1. Dramatic improvement in survival after lung transplantation over time: a single center experience
- Author
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Costache, V., Chavanon, Olivier, St Raymond, C., Sessa, Carmine, Durand, Michel, Duret, Joël, Bach, Vincent, Porcu, P., Hacini, Rachid, Aubert, Axel, Chaffanjon, Philippe, Cochet, E., Brichon, Pierre-Yves, Coltey, Bérangère, Cracowski, Claire, Bertrand, Dominique, Schwebel, Carole, Barnoud, Didier, Brambilla, Elisabeth, Lantuéjoul, Sylvie, Ferretti, Gilbert, Pin, Isabelle, Blin, Dominique, Pison, Christophe, Transplantation Group, Grenoble Lung, Clinique de chirurgie cardiaque, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Clinique de réanimation médicale, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Clinique Chirurgie thoracique, vasculaire et endocrinienne, Service d'hospitalisation Urgences Pneumologiques - Mucoviscidose Adulte, Clinique de pneumologie, CHU Grenoble, Département d'anatomie et cythologie pathologique, CHU Grenoble-Hôpital Michallon, Clinique Universitaire de Radiologie et Imagerie Médicale, and Vesin, Aurélien
- Subjects
Lung Diseases ,Male ,medicine.medical_specialty ,Cystic Fibrosis ,Heart-Lung Transplantation ,Hypertension, Pulmonary ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Single Center ,Gastroenterology ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Lung transplantation ,Pulmonary rehabilitation ,Survivors ,Retrospective Studies ,Transplantation ,COPD ,Lung ,business.industry ,Graft Survival ,Interstitial lung disease ,medicine.disease ,Survival Analysis ,Pulmonary hypertension ,3. Good health ,Surgery ,medicine.anatomical_structure ,030228 respiratory system ,Respiratory failure ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Lung Transplantation - Abstract
International audience; Lung transplantation (LT) is a recognized procedure for selected patients with end-stage respiratory failure. We performed 123 LT, including 32 single lung, 84 double lung, and 7 heart-lung transplantations in 48 patients with chronic obstructive pulmonary disease (COPD), 13 patients with pulmonary hypertension (PH), 33 with cystic fibrosis (CF), and 29 with interstitial lung disease (ILD) between July 1990 and January 2008. Survival was compared for periods before and after December 2001. The mean age of patients was 44.4 years (range 16-66.5 years); 84 (69%) were men. Before LT, 1 second forced expiratory volume was 28.7% +/- 18.1% and PaCO(2) = 6.3 kPa. Fifty-five patients were on noninvasive ventilation. Cold ischemia time was 320 +/- 91 minutes. Cardiopulmonary bypass (CPB) was used in 77 patients (64%). There were 18 early surgical reinterventions, 8 extracorporeal membrane oxygenations, and 38 bronchial stent insertions among 206 at-risk bronchial sutures. Crude survivals were 69%, 58%, 41%, and 18% at 1, 2, 5, and 10 years, respectively. Comparing before (n = 70 with 15 CF) vs after December 2001 (n = 53 with 17 CF), survivals were 63% vs 78%, 51% vs 71%, and 33% vs 60% at 1, 2, and 5 years, respectively (P = .01) and for CF patients, 52% vs 100%, 52% vs 94%, and 25% vs 94% at 1, 2, and 5 years, respectively (P = .005). There was significant improvement in survival before and after 2001 in 123 LT and particularly among CF patients. Improvement in survival after LT may be related to the sum of numerous changes in our practice since December 2001, including the use of pulmonary rehabilitation pre-LT, extracellular pneumoplegia, statins, macrolides for chronic rejection, monitoring of Epstein-Barr blood load, changes in maintenance immunosuppressants, as well as position movement up the coordinator nurse and learning curve.
- Published
- 2009