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Your search keyword '"Short bowel syndrome"' showing total 2 results
2 results on '"Short bowel syndrome"'

1. Long-term incidence and characteristics of intestinal failure in Crohn's disease: a multicenter study.

Author

Watanabe, Kazuhiro, Sasaki, Iwao, Fukushima, Kouhei, Futami, Kitaro, Ikeuchi, Hiroki, Sugita, Akira, Nezu, Riichiro, Mizushima, Tsunekazu, Kameoka, Shingo, Kusunoki, Masato, Yoshioka, Kazuhiko, Funayama, Yuji, Watanabe, Toshiaki, Fujii, Hisao, and Watanabe, Mamoru

Subjects
*INTESTINAL diseases, *CROHN'S disease, *RETROSPECTIVE studies, *HOSPITAL admission & discharge, *SHORT bowel syndrome, *KAPLAN-Meier estimator
Abstract

Background: The aim of this study was to clarify the risk and characteristics of intestinal failure (IF) in patients with Crohn's disease (CD). Methods: The present study was a retrospective study in 12 hospitals. CD patients who underwent initial surgery at any of the 12 hospitals between 1970 and 2009 were collected ( n = 1,703). Those who developed IF were reviewed ( n = 68), and the cumulative risk of IF was analyzed by the Kaplan-Meier method. In addition, IF patients who underwent initial surgery at other hospitals and were then treated at any of the 12 hospitals were also reviewed ( n = 33). Thus, a total of 101 IF patients were collected, and the cumulative risk of IF-related death was analyzed. Results: The cumulative risk of IF after the initial surgery was 0.8 % (5 years), 3.6 % (10 years), 6.1 % (15 years), and 8.5 % (20 years). In CD patients with IF, mean age at initial surgery, IF occurrence, and present age at the time of the study were 28.2, 38.2, and 46.1 years, respectively. The mean number of surgeries per patient was 3.3. The mean length of the remnant small bowel was 163 cm. Twelve IF patients (12 %) had died and the cumulative risk of IF-related death by the time from the occurrence of IF was 1.1 % (3 years), 3.7 % (5 years), 6.5 % (7 years), and 8.9 % (10 years). Conclusion: The occurrence of IF and IF-related death in CD patients is not rare over the long term. There is a pressing need to develop strategies for the prevention and management of IF. [ABSTRACT FROM AUTHOR]

Published
2014
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2. NOD2 mutations are associated with the development of intestinal failure in the absence of Crohn's disease

Author

Holger Schäffler, Johannes Reiner, Maria B. Witte, Chih-Jen Hsieh, Gunnar Blumenstock, Georg Lamprecht, Silvio Nadalin, Alfred Königsrainer, and Nina Schneider

Subjects
Adult, Short Bowel Syndrome, medicine.medical_specialty, Adolescent, Genotype, Nod2 Signaling Adaptor Protein, Critical Care and Intensive Care Medicine, Gastroenterology, Polymorphism, Single Nucleotide, Cohort Studies, Young Adult, Crohn Disease, Gene Frequency, Internal medicine, Intestinal failure, NOD2, medicine, Humans, Genetic Predisposition to Disease, Child, Allele frequency, ATG16L1, Aged, Crohn's disease, Nutrition and Dietetics, business.industry, Middle Aged, Short bowel syndrome, medicine.disease, digestive system diseases, Transplantation, Intestines, Intestinal Diseases, Cohort, Immunology, Mutation, business, Parenteral Nutrition, Home
Abstract

Summary Background & aims Short bowel syndrome (SBS) and intestinal failure (IF) are multi-factorial conditions which in adults result from extensive intestinal resection. NOD2 is an intracellular pattern recognition receptor associated with CD. An unexpected high frequency of NOD2 mutations has been found in patients undergoing intestinal transplantation (35%). The role of NOD2 in a cohort with SBS/IF not specifically requiring intestinal transplantation has not been studied yet. Methods The course of 85 patients with non-malignant SBS/IF was characterized. The major NOD2 mutations, as well as ATG16L1 and IL23R were determined. The allele frequencies were compared to the published frequencies of CD patients and controls. Results In non-CD patients (72%) allele frequencies of NOD2 mutations were statistically more frequent than in controls (14% vs 6%, p = 0.006). In CD patients (28%) allele frequencies were not different between SBS and controls (29% vs 22%, p = 0.23). NOD2 mutations were neither associated with parameters potentially heralding the need for transplantation nor with an earlier time to the indication for intestinal transplantation. Conclusions NOD2 mutations are associated with the development of SBS/IF in the absence of CD, but not with specific complications. NOD2 mutations may increase the risk for more extensive intestinal resection or may impair intestinal adaptation.

Published
2012

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