategies were compared for women under 35-year of age: 1A) triple test (TT), 2A); combined test (CT), 3A) Non-invasive Prenatal Screening Test by using cell free fetal DNA (NIPT), 4A) and 5A) NIPT as a second-step screening for high-risk patients detected by either TT, or CT respectively. For women >= 35-year of age, 1B) implementing invasive test (amniocentesis-AC) and 2B) NIPT for all women were compared. Data was analyzed to obtain the outcomes, total costs, the cost per women and the incremental cost-effectiveness ratios (ICERs) for screening strategies. Results: Among the current strategies for women under 35 years old, CT is clearly dominated to TT, as it is more effective and less costly. Although, the current routine practice (2A) is the least-costly strategy, implementing NIPT as a second step screening to high-risk women identified by CT (5A) would be more effective than 2A; leading to a 10.2% increase in the number of detected DS cases and a 96.3% reduction in procedural related losses (PRL). However, its cost to the Social Security Institution that is a public entity would be 17 times higher and increase screening costs by 1.5 times. Strategy 5A would result in an incremental cost effectiveness of 6,873,082 (PPP) US$ when compared to the current one (2A). Strategy 1B-for offering AC to all women >= 35-year of age is dominated over NIPT (2B), as it would detect more DS cases and would be less costly. On the other hand, there would be 206 PRL associated with AC, but NIPT provides clear clinical benefits as there would be no PRL with NIPT. Conclusions: NIPT leads to very high costs despite its high effectiveness in terms of detecting DS cases and avoiding PRL. The cost of NIPT should be dec
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- 2019
19. Gestational outcomes of pregnant women who have had invasive prenatal testing for the prenatal diagnosis of spinal muscular atrophy
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Örgül, Gökçen, Çelik, Tolga Hasan, Bora, Gamze, Çakar, Ayşe Nur, Tanaçan, Atakan, Yurter, Hayat Erdem, Soyak, Burcu, Haklı, Duygu Aydın, Örgül, Gökçen, Çelik, Tolga Hasan, Bora, Gamze, Çakar, Ayşe Nur, Tanaçan, Atakan, Yurter, Hayat Erdem, Soyak, Burcu, and Haklı, Duygu Aydın
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Spinal muscular atrophy (SMA) is a neurodegenerative disease which is characterised by progressive degeneration of motor neurons in the anterior horns of the spinal cord. It is a mainly chromosome 5-linked genetic disorder, with recessive inheritance and it can be diagnosed prenatally. Objective. To communicate the importance of prenatal diagnosis of spinal muscular atrophy (SMA) and to demonstrate the gestational outcomes of disease carrier pregnant women who have had invasive prenatal testing (IPT). Methods. We retrospectively evaluated 113 pregnancies of 76 patients who were referred to the Division of Perinatal Medicine at Haçettepe University in Ankara, Turkey for the prenatal diagnosis of SMA between 2000 and 2015. We evaluated the screening results and gestational outcomes of the patients. The pregnancy outcomes were compared with a control group of 179 patients. The Beksac Obstetrics Index (BOI) was used for the comparison of obstetrical histories/backgrounds of the study and control groups. Results. Chorionic villus sampling (CVS) and amniocentesis (AC) were performed in 83 (73.5%) and 30 (26.5%) cases, respectively. In 24 cases (21.2%), the fetuses were found to be disease-positive and 23 of them were terminated. The median gestational day at birth (p0.001), median birthweights (p=0.002) and median BOI (p=0.001) of the study and control groups were compared and the differences were statistically significant. Conclusion. Prenatal diagnosis of SMA is very important and a nationwide special antenatal care programme must be established for better diagnosis and eradication of this genetic disorder.
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- 2019
20. Factors influencing the success of cord blood collection: A tertiary perinatal medicine center’s experience
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Örgül, Gökçen, Beksaç, Mehmet Sinan, Tanaçan, Atakan, Yurdakul, Pınar, Aktoz, Fatih, Örgül, Gökçen, Beksaç, Mehmet Sinan, Tanaçan, Atakan, Yurdakul, Pınar, and Aktoz, Fatih
- Abstract
This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord blood unit groups (P 0.001 for all). No cord blood units were discarded owing to contamination-related issues. The mean gestational age for pregnant women whose umbilical cord blood was stored was 36.6 ± 1.0 weeks. Conclusion: Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were significantly different between the eligible and discarded cord blood unit groups. The low rate of specimen storage was most likely because of the unique characteristics of perinatal medicine patients. Physicians should choose appropriate donors for cord blood collection to increase the rate of cord blood utilization.
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- 2019
21. Factors influencing the success of cord blood collection: A tertiary perinatal medicine center’s experience
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Yurdakul, Pınar, Tanaçan, Atakan, Aktoz, Fatih, Örgül, Gökçen, Beksaç, Mehmet Sinan, Yurdakul, Pınar, Tanaçan, Atakan, Aktoz, Fatih, Örgül, Gökçen, and Beksaç, Mehmet Sinan
- Abstract
This study aimed to evaluate the effects of certain maternal, fetal, and umbilical cord blood unit factors on storage and/or discard incidence of collected cord blood units from perinatal medicine patients. Materials and methods: A total of 273 cord blood units collected between January 2011 and December 2016 in the Division of Perinatology of Hacettepe University Hospital were evaluated retrospectively in this study. Results: Of the collected cord blood units, 53.8% (147/273) were stored. Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were statistically significantly different between the eligible and discarded cord blood unit groups (P 0.001 for all). No cord blood units were discarded owing to contamination-related issues. The mean gestational age for pregnant women whose umbilical cord blood was stored was 36.6 ± 1.0 weeks. Conclusion: Infant birth weight, cord blood unit volume, total nucleated cell count, and CD34+ cell count were significantly different between the eligible and discarded cord blood unit groups. The low rate of specimen storage was most likely because of the unique characteristics of perinatal medicine patients. Physicians should choose appropriate donors for cord blood collection to increase the rate of cord blood utilization.
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- 2019
22. Retrospektive evaluation of pre- and postnatally diagnosed gastrointestinal tract obstructions
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Örgül, Gökçen, Beksaç, Mehmet Sinan, and Kadın Hastalıkları ve Doğum Anabilim Dalı
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Retrospective studies ,Intestinal obstruction ,Pregnancy ,Diagnosis ,Prenatal diagnosis ,Obstetrics and Gynecology ,Kadın Hastalıkları ve Doğum ,Gastrointestinal diseases ,Congenital abnormalities ,Ultrasonography - Abstract
Prenatal ultrasonografi sırasında özofagus, ileum, jejunum, kolon, rektum ve anüs gibi gastrointestinal sistem (GİS) organlarının konjenital tıkanıklıklarına ait bir takım işaretler saptanabilmektedir. Obstrüksiyonun lokalizasyonu, lezyonun derecesi (kısmi veya tam), eşlik eden malformasyonların varlığı ve tarama esnasındaki gebelik haftası gibi çeşitli faktörler prenatal tanıyı etkilemektedir. Bizde merkezimizdeki doğum öncesi ve sonrası dönemde tanı koyulan GİS obstrüksiyonlarını değerlendirmeyi amaçladık. Çalışmamız 34 prenatal ve 22 postnatal GİS malformasyon tanısı alan bebeği kapsamaktadır. GİS obstrüksiyonları tıkanıklık seviyesine göre 5 gruba ayrıldı (A. Özofagus, B. Mide ve proksimal duodenum, C. İnce bağırsak, D. Kalın bağırsak, E. Çoklu obstruksiyonlar). Tüm olgular birlikte ele alındığında doğum öncesi teşhis oranı % 60,7 olarak bulundu. Eşlik eden yapısal anomali ve anöploidi oranları sırasıyla %21,4 ve %5,4 idi. Doğumdan sonraki ilk günde, 12 yenidoğan çeşitli sebeplerden ötürü ölmüştür. Kalan 44 hastanın 43'ü kendi klinik durumları göz önüne alınarak opere edilmişlerdir. Doğumdan ameliyata kadar geçen süre ortalama 4,5 (1–56) gün idi. Farklı komplikasyonlar sebebiyle 12 postoperatif ölüm vardı, 1 hasta ise 2 yaşında hayatını kaybetmiştir. Sonuç olarak, 56 bebeğin 31'i (%55,4) takip süresince hayatta kalmıştır. Grup A'dan E'ye doğru gidildikçe doğum öncesi tanı oranı sırasıyla %57,2; %85,8; %75; %25 ve %80'dir. Ortanca doğum ağırlığı grup A'dan D'ye gidildikçe istatistiksel olarak anlamlı derecede artmıştır (p=0.04). Ancak gruplar arasında Apgar skoru, eşlik eden anomalilerin oranı, ameliyata kadar geçen süre ve opere olan bebek sayısı açısından istatiksel olarak anlamı fark saptanmamıştır. Tüm bulgular prenatal ultrasonografinin önemini ve özelikle üst GİS anomaliler de yüksek prenatal tanı başarısını göstermektedir. Sonuç olarak, GİS malformasyonlarının doğum öncesi tanısı birçok faktöre bağlıdır. Double bubble, polihidramniyoz, genişlemiş bağırsak segmentleri ve midenin görüntülenememesi gibi indirekt bulgular olmasına karşın, erken prenatal tanı zordur ve bazı olgularda tanı doğum sonrasına kalabilmektedir. GİS obstruksiyonu şüphesi olan olgularda fetal anatomi dikkatli bir biçimde değerlendirilmeli ve eşlik eden kromozom anomalileri açısından dikkatli olunmalıdır.Anahtar Kelimeler: Gastrointestinal Sistem, Gebelik, Konjenital Anomaliler, Prenatal Tanı,Prenatal Ultrason Congenital obstruction of the gastrointestinal tract (GIT) organs such as esophagus, ileum, jejunum, colon, rectum and anus may have signs at the time of prenatal ultrasonography. The prenatal detection is influenced by several factors as the site of obstruction, degree of the lesion (partial or complete), occurrence of associated malformations and the gestational week at screening. We aimed to evaluate pre- and post-natally diagnosed GIT obstructions in our center. Our study is consisted of 34 prenatally and 22 postnatally diagnosed babies with GIT malformations. GIT obstructions were divided into 5 groups according to the level of obstruction (A. Esophagus, B. Stomach and proximal duodenum, C. Small intestine, D. Large intestine, E. Multiple obstructions). Prenatal detection rate was found to be 60.7% among all cases. Associated structural malformation and aneuploidy rates were 21.4% and 5.4%, respectively. Twelve neonates died within the first day after birth due to various reasons. The remaining 43 of 44 patients underwent surgery at different times according to their clinical conditions. The mean time between birth and surgery was 4.5 days (range, 1–56 days). There were 12 postoperative deaths due to various complications, and 1 patient died at an age of 2 years. Overall, 31 of 56 (55.4%) babies were alive during the follow-up period. The successful prenatal diagnosis rate was 57.2%, 85.8%, 75%, 25% and 80% in groups A to E, respectively. The median birth weight increased significantly in groups A to D (p=0.04). However, there was no difference between groups in terms of Apgar scores, associated abnormality rate, time to surgery, and number of operated babies. All of these findings demonstrate the importance of prenatal ultrasonography and prenatal detection performance for upper GIT abnormalities. In conclusion, the prenatal diagnosis of GIT malformations depends on multiple factors. Although there are some signs such as double bubble, polyhydramnios, enlarged bowel, and failure to visualize the stomach, early prenatal diagnosis is difficult and can be delayed after birth in some cases. On suspicion of GIT obstruction, clinicians should evaluate the fetal anatomy carefully and be aware of associated chromosomal abnormalities.Keywords: Congenital abnormalities; Gastrointestinal tract; Pregnancy; Prenatal diagnosis;Prenatal Ultrasonography 67
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- 2018
23. First trimester complete blood cell indices in early and late onset preeclampsia
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Örgül, Gökçen, primary, Aydın Haklı, Duygu, additional, Özten, Gonca, additional, Fadiloğlu, Erdem, additional, Tanacan, Atakan, additional, and Beksaç, Mehmet Sinan, additional
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- 2019
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24. The Impact of 17Β Estradiol Level Variations on Blood Lymphocyte Counts Among Healthy Females
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ÖRGÜL, Gökçen, YÜCESOY, H. Meltem, PORTAKAL, Oytun, BEKSAÇ, Meral, and BEKSAÇ, M. Sinan
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17 β estradiol,lenfosit,beyaz kan hücreleri ,17β-estradiol,lymphocyte,white blood cells - Abstract
Amaç: Kadınlardaki 17β Estradiol (E2) düzeylerinin kan lenfositleriüzerine olan etkisini araştırmak.Yöntemler: 428 sağlıklı kadından kan örnekleri elde edildi. Serum E2düzeyleri, katı faz enzimiyle etiketlenmiş kemilüminesans yöntemi ileölçüldü. Tam kan sayımı, tam otomatik hücre sayacı ile gerçekleştirildi.Beyaz kan hücresi diferansiyasyonu, lenfositler dahil olmak üzere, hacim,iletkenlik ve beş parçalı dağılım ölçümleri (VCS teknolojisi) kullanılarakgerçekleştirildi. Toplam lenfosit sayısına göre 4 grup oluşturuldu, Objective: To investigate the effects of 17β-estradiol (E2) levels onblood lymphocyte counts in women.Methods: Blood samples were obtained from 428 healthy women. SerumE2 levels were measured using the solid-phase enzyme-labelledchemiluminescent method. Complete blood count was performed bya fully automated cell counter. White blood cell differential, includinglymphocytes, was performed by volume, conductivity, and five-partscatter measurements (VCS technology). The participants were dividedinto four groups, according to the blood lymphocyte levels
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- 2017
25. Factors influencing the success of cord blood collection: a tertiary perinatal medicine center’s experience
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TANAÇAN, Atakan, primary, YURDAKUL, Pınar, additional, AKTOZ, Fatih, additional, ÖRGÜL, Gökçen, additional, BEKSAÇ, Meral, additional, and BEKSAÇ, Mehmet Sinan, additional
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- 2018
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26. Pregnancy in papillary thyroid cancer survivors
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Beksaç, Kemal, primary, Aktoz, Fatih, additional, Örgül, Gökçen, additional, Çelik, Hasan Tolga, additional, Özgü-Erdinç, A. Seval, additional, and Beksaç, M. Sinan, additional
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- 2018
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27. Non-immune hydrops fetalis: a retrospective analysis of 151 autopsies performed at a single center
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Kaykı, Gözdem, primary, Güçer, Şafak, additional, Akçören, Zuhal, additional, Orhan, Diclehan, additional, Talim, Beril, additional, Yurdakök, Murat, additional, Yiğit, Şule, additional, Boduroğlu, Osman Koray, additional, Utine, Gülen Eda, additional, Örgül, Gökçen, additional, and Beksaç, M. Sinan, additional
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- 2018
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28. Total Blood Lymphocyte Count Alteration During and after Pregnancy
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Örgül, Gökçen, primary, Soyak, Burcu, additional, Portakal, Oytun, additional, Beksaç, Meral, additional, and Beksaç, M. Sinan, additional
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- 2017
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29. Retrospective evaluation of pregnant women with celiac disease
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Beksaç, Kemal, primary, Örgül, Gökçen, additional, Çağan, Murat, additional, Karaağaoğlu, Ergun, additional, Arslan, Serap, additional, and Beksaç, Mehmet Sinan, additional
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- 2017
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30. First trimester complete blood cell indices in early and late onset preeclampsia.
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Örgül, Gökçen, Haklı, Duygu Aydın, Özten, Gonca, Fadiloğlu, Erdem, Tanacan, Atakan, and Beksaç, Mehmet Sinan
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PREECLAMPSIA ,FIRST trimester of pregnancy ,BLOOD cell count ,NEUTROPHILS ,CONTROL groups - Abstract
Copyright of Turkish Journal of Obstetrics & Gynecology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2019
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31. Gebeliğin ilk üç ayındaki kan TSH düzeyi ile Down sendromu tarama testleri arasındaki ilişki.
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Örgül, Gökçen, Doğan, Devrim Rüzgar, Portakal, Oytun, and Beksaç, M. Sinan
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- *
THYROTROPIN , *CHORIONIC gonadotropins , *GONADOTROPIN , *DOWN syndrome , *MOTHERS - Abstract
Purpose: Down syndrome screening with first trimester combined test is recommended for all pregnancies. It is unclear, whether thyroid stimulating hormone (TSH) affects secretion of free beta subunit human chorionic gonadotropin (fß-hcg) and pregnancy-related plasma protein (PAPP-A). We aimed to investigate the effect of serum thyroid stimulating hormone (TSH) levels on the combined test results. Materials and Methods: First trimester TSH levels together with nuchal translucency (NT(fß-hcg and PAPPA results of 297 patients were included in this study. Patients were divided into four groups according to their TSH levels; Group 1 (<0.1 µL / ml), Group 2 (0.1-2.5 µlU / ml), Group 3 (2.5-3.5 µlU / ml) and Group 4 (> 3.5 µlU / ml). Groups were compared in terms of NT, PAPP-A and fß-hcg levels. Results: The mean PAPP-A (MoM) value was found to be 0.99 in group 1, 1.12 in group 2, 1.03 in group 3, and 0.95 in group 4. Mean fß-hcg (MoM) value was 1.36 in group 1, 1.29 in group 2, 1.05 in group 3, and 1.32 in group 4. The mean N T measurement was 1.27 ± 0.25, 1.33 ± 0.38, 1.34 ± 0.33 and 1.32 ± 0.37 mm, from group 1 to group 4, respectively. There was no statistically significant difference between groups in terms of PAPP-A, fß-hcg and NT. Conclusion: The present study have shown that first trimester TSH levels do not affect combined test parameters. Prenatal screening by using NT, fß-hCG and PAPP-A seems to be safe for pregnant women with hypothyroidism or hyperthyroidism. [ABSTRACT FROM AUTHOR]
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- 2018
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32. 36-37 haftalık nullipar gebelerde ultrasonografi ile yapılan servikal uzunluk ölçümü ve gebelik sonlanma zamanı arasındaki ilişki
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Örgül, Gökçen, Göçmen, Ahmet, and Kadın Hastalıkları ve Doğum Anabilim Dalı
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Obstetrics and Gynecology ,Kadın Hastalıkları ve Doğum - Abstract
Amaç: Herhangi bir risk faktörü taşımayan nullipar hastalardaki miad aşımı gebeliklerin öngörülebilmesi için 36-37. haftalar arasında yapılacak basit bir ultrasonografi muayenesinin yol gösterici olup olamayacağıdır.Yöntem: Antenatal takibi süresince fetal ve maternal anormallik saptanmamış olan 36-37 haftalık primipar tekil gebeliği olan 75 hasta poliklinik şartlarında muayene edilerek çalışmaya dahil edilmiştir. Hastaların rutin ultrasonografi kontrolüne servikal uzunluk ölçümü eklenmiştir. Hastalar gerekli sıklıkla takibe çağrılarak doğuma dek izlenmiştir. Doğum sonrası elde edilen veriler ile transvajinal ultrasonografi aracılığıyla ölçülen servikal uzunluk karşılaştırılmıştır. Bulgular: Olguların servikal uzunlukları; saptanan doğum haftaları, hastaların indüksiyon gereksinimi ve doğum şekilleri ile kıyaslandı. Doğum haftası 41 haftanın altında olan 43 (%57.3) olgu bulunurken, doğum haftası 41 hafta ve üzerinde olup miad aşımı kabul edilen 32 (%42.7) olgu bulunmaktadır. Doğum şekilleri incelendiğinde ise olguların %61.3'ü (n=46) normal spontan doğum, %38.7'si (n=29) sezaryen doğum yapmıştır. Olguların %46.7'sinde (n=35) indüksiyon ihtiyacı görülürken, %53.3'ünde (n=40) indüksiyon ihtiyacı görülmemiştir.Doğumu miadında olan olguların servikal uzunlukları ortalaması 27.42±8.95 mm, miad aşımı olan olguların ise ortalaması 34.03±7.92 mm'dir. Buna göre, doğum haftasına göre olguların servikal uzunlukları arasında istatistiksel olarak ileri düzeyde anlamlı farklılık saptanmıştır (p
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- 2013
33. Predicting the fetal weight by ultrasonography for isolated polyhydramnios: Comparison of 14 formulas.
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Yılmaz Ergani, Seval, Çakır, Betül Tokgöz, Akay, Arife, Ulusoy, Can Ozan, Akdaş Reis, Yıldız, Sarsmaz, Kemal, Örgül, Gökçen, Esin, Sertaç, and Çağlar, Ali Turhan
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- *
FETAL ultrasonic imaging , *POLYHYDRAMNIOS , *BIRTH weight , *PREGNANT women , *FORECASTING - Abstract
Objective Methods Results Conclusion To recalculate the estimated fetal weight (EFW) based on ultrasound measurements in patients complicated with isolated polyhydramnios, using 14 current formulas to observe which formula better predicts the EFW.This study examined pregnant women who gave birth in the hospital between January 2015 and January 2020. Maximum vertical pocket (MVP) was classified as, mild, moderate, and severe polyhydramnios, and the patients' measurements were reanalyzed using 14 formulas. The estimation of birth weight (EBW) alongside observed birth weight (OBW) facilitated the computation of statistical indices, namely the mean absolute percentage error (MAPE) expressed as [(EBW – OBW)/OBW × 100], the mean percentage error (MPE) denoted as (EBW – OBW)/(OBW × 100), and their corresponding 95% confidence intervals.A total of 564 polyhydramnios patients were included in the study. When looking at the MAPE, the lowest rate (7.65) was found in the Hadlock 2 formula. Hadlock 1, Hadlock 3, and Shinozuka formulas demonstrated MAPE values most closely aligned with Hadlock 2. Weiner I and Thurnau were the formulas with the highest MAPE values. When the cut‐off values for MAPE were taken as 10%, 4/14 of the formulas (Weiner I–II, Vintzleos and Thurnau) gave results above 10%. Among 14 formulas, 3 (21.4%) had positive (sonographic overestimation) (Hadlock 3, Shinozuka, and Vintzleos) and the other 11 (78.6%) had negative MPE (sonographic underestimation).The Hadlock 2 formula had the lowest MAPE in predicting birth weight in patients with polyhydramnios, closely followed by the Hadlock 1, Hadlock 3, and Shinozuka formulas. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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34. The role of the Chitinase 3-Like 1 (CHI3L1) genes in the preeclampsia pathophysiology.
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Mammadova N, Özler S, Özdemir BG, Avcı F, Koçak N, Çintesun E, Örgül G, and Çelik Ç
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- Humans, Female, Pregnancy, Adult, Case-Control Studies, Real-Time Polymerase Chain Reaction, Young Adult, Polymorphism, Single Nucleotide, Genotype, Risk Factors, Gene Frequency, Pre-Eclampsia genetics, Chitinase-3-Like Protein 1 genetics, Chitinase-3-Like Protein 1 blood, Severity of Illness Index, Genetic Predisposition to Disease genetics
- Abstract
Objective: The aim of this study was to investigate the relationship between Chitinase 3-Like 1 gene polymorphisms and the occurrence of preeclampsia in a selected cohort of pregnant women., Methods: A total of 75 pregnant women participated in the study, 35 of whom were diagnosed with preeclampsia, while 40 served as healthy controls. The preeclamptic group was subdivided based on severity. Real-time polymerase chain reaction was employed to analyze the serum samples for variations in Chitinase 3-Like 1 gene polymorphisms., Results: The rs880633 polymorphism was found to be significantly more frequent in the control group (80%) compared with the overall preeclamptic group (60%) (p<0.05). In the severity-based subgroups, rs880633 appeared in 57.1% of non-severe and 61.9% of severe preeclamptics. Contrarily, the heterozygous form of rs7515776 polymorphism showed a significantly higher prevalence in the preeclamptic cohort (p<0.05), without distinctions in severity subgroups., Conclusion: The study suggests that the rs880633 polymorphism may serve a protective role against the development of preeclampsia, whereas the rs7515776 polymorphism may be associated with an elevated risk. Further research is warranted to elucidate the clinical implications of these findings.
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- 2024
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35. Perinatal outcomes of twenty-five human immunodeficiency virus-infected pregnant women: Hacettepe University experience
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İnkaya AÇ, Örgül G, Halis N, Alp Ş, Kara A, Özyüncü Ö, Yurdakok M, Ünal S, and Beksaç MS
- Abstract
Objective: To evaluate perinatal outcomes in human immunodeficiency virus (HIV) infected pregnant women in Turkey., Material and Methods: Maternal characteristics, pregnancy complications, laboratory findings including HIV load, CD4 cell count, CD4/CD8 ratio, neonatal features and final HIV status of the baby were retrospectively analyzed., Results: The sample included 26 singleton pregnancies, from 25 HIV-infected women. The ethnicities were Turkish (n=18), East European (n=4), Asian (n=2) and African (n=2). The majority (76.9%) was aware of their HIV status before becoming pregnant. Four cases (15.3%) were diagnosed during pregnancy and two (7.8%) at the onset of labor. The results for median HIV viral load, CD4 count, and CD4/CD8 ratio at birth were 20 copies/mL (0-34 587), 577/mm
3 (115-977), and 0.7 (0.1-1.9), respectively. The HIV viral load rate was 5.5% in eighteen women taking anti-retroviral treatment. The rates of gestational diabetes mellitus, gestational hypertension, intrauterine growth restriction, and preterm delivery were 3.8%, 3.8%, 7.6%, and 8% (numbers are 1;1;2;2), respectively. The mean gestational week at birth was 38 weeks and mean birthweight is 2972±329 g. Two babies were congenitally infected with HIV (infection rate of 8.3%). There was one needle-related accident during surgery., Conclusion: Timely diagnosis of HIV infection during pregnancy is important for preventing mother to child transmission. HIV infected women may give birth to HIV negative babies with the help of a multidisciplinary team, composed of perinatology, infectious diseases, and pediatrics specialists.- Published
- 2020
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36. Pregnancy in papillary thyroid cancer survivors
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Beksaç K, Aktoz F, Örgül G, Çelik HT, Özgü-Erdinç AS, and Beksaç MS
- Abstract
Objective: To evaluate “papillary thyroid carcinoma-pregnancy” interaction among cancer survivors., Material and Methods: The clinical records of 8 pregnant women who received treatment for papillary thyroid cancer before their pregnancy were evaluated. Clinical features, pregnancy/perinatal outcomes and high-risk factors were compared with 45 controls who were randomly assigned from the institutional perinatal medicine database., Results: Patients in the cancer group were older than the control group (34.3 vs 29.8 years). The cesarean section rate was higher (62.5% vs 33.3%) and the APGAR scores at the 1
st and 5th minutes were lower in the cancer group., Conclusion: Management of pregnancies with papillary thyroid cancer treatment and follow-up requires a multidisciplinary approach with careful antenatal care and perinatal surveillance. Patients who have received papillary thyroid cancer treatment can safely undergo pregnancy.- Published
- 2018
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- View/download PDF
37. Retrospective evaluation of pregnant women with celiac disease.
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Beksaç K, Örgül G, Çağan M, Karaağaoğlu E, Arslan S, and Beksaç MS
- Abstract
Objective: To show celiac disease (CD) and its poor pregnancy outcome relationship, and to demonstrate the importance of a gluten-free diet together with low-dose low-molecular-weight heparin (LMWH) and low-dose corticosteroid (LDC) in the management of pregnancies with CD., Material and Methods: This study consisted of 2 groups of patients. Six patients with CD (control group) on a gluten-free diet were monitored during their first pregnancies within the framework of antenatal care program and their pregnancy outcomes were compared with eight poorly-treated pregnant patients with CD (study group) who were referred from other medical institutions. LMWH (enoxaparine 1x2000 Anti-XA IU/0.2 mL/day), and LDC (methylprednisolone 1x4 mg p.o/day) were used in the control group. Their obstetric histories and outcomes of their last pregnancies were compared. The patients' obstetric risk levels were evaluated using the "Beksac Obstetrics Index" (BOI)., Results: There were miscarriages in 50% of the study group. There were also 50% and 75% preterm deliveries in the control and study groups, respectively. The BOI of the study group was significantly worse than the control group (1.31 vs. 0.31±0.21, p<0.01). There were no statistically significant differences between age (24±4.7 vs 31.7±6 years, p=0.448), gestational day of birth (259.3±8.5 vs 246.6±24.3), birthweight (2691±698 vs 2262±359 g, p=0.394), and cesarean section rates (p=0.118)., Conclusion: CD is a risk factor for adverse pregnancy outcome. Miscarriage and preterm labor are critical complications in pregnancies complicated by CD. A gluten-free diet is important in the treatment. LMWH and LDC seem to be helpful in the management of pregnant women with CD.
- Published
- 2017
- Full Text
- View/download PDF
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