1. Relationship between cancer mortality and environmental cadmium exposure in the general Japanese population in cadmium non-polluted areas.
- Author
-
Watanabe, Yuuka, Nogawa, Kazuhiro, Nishijo, Muneko, Sakurai, Masaru, Ishizaki, Masao, Morikawa, Yuko, Kido, Teruhiko, Nakagawa, Hideaki, and Suwazono, Yasushi
- Subjects
- *
ENVIRONMENTAL exposure , *CANCER-related mortality , *CADMIUM poisoning , *CADMIUM , *COMPETING risks , *REGRESSION analysis , *CONFIDENCE intervals , *RELATIVE medical risk , *RESEARCH , *POLLUTANTS , *RESEARCH methodology , *EVALUATION research , *MEDICAL cooperation , *COMPARATIVE studies , *QUESTIONNAIRES , *TUMORS , *ODDS ratio , *CREATININE , *LONGITUDINAL method - Abstract
The aim of the present study was to evaluate the effect of environmental cadmium (Cd) exposure indicated by urinary Cd (U-Cd) on cancer mortality in the general Japanese population. A 19-year cohort study was conducted in 1107 men and 1697 women who lived in three Cd non-polluted areas in Japan. Mortality risk ratio and 95% confidence interval (95%CI) for continuous U-Cd were estimated for all malignant neoplasms and specific cancers using a Fine and Gray competing risks regression model. The all-cause, including cancer and non-cancer mortality rates per 1000 person-years were 29.8 and 13.9 in men and women, respectively. By using Fine and Gray's method, continuous U-Cd adjusted for creatinine (+1 μg/g cre) was significantly related to mortalities for all malignant neoplasms (risk ratio = 1.06, 95%CI: 1.02-1.11) and pancreas (risk ratio = 1.13, 95%CI: 1.03-1.24) in women. In the present study, U-Cd was significantly associated with increased cancer mortality in the general Japanese population, indicating that environmental Cd exposure adversely affects the life prognosis in Cd non-polluted areas in Japan. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF