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The occurrence of 21 selected pharmaceutically active compounds (PhACs) in river water was examined; meanwhile the presence and removal of these PhACs at different water treatment steps in two conventional drinking water treatment plants (DWTPs) were evaluated. Monitoring results showed that of all 21 target PhACs, twelve PhACs were ubiquitously detected in water samples from the Yangtze river and its two tributaries (Jialing River and Huaxi stream), whereas alodipine was not found in any river water sample. The concentrations of PhACs detected in Huaxi stream were statistically significantly higher than those found in the Jialing River and the Yangzi River because of the direct discharges of uncontrolled domestic sewage and poultry wastewater and the abuse of PhACs in the rural areas served by the Huaxi stream. An environmental risk assessment of PhACs based on the risk quotient value approach indicated that sulfamethoxazole, ofloxacin and dehydrated erythromycin and clofibric acid had a medium risk, and the mixture of the studied PhACs showed high risk for the aquatic ecosystems. Fourteen out of 21 target PhACs were found in the raw water of the two studied DWTPs with azithromycin having the highest concentration (about 20 ng/L). Following the conventional water treatment processes, the studied PhACs were found to be removed by an average of 54 and 48% in DWTP A and DWTP B, respectively. Among the target PhACs, six and three PhACs were detected in finished water of DWTP B and DWTP A, respectively. This is the first study in southwestern China reporting the presence of PhACs in surface water and drinking water. [ABSTRACT FROM AUTHOR]

Abstract: The occurrence, removal and ecotoxicological assessment of 21 pharmaceutically active compounds (PhACs) including antibiotics, analgesics, antiepileptics, antilipidemics and antihypersensitives, were studied at four municipal wastewater treatment plants (WWTP) in Chongqing, the Three Gorges Reservoir Area. Individual treatment unit effluents, as well as primary and secondary sludge, were sampled and analyzed for the selected PhACs to evaluate their biodegradation, persistence and partitioning behaviors. PhACs were identified and quantified using high performance liquid chromatography/tandem mass spectrometry after solid-phase extraction. All the 21 analyzed PhACs were detected in wastewater and the target PhACs except acetaminophen, ibuprofen and gemfibrozil, were also found in sludge. The concentrations of the antibiotics and SVT were comparable to or even higher than those reported in developed countries, while the case of other target PhACs was opposite. The elimination of PhACs except acetaminophen was incomplete and a wide range of elimination efficiencies during the treatment were observed, i.e. from “negative removal” to 99.5%. The removal of PhACs was insignificant in primary and disinfection processes, and was mainly achieved during the biological treatment. Based on the mass balance analysis, biodegradation is believed to be the primary removal mechanism, whereas only about 1.5% of the total mass load of the target PhACs was removed by sorption. Experimentally estimated distribution coefficients (<500L/kg, with a few exceptions) also indicate that biodegradation/transformation was responsible for the removal of the target PhACs. Ecotoxicological assessment indicated that the environment concentrations of single compounds (including sulfadiazine, sulfamethoxazole, ofloxacin, azithromycin and erythromycin-H2O) in effluent and sludge, as well as the mixture of the 21 detected PhACs in effluent, sludge and receiving water had a significant ecotoxicological risk to algae. Therefore, further control of PhACs in effluent and sludge is required before their discharge and application to prevent their introduction into the environment. [Copyright &y& Elsevier]

To standardize the diagnosis and management of Barrett's esophagus (BE) in China, the Chinese Society of Gastroenterology convened the Second National Conference on BE in June 2011 in Chongqing, China. After intense discussion among experts in this field and an extensive review of the literature, a revised consensus on the diagnosis and management of BE was generated. [ABSTRACT FROM AUTHOR]