1. Induction of the metabolism of etizolam by carbamazepine in humans.
- Author
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Kondo, S., Fukasawa, T., Yasui-Furukori, N., Aoshima, T., Suzuki, A., Inoue, Y., Tateishi, T., and Otani, K.
- Subjects
CARBAMAZEPINE ,ANTICONVULSANTS ,DRUGS ,DRUG metabolism ,DRUG interactions ,PHARMACOKINETICS - Abstract
Objective: To examine the effect of carbamazepine on the single oral dose pharmacokinetics of etizolam. Methods: Eleven healthy male volunteers received carbamazepine 200 mg/day or placebo for 6 days in a double-blind, randomized, crossover manner, and on the sixth day they received a single oral 1-mg dose of etizolam. Blood samplings and evaluation of psychomotor function by the Digit Symbol Substitution Test and Stanford Sleepiness Scale were conducted up to 24 h after etizolam dosing. Plasma concentration of etizolam was measured using high-performance liquid chromatography. Results: Carbamazepine treatment significantly decreased the peak plasma concentration (17.5±4.1 ng/ml versus 13.9±4.1 ng/ml; P<0.05), total area under the plasma concentration-time curve (194.8±88.9 ng h/ml versus 105.9±33.0 ng h/ml; P<0.001), and elimination half-life (11.1±4.6 h versus 6.8±2.8 h; P<0.01) of etizolam. No significant change was induced by carbamazepine in the two pharmacodynamic parameters. Conclusions: The present study suggests that carbamazepine induces the metabolism of etizolam. [ABSTRACT FROM AUTHOR]
- Published
- 2005
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