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Shear wave elastography is emerging as a clinically valuable diagnostic tool to differentiate between benign and malignant breast masses. Elastography techniques assume that soft tissue can be modelled as a purely elastic medium. However, this assumption is often violated as soft tissue exhibits viscoelastic properties. In order to explore the role of viscoelastic parameters in suspicious breast masses, a study was conducted on a group of patients using shear wave dispersion ultrasound vibrometry in the frequency range of 50–400 Hz. A total of 43 female patients with suspicious breast masses were recruited before their scheduled biopsy. Of those, 15 patients did not meet the data selection criteria. Voigt model based shear elasticity showed a significantly (p = 7.88x10-6) higher median value for the 13 malignant masses (16.76±13.10 kPa) compared to 15 benign masses (1.40±1.12 kPa). Voigt model based shear viscosity was significantly different (p = 4.13x10-5) between malignant (8.22±3.36 Pa-s) and benign masses (2.83±1.47 Pa-s). Moreover, the estimated time constant from the Voigt model, which is dependent on both shear elasticity and viscosity, differed significantly (p = 6.13x10-5) between malignant (0.68±0.33 ms) and benign masses (3.05±1.95 ms). Results suggest that besides elasticity, viscosity based parameters like shear viscosity and time constant can also be used to differentiate between malignant and benign breast masses. [ABSTRACT FROM AUTHOR]

Transient elastography quantifies the propagation of a mechanically generated shear wave within a soft tissue, which can be used to characterize the elasticity and viscosity parameters of the tissue. The aim of our study was to combine numerical simulation and clinical assessment to define a viscoelastic index of liver tissue to improve the quality of early diagnosis of liver fibrosis. This is clinically relevant, as early fibrosis is reversible. We developed an idealized two-dimensional axisymmetric finite element model of the liver to evaluate the effects of different viscoelastic values on the propagation characteristics of the shear wave. The diagnostic value of the identified viscoelastic index was verified against the clinical data of 99 patients who had undergone biopsy and routine blood tests for staging of liver disease resulting from chronic hepatitis B infection. Liver stiffness measurement (LSM) and the shear wave attenuation fitting coefficient (AFC) were calculated from the ultrasound data obtained by performing transient elastography. Receiver operating curve analysis was used to evaluate the reliability and diagnostic accuracy of LSM and AFC. Compared to LSM, the AFC provided a higher diagnostic accuracy to differentiate early stages of liver fibrosis, namely F1 and F2 stages, with an overall specificity of 81.48%, sensitivity of 83.33% and diagnostic accuracy of 81.82%. AFC was influenced by the level of LSM, ALT. However, there are no correlation between AFC and Age, BMI, TBIL or DBIL. Quantification of the viscoelasticity of liver tissue provides reliable measurement to identify and differentiate early stages of liver fibrosis. [ABSTRACT FROM AUTHOR]