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A highly efficient, novel, two‐phase liquid method using phase transfer catalyst is reported to prepare β‐lactam‐conjugated silver nanoparticles as an approach to improve antibacterial activity of β‐lactams. In the method assisted by cetyltrimethylammonium bromide, NaBH4 reduced AgNO3 producing silver NPs that are coated with β‐lactams. The studies conducted provide a generalized method applicable to all types of β‐lactam substrates for capping on silver NPs. The NPs have been characterized by UV–Visible, Fourier transform infrared spectroscopy, x‐ray diffraction, transmission electron microscopy, and dynamic light scattering methods. [ABSTRACT FROM AUTHOR]

This document provides information on the synthesis and characterization of novel β-lactam compounds. The authors conducted studies using different starting materials and reaction conditions, and the results are summarized in tables and schemes. The document also includes detailed experimental procedures and characterization data for the synthesized compounds, such as physical properties and spectroscopic data. The information presented can be useful for researchers studying β-lactam compounds and their properties. The authors acknowledge their affiliations and declare no conflicts of interest. Additional characterization spectra can be found in a separate publication. [Extracted from the article]

A novel, facile, highly efficient and stereoselective protocol for the synthesis of cis-3-allyl-3-phenylsulfinyl-β-lactams and 3-allylidene-β-lactams from cis-3-allyl-3-phenylthio-β-lactams using Selectfluor both as an oxidizing agent and as an eliminating agent with temperature as a control parameter over the reaction outcome has been reported. The methodology is able to conquer the earlier reported shortcomings of long reaction time (24–90 hrs.) and lack of control over product ratio. The synthesized compounds will serve as important synthons for compounds of enhanced biological activity and potency. [ABSTRACT FROM AUTHOR]

An operationally simple, highly efficient and stereoselective method for oxidation of trans‐3‐phenylthio‐β‐lactams to trans‐3‐phenylsulfinyl‐β‐lactams is reported. High selectivity and yields were obtained under mild conditions. The probable mechanistic scheme for the formation of oxidized product is proposed. [ABSTRACT FROM AUTHOR]