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Patient: Male, 41 Final Diagnosis: Non-Hodgkin’s lymphoma Symptoms: Fast-growing subcutaneous tumors with lower-extremity edema Medication: — Clinical Procedure: — Specialty: Hematology Objective: Unusual clinical course Background: Diffuse large B-cell lymphoma (DLBCL) accounts for the large majority of AIDS-related non-Hodgkin’s lymphoma (NHL). DLBCL usually arises in lymph nodes, presenting as a painless rapid swelling mass in the neck, armpit, or groin. Case Report: Here, we report a case of DLBCL that needed only 3 months to develop a tumor 20×15 cm in diameter in the right groin and even caused scrotum swelling and lower-extremity edema. Furthermore, this case of DLBCL had developed other 3 subcutaneous tumors in the chest wall and their diameters were 16×9 cm, 7×7 cm, and 3×3 cm. A thoracic computed tomography (CT) scan presented with bilateral pleural effusion and the chest wall tumors with rib lesions. Conclusions: It is rare that a DLBCL needed only 3 months to develop a tumor 20×15 cm in diameter and even caused scrotum swelling and unilateral lower-extremity edema due to the large mass located in the right groin. Furthermore, it is extremely rare that this lymphoma infiltrated the chest wall and even resulted in rib lesions.

Patient: Male, 52 Final Diagnosis: Cryptococcosis Symptoms: Forehead skin lesions and fever Medication: — Clinical Procedure: — Specialty: Infectious Diseases Objective: Unusual clinical course Background: Cryptococcus neoformans (C. neoformans) infection is one of the most common opportunistic infections in AIDS patients. C. neoformans usually infects the central nervous system (CNS) and/or lungs with typical clinical manifestation. Case Report: Here, we report the case of a 52-year-old HIV-1-infected man with disseminated cryptococcosis, including sub-acute meningitis, pulmonary, and cutaneous cryptococcosis, but only skin lesion served as the chief complaint. Moreover, the results of cerebrospinal fluid (CSF) tests and lung computed tomography (CT) scan were atypical. Conclusions: We present the clinical characteristics of this case and discuss the diagnostic procedure, which will likely help clinicians in making a timely definitive diagnosis of this disease.