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Guangzhou is located in the southern part of China, near the South China Sea, belongs to Guangdong Province. It serves as China's southern gateway to the world and was historically called "The Southern Treasure of the Emperor", playing a crucial role in China's maritime trade history. Throughout Chinese history, Guangzhou underwent several cycles of "closure" and "opening", policies that severely impacted trade. However, foreign merchants never ceased to request permission from the Chinese government to engage in trade. In 1757, Emperor Qianlong decreed Guangzhou as the only one official port for foreign trade. This edict led to the establishment of the one port trading system in Guangzhou, as the Qing government aimed to counter foreign influences and local uprisings while maintaining a self-sufficient small-scale agricultural economy. Western nations and their traders sought opportunities within this system, aspiring to expand trade to other regions of China, even the inland areas. The exclusive status of Guangzhou as China's only one trading port persisted until 1842, following the defeat of the Qing government in the Opium War against Britain, the Nanjing Treaty was signed. This treaty opened Guangzhou, Shanghai, Ningbo, Fuzhou, and Xiamen as trading ports, bringing an end to the one port trading system. The reasons and impacts of the establishment of this system have not been comprehensively analyzed to date. Therefore, this paper based on historical archives, analyzes both the direct and underlying reasons behind Emperor Qianlong's decision and elucidates the system's diverse impacts on various aspects of Qing-era China. [ABSTRACT FROM AUTHOR]

Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed with one or more allergic diseases in Guangzhou, the most populated city of southern China, with leading industrial and commercial centers, between April 2021 and March 2022. Seven allergic diseases (allergic rhinitis (AR), asthma (AS)/cough variant asthma (CVA), atopic dermatitis (AD)/eczema, food allergy (FA), allergic conjunctivitis (AC), drug allergy (DA), and anaphylaxis) were assessed. Positive rates of sensitization to different allergens were measured using an allergen detection system of the UniCAP (Pharmacia Diagnostics, Sweden) instrument platform to compare the groups of allergic multimorbidities against a single entity. Results: There were 659 (51.8%) males and 614 (48.2%) females aged from 4 months to 74 years included in the analysis. The study participants who were diagnosed with allergic diseases had an average of 1.6 diagnoses. Overall, 46.5% (592 of 1273) of the patients had more than one allergic condition, and allergic rhinitis was the most common type of multimorbidity. Women were more likely to suffer from an allergic disease alone, whereas allergic multimorbidities were more likely to be diagnosed in men (p = 0.005). In addition, allergic multimorbidities were common in all age groups, with an incidence ranging from 37.1% to 57.4%, in which children and adolescents were more frequently diagnosed with allergic multimorbidities than adults (18–60 years old) (all p < 0.05). Allergic multimorbidity was observed throughout the year. A difference in the positive rate of allergens sensitization and total immunoglobulin E (tIgE) levels between different allergic multimorbidities was observed. Conclusions: Allergic multimorbidities were very commonly found in nearly half of all patients with allergies. The proportion of allergic multimorbidities varied with the type of disease, sex, age, and allergen distribution pattern. These findings may help clinicians to develop "One health" strategies for the clinical management of allergic diseases. [ABSTRACT FROM AUTHOR]

Multiyear inventories of vehicular emissions in Beijing, Shanghai and Guangzhou from 1995 through 2005 have been developed in this paper to study the vehicle emissions trends in China''s mega cities during the past decade. The results show that the vehicular emissions of CO, HC, NO x and PM10 have begun to slow their growth rates and perhaps even to decline in recent years due to the implementation of measures to control vehicular emissions in these cities. However, vehicular CO2 emissions have substantially increased and still continue to grow due to little fuel economy improvement. Passenger cars and large vehicles (including heavy duty trucks and buses) are the major sources of vehicular CO2 and CO emissions while large vehicles were responsible for nearly 70% and 80% of the vehicular NO x and PM10 emissions in these mega cities. Motorcycles are also important contributors to vehicular emissions in Guangzhou and Shanghai. [Copyright &y& Elsevier]