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The present review provides a comprehensive outlook toward the possibilities of developing a functional in vitro liver tissue model on a paper platform. To this end, we first addressed the suitabil...

Context: Scientific studies are often presented primarily to a group of colleagues at annual scientific meetings. All year rounds are turned into products in congresses. Aims: The aim of the study is to evaluate the extent of the hand surgery in plastic surgery and plastic surgeons' papers related with hand surgery in national congresses; the past eight plastic surgery congresses were classified and presented. Settings and Design: The abstract books of Turkish National Congresses of Plastic, Reconstructive, and Aesthetic Surgery between 2011 and 2018 have been evaluated retrospectively. Subjects and Methods: Distribution of hand surgery according to the topics was evaluated according to the European White Book rules and standards. Distribution of oral and posters and distribution by years were shown. Results: The ratio of hand surgery reports to all reports was 17.3%. Hand and upper extremity surgery topics were presented at 19.7% in the 38th congress, which is the most hand surgery-included congress. The most frequently presented subjects were tumors, flaps, trauma, congenital anomalies, and replantation. Conclusions: Although there are arguments that plastic surgeons have disregarded hand surgery, there is no similar situation for Turkish plastic surgeons in the national platform. It has been found that the most common topics such as tumor excision and repair of the tissue defect were the most presented issues rather than arthroscopy, paralytic hand, and arthritis, which are specific to the hand surgery. Increasing the number of plastic surgery specialists who have been trained with hand surgery as a subspecialty will bring up the subjects that have not been presented in the hand surgery so far, in the future congresses.

In China, master's students in humanities and social sciences (HSS) are becoming the main target of Chinese-language predatory journals. Existing research has not paid enough attention to why these students publish papers in Chinese-language predatory journals. This research interviewed 30 HSS master's students with different majors using semi-structured interviews and Grounded Theory to analyze the data; it found that research discrimination, research context, self-awareness, and individual demand are the main reasons why students publish papers in Chinese-language predatory journals. This study provides the following suggestions in an effort to solve the problem of Chinese-language predatory journals. First, the Chinese government should draw up a blacklist of Chinese-language predatory journals. Second, the research evaluation departments of Chinese universities and research institutions should evaluate the research results of HSS master's students based on this list. Third, Chinese universities or scientific research institutions should strengthen the training of HSS master tutors and increase their awareness of Chinese-language predatory journals. And finally, Chinese HSS master's students should be taught about the hazards of Chinese-language predatory journals in research integrity and ethics courses, and refuse to publish papers in Chinese-language predatory journals.

Objective The aims of this study were to understand the status quo of authors, collaborations between institutions, research hotspots, and research frontiers of fund-sponsored clinical nursing papers and to provide a reference for Chinese scholars to conduct clinical nursing studies in the future. Methods The visualization software CiteSpace was used to analyze fund-sponsored clinical nursing papers published between 2012 and 2016 in 12 core journals of nursing. Results In the clinical nursing field, there are many cooperative author groups; however, the collaborations between institutions are not close and exist mainly within the same province or city. High-frequency keywords have revealed the four clinical nursing research hotspots of population, diseases, nursing intervention, and others. Chinese medicine nursing, prevention, treatment and nursing, and new technology-aided nursing of ventilator-associated pneumonia are the study frontiers of clinical nursing. Conclusions Clinical nursing studies are rich in content and cover a wide range of areas, and their hotspots and frontiers are closely related to the requirements of clinical nursing. Collaborations across regions, provinces, and cities are not adequate; there is an urgent need to strengthen the cross-regional exchanges and collaborations to promote the further development of clinical nursing.

ESSKA is constantly committed to promoting the improvement of scientific quality through the publication of books and the organization of dedicated conferences. In line with this commitment, this interview paper was crated with the aim of being useful for all the young scientists and orthopaedics keen in musculoskeletal and sport medicine research. Three Editors from the most important journals in our field were invited to participate: Jon Karlsson from Knee Surgery Sport Traumatology and Arthroscopy, Bruce Reider from The American Journal of Sport Medicine and Edward Wojtys from Sports Health.

BackgroundThere is a clear gender gap in scientific authorship. Although the proportions of female authors in medicine and psychiatry have increased over the past decades, women are still underrepresented.AimsTo analyse authorship gender trends in eating disorder research.MethodFirst and last author gender in research articles on eating disorders during the period 1997–2016 were assessed in eating disorder specialty journals, high-impact psychiatry journals and high-impact clinical psychology journals.ResultsThe total number of papers on eating disorders increased substantially over the observation period, although a decrease was observed in high-impact psychiatry journals. Female authorship increased in both specialty journals and high-impact psychiatry journals. Authors were significantly less likely to be female in high-impact psychiatry and clinical psychology journals than in speciality journals.ConclusionsEating disorder research has been increasingly allocated to specialty journals over the past 20 years. A consistent gender gap between specialty and high-impact journals exists.Declaration of interestC.M.B is a grant recipient from Shire Pharmaceuticals, Inc. and has participated as a member of their scientific advisory board. These positions are unrelated to the content of this article.

Background: Though women increasingly make up the majority of medical-school and other science graduates, they remain a minority in academic biomedical settings, where they are less likely to hold leadership positions or be awarded research funding. A major factor is the career breaks that women disproportionately take to see to familial duties. They experience a related, but overlooked, hurdle upon their return: they are often too old to be eligible for 'early-career researcher' grants and 'career-development' awards, which are stepping stones to leadership positions in many institutions and which determine the demographics of their hierarchies for decades to come. Though age limits are imposed to protect young applicants from more experienced seniors, they have an unintended side effect of excluding returning workers, still disproportionately women, from the running. Methods: In this joint effort by the European Society of Clinical Microbiology and Infectious Diseases, the Federation of European Microbiological Societies, the Infectious Disease Society of America, the International Society for Infectious Diseases and the Swiss Society for Infectious Diseases, we invited all European Congress of Clinical Microbiology and Infectious Diseases-affiliated medical societies and funding bodies to participate in a survey on current 'early-career' application restrictions and measures taken to provide protections for career breaks. Recommendations: The following simple consensus recommendations are geared to funding bodies, academic societies and other organizations for the fair handling of eligibility for early-career awards: 1. Apply a professional, not physiological, age limit to applicants. 2. State clearly in the award announcement that career breaks will be factored into applicants' evaluations such that: • Time absent is time extended: for every full-time equivalent of career break taken, the same full-time equivalent will be extended to the professional age limit. • Opportunity costs will also be taken into account: people who take career breaks risk additional opportunity costs, with work that they did before the career break often being forgotten or poorly documented, particularly in bibliometric accounting. Although there is no standardized metric to measure additional opportunity costs, organizations should (a) keep in mind their existence when judging applicants' submissions, and (b) note clearly in the award announcement that opportunity costs of career breaks are also taken into account. 3. State clearly that further considerations can be undertaken, using more individualized criteria that are specific to the applicant population and the award in question. The working group welcomes feedback so that these recommendations can be improved and updated as needed.

Figures and analysis scripts for "Investigating the replicability of preclinical cancer biology" (https://doi.org/10.7554/eLife.71601)

Materials and methodology to replicate the study 'Women do not shy away from competition: Competition in Same-gender and Cross-gender Friendship Dyads'

Several months prior to the presentation of this paper at the 2021 Vienna Lecture in Canadian Studies, I invited Canadian Studies students at the University of Vienna to participate in CANADA IS…WHAT?! by sharing some of their “thoughts and impressions, dreams and nightmares, images and memories, hopes, fears and random musings about this place called Canada.” I then engaged participant contributions through a performative artistic self-reflection on the intersections of family history and national memory. This paper is the product of that exploration and is framed as a conversation between me, a second-generation settler-Canadian of Dutch descent, and an audience of faculty and students at the Centre for Canadian Studies at the University of Vienna. For more information on CANADA IS WHAT?! and a glimpse of participant contributions, visit helenevosters.com/2021/02/14/canada-is-what/.

The image of nursing is impoverished since the hundred years of professional identity of this age-old profession. Nursing image among the public is relying on the image of nursing in media. Nurses are vital members of the health care team and work tirelessly to provide quality care to the patient. A professional image is pivotal to motivate people to have nursing as a career choice. Nurses are central resources of any health institution and their role as a carer is crucial to push the quality of care and health outcomes of health services. Nurses are known to work with compassion and competence with the patient’s best interest in mind having good academic knowledge and understanding of their work with evidence-based practice. Nurses facing an identity crisis as professional and likely sources are neglecting behavior of media and public image of nursing as assistant of physicians. The nursing profession is facing new challenges part from biased policies of the government, on the public forum as an independent professional. Keywords: Nursing, Professionalism, Media, Society, Image, Physicians.

Resumo: Este artigo se propoe a analisar tres tipos de estruturas sintaticas com o verbo acabar em portugues do Brasil: aquelas com o verbo acabar seguido de oracao cujo verbo esta no gerundio ( eu acabei escrevendo o artigo ); aquelas em que o mesmo verbo e seguido de preposicao por e oracao infinitiva ( eu acabei por escrever o artigo ); e aquelas em que o verbo e seguido de um CP finito ( acabou que eu escrevi o artigo ). As tres estruturas veiculam um sentido proximo: um conjunto de circunstâncias ou eventos subentendidos ou mencionados no contexto culminam ou causam o evento expresso pela oracao que segue o verbo acabar , e nas tres construcoes o verbo acabar comporta-se como tipico verbo de alcamento. O trabalho defende que, no contexto sintatico desses tres tipos de complemento frasal, o significado da raiz do verbo acabar inclua um superevento, chamemo-lo S, que reune o conjunto de circunstâncias ou eventos referidos acima, e estabelece que tal conjunto culmina ou causa o evento (ou um estado resultante ou associado a tal evento) veiculado pela oracao complemento. O texto tambem mostra que os diferentes complementos frasais podem estabelecer relacoes temporais distintas entre a culminacao do superevento S e o tempo do evento expresso pela oracao subordinada, e tambem tem propriedades sintaticas distintas, como a possibilidade ou nao de topicalizacoes ou focalizacao contrastiva dentro da oracao subordinada, em sua periferia esquerda. Palavras-chave: verbos aspectuais; verbos alcamento; semântica temporal; periferia esquerda. Abstract: This article aims to analyze three types of syntactic structures with the verb acabar in Brazilian Portuguese: those with the verb acabar followed by a gerund clause ( eu acabei escrevendo o artigo – I ended up writing the paper ); those in which the same verb is followed by the preposition por and an infinitive clause ( eu acabei por escrever o artigo – I ended up writing the paper (I finished for write the paper) ); and those in which the verb is followed by a finite CP ( acabou que eu escrevi o artigo – I ended up writing the paper (finished that I wrote the paper) ). The three structures convey a close meaning, which includes a set of circumstances or events implied or mentioned in the context that culminates or causes the event expressed by the clause following the verb acabar , and in the three constructions the verb acabar behaves as a typical raising verb. The work argues that in the syntactic context of these three types of phrasal complement the meaning of the root of the verb acabar includes a superevent, let us call it S , which brings together the set of circumstances or events referred to above, and establishes that such set culminates or causes the event (or a state resulting or associated with such an event) conveyed by the complement clause. The paper also shows that the different phrasal complements can establish distinct temporal relationships between the culmination of the superevent S and the time of the event expressed by the subordinate clause, and also have distinct syntactic properties, such as the possibility of topicalization or contrastive focusing within the subordinate clause, in its left periphery. Keywords: aspectual verbs; raising verbs; tense semantics; left periphery.

Background Acquired brain injury (ABI) is damage to the brain that occurs after birth caused either by a traumatic or by a nontraumatic injury. The rehabilitation process following ABI should be performed by a multi-professional team, working in an interdisciplinary way, with the aim of organizing a comprehensive and holistic approach to persons with every severity of ABI. This Evidence Based Position Paper represents the official position of the European Union through the UEMS Physical and Rehabilitation Medicine (PRM) Section and designates the professional role of PRM physicians for people with ABI. The aim was to formulate recommendations on the PRM physician's professional practice for persons with ABI in order to promote their functioning and enhance quality of life. Methods This paper has been developed according to the methodology defined by the Professional Practice Committee of the UEMS-PRM Section: a systematic literature search has been performed in PubMed and Core Clinical Journals. On the basis of the selected papers, recommendations have been made as a result of five Delphi rounds. Results The literature review as well as thirty-one recommendations are presented. Conclusions The expert consensus is that structured, comprehensive and holistic rehabilitation program delivered by the multi-professional team, working in an interdisciplinary way, with the leadership and coordination of the PRM physician, is likely to be effective, especially for those with severe disability after brain injury.

The histone acetyltransferase HBO1 (KAT1) is required for histone H3 lysine 14 acetylation, which is crucial for embryonic development. A new paper in Development reveals that, in the vascular system, HBO1 is required in endothelial cells for sprouting angiogenesis regulation. To hear more about the story, we caught up with first author Zoe Grant and senior authors Professor Anne Voss, Associate Professor Tim Thomas and Leigh Coultas, Business Development Manager, from the Walter and Eliza Hall Institute of Medical Research (WEHI), Australia.

Floods kill several people every year in both developed and developing countries. The transfer of research findings from the academic community to practitioners, policy-makers and citizens may reduce the impact of floods on mortality. This systematic review analyzes 44 scientific articles extracted from WOS and SCOPUS databases written in English, published between 2010 and 2020, and focuses on flood fatalities. The first main finding of this review is the classification of drivers of flood mortality into two groups: the first group relates to the environment and the second group relates to the victims. The second main finding is the identification of strategies to practically cope with the identified drivers of flood fatalities. The main lacks of the review concern: a) the unavailability of papers based on flood fatality occurrence in developing countries and b) the absence of data focusing on people who have survived floods. This review amplifies useful findings, best practices, and lessons learned that can be useful for administrators, risk managers, and teachers of primary and secondary schools to mitigate the impact of future floods on human life.

The Canadian physician Sir William Osler is a key figure in the history of modern medicine. He encouraged lifelong learning for doctors, starting with bedside teaching. Contemporary with Old World figures such as Pasteur in Paris and Virchow in Berlin, he played a major role in raising awareness among clinicians of the importance of the scientific basis for the practice of medicine. He championed a rational approach to treatment and did much to encourage avoidance of ‘unnecessary drugging’ by prescribers. He is credited with playing a key role in improving education of medical students and postgraduate education of doctors, with important benefits for the care of hospital patients. He also had a major influence on his medical colleagues through founding and leading medical societies. A century on from his death in December 1919, his specific contributions and how he achieved them are not well known. The aim of this article is to consider the evidence that Osler was an influential medical leader and to reflect on the extent to which the achievements which resulted from his leadership are relevant to modern clinical medicine. Questions of interest include his leadership style, what made for his success as a leader, his medical achievements both in North America and in England, his own insight into leadership and how he was viewed by his peers.

Objectives Compassionate care is a core value of healthcare practice. In the post-Francis arena, the Shape of Caring review scrutinised healthcare education and training. The aim of the review was to better enable healthcare providers in delivering compassionate care and support to people with complex challenging health needs today and in the future. The review also reiterated the role of educators and universities in developing curricula capable of promoting compassionate care. Despite the review focussing upon the nursing profession, this paper suggests there is a similar role for radiography educators in delivering curricula suitable for promoting compassionate care. Potential pedagogic methods and their suitability within the radiography education setting will be considered. Key findings Relationships and emotions were noted as important aspects of promoting compassionate care. The themes ‘practising compassionately’ and ‘individual and relationship factors …’ are of particular relevance to education. Conclusions Compassion remains a priority in policy which must be promoted to students as an integral aspect of healthcare education. A facilitated discussion of students' reflections around practice experiences to promote compassion is suggested. Supplemented by service user stories, students would be able to develop the skills needed to ‘practise compassionately’.

Forward is the direction to which research looks. But, scientists read prior literature for background and context, casting a retrospective glance to the past, albeit from a different vantage point. How do we evaluate the value of a scientific paper? Citations? Downloads? Or, more philosophically, the directions of inquiries it potentiated, and areas opened up? In retrospective analysis, counterfactual is the common tool in the social scientist’s armamentarium. Natural scientists, on the other hand, glean prospectively. Retrospective in analysis but yet prospective in outlook in what appears as a dichotomy. But, on closer examination, which is in harmony. From the contemporary vintage and using a prospective angle, this commentary casts light on a foundational paper that illuminated hitherto unknown functions of structural maintenance of chromosome (Smc) complex in mediating chromosome integrity and potentiating entry into subsequent phase of the DNA damage response.

This meta-analysis examines the inconsistent findings across experimental studies that compared children’s learning outcomes with digital and paper books. We quantitatively reviewed 39 studies reported in 30 articles (n = 1,812 children) and compared children’s story comprehension and vocabulary learning in relation to medium (reading on paper versus on-screen), design enhancements in digital books, the presence of a dictionary, and adult support for children aged between 1 and 8 years. The comparison of digital versus paper books that only differed by digitization showed lower comprehension scores for digital books. Adults’ mediation during print books’ reading was more effective than the enhancements in digital books read by children independently. However, with story-congruent enhancements, digital books outperformed paper books. An embedded dictionary had no or negative effect on children’s story comprehension but positively affected children’s vocabulary learning. Findings are discussed in relation to the cognitive load theory and practical design implications.

The application of single-cell mRNA sequencing technologies to plant embryos promises to reveal the gene expression dynamics underlying cell-type differentiation. A new paper in Development reports the generation of high-quality transcriptomes from single embryonic nuclei without contamination from maternal tissues. To find out more about the story, we caught up with first author Ping Kao and his supervisor Michael Nodine, who recently moved from the Gregor Mendel Institute in Vienna to become Assistant Professor in the Laboratory of Molecular Biology at Wageningen University in the Netherlands.

o El propósito de este estudio es describir el estado actual de la publicación de investigaciones y las tendencias en el aprendizaje invertido, que se encuentran en "Web of Science" durante el período 2014-2018. Hay 262 artículos investigados, publicados e indexados en "Web of Science" con la palabra clave: "aprendizaje invertido" y "aula invertida". Los resultados del estudio se analizan según la revista de publicación según estos criterios: autor, países, agencias de financiación, tipos de documentos, idiomas, organización, años de publicación y título de la fuente. El aprendizaje invertido cambia la clase tradicional dando la vuelta al aula en el sentido de escuchar las videoconferencias en casa y realizar actividades dinámicas en grupo en el aula. Esto involucra a los estudiantes en el aprendizaje activo, el pensamiento crítico y mejora las habilidades interpersonales.Se recomienda a los autores explorar la posibilidad de utilizar este método, experimentar y publicar los hallazgos que permitan crear mejores prácticas y un marco unificado para instructores líderes que deseen adoptar esta metodología de enseñanza. Palabras clave: aprendizaje invertido, aula invertida, análisis de contenido, The purpose of this study is to describe the current state of research publication and trends in flipped learning, found on ‘Web of Science’ during the period 2014–2018. There are 262 papers investigated, published and indexed on ‘Web of Science’ with the keyword: “flipped learning” and “flipped classroom”. The results of the study are analysed according to the journal of publication by these criteria: author, countries, funding agencies, document types, languages, organisation, publication years and source title. Flipped learning changes the traditional lecturing by flipping the classroom in the sense of listening to the video lectures at home and doing dynamic, group-based activities in the classroom. This engages the students in active learning, critical thinking, and meliorates interpersonal skills.It is recommended to authors to explore the possibility of utilising this method, experimenting and publish the findings which allows to create best practices and a unified framework for leading instructors who want to adopt this teaching methodology. Keywords: Flipped learning, flipped classroom, content analysis

The application of single-cell mRNA sequencing technologies to plant embryos promises to reveal the gene expression dynamics underlying cell-type differentiation. A new paper in Development reports the generation of high-quality transcriptomes from single embryonic nuclei without contamination from maternal tissues. To find out more about the story, we caught up with first author Ping Kao and his supervisor Michael Nodine, who recently moved from the Gregor Mendel Institute in Vienna to become Assistant Professor in the Laboratory of Molecular Biology at Wageningen University in the Netherlands.

This book identifies the 50 key scientific articles in the field of vascular and endovascular surgery. It provides a commentary to each carefully selected paper and explains why these papers are so important, thus providing every surgeon with the foundation stones of knowledge in this fast-moving area. There has been an exponential increase in the volume and quality of published research relating to vascular and endovascular surgery in recent decades. Among thousands of articles, a small fraction is truly "game changing." Such studies form the foundations of vascular surgery today and the selection of papers within this book provide the 50 landmark papers every 21st-century vascular and endovascular surgeon needs to know. A valuable reference not only to the established surgeon, but also to vascular surgery residents and trainees, as well as to more experienced surgeons as they continue to learn new techniques and approaches and to improve their knowledge of vascular disorders and treatments. The papers provide an evidence-based resource for those surgeons preparing for professional exams and may inspire clinicians to produce new research. About the Editors Juan Carlos Jimenez MD, MBA Professor of Surgery Gonda (Goldschmied) Vascular Center David Geffen School of Medicine at UCLA Los Angeles, California Samuel Eric Wilson, MD Distinguished Professor of Surgery and Chair Emeritus University of California Irvine Irvine, California

A medical researcher who took a political appointment with the Trump administration while working on a major international meta-analysis of potential covid-19 treatments leaked a preprint version of the research to senior government colleagues last year, documents released in a congressional investigation show.1 Paul Alexander, a former assistant professor at McMaster University in Canada who specialises in health research methods, wrote in an email to Stephen Hahn, commissioner of the Food and Drug Administration (FDA), that the research lent support to a role for hydroxychloroquine. The FDA authorised the antimalarial on an emergency basis last April under pressure from Trump, but revoked this in June, citing the drug’s “known risks” and stating that it was “no longer reasonable to …

1.1. Cardiovascular disease and dyslipidemia: prevalence and global economic impact Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, reaching 31% of deaths in 2012 [1]. In particular, atherosclerosis and ischemic heart disease (IHD) are the main causes of premature death in Europe and are responsible for 42% of deaths in women and 38% in men under 75 years old [2]. The global economic impact of CVD is estimated to have been US $906 billion in 2015 and is expected to rise by 22% by 2030 [3]. Cardiovascular diseases also represent the major cause of disability in developed countries. It has been estimated that their growing burden could lead to a global increase in loss of disability-adjusted life years (DALYs), from a loss of 85 million DALYs in 1990 to a loss of ~150 million DALYs in 2020, becoming a major non-psychological cause of lost productivity [4]. Several risk factors contribute to the etiology and development of CVD; they are divided into those modifiable through lifestyle changes or by taking a pharmacologic treatment (e.g. for hypertension, smoking, diabetes mellitus, hypercholesterolemia) and those that are not modifiable (age, male gender, and family history) [5]. Elevated total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) blood concentrations are the major modifiable risk factors for coronary heart disease (CHD), whereas high concentrations of plasma high-density lipoprotein cholesterol (HDL-C) in certain conditions are considered protective [6]. Moreover, LDL-C remains a fundamental CV risk factor (and a main target of therapy) even when statins are largely used in the general population [7]. An examination of the data of 18 053 participants aged ≥ 20 years who participated in the National Health and Nutrition Examination Surveys (NHANES) from 1999 to 2006 showed that the unadjusted prevalence of hypercholesterolemia ranged from 53.2% to 56.1% in United States adults [8]. Differences related to gender and race or ethnicity were observed; in particular, a lower rate of control was found among women than men and lower rates of having a cholesterol check and being told about hypercholesterolemia were reported by African Americans and Mexican Americans than whites [8]. A recent report from the American Heart Association confirmed that in the US only 75.7% of children and 46.6% of adults present targeted TC levels (TC < 170 mg/dl for children and < 200 mg/dl for adults, in untreated individuals) [9]. The pattern is similar in other Western countries [10, 11].

The number of elderly people as a proportion of the world’s population is growing significantly. Special attention to the accessibility and mobility requirements of this group is needed. The contribution of this paper is a review of travel patterns, mode preferences, infrastructure solutions, accessibility indices, mode choice models and datasets as they relate to elderly mobility. Key findings highlight the role of residential location characteristics in shaping elderly travel patterns, helping to explain why research on elderly travel has largely relied on case studies to date. The review also summarizes a range of indices that have been developed to measure public transport and walking accessibility among the elderly, including distance and time-based methods. Future research should consider the dominance of private transport in facilitating elderly mobility and its implications for cities experiencing an aging population.

Introduction Scoliosis and other spinal deformities involve 3-4% of the population during growth. Their so-called conservative treatment is in the field of competence of physical and rehabilitation medicine (PRM) physicians. This evidence based position paper represents the official position of the European Union through the European Union of Medical Specialists (UEMS) - PRM Section. The aim of the paper was to improve PRM specialists' professional practice for patients with spinal deformities during growth. Evidence acquisition A systematic review of the literature and a Consensus procedure with 26 recommendations by means of a Delphi method process has been performed involving the delegates of all European countries represented in the UEMS-PRM Section. Evidence synthesis the systematic literature review is reported together with 26 recommendations coming from the Consensus Delphi procedure. Conclusions The professional role of PRM physicians in spinal deformities during growth is to propose a complete PRM treatment for the patients considering all the concurring diseases and pathologies, impairments, activity limitations and participation restrictions. The PRM physician's role is to coordinate the individual PRM project developed in team with other health professionals and medical specialists, in agreement with the patient and his family, according to the specific medical diagnoses.

Our aim was to summarise current published evidence about the prognosis of various techniques of craniofacial distraction osteogenesis, particularly its indications, protocols, and complications. Published papers were acquired from online sources using the keywords "distraction osteogenesis", "Le Fort III", "monobloc", and "syndromic craniosynostosis" in combination with other keywords, such as "craniofacial deformity" and "midface". The search was confined to publications in English, and we followed the guidelines of the PRISMA statement. We found that deformity of the skull resulted mainly from Crouzon syndrome. Recently craniofacial distraction has been achieved by monobloc distraction osteogenesis using an external distraction device during childhood, while Le Fort III distraction osteogenesis was used in maturity. Craniofacial distraction was indicated primarily to correct increased intracranial pressure, exorbitism, and obstructive sleep apnoea in childhood, while midface hypoplasia was the main indication in maturity. Overall the most commonly reported complications were minor inflammatory reactions around the pins, and anticlockwise rotation when using external distraction systems. The mean amount of bony advancement was 12.3mm for an external device, 18.6mm for an internal device and 18.7mm when both external and internal devices were used. Treatment by craniofacial distraction must be validated by long-term studies as there adequate data are lacking, particularly about structural relapse and the assessment of function.

The culture of Chinese white spirit is time-honored, and it’s loved by all Chinese people, so it’s also important of white spirit packaging. The paper puts forward a new and green solution of white spirit packaging with paper bottle, it’s made with mulberry/rice paper and animal blood. The paper bottle is light and green, and increases the white spirit’s nutrition value. There are several physical and chemical tests in the paper just to justify the new bottle’s performance. Physical performance test includes appearance defect test, compression and stacking test, impact resistance test, water impact strength test, permeability test and so on. Chemical performance evaluation includes stability, compatibility and endurance.

\Electronic portfolios offer many advantages to their paper-based counterparts, including, but not limited to working on ICT skills, adding multimedia and easier sharing of the portfolio. Previous research showed that the quality of a portfolio does not depend on the medium used. In this article the perceived support for self-reflection of an electronic portfolio and a paper-based portfolio in the same ecological setting are compared. We made use of the fact that during this study about half of the first year medical students was using an electronic portfolio (n = 157) and the other half a paper-based portfolio (n = 190). Nine questions were added to the standard end of the block evaluation, which is handed to 25 percent of year one educational groups. Findings suggest that perceptions about the support for self-reflection, and the usefulness of compiling a portfolio, do not differ between students using an electronic portfolio and students using a paper-based portfolio. Résumé : Les portfolios électroniques offrent de nombreux avantages comparativement à leurs homologues de papier, entre autres la possibilité de perfectionner les compétences liées aux TIC, d’ajouter des éléments multimédias et de partager plus facilement le portfolio. Des études précédentes ont montré que la qualité d’un portfolio ne dépend pas du support utilisé. Dans le présent article, nous comparons l’aide à l’autoréflexion perçue pour un portfolio électronique et un portfolio sur support papier dans le même environnement. Dans le cadre de cette étude, nous avons profité du fait qu’environ la moitié des étudiants de première année en médecine utilisait un portfolio électronique (n = 157) et l’autre moitié, un portfolio sur support papier (n = 190). Neuf questions ont été ajoutées à l’évaluation normale remise à 25 pour cent des groupes de première année à la fin du bloc de formation. Les résultats suggèrent que les perceptions des étudiants à l’égard de l’aide à l’autoréflexion et de l’utilité de compiler un portfolio ne diffèrent pas entre les utilisateurs de portfolios électroniques et les utilisateurs de portfolios sur support papier.

This research was comparing science virtual and paper-based test in measuring grade 7 students’ critical thinking based on Multiple Intelligences and gender. Quasi experimental method with within-subjects non-experimental design was conducted in this research in order to obtain the data. The population of this research was all seventh grade students in ten classes of one public secondary school in Bandung. There were 71 students within two classes taken randomly became the sample in this research. The data are obtained through 28 questions with a topic of living things and environmental sustainability that constructed based on eight critical thinking elements proposed by Inch and then the questions provided in science virtual and paper-based test. The data was analyzed by using paired-samples t test when the data are parametric and Wilcoxon signed ranks test when the data are non-parametric. In general comparison, the p-value of the comparison between science virtual and paper-based tests’ score is 0.506, indicated that there are no significance difference between science virtual and paper-based test based on the tests’ score. Furthermore, the Asymp. Sig. Values resulted from the comparison based on Multiple Intelligences are 0.935 for naturalist, 0.074 for musical, 0.654 for logical, 0.877 for existential, 0.329 for interpersonal, 0.129 for kinesthetic, 0.055 for verbal, 0.781 for intrapersonal, and 0.722 for visual intelligences, thus indicated that there is also no significance difference between science virtual and paper-based test based on students’ Multiple Intelligences. Moreover, the p-values resulted from the comparison based on gender are 0.758 for male and 0.540 for female, this is also indicated that there is no significance difference based on gender. The results are furthermore supported by the students’ attitude result which is 3.15 from the scale from 1 to 4, indicated that they have positive attitudes towards science virtual test. Moreover, teachers involved in this research were interviewed to know how their perspectives towards science virtual test is, and they agree that computer-based test like science virtual test are far beyond the limitation of paper-based test and expected similar test to be implemented as the common assessment tool as it provides many advantages. ;---Penelitian ini membandingkan Science Virtual Test dan tes berbasis kertas dalam mengukur kemampuan berpikir kritis siswa kelas 7 berdasarkan kecerdasan majemuk dan jenis kelamin. Metode non eksperimen/kuasi eksperimen dengan design within-subjects dilakukan dalam penelitian ini untuk mendapatkan data. Populasi penelitian ini adalah semua siswa kelas tujuh di sepuluh kelas salah satu SMP negeri di Bandung. Ada 71 siswa dalam dua kelas yang diambil secara acak menjadi sampel dalam penelitian ini. Data dalam penelitian ini diperoleh melalui 28 pertanyaan dengan topik makhluk hidup dan kelestarian lingkungan yang dibangun berdasarkan delapan elemen berpikir kritis yang di ajukan oleh Inch dan kemudian diintegrasikan dalam Science Virtual Test dan tes berbasis kertas. Data dianalisis dengan menggunakan paired-samples t test apabila data bersifat parametrik dan Wilcoxon signed rank test bila data bersifat non-parametrik. Dalam perbandingan secara umum, nilai p dari perbandingan antara nilai ujian Science Virtual Test dan tes berbasis kertas adalah 0,506, menunjukkan bahwa tidak ada perbedaan yang signifikan antara Science Virtual Test dan tes berbasis kertas berdasarkan skor tes. Selanjutnya, Asymp. Sig. Nilai yang dihasilkan dari perbandingan berdasarkan Multiple Intelligences adalah 0,935 untuk naturalis, 0,074 untuk musikal, 0,654 untuk logika, 0,877 untuk eksistensial, 0,329 untuk interpersonal, 0,199 untuk kinestetik, 0,055 untuk verbal, 0,781 untuk intrapersonal, dan 0,722 untuk kecerdasan visual, sehingga ditunjukkan bahwa tidak ada perbedaan signifikan antara Science Virtual Test dan berbasis kertas berdasarkan Multiple Intelligences siswa. Selain itu, nilai p yang dihasilkan dari perbandingan berdasarkan jenis kelamin adalah 0,758 untuk laki-laki dan 0,540 untuk perempuan, hal ini juga menunjukkan bahwa tidak ada perbedaan signifikan berdasarkan jenis kelamin. Hasil penelitian ini selanjutnya didukung oleh hasil kuesioner sikap siswa terhadap Science Virtual Test yaitu 3,15 dari skala 1 sampai 4, menunjukkan bahwa mereka memiliki sikap positif terhadap Science Virtual Test. Selain itu, para guru yang terlibat dalam penelitian ini diwawancarai untuk mengetahui bagaimana perspektif mereka terhadap Science Virtual Test, dan mereka setuju bahwa tes berbasis komputer seperti Science Virtual Test jauh melampaui batasan tes berbasis kertas dan tes serupa diharapkan untuk dapat diterapkan sebagai tes secara umum karena memberikan lebih banyak keuntungan dibanding tes berbasis kertas.

Famous for pioneering the oxygenation of nitrous-oxide anesthetics, Chicago surgeon Edmund Andrews trusted the Manhattan-based Colton Dental Association's claim that they had conducted 75,000 nitrous-oxide anesthetics without a single mortality. Those statistics were cited in Andrews' 1870 journal article on anesthetic risks and then, remarkably, advertised on the business cards of dentist James M. Spencer, Jr., of Gouverneur, New York.

1. Is there an association between stress and periodontitis? JM Coelho, SS Miranda, SS da Cruz, et al. Is there association between stress and periodontitis? Clinical Oral Investigations. 2020; 24: 2285-94. 2. Is there an association between periodontitis and all-cause and cancer mortality? P Chung, T Chan. Association between periodontitis and all-cause and cancer mortality: retrospective elderly community cohort study. BMC Oral Health. 2020; 20: 168.

Qualitative observational data from strategy workshops and documents, copies of slides, and emails used for inductive qualitative analysis.

Organic synthesis allows scientists to construct and modify organic compounds using a continuously growing arsenal of reactions and methodologies [...]

Carbon screen-printed electrodes (SPEs) are recognized as disposable, single-use, and inexpensive sensors to measure various analytes, including phosphates. SPEs have multiple applications using cyclic voltammetry (CV), which is a powerful electrochemical technique used to investigate the redox reactions of specific analytes. However, high demand for SPEs in laboratories creates questions about their economical feasibility and disposal after a single-use, while it has been found that polishing the surfaces of SPEs shows potential for reuse. The aim of this study was to examine the effect of polishing SPEs using office paper on their reproducibility, repeatability, and amperometric response for phosphate electrochemical sensing. The effect was determined by measuring the peak currents of the CV scans of phosphate analytes before and after SPE polishing. The sensitivity, limit of detection, and reproducibility of the electrochemical phosphate test were significantly improved by polishing the SPEs with office paper. For example, the paper polished SPEs increased the phosphate sensitivity response by 63.6% and showed reuse efficacy up to successive 20 CV cycles. Compared to carbon pretreatment methods that use chemicals in SPE mechanical polishing, the proposed paper polishing method is eco-friendly, cost-effective, and shows great promise towards more sustainable phosphate tests.

Researchers whose rapid investigations into possible covid treatments that helped to save over a million lives worldwide have won a top prize in this year’s BMJ Awards. The Recovery collaborative group’s trial, which was the first to show that the inexpensive steroid dexamethasone improved survival among patients with covid-19 who had severe respiratory complications, was awarded The BMJ ’s research paper of the year.1 It found that dexamethasone reduced the risk of death by a third among patients on ventilators and by almost a fifth among those on oxygen. The award judges praised the “landmark” NHS study. They said, “The setup of …

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology: Editorial

This study examined unit and item nonresponse rates and ancillary information provided for Web- and paper-based versions of a questionnaire administered to school counselors. Results indicate that the unit nonresponse rate was higher for the Web-based version but that the patterns of item nonresponse found generally did not differ between the media. Implications for counselors are discussed.

Department of Emergency Medicine, Sapienza University, Post Graduate School in Emergency-Urgency Medicine, Sant’Andrea Hospital, Rome, Italy University of North Dakota School of Medicine and Biomedical Sciences Grand Forks, ND, USA Department of Medicine, University of Padova, Italy Department of Emergency Medicine, Cleveland Clinic, Cleveland, OH, USA Department of Nephrology, Dialysis and Dietology, SM della Misericordia Hospital, Rovigo, Italy Cardiovascular Department, San Filippo Neri Hospital, Rome, Italy Department of Nephrology Dialysis and Transplantation, International Renal Research Institute (IRRIV), San Bortolo Hospital, Vicenza, Italy GREAT: Global Research in Acute Conditions Team Network

This paper reports the findings from a study to investigate health care professionals&rsquo, views regarding the use and acceptability of two similar paper-based advance care planning (ACP) documents designed for older adults in their last year of life to inform end-of-life care provision. Participants&rsquo, views of using PEACE (Proactive Elderly Persons Advisory Care), a nurse led model with community geriatrician oversight, and PACe (proactive anticipatory care plan), a general practitioner (GP) led model implemented by two clinical commissioning groups (CCGs) as part of a wider pilot to determine their ability to improve end-of-life care provision, were explored. Hospital admission avoidance matrons took part in face to face interviews and care staff employed in private residential care homes took part in individual telephone interviews to explore their views of using the PEACE tool. Telephone interviews were conducted with GPs to explore their views of PACe. GPs and admission avoidance matrons were employed by CCGs and all study participants were recruited from the South East of England, where data collection took place in 2015. The data were analysed thematically. Findings from the study demonstrate how both tools provide a focus to ACP discussions to inform individual end-of-life care preferences. The importance of relationships was a pivotal theme established, trusting inter-professional relationships to enable multidisciplinary teamwork and a prior relationship with the older person (or their proxy in the case of cognitive impairment) to enable such conversations in the first place. Both tools enabled participants to think critically and reflect on their own practice. Notwithstanding participants&rsquo, views to improve their layout, using a paper-based approach to deliver streamlined ACP and end-of-life care was a theme to emerge as a potential barrier, and highlighted problems with accessing paper-based documentation, accuracy and care co-ordination in the context of multidisciplinary team working. The value of technology in overcoming this barrier and underpinning ACP as a means to help simplify service provision, promote integrated professional practice and provide seamless care, was put forward as a way forward.

This position paper will: 1. Provide an update on relevant current developments in the education, training and positioning of clinician nurse scientists; 2. Provide and promote a rational argument for the development of the clinician nurse scientist role; and 3. Discuss issues related to capacity building in clinical research in neuroscience nursing, with specific reference to and support for the cerebrovascular (stroke) specialty nursing area.

Background: Due to the aging of the population, cancer has become a health priority worldwide. While the number of elderly cancer patients is rapidly increasing, many barriers still exist to their effective management. Compared with their younger counterparts, the elderly are less likely to receive optimal medical, psychological and spiritual treatment provided in a culturally competent manner. Design: The scanty literature on cultural competence in elderly cancer patients has been reviewed. Additional material has been selected based on the authors' clinical research in medical oncology and psycho-oncology, and on their scholarly work in anthropology and bioethics. Results: The aging process is a synergistic product of biological, behavioral and social issues within a cultural context. Knowledge about how older people understand, perceive and experience their illness trajectory and make choices is essential to the planning and delivering of effective cancer care. Conclusion: This position paper of the SIOG Task Force on Cultural Competence in the Elderly creates awareness of the influence of culture in geriatric oncology. Negotiating cross-cultural issues in geriatric oncology helps managing possible conflicts between patients, families and physicians over differing health care values, beliefs, or practices. Possible areas of future scholarly investigation and clinical research are identified.

Recibido 7 de abril de 2014 • Corregido 14 de setiembre de 2014 • Aceptado 22 de setiembre de 2014Esta investigación gira en torno a las propiedades de la lingüística textual, estudio que se enmarca en el enfoque cualitativo. Se analizan diversos borradores de un trabajo de investigación producido por dos estudiantes universitarios; también, las programaciones de aula y libros de texto de la asignatura de castellano y literatura de bachillerato, al igual que las asignaturas de la licenciatura de educación de una universidad. La información obtenida en los borradores indica que al estudiantado se le dificulta dar coherencia y cohesionar los escritos; sin embargo, logran seleccionar el lenguaje adecuado según el ambiente donde va a circular el escrito. Las dificultades quizás se deban a que las programaciones de bachillerato no contienen este tema y en los libros de texto como en algunas asignaturas universitarias es muy poco tratado. En conclusión, el profesorado debe introducir la temática de las propiedades de la lingüística textual en las programaciones, para contribuir con el educando a superar las deficiencias al respecto. This research project revolves around the properties of text linguistics under a qualitative approach. The author analyzed drafts of a research paper by two university students as well as lesson plans and textbooks of high school Spanish Language and Literature courses and lesson plans of courses from the Licentiate degree in Education. According to the information from the drafts, students struggle with coherence and cohesion in writing; however, they succeed in choosing the correct language for the type of writing. Difficulties are most likely due to fact that this topic is not included in secondary education plans and is not commonly addressed in textbooks or university classes. In conclusion, teachers should include the properties of text linguistics in their lesson plans in order to help students overcome these difficulties.