1. Patterns of Amino Acids near Signal-Sequence Cleavage Sites.
- Author
-
von Heijne, Gunnar
- Subjects
ENDOPLASMIC reticulum ,AMINO acids ,PROTEINS ,SCISSION (Chemistry) ,EUKARYOTIC cells ,AMINO acid sequence - Abstract
According to the signal hypothesis, a signal sequence, once having initiated export of a growing protein chain across the rough endoplasmic reticulum, is cleaved from the mature protein at a specific site. It has long been known that some part of the cleavage specificity resides in the last residue of the signal sequence, which invariably is one with a small, uncharged side-chain, but no further specific patterns of amino acids near the point of cleavage have been discovered so far. In this paper, some such patterns, based on a sample of 78 eukaryotic signal sequences, are presented and discussed, and a first attempt at formulating rules for the prediction of cleavage sites is made. [ABSTRACT FROM AUTHOR]
- Published
- 1983
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