1. Rapid, point-of-care diagnosis of tuberculosis with novel Truenat assay: Cost-effectiveness analysis for India’s public sector.
- Author
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Lee, David J., Kumarasamy, Nagalingeswaran, Resch, Stephen C., Sivaramakrishnan, Gomathi N., Mayer, Kenneth H., Tripathy, Srikanth, Paltiel, A. David, Freedberg, Kenneth A., and Reddy, Krishna P.
- Subjects
HEALTH facilities ,TUBERCULOSIS diagnosis ,PUBLIC sector ,LIFE expectancy ,MULTIDRUG-resistant tuberculosis ,THERAPEUTICS ,POINT-of-care testing - Abstract
Background: Truenat is a novel molecular assay that rapidly detects tuberculosis (TB) and rifampicin-resistance. Due to the portability of its battery-powered testing platform, it may be valuable in peripheral healthcare settings in India. Methods: Using a microsimulation model, we compared four TB diagnostic strategies for HIV-negative adults with presumptive TB: (1) sputum smear microscopy in designated microscopy centers (DMCs) (SSM); (2) Xpert MTB/RIF in DMCs (Xpert); (3) Truenat in DMCs (Truenat DMC); and (4) Truenat for point-of-care testing in primary healthcare facilities (Truenat POC). We projected life expectancy, costs, incremental cost-effectiveness ratios (ICERs), and 5-year budget impact of deploying Truenat POC in India’s public sector. We defined a strategy “cost-effective” if its ICER was
- Published
- 2019
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