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Start Over Topic artificial skin Publication Year Range Last 50 years
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1. Automatic quantitative analysis of structure parameters in the growth cycle of artificial skin using optical coherence tomography

Author

Ruihang Zhao, Yakun Ge, Mingen Xu, Han Tang, Chen Xu, and Ling Wang

Subjects
Paper, Skin Neoplasms, Microscope, Materials science, Interface (computing), Biomedical Engineering, Surface finish, Artificial skin, law.invention, Biomaterials, Optical coherence tomography, law, Microscopy, medicine, Surface roughness, Humans, General, artificial skin, Skin, Skin, Artificial, optical coherence tomography, adaptive interface detection, medicine.diagnostic_test, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, roughness model, Tomography, Algorithms, Tomography, Optical Coherence, Biomedical engineering
Abstract

Significance: Artificial skin (AS) is widely used in dermatology, pharmacology, and toxicology, and has great potential in transplant medicine, burn wound care, and chronic wound treatment. There is a great demand for high-quality AS product and a non-invasive detection method is highly desirable. Aim: To quantify the constructure parameters (i.e., thickness and surface roughness) of AS samples in the culture cycle and explore the growth regularities using optical coherent tomography (OCT). Approach: An adaptive interface detection algorithm is developed to recognize surface points in each A-scan, offering a rapid method to calculate parameters without constructing OCT B-scan pictures and further achieving realizing real-time quantification of AS thickness and surface roughness. Experiments on standard roughness plates and H&E-staining microscopy were performed as a verification. Results: As applied on the whole cycle of AS culture, our method’s results show that during the air–liquid culture, the surface roughness of the skin first decreases and then exhibits an increase, which implies coincidence with the degree of keratinization under a microscope. And normal and typical abnormal samples can be differentiated by thickness and roughness parameters during the culture cycle. Conclusions: The adaptive interface detection algorithm is suitable for high-sensitivity, fast detection, and quantification of the interface with layered characteristic tissues, and can be used for non-destructive detection of the growth regularity of AS sample thickness and roughness during the culture cycle.

Published
2021

2. Gecko‐Inspired Paper Artificial Skin for Intimate Skin Contact and Multisensing.

Author

Gao, Bingbing, Wang, Xuan, Li, Tong, Feng, Zhangqi, Wang, Chunyan, and Gu, Zhongze

Subjects
*ARTIFICIAL skin, *GECKOS, *MICROFLUIDICS, *TOUCH, *POLYVINYLIDENE fluoride, *PIEZOELECTRICITY, *NITROCELLULOSE
Abstract

Touch sensing is the most basic but important way for organisms to interact with the outside world, and thus, fingertip skin has been widely studied to enable the manufacture of artificial skin. Sensitive multisensing integrated with perfect adhesion performance is crucial for synchronous and sensitive human physical and biochemical indicator monitoring. Here, a gecko‐inspired nanotentacle skin integrated with a microfluidic system and a polyvinylidene fluoride (PVDF)‐based piezoelectricity nanogenerator (PENG) is proposed for simultaneous multisensing. The obtained 3D nitrocellulose (NC) nanotentacle array paper is flexible and freestanding. Stainless stamps are used to imprint lithography patterns (microfluidic channels) on the NC paper, and channels with three branches are used for sweat split‐flow and sensing of pH, urea, and lactic acid. Meanwhile, the patterned substrate is integrated with a PENG, and the nanotentacles allow the substrate to conformally fit to rough skin, thus enabling sensitive sensing of micromotions (pulse beats). The results indicate that the multifunctional skin sensor is capable of sensitively monitoring the human state, thereby serving as an inspiring example for the construction of next‐generation skin with smart sensing systems. Furthermore, our sensors are amenable to a variety of applications, such as personal care, artificial skin, and human–machine interactions. A gecko‐inspired nanotentacle‐array‐based paper artificial skin for enhanced health and motion monitoring is proposed. The skin is integrated with a microfluidics system and polyvinylidene fluoride (PVDF) piezoelectricity nanogenerator for sweat index sensing and wrist pulse measurement during exercise. [ABSTRACT FROM AUTHOR]

Published
2019
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