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Objective: We aimed to determine if any of the second trimester serum marker levels had a significant association with birth weight in uncomplicated pregnancies. Material and Method: Five hundred and forty pregnant women whose second trimester (16-18 weeks) aneuploidy screening and delivery was performed at SBU Zekai Tahir Burak Health Application and Research Center Obstetrics and Gynecology Clinic, are included in this retrospective study. All women had their last menstrual period confirmed by their first trimester ultrasound. Levels of maternal serum alpha-fetoprotein (AFP), β-human chorionic gonadotropin (hCG), and unconjugated estriol (uE3) were calculated as coefficients of the median (MoM). Associations between the second trimester markers levels and infant birth weights were assessed using correlation analysis. The effects of various contributing factors on birth weight were investigated with linear regression analysis. Results: There were significant negative correlations between maternal age at screening (r =-0.48; p =0.03), maternal serum AFP level (r =-0.45; p =0.03) and birth weight of the newborn. Besides, there were positive correlations between amount of weight gain during pregnancy (r =0.44; p =0.04), maternal serum uE3 level (r =0.47; p =0.03) and birth weight of newborn. However, maternal weight and BMI at screening and maternal serum β hCG level did not have a significant correlation with birth weight of newborn. However, maternal serum uE3 level was the only factor that affected the birth weight on linear regression model. Conclusion: Second trimester maternal serum uE3 level might be useful in predicting birth weight among uncomplicated pregnant women. [ABSTRACT FROM AUTHOR]