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The approach to epistemic cultures exposes the differences in the construction of the processes of production and creation of knowledge between the different academic fields, which, in turn, implies the fragmentation of knowledge. The digital humanities are an inter and transdisciplinary field composed of different epistemic cultures marked by different knowledge production practices that differ from each other. In the current scenario of academic communication, the discourse around open practices in the course of research has increasingly taken a prominent place. However, this discourse, under the open science paradigm, proves to be more framed in the context of the epistemic cultures of science, and does not fully consider other domains of knowledge. This study aims to frame the epistemic cultures of the digital humanities in the discourse of openness of knowledge, through a literature review about digital humanities and open science. Its conclusion points to the need to adopt a specific discourse around the openness of knowledge, which considers the diversity of academic communication practices, including those that are specific to the humanities, as well as to the fact that the digital humanities can contribute to the consolidation of this discourse. [ABSTRACT FROM AUTHOR]