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Start Over Topic fibrinolysin Publication Year Range Last 50 years
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1. Effects of the Schirmer test on the fibrinolytic system in the tear fluid.

Author

van Setten GB, Stephens R, Tervo T, Salonen EM, Tarkkanen A, and Vaheri A

Subjects
Humans, Fibrinolysin metabolism, Paper, Plasminogen Activators metabolism, Specimen Handling methods, Tears metabolism
Abstract

Human tear fluid was collected with blunted glass capillaries before and after performing the Schirmer test (ST). The test caused an increase in the tear fluid (TF) plasmin concentration (from 0.40 +/- 0.29 microgram ml-1 (mean +/- S.E.M.) to 1.14 +/- 0.26 microgram ml-1; Mann-Whitney test P less than 0.001) and a decrease in plasminogen activator activity (from 2.04 +/- 0.24 IU ml-1 to 1.04 +/- 0.17 IU ml-1; Mann-Whitney test P less than 0.002). In the filter paper used for ST, that segment that had been in contact with the conjunctiva (5 mm) usually contained higher amounts of plasmin than the following 5 mm of the paper overhanging the lidmargin. The present results indicate that the TF collection may affect the plasminogen activator-plasmin system in TF, depending on the collection method used.

Published
1990
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2. Effects of the Schirmer test on the fibrinolytic system in the tear fluid

Author

E M Salonen, Timo Tervo, G.-B. van Setten, Antti Vaheri, Ross W. Stephens, and Ahti Tarkkanen

Subjects
Paper, medicine.medical_specialty, Plasmin, Plasminogen activator activity, Specimen Handling, Plasminogen Activators, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Ophthalmology, medicine, Humans, Schirmer test, Fibrinolysin, 030304 developmental biology, Collection methods, 0303 health sciences, Chemistry, Sensory Systems, Surgery, Tears, Intraocular fluid, 030221 ophthalmology & optometry, Plasminogen activator, medicine.drug
Abstract

Human tear fluid was collected with blunted glass capillaries before and after performing the Schirmer test (ST). The test caused an increase in the tear fluid (TF) plasmin concentration (from 0.40 +/- 0.29 microgram ml-1 (mean +/- S.E.M.) to 1.14 +/- 0.26 microgram ml-1; Mann-Whitney test P less than 0.001) and a decrease in plasminogen activator activity (from 2.04 +/- 0.24 IU ml-1 to 1.04 +/- 0.17 IU ml-1; Mann-Whitney test P less than 0.002). In the filter paper used for ST, that segment that had been in contact with the conjunctiva (5 mm) usually contained higher amounts of plasmin than the following 5 mm of the paper overhanging the lidmargin. The present results indicate that the TF collection may affect the plasminogen activator-plasmin system in TF, depending on the collection method used.

Published
1990