1. Prior Cocaine Self-Administration Increases Response-Outcome Encoding That Is Divorced from Actions Selected in Dorsal Lateral Striatum.
- Author
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Burton, Amanda C., Bissonette, Gregory B., Zhao, Adam C., Patel, Pooja K., and Roesch, Matthew R.
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DRUG abuse , *LABORATORY rats , *DECISION making , *NEURONS , *NEUROSCIENCES - Abstract
Dorsal lateral striatum (DLS) is a highly associative structure that encodes relationships among environmental stimuli, behavioral responses, and predicted outcomes. DLS is known to be disrupted after chronic drug abuse; however, it remains unclear what neural signals in DLS are altered. Current theory suggests that drug use enhances stimulus-response processing at the expense of response- outcome encoding, but this has mostly been tested in simple behavioral tasks. Here, we investigated what neural correlates in DLS are affected by previous cocaine exposure as rats performed a complex reward-guided decision-making task in which predicted reward value was independently manipulated by changing the delay to or size of reward associated with a response direction across a series of trial blocks. After cocaine self-administration, rats exhibited stronger biases toward higher-value reward and firing in DLS more strongly represented action- outcome contingencies independent from actions subsequently taken rather than outcomes predicted by selected actions (chosen-outcome contingencies) and associations between stimuli and actions (stimulus-response contingencies). These results suggest that cocaine self-administration strengthens action- outcome encoding in rats (as opposed to chosen-outcome or stimulus- response encoding), which abnormally biases behavior toward valued reward when there is a choice between two options during rewardguided decision-making. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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