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Search Results
2. The River of Aural Serenity: selected papers from the 2017 Annual Conference of the National Hearing Conservation Association.
- Author
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Tufts JB and Giguère C
- Subjects
- Hearing Loss epidemiology, Hearing Loss physiopathology, Hearing Loss psychology, Humans, Protective Factors, Risk Factors, Auditory Perception, Hearing, Hearing Loss prevention & control, Preventive Health Services
- Published
- 2018
- Full Text
- View/download PDF
3. Making sound waves: selected papers from the 2016 annual conference of the National Hearing Conservation Association.
- Author
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Murphy WJ and Le Prell CG
- Subjects
- Hearing Loss diagnosis, Hearing Loss epidemiology, Hearing Loss physiopathology, Hearing Tests, Humans, Risk Factors, Audiology methods, Biomedical Research methods, Hearing, Hearing Loss prevention & control
- Published
- 2017
- Full Text
- View/download PDF
4. British Society of Audiology short papers meeting on experimental studies of hearing and deafness. University of Keele, 21-22 September 2000. Abstracts.
- Subjects
- Humans, Deafness, Hearing
- Published
- 2001
- Full Text
- View/download PDF
5. British Society of Audiology Short Papers Meeting on Experimental Studies of Hearing and Deafness. University of Essex, 21-22 September 1999. Abstracts.
- Subjects
- Animals, Humans, Audiology, Hearing, Hearing Disorders
- Published
- 2000
6. British Society of Audiology short papers meeting on experimental studies of hearing and deafness. London, United Kingdom, 15-16 September, 1998. Abstracts.
- Subjects
- Animals, Humans, Hearing, Hearing Disorders
- Published
- 1999
7. British Society of Audiology Short Papers Meeting on Experimental Studies of Hearing and Deafness. Nottingham, 22-23 September 1997. Abstracts.
- Subjects
- Animals, Humans, Audiology, Hearing, Hearing Disorders
- Published
- 1998
8. British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Cambridge, United Kingdom, 22-23 September 1996. Abstracts.
- Subjects
- Animals, Humans, Audiology, Deafness, Hearing
- Published
- 1997
9. British Society of Audiology short papers meeting on experimental studies of hearing and deafness. 22-23 September 1994.
- Subjects
- Animals, Humans, Research, Deafness, Hearing
- Published
- 1995
- Full Text
- View/download PDF
10. Paper Patching Versus Watchful Waiting of Traumatic Tympanic Membrane Perforations: A Meta-Analysis
- Author
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Nidal Muhanna, Ophir Handzel, Liam Simani, Yahav Oron, Omer J Ungar, Rani Abu Eta, Gilad Horowitz, and Anton Warshavsky
- Subjects
Adult ,Male ,Paper ,medicine.medical_specialty ,Tympanic Membrane ,Adolescent ,medicine.medical_treatment ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Hearing ,Healing rate ,Intervention (counseling) ,Medicine ,Humans ,030212 general & internal medicine ,030223 otorhinolaryngology ,Child ,Watchful Waiting ,Tympanic Membrane Perforation ,Aged ,Wound Healing ,business.industry ,Evidence-based medicine ,Recovery of Function ,Middle Aged ,Confidence interval ,Surgery ,Otorhinolaryngology ,Relative risk ,Meta-analysis ,Child, Preschool ,Female ,Tissue Adhesives ,business ,Watchful waiting - Abstract
OBJECTIVES/HYPOTHESIS The aim of the study was to investigate the healing rates, the restoration of hearing, and the time for complete healing of paper patching versus watchful waiting for traumatic tympanic membrane perforations (TTMPs). STUDY DESIGN Systematic review with meta analysis. METHODS Publications were selected by a search on "PubMed," "Embase," and "Web of Science." A meta-analysis of risk ratios for paper patching (intervention arm) and watchful waiting (control arm) was performed. RESULTS Five studies describing 393 TTMPs were included in the quantitative meta-analysis. TTMP healing rates ranged between 84.2% and 95.2% in the intervention arm and between 76.7% and 84.8% in the control arm. The pooled risk ratio of healed TTMPs was significantly higher in the intervention arm than in the control arm (risk ratio: 1.12, 95% confidence interval: 1.04-1.21). CONCLUSIONS TTMPs have high healing potential with and without intervention. The healing rate of paper patching was superior to that of watchful waiting alone. LEVEL OF EVIDENCE NA Laryngoscope, 131:2091-2097, 2021.
- Published
- 2021
11. British Society of Audiology. Short papers meeting on experimental studies of hearing and deafness. Cambridge, 22nd and 23rd September 1988. Abstracts.
- Subjects
- Animals, Humans, Deafness, Hearing physiology
- Published
- 1989
- Full Text
- View/download PDF
12. British Society of Audiology: short papers meeting on experimental studies of hearing and deafness. 9 and 10 July 1985. Abstracts.
- Subjects
- Animals, Humans, Deafness, Hearing
- Published
- 1987
- Full Text
- View/download PDF
13. British Society of Audiology short papers meeting on experimental studies of hearing and deafness, University of Keele, 21-22 March 1983. Abstracts.
- Subjects
- Animals, Humans, Hearing physiology
- Published
- 1983
- Full Text
- View/download PDF
14. References to contemporary papers on acoustics.
- Author
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White FE and Teas DC
- Subjects
- Humans, Acoustics, Bibliographies as Topic, Hearing physiology, Noise
- Abstract
In most of the following references, the author's name is followed by the title of the paper or book in boldface, the journal, the volume number in boldface, the issue number in parentheses, the page reference, and lastly, in parentheses, the year. Where reference is made to abstract journals that number their abstracts, the abstract number is given instead of a page reference. Abstracts in Annales des Tèlècommunications are in French and those for Referativnyi Zhurnal, Fizika (three series, E, I, Zh) are in Russian [where, e.g., Ref. Zh. Fiz. 7 E425 (1979) means: July issue, E, abstract no. 425, year 1979.] When possible, the abbreviations for the names of the journals follow those in Bibliographic Guide for Editors & Authors (1974). A number preceded by the letters AD, DE, PB, or N refers to the accession/report number of the Government Reports Announcements & Index. The numbers to the left of the sections and sub-sections in this volume correspond to those that appear in the Classification of Subjects preceding the index in the June 1983 issue of JASA. Compiled from various sources. For many of the journals referred to here, those interested will find their addresses in either the semi-annual Author Index of Physics Abstracts or the annual Physics Briefs: List of Abstracted Periodical and Serial Publications.
- Published
- 1983
15. British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Brighton, 30 September-1 October 1986. Abstracts.
- Subjects
- Animals, Cochlea anatomy & histology, Cochlea physiology, Deafness, Hearing
- Published
- 1987
- Full Text
- View/download PDF
16. Does glutaric aciduria type 1 affect hearing function?
- Author
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Özgedi K DD, Tokgöz Yılmaz S, Gürbüz BB, Si Vri HS, and Sennaroğlu G
- Subjects
- Amino Acid Metabolism, Inborn Errors, Audiometry, Pure-Tone methods, Auditory Threshold physiology, Brain Diseases, Metabolic, Glutaryl-CoA Dehydrogenase deficiency, Humans, Hearing physiology, Hearing Loss diagnosis
- Abstract
This study aimed to evaluate audiological findings among patients with glutaric aciduria type 1 (GA-1). We used a large test battery for the audiological evaluation of 17 individuals with GA-1 (the study group) and 20 healthy individuals (the control group). Conventional audiometry (0.125-8 kHz), distortion product otoacoustic emissions (DPOAEs) (1, 1.5, 2, 3, 4, 6, and 8 kHz), contralateral suppression of otoacoustic emissions, and auditory brainstem response (ABR) ( 30, 50, 70 and 90 dB nHL) were measured for all participants (n = 37). Mild sensorineural hearing loss was found in 77.47% (n = 13) of the patients with GA-1, and normal hearing thresholds were seen in 23.53% (n = 4). There were three asymptomatic patients at the time of diagnosis [two developed mild mental motor retardation (MMR) and one developed severe MMR during the follow-up], one with a normal hearing threshold and two with mild hearing loss), and 14 symptomatic patients (three with normal hearing thresholds and 11 with mild hearing loss). Seven of the symptomatic patients diagnosed following an encephalopathic crisis required intensive care and showed significantly worse hearing thresholds than those without symptoms [20.86 ± 4.47 vs. 15.44 ± 3.96 decibel hearing level (dB HL), p = 0.039*], while five had mild-to-moderate hearing loss. Acute encephalopathic crisis had a negative effect on hearing function in the symptomatic patients. The emission and contralateral suppression amplitude values of the study group were significantly lower compared to the control group (p < 0.05). The I-V interpeak latency and absolute latencies of ABR waves I, III, and V of the study group were observed to be significantly prolonged and morphologically distorted compared to those of the control group (p < 0.05). Five patients had MMR, and three had moderate MMR; all eight had mild-to-moderate hearing loss. In addition, of the eight patients with mild MMR, four had mild hearing loss. In particular, the morphological findings of ABR waves were significantly worse in the patients with severe and moderate MMR (p < 0.05). There was a significant correlation between a macrocephaly history (12 patients) and hearing loss (p = 0.041*). Magnetic resonance imaging findings were evaluated in all the 17 patients with GA-1, and typical fronto-temporal atrophy and sylvian fissure enlargement were observed. Our findings support that GA-1 is associated with auditory impairment, primarily in symptomatic patients. Adequate audiological test battery evaluation is essential in this context, particularly for symptomatic patients with a history of encephalopathic crises., (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2022
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17. The effectiveness of repairment of traumatic tympanic membrane perforations with cigarette paper.
- Author
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Akkoca, Özlem, Kaytez, Selda Kargın, Kaptan, Zeynep, and Özdemir, Coşkun
- Subjects
EAR surgery ,HEARING ,ACQUISITION of data methodology ,TYMPANIC membrane perforation ,RETROSPECTIVE studies ,TREATMENT effectiveness ,PRE-tests & post-tests ,MEDICAL records ,AUDIOMETRY ,DESCRIPTIVE statistics ,EVALUATION - Abstract
Copyright of Turkish Journal of Trauma & Emergency Surgery / Ulusal Travma ve Acil Cerrahi Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2022
- Full Text
- View/download PDF
18. Using Rasch Analysis to Assess and Improve the Measurement Properties of a Questionnaire With Few Items: The York Binaural Hearing-Related Quality of Life (YBHRQL) Questionnaire.
- Author
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Summerfield AQ and Kitterick PT
- Subjects
- Humans, Reproducibility of Results, Treatment Outcome, Surveys and Questionnaires, Psychometrics methods, Quality of Life, Hearing
- Abstract
Objectives: The York Binaural Hearing-Related Quality of Life questionnaire is a condition-specific preference-based instrument sensitive to advantages of binaural over monaural hearing. Respondents use 5-point scales to report the difficulty experienced with three dimensions of listening that are easier or more successful when hearing is binaural: understanding speech in spatially separated noise, localizing sources of sound in azimuth, and the associated effort and fatigue. Previously, a preference value was estimated for each combination of dimension and level so that a value of binaural utility could be assigned to a respondent to inform analyses of cost effectiveness. The present objective was to determine whether the questionnaire conforms with the Rasch model sufficiently well for estimates of the binaural abilities of respondents to be obtained on an interval scale to inform parametric analyses of clinical effectiveness., Design: Data were obtained from unilateral cochlear implantees (N = 418; 209 ≤62 years; 209 ≥63 years) and members of the public (N = 325; 207 ≤62 years; 118 ≥63 years). A subset of implantees (N = 118) responded at test and retest. Responses were fitted to the partial credit model using the Extended Rasch Modeling package. Conformity with the model was evaluated in six ways: the ordering of response categories ( Monotonicity ) was assessed with plots of response probability against ability; differential item functioning ( DIF ) was assessed by analyses of variance of standardized response residuals; alignment of participants' abilities with item difficulties ( Targeting ) was assessed with person-item maps; fit to the model ( Fit ) was assessed by comparing the means and variabilities of observed and expected responses, and by comparing observed values with analyses of simulated datasets; the hypothesis that item difficulties and participants' abilities were measured on a single underlying scale ( Unidimensionality ) was assessed with principal components analyses of standardized response residuals., Results: Values of fit statistics were toward the lower end of the acceptable range. Comparisons with analyses of simulated datasets showed that low values were primarily the result of the structural limitation of including only three items. Modal values of the probabilities of response categories were ordered monotonically, but some response thresholds were disordered because of under-use of one category. Pooling categories to correct disordered thresholds resulted in estimates of ability that were less discriminatory of differences within and between groups, and showed less reproducibility between test and retest, than did the original estimates. Neither source-related DIF nor gender-related DIF arose. Uniform age-related DIF arose for the speech-in-noise item and could be managed by resolving the item. The resulting estimates of ability and difficulty were well targeted and unidimensional., Conclusions: The York Binaural Hearing-Related Quality of Life questionnaire, with three items each with five response categories, conforms with the Rasch model sufficiently well to yield practically useful measures of the abilities of participants. The trait measured by the questionnaire aligns with the ability to benefit from binaural hearing. More discriminatory measurement of this ability would be achieved with more items. Nonetheless, the questionnaire possesses the virtue that responses to the same three questions can be scored in different ways to inform parametric analyses of both cost-effectiveness and clinical effectiveness., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
- Full Text
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19. COMPARISON OF ELECTRONIC AND PAPER AND PENCIL ADMINISTRATION OF THE PARENTING STRESS INDEX - SHORT FORM (PSI-SF).
- Author
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Aiello, Camila Piccini, da Silva, Ana Pietra, and Ferrari, Deborah Viviane
- Abstract
Copyright of Revista CEFAC is the property of Revista CEFAC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2014
- Full Text
- View/download PDF
20. Hearing water temperature: Characterizing the development of nuanced perception of sound sources.
- Author
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Agrawal T and Schachner A
- Subjects
- Adult, Humans, Child, Adolescent, Child, Preschool, Temperature, Acoustic Stimulation methods, Sound, Auditory Perception, Hearing
- Abstract
Without conscious thought, listeners link events in the world to sounds they hear. We study one surprising example: Adults can judge the temperature of water simply from hearing it being poured. We test the development of the ability to hear water temperature, with the goal of informing developmental theories regarding the origins and cognitive bases of nuanced sound source judgments. We first confirmed that adults accurately distinguished the sounds of hot and cold water (pre-registered Experiments. 1, 2; total N = 384), even though many were unaware or uncertain of this ability. By contrast, children showed protracted development of this skill over the course of middle childhood (Experiments. 2, 3; total N = 178). In spite of accurately identifying other sounds and hot/cold images, older children (7-11 years) but not younger children (3-6 years) reliably distinguished the sounds of hot and cold water. Accuracy increased with age; 11-year old's performance was similar to adults. Adults also showed individual differences in accuracy that were predicted by their amount of prior relevant experience (Experiment 1). Experience may similarly play a role in children's performance; differences in auditory sensitivity and multimodal integration may also contribute to young children's failures. The ability to hear water temperature develops slowly over childhood, such that nuanced auditory information that is easily and quickly accessible to adults is not available to guide young children's behavior. HIGHLIGHTS: Adults can make nuanced judgments from sound, including accurately judging the temperature of water from the sound of it being poured. Children showed protracted development of this skill over the course of middle childhood, such that 7-11-year-olds reliably succeeded while 3-6-year-olds performed at chance. Developmental changes may be due to experience (adults with greater relevant experience showed higher accuracy) and the development of multimodal integration and auditory sensitivity. Young children may not detect subtle auditory information that adults easily perceive., (© 2022 John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
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21. Application of Rasch Analysis to the Evaluation of the Measurement Properties of the Hearing Handicap Inventory for the Elderly.
- Author
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Heffernan E, Weinstein BE, and Ferguson MA
- Subjects
- Aged, Humans, Psychometrics, Reproducibility of Results, Surveys and Questionnaires, United Kingdom, Hearing, Quality of Life
- Abstract
Objectives: The aim of this research was to evaluate the measurement properties of the Hearing Handicap Inventory for the Elderly (HHIE). The HHIE is one of the most widely used patient-reported outcome measures in audiology. It was originally developed in the United States in the 1980s as a measure of the social and emotional impact of hearing loss in older adults. It contains 25 items that are accompanied by a 3-point response scale. To date, the measurement properties of the HHIE have primarily been assessed via traditional psychometric analysis techniques (e.g., Cronbach's alpha and Principal Components Analysis). However, traditional techniques are now known to have several limitations in comparison to more modern approaches. Therefore, this research used a modern psychometric analysis technique, namely Rasch analysis, to evaluate the HHIE., Design: Rasch analysis was performed on HHIE data collected from 380 adults with hearing loss. The participants were principally recruited from the participant database of the National Institute for Health Research Nottingham Biomedical Research Centre in the United Kingdom. Additional participants were recruited from two UK audiology clinics and the online forum of a UK hearing loss charity. Rasch analysis was used to assess the measurement properties of the HHIE (i.e., fit to the Rasch model, unidimensionality, targeting, and person separation reliability) and its individual items (i.e., response dependency, fit, Differential Item Functioning, and threshold ordering)., Results: The HHIE was found to have several strong measurement properties. Specifically, it was well-targeted and had high person separation reliability. However, it displayed poor fit to the Rasch model and was not unidimensional. The majority of the items were free of response dependency (i.e., redundancy) and were suited to the 3-point response scale. However, two items were found to be better suited to a dichotomous response scale. Furthermore, nine items were identified as being candidates for removal from the questionnaire, as they exhibited poor fit and/or Differential Item Functioning (i.e., item bias) associated with gender. The measurement properties of the HHIE could be improved by removing these items and adjusting the scores of the two items that require a dichotomous response scale. These amendments resulted in a 16-item version of the HHIE that had good fit to the Rasch model and that was unidimensional., Conclusions: It is vital to ensure that high-quality outcome measures are used in audiology research and practice. This study evaluated one of the foremost outcome measures in this field: the HHIE. The results demonstrated that the HHIE had several strong measurement properties. Amending the HHIE, such as by removing items exhibiting poor fit, could further enhance its quality. A unique aspect of this study was the application of Rasch analysis to the evaluation of the HHIE. It is recommended that future studies use modern techniques to develop and identify high-quality, hearing-specific outcome measures.
- Published
- 2020
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22. Introduction to the special issue:Select papers from the hearing across the lifespan (HEAL) 2018 conference
- Author
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Sophia E. Kramer, Ferdinando Grandori, Gabriella Tognola, Larry E. Humes, Otolaryngology / Head & Neck Surgery, APH - Quality of Care, and APH - Aging & Later Life
- Subjects
Speech and Hearing ,medicine.medical_specialty ,Medical education ,Hearing ,Longevity ,MEDLINE ,medicine ,Humans ,Audiology ,Periodicals as Topic ,Psychology - Abstract
[Figure: see text].
- Published
- 2019
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23. Studying the Relation Between Stakeholder Input and Higher Education Policy.
- Author
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Lackner, Elisabeth Josefine
- Subjects
EDUCATION policy ,STAKEHOLDERS ,POLITICAL communication ,EDUCATIONAL quality ,EDUCATIONAL planning - Abstract
This study describes a key feature of modern, democratic policy making, namely the relation between stakeholder input and policy output. In the Nordic countries, there are long traditions for and democratic values attached to the dialogue between the government and civil society when developing policies for the educational sector. The case presented here is the hearing process held by the Norwegian Ministry of Education and Research in 2017 prior to the launch of a white paper on quality culture in higher education. The potential coherence between input by stakeholder groups and the quality measures proposed in the white paper is investigated. The theoretical framework comprises the concept of 'uploading' borrowed from research on EU policy making and discursive institutionalism to analyse the representation of input by stakeholder groups when they attempt to 'upload' their priorities into the white paper. The methodological approach is content analysis of the hearing responses and the white paper. The findings show that stakeholders from the higher education sector and employer groups had a higher degree of coherence with the proposed measures in the white paper, and universities and colleges had a lower degree of input that was represented. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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24. [Infrasound - implications for human medicine].
- Author
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Vahl JM, Keppeler JVA, Krahe D, Bahrke-Rein K, Reiter R, Hoffmann TK, and Goldberg-Bockhorn E
- Subjects
- Humans, Sound, Hearing
- Abstract
Infrasound describes ubiquitous, low-frequency sound (< 20 Hz) in the environment with a long wavelength below the median hearing threshold, which can nevertheless be heard and tactilely perceived, depending on the sound pressure level and frequency spectrum. In nature, infrasound emissions usually occur only in the low-threshold range. Nevertheless, after strong and chronic exposure to usually artificially generated infrasound emissions, various effects on the ear and the body, sometimes questionably critical to health, can be observed. Correct measurement and assessment of infrasound sources is complex and controversial. Established guidelines are scarce. Innovative research areas include infrasound monitoring for evaluation of natural events and infrasound applications in medicine. In the future, it is hoped that new insights will be gained from infrasound research and that a more extensive classification in occupational medicine will be possible., (© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)
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- 2022
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25. The extra ear (or an ear on an arm) [Paper in: The 'Improved' Body: Animals and Humans, Britton, Stephanie (ed.).]
- Author
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Stelarc
- Published
- 2002
26. Journal of Speech Language and Hearing research with select papers from the 10th international seminar on speech production (ISSP) in Cologne
- Author
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Fuchs, S., Lancia, Leonardo, LPP - Laboratoire de Phonétique et Phonologie - UMR 7018 (LPP), Université Sorbonne Nouvelle - Paris 3-Centre National de la Recherche Scientifique (CNRS), and Fuchs S. & Lancia L.
- Subjects
Hearing ,[SHS.LANGUE]Humanities and Social Sciences/Linguistics ,ComputingMilieux_MISCELLANEOUS ,Language - Abstract
International audience
- Published
- 2016
27. Guest Editorial: Hearing Care for All-An Opportunity to Globally Unite to Address Inequities in Hearing Health.
- Author
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McMahon CM
- Subjects
- Humans, Hearing, Hearing Tests
- Abstract
Competing Interests: The author has no conflicts of interest to disclose.
- Published
- 2021
- Full Text
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28. British Society of Audiology Short Papers Meeting on Experimental Studies of Hearing and Deafness: Abstracts.
- Author
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Palmer, A. R., Rosen, S., and Furness, D.
- Subjects
- *
RESEARCH , *HEARING , *DEAFNESS , *BIOLOGICAL transport , *CHOLINERGIC receptors , *CELL communication , *INNER ear - Abstract
Presents abstracts of research papers on hearing and deafness. "Ion Transport by Prestin in the Outer Hair Cell Membrane," by I. Harding and J. F. Ashmore; "Current-Voltage Characteristics of the Acetylcholine Receptor in Outer Hair Cells," by M. G. Evans; "Intercellular Communication in the Inner Ear Examined by Fluorescence Recovery After Photobleaching," by R. Nickel, D. Becker and Andrew Forge.
- Published
- 2003
- Full Text
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29. Paper-patch myringoplasty with CO2 laser for chronic TM perforation
- Author
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Sung Min Jin, Myung Gu Kim, Sang Hyuk Lee, and Kyung Chul Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Myringoplasty ,Young Adult ,Hearing ,medicine ,Humans ,Local anesthesia ,Severe complication ,Tympanic Membrane Perforation ,Aged ,Retrospective Studies ,Co2 laser ,business.industry ,Significant difference ,Tympan ,General Medicine ,Middle Aged ,Surgery ,Treatment Outcome ,Otorhinolaryngology ,Chronic Disease ,Lasers, Gas ,Audiometry, Pure-Tone ,Female ,Laser Therapy ,business ,Follow-Up Studies - Abstract
Chronic tympanic membrane (TM) perforations are a common problem in otolaryngology. However, there are controversies of how best to treat TM perforation. Recently, we successfully managed TM perforation with paper patch after trimming the perforated TM margin with the CO2 laser. The purpose of this report is to demonstrate the trial of this method and effectiveness. The authors conducted a retrospective case series from March 2000 to January 2005. Ninety patients underwent paper-patch myringoplasty with the CO2 laser. The procedure was performed in an office setting under local anesthesia. We investigated perforation size and postoperative success rate. Successful closure of the TM was achieved in 52.2% of cases (47/90) without any severe complication. The procedure was successful in 16 of 19 (84.2%) cases in perforation smaller than 2 mm, 19 of 29 (63.0%) cases when the size was 2-4 mm, 10 of 25 (40.0%) cases when the size was 4-6 mm, and 2 of 17 (11.8%) cases when the size wasor =6 mm. A significant difference was found: Perforation with4 mm had the higher closure rate (chi2 test, P0.01). There was no correlation between the size of perforation and the number of patch graft (chi2 test, P0.05). The results showed paper-patch myringoplasty after CO2 laser trimming is simple and safe to perform, and suitable as an outpatient procedure, especially in small perforations (4 mm).
- Published
- 2007
30. Serotonin distribution in the brain of the plainfin midshipman: Substrates for vocal-acoustic modulation and a reevaluation of the serotonergic system in teleost fishes.
- Author
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Timothy M and Forlano PM
- Subjects
- Acoustics, Animals, Brain physiology, Brain Mapping, Immunohistochemistry, Auditory Pathways physiology, Batrachoidiformes anatomy & histology, Batrachoidiformes physiology, Hearing physiology, Neural Pathways physiology, Serotonergic Neurons physiology, Serotonin physiology, Vocalization, Animal physiology
- Abstract
Serotonin (5-HT) is a modulator of neural circuitry underlying motor patterning, homeostatic control, and social behavior. While previous studies have described 5-HT distribution in various teleosts, serotonergic raphe subgroups in fish are not well defined and therefore remain problematic for cross-species comparisons. Here we used the plainfin midshipman fish, Porichthys notatus, a well-studied model for investigating the neural and hormonal mechanisms of vertebrate vocal-acoustic communication, to redefine raphe subgroups based on both stringent neuroanatomical landmarks as well as quantitative cell measurements. In addition, we comprehensively characterized 5-HT-immunoreactive (-ir) innervation throughout the brain, including well-delineated vocal and auditory nuclei. We report neuroanatomical heterogeneity in populations of the serotonergic raphe nuclei of the brainstem reticular formation, with three discrete subregions in the superior raphe, an intermediate 5-HT-ir cell cluster, and an extensive inferior raphe population. 5-HT-ir neurons were also observed within the vocal motor nucleus (VMN), forming putative contacts on those cells. In addition, three major 5-HT-ir cell groups were identified in the hypothalamus and one group in the pretectum. Significant 5-HT-ir innervation was found in components of the vocal pattern generator and cranial motor nuclei. All vocal midbrain nuclei showed considerable 5-HT-ir innervation, as did thalamic and hindbrain auditory and lateral line areas and vocal-acoustic integration sites in the preoptic area and ventral telencephalon. This comprehensive atlas offers new insights into the organization of 5-HT nuclei in teleosts and provides neuroanatomical evidence for serotonin as a modulator of vocal-acoustic circuitry and behavior in midshipman fish, consistent with findings in vocal tetrapods., (© 2020 Wiley Periodicals LLC.)
- Published
- 2020
- Full Text
- View/download PDF
31. Frameworks for Change in Hearing Research: Valuing Qualitative Methods in the Real World.
- Author
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Rapport F and Hughes SE
- Subjects
- Humans, Qualitative Research, Health Personnel, Hearing
- Abstract
In this article, we examine ecological validity in hearing science from a qualitative methodological perspective. We present an overview of qualitative methods, presenting their key characteristics and contrasting these techniques with quantitative approaches to enquiry. We argue that ecological validity sits at the heart of the qualitative paradigm and seek to clearly emphasize the methodological gap that could be effectively filled by qualitative or mixed methods. In doing so, we discuss qualitative methods that may work particularly well in enhancing ecological validity in hearing science and explore their range of applications in this field. These approaches can be applied to a wide range of hearing health research questions to present a unique understanding of people's experiences of disease and disability, indicating gradations of personal health and illness in nuanced ways. We acknowledge and commend the current expansion of qualitative methods within hearing science and present recommendations for increasing ecological validity, both in the design of future studies and in the context of the wider research cycle. We call on qualitative researchers to strive for transparency, rigor, and trustworthiness and highlight challenges to be overcome if qualitative methods are to contribute to effective, efficient research strategies. To facilitate the transference of high-quality research findings into practice, we stress the need for joined-up working to create a research culture that promotes coproduction of ecologically valid research designs, involving not only hearing researchers but also implementation scientists, hearing healthcare professionals and, most importantly, people with hearing loss for whom these efforts could make a difference.
- Published
- 2020
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32. Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes.
- Author
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Perrino PA, Talbot L, Kirkland R, Hill A, Rendall AR, Mountford HS, Taylor J, Buscarello AN, Lahiri N, Saggar A, Fitch RH, and Newbury DF
- Subjects
- Age Factors, Animals, Auditory Perceptual Disorders physiopathology, Auditory Perceptual Disorders psychology, Child, Child, Preschool, Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Genome-Wide Association Study, Hearing Disorders physiopathology, Hearing Disorders psychology, Heterozygote, Humans, Language Development Disorders physiopathology, Language Development Disorders psychology, Longitudinal Studies, Male, Mice, 129 Strain, Mice, Knockout, Phenotype, Risk Assessment, Risk Factors, United Kingdom, Vocalization, Animal, Whole Genome Sequencing, Auditory Perception genetics, Auditory Perceptual Disorders genetics, Child Language, Extracellular Matrix Proteins genetics, Hearing genetics, Hearing Disorders genetics, Language Development Disorders genetics, Polymorphism, Single Nucleotide
- Abstract
Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language. In this paper, we consider the relationship between genetic variants, hearing, auditory processing and language development. We employ whole genome sequencing in a discovery family to target association and gene x environment interaction analyses in two large population cohorts; the Avon Longitudinal Study of Parents and Children (ALSPAC) and UK10K. These investigations indicate that USH2A variants are associated with altered low-frequency sound perception which, in turn, increases the risk of developmental language disorder. We further show that Ush2a heterozygote mice have low-level hearing impairments, persistent higher-order acoustic processing deficits and altered vocalizations. These findings provide new insights into the complexity of genetic mechanisms serving language development and disorders and the relationships between developmental auditory and neural systems.
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- 2020
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33. Mozart or pop music? Effects of background music on wine consumers
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De Luca, Modesto, Campo, Raffaele, and Lee, Rosalind
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- 2019
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34. Relationship Between Chloroquine or Hydroxychloroquine Use and Hearing Disorders: A Systematic Review and Meta-Analysis.
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Renata José, Maria, da Silva Ortega, Jéssica, Correia Baran, Jordana Batista, Lüders, Débora, de Oliveira Gonçalves, Claudia Giglio, Simone Zeigelboim, Bianca, Meira Taveira, Karinna Veríssimo, Fernando Polanski, José, Sampaio Santos, Rosane, de Castro Corrêa, Camila, and Miranda de Araujo, Cristiano
- Subjects
HEARING disorders ,CHLOROQUINE ,HYDROXYCHLOROQUINE ,CLINICAL trials ,AUDITORY pathways - Abstract
Background and Objectives: Chloroquine and its analog hydroxychloroquine are derivatives of 4-aminoquinoline and are regularly used in the treatment of malaria and autoimmune diseases. Among the side effects of these drugs, alterations associated with the auditory system are frequently mentioned. Thus, the aim of this systematic review is to systematically review publications on hearing disorders and chloroquine or hydroxychloroquine use. Materials and Methods: Inclusion criteria were observational or interventional studies on audiological assessment in participants who were using chloroquine or hydroxychloroquine. The methodological quality was independently assessed by two reviewers using the Meta-Analysis of Statistics: assessment and review Instrument. The certainty of the evidence was assessed using the GRADE tool. Results: A total of 1,372 non-duplicate papers were screened, out of which 17 were included in the final qualitative synthesis, and 5 studies in the meta-analysis. The odds ratio for the two subgroups evaluated did not show significance with no heterogeneity between the effects observed between the different diseases (I²=0%) and obtaining the global estimate of 0.76 (95% confidence interval [CI]=0.41-1.39; p>0.05). Despite the inclusion of papers with different disease samples, the heterogeneity observed in the analysis was low (I²= 0%) and prediction interval (95% PI=0.32-1.80; p>0.05) remained close to that estimated by the CI (95% CI=0.41-1.39; p>0.05). The certainty of the evidence assessed by the GRADE tool was considered very low due to the risk of bias, indirect evidence, and imprecision. Conclusions: The findings of this study suggest that the use of chloroquine/hydroxychloroquine is not associated with hearing disorders. [ABSTRACT FROM AUTHOR]
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- 2024
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35. Happy ears for many years: selected papers from the 2018 Annual Conference of the National Hearing Conservation Association.
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Casali, John G. and Murphy, William J.
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- *
NOISE control , *CONFERENCES & conventions , *AUDITORY perception , *COCHLEA , *DIAGNOSIS , *FIREARMS , *HEARING , *MEDICAL societies , *NOISE , *OTOACOUSTIC emissions , *RADIATION dosimetry , *PRODUCT design , *HEARING protection - Abstract
An introduction to the journal is presented which discusses topics within the issue including various aspects of small caliber firearm noise exposures, firearm noise that is not typically experienced by persons using firearms at a target range or when hunting, and noise exposure risks.
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- 2019
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36. Remodelling the corporate visual identity construct : A reference to the sensory and auditory dimension
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Bartholmé, Roland H. and Melewar, T. C.
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- 2011
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37. Incorporating Patient Narratives to Enhance Audiological Care and Clinical Research Outcomes
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Khaya D. Clark, Angela C. Garinis, and Dawn Konrad-Martin
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Care process ,medicine.medical_specialty ,Quality management ,Special Issue: Selected Papers From the 9th Biennial National Center for Rehabilitative Auditory Research Conference ,Patient narratives ,Translational research ,Audiology ,Speech and Hearing ,Clinical research ,Hearing ,Nursing ,Component (UML) ,Key (cryptography) ,medicine ,Humans ,Correction of Hearing Impairment ,Prospective Studies ,Clinical care ,Hearing Loss ,Psychology - Abstract
Purpose The engagement of patients as key stakeholders in their experience of care processes is a critical component of quality improvement efforts for both clinical care and translational research. Increasingly, health care systems are soliciting input from patients on care processes and experiences through surveys, patient interviews, and patient video narratives. The purpose of this viewpoint article is twofold: (a) to describe the increasing role of patient narratives about their experiences with adverse health conditions to inform patient-centered research and quality improvement efforts and (b) to present three patient narratives that highlight the real-world impacts of hearing loss and tinnitus, the life enhancing impacts of aural rehabilitation, and the importance of prospective ototoxicity monitoring in individuals with complex health conditions. Conclusion Patient narratives provide individual patient perspectives that can be used to build awareness of the range of experiences and impact of hearing disorders, and to explore patient preferences for when and how to implement hearing-related clinical services.
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- 2021
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38. Comment on paper entitled, “An inversion of Freedman’s ‘image pulse’ model in air” [J. Acoust. Soc. Am. 119(2), 965–975 (2006)].
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Hickling, Robert and Gaunaurd, Guillermo C.
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- *
ECHOLOCATION (Physiology) , *UNDERWATER acoustics , *BACKSCATTERING , *HEARING , *SOUND - Abstract
Echolocation (i.e., perceiving objects using acoustic echoes) is well-known in underwater detection and to a lesser extent in robot guidance and machine perception. The paper by Tsakiris and McKerrow is concerned with machine perception in air using Freedman’s asymptotic model, which was originally developed to predict the backscattering multiple-echo effect observed in sonar detection. This effect was subsequently shown to be due to the elastic response of underwater targets. Freedman’s model can be used in air because the acoustic target is assumed to be rigid. Also, the model’s prediction of multiple echoes can be used to obtain information about the shape of the target. This is the so-called inversion of the Freedman model by Tsakiris and McKerrow. In their paper, various simple bodies are tested in air using ultrasound and it is shown that the model provides relatively poor information about body shape. Several explanations are given. However, one explanation is not considered, namely that the model itself is not satisfactory. First, there is poor agreement with exact backscattering theory. Second, deriving information about target shape from the multiple echoes predicted by the model is a highly questionable procedure. Both these aspects are examined here. [ABSTRACT FROM AUTHOR]
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- 2006
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39. Cooling the Cochlea: Slowing Down Metabolism May Be a Way of Protecting Hearing from Surgical Trauma.
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Bell, Andrew and Jedrzejczak, W. Wiktor
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INDUCED hypothermia ,CARDIOPULMONARY bypass ,NOISE-induced deafness ,COCHLEA ,LITERATURE reviews ,HYPOTHERMIA ,COCHLEAR implants - Abstract
Background and Objectives: This narrative review of the literature explores the effect of body temperature on hearing. In particular, its focus is on extended high frequency (EHF) hearing—the range beyond the standard audiometric limit of 8 kHz. Such high frequencies are the first to be affected by noise-induced hearing loss, and so monitoring them can provide an early warning sign of incipient damage. Materials and Methods: This review builds on a personal literature database of 216 references covering the general topic of EHF hearing; the procedure was to then identify papers related to whole-body or cochlear cooling. A starting point was the paper by Munjal et al. who in 2013 reported changes of up to 15–30 dB in the EHF thresholds of subjects who had undergone cardiopulmonary bypass (CBP) surgery, which typically involves mild to moderate hypothermia—cooling of the blood—to reduce cellular oxygen demand and minimise tissue damage. Results: Reviewing the surrounding literature, we find that although CBP surgery by itself can impair hearing thresholds, lower body and cochlear temperatures in general provide neuroprotective effects. A connection between hearing loss and CBP surgery has been periodically documented, but the mechanism behind it has yet to be conclusively identified. Conclusions: The observations reviewed here tend to confirm the otoprotective effects of cooling. We consider that the high sensitivity of EHF thresholds to temperature is a major factor that has not been sufficiently recognised, although it has important implications for otological research and practice. Two important inferences are that, first, monitoring EHF thresholds might have considerable value in audiology, and, second, that lowering temperature of the cochlea during cochlear implantation might provide substantially better hearing preservation, as some researchers have already suggested. [ABSTRACT FROM AUTHOR]
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- 2023
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40. In-air hearing in Hawaiian monk seals: implications for understanding the auditory biology of Monachinae seals
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Ruscher, Brandi, Sills, Jillian M., Richter, Beau P., and Reichmuth, Colleen
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Male ,0106 biological sciences ,Audiogram ,medicine.medical_specialty ,Life on Land ,Seals, Earless ,Physiology ,Hawaiian monk seal ,Audiology ,Medical and Health Sciences ,010603 evolutionary biology ,01 natural sciences ,Hawaii ,Behavioral Neuroscience ,Hearing ,otorhinolaryngologic diseases ,Elephant seal ,medicine ,Phocid ,Animals ,Neomonachus schauinslandi ,Auditory anatomy ,Ecology, Evolution, Behavior and Systematics ,Original Paper ,Hearing ability ,Seals ,Neurology & Neurosurgery ,biology ,Endangered ,010604 marine biology & hydrobiology ,Ear ,Auditory Threshold ,Biological Sciences ,Critical ratio ,biology.organism_classification ,Mirounga angustirostris ,Hearing range ,Earless ,Animal Science and Zoology - Abstract
The auditory biology of Monachinae seals is poorly understood. Limited audiometric data and certain anatomical features suggest that these seals may have reduced sensitivity to airborne sounds compared to related species. Here, we describe the in-air hearing abilities of a Hawaiian monk seal (Neomonachus schauinslandi) trained to participate in a psychophysical paradigm. We report absolute (unmasked) thresholds for narrowband signals measured in quiet conditions across the range of hearing and masked thresholds measured in the presence of octave-band noise at two frequencies. The behavioral audiogram indicates a functional hearing range from 0.1 to 33 kHz and poor sensitivity, with detection thresholds above 40 dB re 20 µPa. Critical ratio measurements are elevated compared to those of other seals. The apparently reduced terrestrial hearing ability of this individual—considered with available auditory data for a northern elephant seal (Mirounga angustirostris)—suggests that hearing in Monachinae seals differs from that of the highly sensitive Phocinae seals. Exploration of phylogenetic relationships and anatomical traits support this claim. This work advances understanding of the evolution of hearing in amphibious marine mammals and provides updated information that can be used for management and conservation of endangered Hawaiian monk seals. Supplementary Information The online version contains supplementary material available at 10.1007/s00359-021-01498-y.
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- 2021
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41. Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys
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Zhuoer Sun, Yong Tao, Neng Gong, Hao Wu, Zhenzhe Cheng, Chenxi Jin, and Zhen Xu
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Aging ,medicine.medical_specialty ,Hearing loss ,Population ,Presbycusis ,non-human primate ,Neural degeneration ,Biology ,Audiology ,Hearing ,deafness ,biology.animal ,Hair Cells, Auditory ,Evoked Potentials, Auditory, Brain Stem ,otorhinolaryngologic diseases ,medicine ,Animals ,Auditory system ,neural degeneration ,education ,Spiral ganglion ,education.field_of_study ,medicine.diagnostic_test ,Marmoset ,Cell Biology ,medicine.disease ,Macaca mulatta ,age-related hearing loss ,medicine.anatomical_structure ,Nerve Degeneration ,sense organs ,medicine.symptom ,Audiometry ,Spiral Ganglion ,Research Paper - Abstract
The aging of the population and environmental noise have contributed to high rates of presbycusis, also known as age-related hearing loss (ARHL). Because mice have a relatively short life span, murine models have not been suitable for determining the mechanism of presbycusis development and methods of diagnosis. Although the common marmoset, a non-human primate (NHP), is an ideal animal model for studying age-related diseases, its auditory spectrum has not been systematically studied. Auditory brainstem responses (ABRs) from 38 marmosets of different ages demonstrated that auditory function correlated with age. Hearing loss in geriatric common marmosets started at ultra-high frequency (>16 kHz), then extended to lower frequencies. Despite age-related deterioration of ABR threshold and amplitude in marmosets, outer hair cell (OHC) function remained stable at all ages. Spiral ganglion neurons (SGNs), which are the first auditory neurons in the auditory system, were found to degenerate distinctly in aged common marmosets, indicating that neural degeneration caused presbycusis in these animals. Similarly, age-associated ABR deterioration without loss of OHC function was observed in another NHP, rhesus monkeys. Audiometry results from these two species of NHP suggested that NHPs were ideal for studying ARHL and that neural presbycusis at high frequency may be prevalent in primates.
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- 2021
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42. A study on stress and resilience among hearing-impaired people during the COVID-19 pandemic
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Hilal Mecit, Betul Kagitcibasi, Fahrettin Deniz Senli, Şule Kaya, Mustafa Karabulut, KNO, and RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience
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acute stress ,Cross-sectional study ,Turkish ,media_common.quotation_subject ,ORIGINAL PAPERS ,DISTRESS ,AGE ,Quality of life ,Acquired immunodeficiency syndrome (AIDS) ,Hearing ,COVID‐19 ,QUALITY-OF-LIFE ,Surveys and Questionnaires ,Pandemic ,medicine ,Humans ,ANXIETY ,Pandemics ,resilience ,media_common ,Original Paper ,business.industry ,SARS-CoV-2 ,Ear/Nose/Throat ,COVID-19 ,General Medicine ,hearing impairment ,ASSOCIATION ,medicine.disease ,language.human_language ,Distress ,Cross-Sectional Studies ,language ,Anxiety ,Psychological resilience ,medicine.symptom ,business ,Clinical psychology - Abstract
Aim The aim of the study is to determine the acute stress and psychological resilience level of people with hearing impairment during the COVID‐19 pandemic and to investigate the relationship between the grade of hearing impairment, psychological resilience and perceived stress level in this period. Methods A cross‐sectional study. A total of 135 hearing‐impaired individuals using hearing aids (study group) and 125 healthy individuals (control group) participated. The Turkish versions of the Acute Stress Symptoms Scale (ASSS) and Brief Resilience Scale (BRS) were applied to all participants. The Turkish version of Amsterdam Inventory for Auditory Disability and Handicap (T‐AIADH) was also applied to the study group in addition to other scales. The presence of any difference between the groups in terms of ASSS and BRS scores was investigated. Results There was a statistically significant difference between the control group and the study group in terms of ASSS results (Z = −4.4, P = .00). No statistically significant difference was found between the control group and the study group in terms of BRS scores (Z = −0.248, P = .804). Furthermore, T‐AIADH scale was observed not to correlate either with ASSS or BRS (P > .05). In the study group, the change in income level after the pandemic, age and sex variables were determined as a significant predictor of ASSS. Conclusion Identifying risks and protective factors for hearing‐impaired individuals at the early stage of the epidemic is considered to be of critical importance to predict the psychological impact of both the epidemic and the response to the COVID‐19 health crisis and to reduce stress.
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- 2021
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43. Dual impairments in visual and hearing acuity and age-related cognitive decline in older adults from the Rancho Bernardo Study of Healthy Aging
- Author
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Gail A. Laughlin, Humberto Parada, Linda K. McEvoy, Frances R. Nedjat-Haiem, and Mingan Yang
- Subjects
Male ,Aging ,medicine.medical_specialty ,Longitudinal study ,Visual acuity ,Hearing loss ,Visual impairment ,Vision Disorders ,Audiology ,Healthy Aging ,03 medical and health sciences ,0302 clinical medicine ,Hearing ,medicine ,Humans ,Verbal fluency test ,Cognitive Dysfunction ,Longitudinal Studies ,Cognitive decline ,Hearing Loss ,Aged ,Mini–Mental State Examination ,medicine.diagnostic_test ,business.industry ,Cognition ,General Medicine ,030221 ophthalmology & optometry ,Female ,Geriatrics and Gerontology ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Research Paper - Abstract
Background We examined the associations between dual impairments in visual and hearing acuity and aging-related cognitive decline. Methods This was a longitudinal study of adults who had visual and hearing acuity and cognitive function assessed in 1992–1996 and were followed for up to 24 years (mean = 7.3 years), with up to five additional cognitive assessments. Visual impairment was defined as vision worse than 20/40, hearing impairment as pure-tone average thresholds >25 dB. Associations were tested using linear mixed-effects regressions. Results Of 1,383 participants, 293 had visual impairment, 990 had a hearing impairment and 251 had both deficits. In fully adjusted models, low visual acuity was associated with poorer Mini-Mental State Examination (MMSE; β = −0.29) and Trail-Making Test Part B (Trails B; β = 13.22) performance, and with faster declines in MMSE (β = −0.12) and Trails B (β = 1.84). The combination of low visual and low hearing acuity was associated with poorer MMSE (β = −0.44) and Trails B (β = 11.20) scores, and with faster declines in MMSE (β = −0.19), Trails B (β = 3.50), and Verbal Fluency Test (VFT; β = −0.14) performance. Associations were similar in men and women. Conclusion Impairments in both vision and hearing are associated with a more rapid decline in cognitive function with aging.
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- 2021
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44. Social workers' experiences of psychological consultation on high risk youth: Helpful, unhelpful, and mediating elements.
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Sproull, Alan J and Johnson, Dan
- Subjects
HEARING ,READABILITY (Literary style) ,SOCIAL workers ,WORK ,NEGOTIATION ,INTERVIEWING ,ADOLESCENCE ,ADOLESCENT psychology ,EXPERIENTIAL learning ,MEDICAL referrals ,PROFESSIONAL competence ,THEMATIC analysis ,ANXIETY ,MENTAL health services - Abstract
Psychological consultation is a key means of informing care and practice with psychological theory and evidence. The current paper sought to investigate what elements of psychological consultation are useful for social workers when consulting on high-risk youth, due to the current gap in the literature. Seven social workers shared their experiences during one-to-one interviews. The data was analysed through thematic analysis and the emerging themes were organised into three categories: Helpful elements, such as a safe space, independent expertise, and a shared understanding; Unhelpful elements, including consultee anxiety and the unheard young person; A Mediating element in the form of feasible recommendations. The implications of these findings are discussed, as well as the limitations of this paper and recommendations for future research. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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45. Auditory DUM neurons in a bush-cricket: inhibited inhibitors
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Andreas Stumpner, Silvia Gubert, Debbra Y. Knorr, and Martin C. Göpfert
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Male ,Auditory Pathways ,Neurite ,Physiology ,Population ,Biology ,Inhibitory postsynaptic potential ,GABA Antagonists ,Gryllidae ,03 medical and health sciences ,Behavioral Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Hearing ,Postsynaptic potential ,medicine ,Animals ,Picrotoxin ,Graded potential ,education ,gamma-Aminobutyric Acid ,Ecology, Evolution, Behavior and Systematics ,Inhibition ,030304 developmental biology ,Neurons ,Original Paper ,0303 health sciences ,education.field_of_study ,Excitatory Postsynaptic Potentials ,Segmental interneurone ,Immunohistochemistry ,Ganglia, Invertebrate ,medicine.anatomical_structure ,Acoustic Stimulation ,Inhibitory Postsynaptic Potentials ,nervous system ,chemistry ,Auditory Perception ,Excitatory postsynaptic potential ,Female ,Animal Science and Zoology ,Soma ,Insect ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Thoracic ganglia of many hearing insects house the first level of auditory processing. In bush-crickets, the largest population of local auditory neurons in the prothoracic processing centre are dorsal unpaired median (DUM) neurons. It has been suggested that DUM neurons are inhibitory using γ-aminobutyric acid (GABA) as transmitter. Immunohistochemistry reveals a population of about 35–50 GABA-positive somata in the posterior medial cluster of the prothoracic ganglion. Only very few small somata in this cluster remain unstained. At least 10 neurites from 10 neurons can be identified. Intracellularly stained auditory DUM neurons have their soma in the cluster of median GABA positive cells and most of them exhibit GABA-immunoreactivity. Responses of certain DUM neurons show obvious signs of inhibition. Application of picrotoxin (PTX), a chloride-channel blocker in insects, changes the responses of many DUM neurons. They become broader in frequency tuning and broader or narrower in temporal pattern tuning. Furthermore, inhibitory postsynaptic potentials (IPSPs) may be replaced by excitatory postsynaptic potentials. Loss of an IPSP in the rising graded potential after PTX-application leads to a significant reduction of first-spike latency. Therefore, auditory DUM neurons receive effective inhibition and are the best candidates for inhibition in DUM neurons and other auditory interneurons. Electronic supplementary material The online version of this article (10.1007/s00359-020-01438-2) contains supplementary material, which is available to authorized users.
- Published
- 2020
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46. Barriers to help-seeking for memory problems in older adults
- Author
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Ann Pearman
- Subjects
medicine.medical_specialty ,Hearing loss ,Convenience sample ,Help-seeking ,Memory complaints ,03 medical and health sciences ,0302 clinical medicine ,Hearing ,Hearing problems ,Surveys and Questionnaires ,Health care ,medicine ,Humans ,030212 general & internal medicine ,Hearing Loss ,Aged ,Memory Disorders ,business.industry ,Patient Acceptance of Health Care ,Memory problems ,Outreach ,Mood ,Cross-Sectional Studies ,Family medicine ,Barriers to care ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Research Paper - Abstract
Key summary points Aim The aim of this study was to investigate potential barriers to help-seeking for memory problems as well as outreach to providers. Findings Participants who endorsed having hearing problems were the most likely to endorse barriers to help-seeking as well as speaking to a physician. Message Physicians and healthcare agencies can work to design outreach for persons who experience barriers, particularly hearing loss., Purpose Early detection of age- and disease-related cognitive problems affords patients the opportunities to receive medical treatment, engage in research, and plan for the future. Understanding help-seeking behavior has potential to aid both patients and clinicians. This study was designed to identify predictors of endorsed barriers to memory-related help-seeking as well as medical help-seeking endorsement. Methods This cross-sectional correlational study used a convenience sample of 97 older adults. The participants answered anonymous questionnaires about subjective memory, mood, and health and several items designed to investigate help-seeking for memory issues. Results Persons who endorsed multiple barriers to help-seeking were more likely to also endorse having hearing problems. In addition, participants who reported that they would not talk to a doctor or physician about memory concerns also had significantly worse subjective hearing. Conclusion Hearing loss may be a particular risk for not seeking help for memory problems. Physicians and healthcare agencies can work to design outreach for persons who experience barriers, such as hearing loss and the concomitant outcomes.
- Published
- 2020
47. Managing NF2-associated vestibular schwannomas in children and young adults: review of an institutional series regarding effects of surgery and bevacizumab on growth rates, tumor volume, and hearing quality
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Isabel Gugel, Marcos Tatagiba, Philip Hartjen, Martin U. Schuhmann, Julian Zipfel, Victor-Felix Mautner, and Lan Kluwe
- Subjects
Neurofibromatosis 2 ,medicine.medical_specialty ,Bevacizumab ,Decompression ,Schwannoma ,Young Adult ,03 medical and health sciences ,Vestibular schwannoma ,0302 clinical medicine ,Hearing ,Genes, Neurofibromatosis 2 ,otorhinolaryngologic diseases ,medicine ,Humans ,Neurofibromatosis type 2 ,Young adult ,Child ,Vestibular system ,Neurofibromin 2 ,Hearing preservation ,Growth rate ,business.industry ,Neuroma, Acoustic ,General Medicine ,medicine.disease ,Tumor Burden ,Surgery ,Treatment Outcome ,Annual Issue Paper ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Neurology (clinical) ,Neurosurgery ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
We reviewed our experience in managing of NF2-associated vestibular schwannoma (VS) in children and young adults regarding the effect of surgery and postoperative bevacizumab treatment. A total of 579 volumetric and hearing data sets were analyzed. The effect of surgery on tumor volume and growth rate was investigated in 46 tumors and on hearing function in 39 tumors. Long-term hearing follow-up behavior was compared with 20 non-operated ears in additional 15 patients. Sixteen operated VS were treated with bevacizumab. Mutation analysis of the NF2 gene was performed in 25 patients. Surgery significantly slowed down VS growth rate. Factors associated with a higher growth rate were increasing patient age, tumor volume, and constitutional truncating mutations. Immediately after surgery, functional hearing was maintained in 82% of ears. Deterioration of hearing was associated with initial hearing quality, larger tumor volumes, and larger resection amounts. Average hearing scores were initially better in the group of non-operated VS. Over time, hearing scores in both groups worsened with a similar dynamic. During bevacizumab treatment of residual tumors, four different patterns of growth were observed. Decompression of the internal auditory canal with various degrees of tumor resection decreases the postoperative tumor growth rates. Carefully tailored BAEP-guided surgery does not cause additional hearing deterioration. Secondary bevacizumab treatment showed heterogenous effects both regarding tumor size and hearing preservation. It seems that postoperative tumor residuals, that grow slower, behave differently to bevacizumab than reported for not-operated faster growing VS.
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- 2020
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48. Comparison of sheep and human middle-ear ossicles: anatomy and inertial properties
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Flurin Pfiffner, Dominik Péus, Ivo Dobrev, Jae Hoon Sim, University of Zurich, and Sim, Jae Hoon
- Subjects
Physiology ,Evolution ,Incus ,Ear, Middle ,610 Medicine & health ,10045 Clinic for Otorhinolaryngology ,Biology ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Behavior and Systematics ,Hearing ,2802 Behavioral Neuroscience ,medicine ,otorhinolaryngologic diseases ,Animals ,Humans ,Malleus ,030223 otorhinolaryngology ,Process (anatomy) ,Ecology, Evolution, Behavior and Systematics ,Ear Ossicles ,Incudostapedial joint ,Original Paper ,Sheep ,Articular surfaces ,Ossicles ,Ecology ,Anatomy ,1314 Physiology ,Middle-ear ossicles ,Short distance ,Surgical access ,Principal moment of inertia ,medicine.anatomical_structure ,1105 Ecology, Evolution, Behavior and Systematics ,Middle ear ,Moment of inertia ,Animal Science and Zoology ,sense organs ,1103 Animal Science and Zoology ,Hinge-like rotational motion ,030217 neurology & neurosurgery - Abstract
The sheep middle ear has been used in training to prepare physicians to perform surgeries and to test new ways of surgical access. This study aimed to (1) collect anatomical data and inertial properties of the sheep middle-ear ossicles and (2) explore effects of these features on sound transmission, in comparison to those of the human. Characteristic dimensions and inertial properties of the middle-ear ossicles of White-Alpine sheep (n = 11) were measured from high-resolution micro-CT data, and were assessed in comparison with the corresponding values of the human middle ear. The sheep middle-ear ossicles differed from those of human in several ways: anteroinferior orientation of the malleus handle, relatively small size of the incus with a relatively short distance to the lenticular process, a large area of the articular surfaces at the incudostapedial joint, and a relatively small moment of inertia along the anterior–posterior axis. Analysis in this study suggests that structure and orientation of the middle-ear ossicles in the sheep are conducive to an increase in the hinge-like ossicular-lever-action around the anterior–posterior axis. Considering the substantial anatomical differences, outcomes of middle-ear surgeries would presumably be difficult to assess from experiments using the sheep middle ear.
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- 2020
49. Interactions between Auditory and Vestibular Modalities during Stimulation with a Combined Vestibular and Cochlear Prosthesis
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Brenda Rebollar, Jay T Rubinstein, James O. Phillips, Amy Nowack, and Leo Ling
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Male ,medicine.medical_specialty ,Physiology ,Hearing Loss, Sensorineural ,medicine.medical_treatment ,Stimulation ,Sensory system ,Nystagmus ,Audiology ,03 medical and health sciences ,Speech and Hearing ,0302 clinical medicine ,Stimulus modality ,Hearing ,Cochlear implant ,Sensation ,otorhinolaryngologic diseases ,medicine ,Humans ,030223 otorhinolaryngology ,Postural Balance ,Vestibular system ,Original Paper ,Semicircular canal ,business.industry ,Hearing Tests ,Middle Aged ,Cochlear Implantation ,Semicircular Canals ,Sensory Systems ,Cochlea ,Cochlear Implants ,Treatment Outcome ,medicine.anatomical_structure ,Vestibular Diseases ,Otorhinolaryngology ,Auditory Perception ,Female ,Vestibule, Labyrinth ,sense organs ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Background: A combined vestibular and cochlear prosthesis may restore hearing and balance to patients who have lost both. To do so, the device should activate each sensory system independently. Objectives: In this study, we quantify auditory and vestibular interactions during interleaved stimulation with a combined 16-channel cochlear and 6-channel vestibular prosthesis in human subjects with both hearing and vestibular loss. Methods: Three human subjects were implanted with a combined vestibular and cochlear implant. All subjects had severe-to-profound deafness in the implanted ear. We provided combined stimulation of the cochlear and vestibular arrays and looked for interactions between these separate inputs. Our main outcome measures were electrically evoked slow-phase eye velocities during nystagmus elicited by brief trains of biphasic pulse stimulation of the vestibular end organs with and without concurrent stimulation of the cochlea, and Likert scale assessments of perceived loudness and pitch during stimulation of the cochlea, with and without concurrent stimulation of the vestibular ampullae. Results: All subjects had no auditory sensation resulting from semicircular canal stimulation alone, and no sensation of motion or slow-phase eye movement resulting from cochlear stimulation alone. However, interleaved cochlear stimulation did produce changes in the slow-phase eye velocities elicited by electrical stimulation. Similarly, interleaved semicircular canal stimulation did elicit changes in the perceived pitch and loudness resulting from stimulation at multiple sites in the cochlea. Conclusions: There are significant interactions between different sensory modalities during stimulation with a combined vestibular and cochlear prosthesis. Such interactions present potential challenges for stimulation strategies to simultaneously restore auditory and vestibular function with such an implant.
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- 2020
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50. Semi-automatic algorithm to build finite element numerical models of the human hearing system from Micro-CT data.
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Caminos L, Chaves G, Garcia-Manrique J, and Gonzalez-Herrera A
- Subjects
- Humans, X-Ray Microtomography, Models, Biological, Tympanic Membrane physiology, Tympanic Membrane diagnostic imaging, Finite Element Analysis, Algorithms, Hearing physiology
- Abstract
Finite Element modeling has been an extended methodology to build numerical model to simulate the behavior of the hearing system. Due to the complexity of the system and the difficulties to reduce the uncertainties of the geometric data, they result in computationally expensive models, sometimes generic, representative of average geometries. It makes it difficult to validate the model with direct experimental data from the same specimen or to establish a patient-oriented modeling strategy. In the present paper, a first attempt to automatize the process of model building is made. The source information is geometrical information obtained from CT of the different elements that compose the system. Importing that data, we have designed the complete procedure to build a model including tympanic membrane, ossicular chain and cavities. The methodology includes the proper coupling of all the elements and the generation of the corresponding finite element model. The whole automatic procedure is not complete, as we need to make some human-assisted decisions; however, the model development time is reduced from 4 weeks to approximately 3 days. The goal of the modeling algorithm is to build a Finite Element Model with a limited computational cost. Several tasks as contour identification or model decimation are designed and integrated in order to follow a semi-automated process that allows generating a patient-oriented model., (© 2024 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
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