1. Rhodomollosides A and B, glycosides of methyl everninate from the aerial parts of Rhododendron molle.
- Author
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Yang, Xue-Rong, Tanaka, Naonobu, Song, Jing-Ru, Lu, Feng-Lai, Yan, Xiao-Jie, Li, Jian-Xing, Zhao, Xue-Ying, Kashiwada, Yoshiki, and Li, Dian-Peng
- Subjects
EXPERIMENTAL design ,PHENOLS ,HIGH performance liquid chromatography ,ANALGESICS ,ANTI-inflammatory agents ,ANIMAL experimentation ,GLYCOSIDES ,PHYTOCHEMICALS ,PLANT extracts ,MOLECULAR structure ,CELL surface antigens ,CHINESE medicine ,ANIMALS ,MICE ,IMMUNODIAGNOSIS - Abstract
Two new glycosides of methyl everninate, rhodomollosides A (1) and B (2), were isolated from the aerial parts of a medicinal plant Rhododendron molle. The structures of 1 and 2 were elucidated on the basis of detailed spectroscopic analyses as well as HPLC analyses for thiazolidine derivatives of their sugar moieties. The sugar moiety of rhodomolloside A (1) was elucidated to be a rare monosaccharide, D-allose, while rhodomolloside B (2) was assigned as a D-glucoside of methyl everninate. Furthermore, they were evaluated for their cytotoxicity against RAW264.7 cells, and for their inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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