1. The antibacterial peptide ABP-CM4: the current state of its production and applications.
- Author
-
Li, Jian, Zhang, Jie, Xu, Xing, Han, Yang, Cui, Xian, Chen, Yu, and Zhang, Shuang
- Subjects
- *
ANTIBACTERIAL agents , *PEPTIDE drugs , *ANTIBIOTICS , *DRUG resistance in microorganisms , *SPECTRUM analysis , *MOLECULAR structure , *ANTINEOPLASTIC agents - Abstract
The increasing resistance of bacteria and fungi to currently available antibiotics is a major concern worldwide, leading to enormous efforts to develop new antibiotics with new modes of actions. Antibacterial peptide CM4 (ABP-CM4) is a small cationic peptide with broad-spectrum activities against bacteria, fungi, and tumor cells, which may possibly be used as a promising candidate for a new antibiotic. For pharmaceutical applications, a large quantity of antimicrobial peptides needs to be produced economically. In this communication, the progress in the structural characteristics, heterologous production, and biological evaluation of ABP-CM4 are reviewed. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF