Search

Objective: To compare the safety and efficacy of anti-leukotrienes and inhaled glucocorticoids as monotherapy in people with asthma. Design: Systematic review of randomised controlled trials comparing anti-leukotrienes with inhaled glucocorticoids for 28 days or more in children and adults. Main outcome measure: Rate of exacerbations that required treatment with systemic glucocorticoids. Results: 13 trials (12 in adults, one in children) met the inclusion criteria; all were in people with mild and moderate asthma. Leukotriene receptor antagonists were compared with inhaled glucocorticoids at a daily dose equivalent to 400–450 μg beclometasone dipropionate. Patients treated with leukotriene receptor antagonists were 60% more likely to suffer an exacerbation requiring systemic glucocorticoids (relative risk 1.6, 95% confidence interval 1.2 to 2.2; number needed to treat 27, 13 to 81). A 130 ml greater improvement (80 ml to 170 ml) in forced expiratory volume in one second and a 19 l/min greater increase (14 l to 24 l) in morning peak expiratory flow rate were noted in favour of inhaled glucocorticoids. Differences in favour of inhaled glucocorticoids were also observed for nocturnal awakenings, use of rescue β2 agonists, and days without symptoms. Risk of side effects was no different between groups, but leukotriene receptor antagonists were associated a 2.5-fold increase risk of withdrawals due to poor asthma control (relative risk 2.5, 1.8 to 3.5). Conclusions: Inhaled glucocorticoids doses equivalent to 400 μg/day beclometasone are more effective than leukotriene receptor antagonists in the treatment of adults with mild or moderate asthma. There is insufficient evidence to conclude on the efficacy of anti-leukotrienes in children. What is already known on this topic In 2000 a Cochrane systematic review tentatively concluded that control of asthma was better in patients treated with inhaled glucocorticoids as single agents than with anti-leukotrienes The 2002 Global Initiative for Asthma guidelines still classify the role of anti-leukotrienes as “under investigation” What this study adds Anti-leukotrienes as single agent are less effective than low doses of inhaled glucocorticoids for patients with mild and moderate persistent asthma

Summary form only given. Much effort has been put in the elucidation of the photochemistry of ClO/sub 2/ in the gas and the condensed phases since the outcome of the reaction pathways may have strong implications for sun-light induced stratospheric chemistry. Gas phase experiments and ab initio calculations have shown the complexity of the photochemical dynamics of ClO/sub 2/, that can dissociate along the pathways ClO+O or Cl+O/sub 2/. It is now clear that the excited state dynamics of the A/spl tilde//sup 2/A/sub 2/ state is determined by a multitude of conical intersections to the optically weak 1/sup 2/A/sub 1/ and the dark 1/sup 1/B/sub 2/ states. In the gas phase the lifetimes of these states before dissociation to the photoproduct can be determined with femtosecond time-resolved mass and photoelectron spectroscopy. We have performed pump-probe spectroscopy with 50 fs temporal resolution, where pump and probe were centered at 403 nm, produced by a frequency-doubled l-kHz amplified Ti:sapphire system, in order to get more insight in the initial dynamics in solution, where features like cage effect, recombination and relaxation to the ground state as well as reaction with the solvent may occur.

This paper explains a design and the comparison of two multi-disc permanent magnet motor. The actuator must provide answers to the volume constraint and torque. This application is employed in land transport for aeronautical field. The axial flux motors become interesting when obtaining large surfaces of air-gap with the traditional machines is no possible. Indeed, surfaces of air-gap are more important in comparison with a radial flux machine, and, in a given volume, they allow to obtain a higher torque. After having shown the multi-air gap structure, we describe the design method from elementary cells. That's why two types the disc-type motor were selected. This paper clearly shows the efficient topology of a disc-type multi-air gap machine.

This paper investigates a scheduling model with certain co-existing features of serial-batching, dynamic job arrival, multi-types of job, and setup time. In this proposed model, the jobs of all types are first partitioned into serial batches, which are then processed on a single serial-batching machine with an independent constant setup time for each new batch. In order to solve this scheduling problem, we divide it into two phases based on job arrival times, and we also derive and prove certain constructive properties for these two phases. Relying on these properties, we develop a two-phase hybrid algorithm (TPHA). In addition, a valid lower bound of the problem is also derived. This is used to validate the quality of the proposed algorithm. Computational experiments, both with small- and large-scale problems, are performed in order to evaluate the performance of TPHA. The computational results indicate that TPHA outperforms seven other heuristic algorithms. For all test problems of different job sizes, the average gap percentage between the makespan, obtained using TPHA, and the lower bound does not exceed 5.41 %.

The Relationship Between Agricultural Prices and Food Prices This paper examines the relationships between agriculture, food processing, trade and retail, and consumers at the macro-economic level in France, between 1978 and 2005. The surplus account method is applied using input-output tables (IOT). In order to do so, volume and price indices are calculated for all the elements of the IOTs' to measure the productivity of agriculture and food processing industries and measure the transfers of purchasing power between various economic agents. Agriculture includes forestry and fishing. Food processing industries are divided into two sub-sectors: meat and dairy, and other food processing industries. Trade and retail activities are measured by marketing margins. To measure relationships between sectors, we use the table of intermediate inputs. Relationships with the rest of the world are taken into account through imports and exports. The subsidies and taxes are introduced either at the stage of production, or at the stage of use of products. Payments of factors in each sector are deducted from income accounts, their volume being calculated like an aggregate of the labour and fixed assets being used., Ce texte examine, sur le plan macroéconomique, les relations entre l'agriculture, les industries agro-alimentaires, le commerce et les consommateurs, en France, entre 1978 et 2005. La méthode des comptes de surplus est appliquée aux tableaux entrées-sorties pour mesurer la productivité de l'agriculture et des industries alimentaires et apprécier les transferts de pouvoir d'achat entre les différents agents. L'agriculture inclut la sylviculture et la pêche. Les industries sont divisées en deux branches, les industries de la viande et du lait et les autres industries alimentaires. L'activité du commerce est mesurée par les marges commerciales. Pour apprécier les relations entre branches, le tableau des entrées intermédiaires est utilisé. Les relations avec l'étranger sont prises en compte à travers les importations et les exportations. Les subventions et les taxes sont introduites soit au stade de la production, soit au stade de l'utilisation des produits. Le revenu des facteurs internes des branches est déduit des comptes d'exploitation, leur volume étant calculé comme un agrégat du travail et du capital fixe utilisés., Butault Jean-Pierre. La relation entre prix agricoles et prix alimentaires. In: Revue française d'économie, volume 23, n°2, 2008. pp. 215-241.

With increased demands, power modules are often required to run at higher temperatures with improved reliability. Solder joint fatigue is a major failure mode for current power modules. Silver sintering die-attach technology significantly improves power module reliability. Due to the reliability problem at the interface between aluminum (Al) wire and a silver (Ag) layer, bonding Ag wire to the Ag layer is highly desired. Ag wire is harder and stiffer than Al wire, resulting in much higher wear and significantly reduced lifetime of consumables. This paper introduced the K&S CuEx™ bond tool and studied coupling and interaction between the bond tool and Ag wire. By optimizing the bonding process, the CuEx™ bond tools achieved 400,000 touchdowns, which is 80× more than the standard bond tool lifetime of 5,000 touchdowns. The difference between the front-cut and rear-cut process is discussed. By studying and optimizing the cutting process, the standard rear-cut cutter blade lifetime is increased 4×, from 50,000 cuts to 200,000 cuts. It is observed that Ag wire did not wear a wire guide much faster than Al wire. The standard wire guide exhibited minimum wear after 200,000 bonds.

Due to current improvements in techniques for islet isolation and transplantation and protocols for immunosuppressants, islet transplantation has become an effective treatment for severe diabetes patients. Many diabetic animal models have contributed to such improvements. In this paper, we focus on 3 types of models with different mechanisms for inducing diabetes mellitus (DM): models induced by drugs including streptozotocin (STZ), pancreatomized models, and spontaneous models due to autoimmunity. STZ-induced diabetes is one of the most commonly used experimental diabetic models and is employed using many specimens including rodents, pigs or monkeys. The management of STZ models is well established for islet studies. Pancreatomized models reveal different aspects compared to STZ-induced models in terms of loss of function in the increase and decrease of blood glucose and therefore are useful for evaluating the condition in total pancreatomized patients. Spontaneous models are useful for preclinical studies including the assessment of immunosuppressants because such models involve the same mechanisms as type 1 DM in the clinical setting. In conclusion, islet researchers should select suitable diabetic animal models according to the aim of the study.

A common task of Web users is querying structured information from Web pages. In this paper we propose a novel query processor for systematically discovering any-k relations from Web search results with conjunctive queries. The 'any-k' phrase denotes that retrieved tuples are not ranked by the system.For realizing this interesting scenario the query processor transfers a structured query into keyword queries that are submitted to a search engine, forwards search results to relation extractors, and then combines relations into result tuples.Unfortunately, relation extractors may fail to return a relation for a result tuple. We propose a solid information theory-based approach for retrieving missing attribute values of partially retrieved relations. Moreover, user-defined data sources may not return at least k complete result tuples. To solve this problem, we extend the Eddy query processing mechanism [14] for our 'querying the Web' scenario with a continuous, adaptive routing model. The model determines the most promising next incomplete row for returning any-k complete result tuples at any point during the query execution process.We report a thorough experimental evaluation over multiple relation extractors. Our experiments demonstrate that our query processor returns complete result tuples while processing only very few Web pages.

This paper presents a novel control strategy for an above-knee powered prosthetic leg that unifies the entire gait cycle, eliminating the need to switch between controllers during different periods of gait. Current control methods divide the gait cycle into several sequential periods each with independent controllers, resulting in many patient-specific control parameters and switching rules that must be tuned by clinicians. Having a single controller could reduce the number of control parameters to be tuned for each patient, thereby reducing the clinical time and effort involved in fitting a powered prosthesis for a lower-limb amputee. Using the Discrete Fourier Transformation, a single virtual constraint is derived that exactly characterizes the desired actuated joint motion over the entire gait cycle. Because the virtual constraint is defined as a periodic function of a monotonically increasing phase variable, no switching or resetting is necessary within or across gait cycles. The output function is zeroed using feedback linearization to produce a single, unified controller. The method is illustrated with simulations of a powered knee-ankle prosthesis in an amputee biped model and with examples of systematically generated output functions for different walking speeds.

This article is based on surveys in 1988 among representative samples totalling 4,247 16‐19 year olds from four areas (Kirkcaldy, Liverpool, Sheffield and Swindon), of whom 1,562 had some experience of Youth Training (YT). The young people's likelihood of entering YT depended primarily on their educational qualifications and where they lived. Trainees’ chances of being kept on by the firms where they were trained depended mainly on their types of schemes and their performances during training, indicated by whether or not they earned any additional qualifications. The chances of those not retained moving immediately to jobs with other firms were more dependent on their school‐leaving qualifications and where they lived. The authors interpret their evidence to argue that employers’ uses of YT in the late‐1980s were creating increasingly clear divisions between sponsorship, contest and warehousing sectors. ∗ This paper is based on evidence from the Economic and Social Research Council's 16‐19 Initiative

The paper explores the uniqueness properties of the subjective probabilities in two axiomatizations of state-dependent preferences. Karni, Schmeidler, and Vind's (KSV 1983) system depends on selecting an arbitrary auxiliary probability, and as such, does not guarantee the uniqueness of the derived subjective probability. However, an axiom system initially designed by Karni and Schmeidler (KS 1981) and further elaborated upon here does guarantee the desired uniqueness as well as a useful property of “stability” of the derived solution. When the preference relation displays state-independence, even the KS probabilities may not agree with those derived from the classic Anscombe-Aumann (AA 1963) theorem. However, we claim that, in this case, the KS rather than the AA probabilities are the appropriate representation of the agent's beliefs.

At present, regarding to the machining of aspheric lens mold, there are two major methods to carry out the on-machine measurement (OMM) — contacting method (CM) and non-contacting method (NCM). Here such two methods are reviewed in detail. CM is mainly based on the contacting probe which is scratching aspheric surface of lens mold to achieve profile data. To be efficient, an idea with 45° tilt of probe is proposed for OMM of lens mold by Suzuki. But generally speaking, the contacting OMM is not so efficient and can only deal with axisymmetric aspheric lens mold. On the contrary, NCM mostly uses laser to achieve aspheric profile without any contact. On ultra-precision lathe, laser scanning system or laser interferometer is mounted on the frame of lathe and transfers measurement data to machining system efficiently. However, most NCMs need stable environment and low working noise except instantaneous phase-shifting shearing interferometry (IPSSI). Therefore, a new idea about IPSSI is proposed in this paper to realize OMM of lens molds. Unfortunately, it's also difficult to test the high numerical aperture aspheric or free-form lens molds. By comparison, the newly-developed fringe reflection (FR) method is becoming the promising method because it features the high efficiency and high accuracy. However, this method has not been used for OMM system yet. Much research should be conducted for FR OMM technology.

The continuous Skyline query has recently become the subject of the several researches due to its wide spectrum of applications such as multi-criteria decision making, graph analysis network, wireless sensor network and data exploration. In these applications, the datasets are huge and have various dimensions. Moreover, they constantly change as time passes. Therefore, this query is considered as a computation intensive operation that finding the result in a reasonable time is a challenge. In this paper, we present an efficient parallel continuous Skyline approach. In our suggested method, the dataset points are sorted and pruned based on Manhattan distance. Moreover, we use several optimization methods to optimize memory usage in comparison with naive implementation. In addition, besides the applied conventional parallelization methods, we partition the time steps based on the number of available cores. The experimental results for a dataset that contains 800k points with 7 dimensions show considerable speedup.

As regions around the world are considering increased integration of key energy, transport or other infrastructure networks, issues build in the design of the supranational national regulation needed in that context are increasingly well recognized. Solutions are however slow to emerge. This paper reviews the challenges and discusses the directions suggested by theory to address these challenges. It highlight the potentially counterproductive effects of common standard policy recommendations discussed at the political level. The paper also identifies key research areas as the review of match between theory and evidence suggest that we still have to address significant gaps in our collective understanding of the impediments to desirable integration efforts., info:eu-repo/semantics/published

This paper presents a novel fuzzy adaptive controller for controlling a class of dead-zone output nonlinear systems with time delays. A new approximate model is first designed to describe a special dead-zone phenomenon encountered by the output mechanism of nonlinear systems, and the proposed smooth model can be conveniently fused with available adaptive fuzzy control techniques. In addition, the coupling effect that the dead-zone output and the time-delayed states coexist in a common coupling function makes the tracking control design more complicated. To further address this difficulty, a compensation method using mean-value theorem with Lyapunov–Krasovskii function is presented in this paper. By using the proposed output dead-zone model, and based on Lyapunov synthesis, a new optimized algorithm is developed to guarantee the prescribed convergence of tracking error and the boundedness of all the signals in the closed-loop systems. Simulations have been implemented to verify the performance of the proposed fuzzy adaptive controller.

Timothy P. Barnard, Cynthia Chou, Indonesian sea nomads; Money, magic, and fear of the Orang Suku Laut. London: RoutledgeCurzon, 2003, xii + 159 pp. -R.H. Barnes, Toos van Dijk, Gouden eiland in de Bandazee; Socio-kosmische ideeën op Marsela, Maluku Tenggara, Indonesië. Leiden: Onderzoekschool voor Aziatische, Afrikaanse en Amerindische studies (CNWS), Universiteit Leiden, 2000, 458 pp. [CNWS Publications 94.] -Andrew Beatty, Peter G. Riddell, Islam and the Malay-Indonesian world; Transmission and responses. Honolulu: University of Hawai'i Press, 2001, xvii + 349 pp. -Peter Boomgaard, Richard H. Grove ,El Niño - history and crisis; Studies from the Asia-Pacific region. Cambridge: White Horse Press, 2000, 230 pp., John Chappell (eds) -Bernardita Reyes Churchill, Florentino Rodao, Franco y el imperio japonés; Imágenes y propaganda en tiempos de guerra. Barcelona: Plaza and Janés, 2002, 669 pp. -Matthew Cohen, Stuart Robson, The Kraton; Selected essays on Javanese courts. Translated by Rosemary Robson-McKillop. Leiden: KITLV Press, 2003, xxvi + 397 pp. [Translation series 28.] -Serge Dunis, Ben Finney, Sailing in the wake of the ancestors; Reviving Polynesian voyaging. Honolulu: Bishop Museum Press, 2003, 176 pp. [Legacy of excellence.] -Heleen Gall, Jan A. Somers, De VOC als volkenrechtelijke actor. Deventer: Gouda Quint, Rotterdam: Sanders Instituut, 2001, x + 350 pp. -David Henley, Harold Brookfield, Exploring agrodiversity. New York: Columbia University Press, 2001, xix + 348 pp. -David Hicks, Ernst van Veen ,A guide to the sources of the history of Dutch-Portuguese relations in Asia (1594-1797). With a foreword by Leonard Blussé. Leiden: Institute for the history of European expansion, 2001, iv + 378 pp. [Intercontinenta 24.], Daniël Klijn (eds) -Nico Kaptein, Donald J. Porter, Managing politics and Islam in Indonesia. London: RoutledgeCurzon, 2002, xxi + 264 pp. -Victor T. King, Monica Janowski, The forest, source of life; The Kelabit of Sarawak. London: British Museum Press, 2003, vi + 154 pp. [Occasional paper 143.] -Dick van der Meij, Andrée Jaunay, Exploration dans la presqu île malaise par Jacques de Morgan 1884. Paris: CNRS Éditions, 2003, xiv + 268 pp. Avec les contributions de Christine Lorre, Antonio Guerreiro et Antoine Verney. -Toon van Meijl, Richard Eves, The magical body; Power, fame and meaning in a Melanesian society. Amsterdam: Harwood academic, 1998, xxii + 302 pp. [Studies in Anthropology and History 23.] -Otto van den Muijzenberg, Florentino Rodao ,The Philippine revolution of 1896; Ordinary lives in extraordinary times. Quezon city: Ateneo de Manila University Press, 2001, xx + 303 pp., Felice Noelle Rodriguez (eds) -Frank Okker, Kees Snoek, Manhafte heren en rijke erfdochters; Het voorgeslacht van E. du Perron op Java. Leiden: KITLV Uitgeverij, 2003, 103 pp. [Boekerij 'Oost en West'.] (met medewerking van Tim Timmers) -Oona Thommes Paredes, Greg Bankoff, Cultures of disaster; Society and natural hazard in the Philippines, 2003, xviii + 232 pp. London: RoutledgeCurzon, 2003, xviii + 232 pp. -Angela Pashia, Lake' Baling, The old Kayan religion and the Bungan religious reform. Translated and annotated by Jérôme Rousseau. Kota Samarahan: Unit Penerbitan Universiti Malaysia Sarawak, 2002, xviii + 124 pp. [Dayak studies monographs, Oral literature series 4.] -Anton Ploeg, Susan Meiselas, Encounters with the Dani; Stories from the Baliem Valley. New York: International center of photography, Göttingen: Steidl, 2003, 196 pp. -Nathan Porath, Robert W. Hefner, The politics of multiculturalism; Pluralism and citizenship in Malaysia, Singapore, and Indonesia. Honolulu: University of Hawai'i Press, 2001, ix + 319 pp. -Jan van der Putten, Timothy P. Barnard, Multiple centres of authority; Society and environment in Siak and eastern Sumatra, 1674-1827. Leiden: KITLV Press, 2003, xvi + 206 pp. [Verhandelingen 210.] -Jan Piet Puype, David van Duuren, Krisses; A critical bibliography. Wijk en Aalburg: Pictures Publishers, 2002, 192 pp. -Thomas H. Slone, Gertrudis A.M. Offenberg ,Amoko - in the beginning; Myths and legends of the Asmat and Mimika Papuans. Adelaide: Crawford House, 2002, xxviii + 276 pp., Jan Pouwer (eds) -Fridus Steijlen, Kwa Chong Guan ,Oral history in Southeast Asia; Theory and method. Singapore: Institute of Southeast Asian studies, 2000, xii + 172 pp., James H. Morrison, Patricia Lim Pui Huen (eds) -Fridus Steijlen, P. Lim Pui Huen ,War and memory in Malaysia and Singapore. Singapore: Institute of Southeast Asian studies, 2000, vii + 193 pp., Diana Wong (eds) -Jaap Timmer, Andrew Lattas, Cultures of secrecy; Reinventing race in Bush Kaliai cargo cults. Madison/London: University of Wisconsin Press, 1998, xliv + 360 pp. -Edwin Wieringa, Kartika Setyawati ,Katalog naskah Merapi-Merbabu; Perpustakaan Nasional Republik Indonesia. Yogyakarta: Penerbitan Universitas Sanata Dharma, Leiden: Opleiding Talen en Culturen van Zuidoost-Azië en Oceanië, 2002, ix + 278 pp. [Semaian 23.], I. Kuntara Wiryamartana, Willem van der Molen (eds) -Julian Millie, Jakob Sumardjo, Simbol-simbol artefak budaya Sunda; Tafsir-tafsir pantun Sunda. Bandung: Kelir, 2003, xxvi + 364 pp. -Julian Millie, T. Christomy, Wawacan Sama'un; Edisi teks dan analisis struktur Jakarta: Djambatan (in cooperation with the Ford Foundation), 2003, viii + 404 pp. -Julian Millie, Dadan Wildan, Sunan Gunung Jati (antara fiksi dan fakta); Pembumian Islam dengan pendekatan struktural dan kultural. Bandung: Humaniora Utama Press, 2002, xx + 372 pp.

The paper is devoted to functional and structural testing of programs. Experimental results of a set of programs are presented. The experiments cover selection of functional tests, analysis of function and line coverage and optimization of test suites. The comparison of code coverage results and selection of the most effective tests are discussed in the relation to the test-first approach for program development. The types of the code not covered by the tests are classified for different categories.

This paper presents the fabrication, characterization, and testing of the photocatalytic potential of a non-modified titania nanotube (TNT) and Sn-modified TNT synthesized through a facile one-step hydrothermal method. Two tin compounds (SnCl2 and SnO2) and aqueous solutions (HCl and SnCl2) were utilized as precursors and acid washing solutions, respectively. Because the Sn-modified TNT was free of calcination, the resulting sample possessed a high Brunauer-Emmett-Teller surface area. In addition, the Sn-modified TNT exhibited higher electron-hole separation efficiency. The photocatalytic reaction rate for the sample with methylene blue and malachite green dye decomposition was governed on the basis of their pre-adsorption abilities. The Sn-modified TNT had more Cl species than the non-modified TNT, resulting in higher pre-adsorption abilities for the methylene blue dye. Even though the Cl species on SnO2-TNT sample surface were removed, a higher electron-hole separation efficiency and anatase-rutile mixed phase can promote the photocatalyst activity of SnO2-TNT. On the other hand, the Cl species on the surface of SnO2-TNT-HCl washing sample appeared to act as one of the adsorption sites and enhance gaseous elemental mercury removal.

In this paper, we present a formulation of state variable based gradient theory to model damage evolution and alleviate numerical instability associated within the post-bifurcation regime. This proposed theory is developed using basic microforce balance laws and appropriate state variables within a consistent thermodynamic framework. The proposed theory provides a strong coupling and consistent framework to prescribe energy storage and dissipation associated with internal damage. Moreover, the temporal evolution equation derived here naturally shows the effect of damage—nucleation, growth and coalescence. In addition, the theoretical framework presented here is easily extendable to the addition of other defects (not shown here), and can be generalized to the development of consistent coupled transport equations for species, such as hydrogen (Bammann et al. in JMPS, 2009, submitted), as well as providing a consistent structure for modeling events at diverse length scales.

The paper presents the results of a comparative study on accelerated aging of specially designed experimental transformers and their corresponding laboratory models. The experimental transformers are 300 kVA, with insulation in line with medium size and large mineral oil immersed power transformers, having different initial water contents in the standard Kraft paper insulation of ca. 1 and 4 %. These transformers were subjected to the rated current and voltage conditions, operating in the irregular parallel operation, whereby the temperature of windings were measured with fiber optics sensors and kept at 105 °C for 460 days. Each transformer was equipped with a removable tank which allowed access to the outer surface of the HV windings. Laboratory experiments were simulating experimental transformers and were performed in Erlenmeyer flasks, containing oil, paper materials, copper and iron in the same proportions as in the active part of the experimental transformers. The parameters that were monitored during aging were the following: degree of polymerization of paper, hot-spot temperature of transformers, water content in paper, and water and furans content in the oil. Estimations of water content in solid insulation of experimental transformers using frequency domain spectroscopy and the Perrier-Lukic moisture equilibrium chart were performed. The experimental results show that shortening of the insulation life, defined by the value of degree of polymerization, increased 2.5 times with increasing moisture content in the cellulose from ca. 1 to 4 %. For both experimental transformers and laboratory models, the relationships between the paper degree of polymerization and the furans content for dry and wet insulation was developed and is presented in the paper.