1. Air pollution and plaque healing in acute coronary syndromes.
- Author
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Russo, Michele, Rinaldi, Riccardo, Camilli, Massimiliano, Bonanni, Alice, Caffè, Andrea, Basile, Mattia, Salzillo, Carmine, Colucci, Michele, Torre, Ilaria, Sanna, Tommaso, Liuzzo, Giovanna, Burzotta, Francesco, Trani, Carlo, Niccoli, Giampaolo, Crea, Filippo, and Montone, Rocco A
- Subjects
ACUTE coronary syndrome ,AIR pollution ,ENDOTHELIUM diseases ,ATHEROSCLEROTIC plaque ,AIR quality monitoring stations ,HEALING - Abstract
Keywords: Air pollution; Plaque healing; Acute coronary syndromes; Thrombosis; Inflammation EN Air pollution Plaque healing Acute coronary syndromes Thrombosis Inflammation 2403 2405 3 07/11/23 20230707 NES 230707 Introduction Plaque healing plays a key role in coronary atherosclerosis[1] and represents "the second hit" required to cause an acute coronary syndrome (ACS) after plaque destabilization, this latter being the "first hit".[[1], [3]] Moreover, an impaired plaque healing has been found in patients with recurrent ACS, suggesting its importance in preventing repeated symptomatic coronary thrombosis.[3] Nonetheless, mechanisms modulating plaque healing are unknown. In first acute coronary syndrome patients, particulate matter 2.5 chronic exposure levels were similar between patients with and without healed plaques in the culprit lesion, while particulate matter 2.5 was higher in those with macrophage infiltration and thin-cap fibroatheroma at the culprit plaque. Among recurrent ACS patients, 6 patients (20.7%) had TCFA at the culprit lesion, and these patients had higher PM2.5 (17.9 ± 3.6 vs. 13.6 ± 3.4 I µ i g/m SP 3 sp , I P i = 0.030) and PM10 (28.8 ± 3.2 vs. 24.2 ± 3.9 I µ i g/m SP 3 sp , I P i = 0.014) exposure levels compared to those without TCFA. [Extracted from the article]
- Published
- 2023
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