Search

Your search keyword '"Bruinsma, Bastiaan"' showing total 2 results
Start Over Author "Bruinsma, Bastiaan" Topic 5-csrtt Publication Year Range Last 50 years
2 results on '"Bruinsma, Bastiaan"'

1. Prefrontal Cortical to Mediodorsal Thalamus Projection Neurons Regulate Posterror Adaptive Control of Behavior

Author

Bruinsma, Bastiaan, Pattij, Tommy, Mansvelder, Huibert D., Anatomy and neurosciences, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Integrative Neurophysiology, and Amsterdam Neuroscience - Cellular & Molecular Mechanisms

Subjects
Male, prefrontal cortex, General Neuroscience, General Medicine, adaptive control, Rats, Thalamus, SDG 3 - Good Health and Well-being, Interneurons, Neural Pathways, Impulsive Behavior, Animals, cognitive control, mediodorsal thalamus, 5-CSRTT
Abstract

Adaptive control is the online adjustment of behavior to guide and optimize responses after errors or conflict. The neural circuits involved in monitoring and adapting behavioral performance following error are poorly understood. The prefrontal cortex (PFC) plays a critical role in this form of control. However, these brain areas are densely connected with many other regions, and it is unknown which projections are critical for adaptive behavior. Here, we tested the involvement of four distinct dorsal and ventral prefrontal cortical projections to striatal and thalamic target areas in adaptive control. We re-analyzed data from published experiments, using trial-by-trial analyses of behavior in an operant task for attention and impulsivity. We find that male rats slow their responses and perform worse following errors. Moreover, by combining retrograde labeling and chemogenetic silencing, we find that dorsomedial prefrontal pyramidal neurons that project to the lateral nucleus of the mediodorsal thalamus (MDL) are involved in posterror performance and timing of responses, specifically with unpredictable delays until stimulus presentation. Together, these data show that dorsal medial PFC (mPFC) projection neurons targeting the lateral MDT regulate adaptive control to flexibly optimize behavioral responses in goal-directed behavior.

Published
2022

2. Prefrontal Cortical Projection Neurons Targeting Dorsomedial Striatum Control Behavioral Inhibition.

Author

Terra, Huub, Bruinsma, Bastiaan, de Kloet, Sybren F., van der Roest, Marcel, Pattij, Tommy, and Mansvelder, Huibert D.

Subjects
*CONTROL (Psychology), *NEURONS, *COGNITION, *ATTENTION control, *PREFRONTAL cortex, *NEURAL pathways
Abstract

A neural pathway from prefrontal cortex (PFC) to dorsal striatum (DS) has been suggested to mediate cognitive control of behavior, including proactive inhibitory control and attention. However, a direct causal demonstration thereof is lacking. Here, we show that selective chemogenetic silencing of corticostriatal PFC neurons in rats increases premature responses. Wireless single-unit electrophysiological recordings of optogenetically identified corticostriatal PFC neurons revealed that the majority of these neurons encode behavioral trial outcome with persistent changes in firing rate. Attentional parameters were not affected by silencing corticostriatal PFC neurons, suggesting that these projection neurons encode a specific subset of cognitive behaviors. Compared to the general non-identified neuronal population in the PFC, frontostriatal neurons showed selective engagement during periods of inhibitory control. Our results demonstrate a role for corticostriatal neurons in inhibitory control and possibly suggest that distinct domains of cognitive control over behavior are encoded by specific projection neuron populations. • Silencing of dorsal frontostriatal projection neurons impairs behavioral inhibition • Frontostriatal neurons are predominantly persistently activated or silenced • Frontostriatal neurons show selective activity dynamics within the mPFC • Activity of frontostriatal neurons is related to behavioral control Terra et al. investigate the role of dorsal mPFC-to-medial dorsal striatum projection neurons in behavioral inhibition. Chemogenetic silencing of frontostriatal neurons results in a loss of behavioral inhibition. Within the mPFC, frontostriatal neurons selectively show persistent changes in activity, related to successful behavioral inhibition. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results