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• COVID-19 management in reception centers for refugees, asylum seekers, and migrants • Strategies to mitigate COVID-19 in vulnerable refugee populations • Outbreak response to COVID-19 in reception centers in Spain 2020 • Priorities when managing COVID-19 in refugee settings before the vaccines Shortly after the declaration of the COVID-19 pandemic, governments around the world were urged to leave no population behind. Following a COVID-19 risk evaluation in a refugee and asylum seekers reception center, in September 2020, we considered the priorities of managing COVID-19 in these settings. We encourage actions on the following four fronts to reduce the COVID-19–associated burden among these vulnerable populations based on our interviews, observations, and recommendations: (i) decongestion, (ii) facilitated testing, (iii) screening for symptoms, and (iv) targeted public health and risk communication. [ABSTRACT FROM AUTHOR]