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Your search keyword '"Askautrud, Hanne A"' showing total 23 results
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23 results on '"Askautrud, Hanne A"'

2. Deep learning for automated scoring of immunohistochemically stained tumour tissue sections – Validation across tumour types based on patient outcomes

Author

Bathen, Tone F., Borgen, Elin, Børresen-Dale, Anne-Lise, Engebråten, Olav, Fritzman, Britt, Hartman-Johnsen, Olaf Johan, Garred, Øystein, Geisler, Jürgen, Geitvik, Gry Aarum, Hofvind, Solveig, Kåresen, Rolf, Langerød, Anita, Lingjærde, Ole Christian, Mælandsmo, Gunhild M., Naume, Bjørn, Russnes, Hege G., Sahlberg, Kristine Kleivi, Sauer, Torill, Skjerven, Helle Kristine, Schlichting, Ellen, Sørlie, Therese, Kildal, Wanja, Cyll, Karolina, Kalsnes, Joakim, Islam, Rakibul, Julbø, Frida M., Pradhan, Manohar, Ersvær, Elin, Shepherd, Neil, Vlatkovic, Ljiljana, Tekpli, Xavier, Kristensen, Gunnar B., Askautrud, Hanne A., Hveem, Tarjei S., and Danielsen, Håvard E.

Published
2024
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7. Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series

Author

Domingo, Enric, Camps, Carme, Kaisaki, Pamela J, Parsons, Marie J, Mouradov, Dmitri, Pentony, Melissa M, Makino, Seiko, Palmieri, Michelle, Ward, Robyn L, Hawkins, Nicholas J, Gibbs, Peter, Askautrud, Hanne, Oukrif, Dahmane, Wang, Haitao, Wood, Joe, Tomlinson, Evie, Bark, Yasmine, Kaur, Kulvinder, Johnstone, Elaine C, Palles, Claire, Church, David N, Novelli, Marco, Danielsen, Havard E, Sherlock, Jon, Kerr, David, Kerr, Rachel, Sieber, Oliver, Taylor, Jenny C, and Tomlinson, Ian

Published
2018
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8. Corrigendum to “Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft”, [Journal of Control Release, 293 (2019) 183–192]

Author

Fusser, Markus, primary, Øverbye, Anders, additional, Pandya, Abhilash D., additional, Mørch, Ýrr, additional, Borgos, Sven Even, additional, Kildal, Wanja, additional, Snipstad, Sofie, additional, Sulheim, Einar, additional, Fleten, Karianne Giller, additional, Askautrud, Hanne Arenberg, additional, Engebraaten, Olav, additional, Flatmark, Kjersti, additional, Iversen, Tore Geir, additional, Sandvig, Kirsten, additional, Skotland, Tore, additional, and Mælandsmo, Gunhild M., additional

Published
2022
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9. Stromal composition predicts recurrence of early rectal cancer after local excision

Author

Jones, Helen J S, Cunningham, Chris, Askautrud, Hanne A, Danielsen, Håvard E, Kerr, David J, Domingo, Enric, Maughan, Tim, Leedham, Simon J, Koelzer, Viktor H, University of Zurich, and Jones, Helen J S

Subjects
2734 Pathology and Forensic Medicine, 10049 Institute of Pathology and Molecular Pathology, 610 Medicine & health, 2722 Histology
Published
2021

12. PTEN and DNA Ploidy Status by Machine Learning in Prostate Cancer

Author

Cyll, Karolina, primary, Kleppe, Andreas, additional, Kalsnes, Joakim, additional, Vlatkovic, Ljiljana, additional, Pradhan, Manohar, additional, Kildal, Wanja, additional, Tobin, Kari Anne R., additional, Reine, Trine M., additional, Wæhre, Håkon, additional, Brennhovd, Bjørn, additional, Askautrud, Hanne A., additional, Skaaheim Haug, Erik, additional, Hveem, Tarjei S., additional, and Danielsen, Håvard E., additional

Published
2021
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14. Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

Author

Skrede, Ole-Johan, primary, De Raedt, Sepp, additional, Kleppe, Andreas, additional, Hveem, Tarjei S, additional, Liestøl, Knut, additional, Maddison, John, additional, Askautrud, Hanne A, additional, Pradhan, Manohar, additional, Nesheim, John Arne, additional, Albregtsen, Fritz, additional, Farstad, Inger Nina, additional, Domingo, Enric, additional, Church, David N, additional, Nesbakken, Arild, additional, Shepherd, Neil A, additional, Tomlinson, Ian, additional, Kerr, Rachel, additional, Novelli, Marco, additional, Kerr, David J, additional, and Danielsen, Håvard E, additional

Published
2020
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15. Regulated expression of a transgene introduced on an oriP/EBNA-1 PAC shuttle vector into human cells

Author

Thorsen Jim, Lindeberg Mona M, Størvold Gro L, Gjernes Elisabet, Askautrud Hanne A, Prydz Hans, and Frengen Eirik

Subjects
Biotechnology, TP248.13-248.65
Abstract

Abstract Background Sequencing of the human genome has led to most genes being available in BAC or PAC vectors. However, limited functional information has been assigned to most of these genes. Techniques for the manipulation and transfer of complete functional units on large DNA fragments into human cells are crucial for the analysis of complete genes in their natural genomic context. One limitation of the functional studies using these vectors is the low transfection frequency. Results We have constructed a shuttle vector, pPAC7, which contains both the EBNA-1 gene and oriP from the Epstein-Barr virus allowing stable maintenance of PAC clones in the nucleus of human cells. The pPAC7 vector also contains the EGFP reporter gene, which allows direct monitoring of the presence of PAC constructs in transfected cells, and the Bsr-cassette that allows highly efficient and rapid selection in mammalian cells by use of blasticidin. Positive selection for recombinant PAC clones is obtained in pPAC7 because the cloning sites are located within the SacBII gene. We show regulated expression of the CDH3 gene carried as a 132 kb genomic insert cloned into pPAC7, demonstrating that the pPAC7 vector can be used for functional studies of genes in their natural genomic context. Furthermore, the results from the transfection of a range of pPAC7 based constructs into two human cell lines suggest that the transfection efficiencies are not only dependent on construct size. Conclusion The shuttle vector pPAC7 can be used to transfer large genomic constructs into human cells. The genes transferred could potentially contain all long-range regulatory elements, including their endogenous regulatory promoters. Introduction of complete genes in PACs into human cells would potentially allow complementation assays to identify or verify the function of genes affecting cellular phenotypes.

Published
2009
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16. Chromatin organisation and cancer prognosis: a pan-cancer study

Author

Kleppe, Andreas, primary, Albregtsen, Fritz, additional, Vlatkovic, Ljiljana, additional, Pradhan, Manohar, additional, Nielsen, Birgitte, additional, Hveem, Tarjei S, additional, Askautrud, Hanne A, additional, Kristensen, Gunnar B, additional, Nesbakken, Arild, additional, Trovik, Jone, additional, Wæhre, Håkon, additional, Tomlinson, Ian, additional, Shepherd, Neil A, additional, Novelli, Marco, additional, Kerr, David J, additional, and Danielsen, Håvard E, additional

Published
2018
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22. Matrix Metalloproteinase 13 Is Induced in Fibroblasts in Polyomavirus Middle T Antigen-Driven Mammary Carcinoma without Influencing Tumor Progression

Author

Nielsen, Boye S., primary, Egeblad, Mikala, additional, Rank, Fritz, additional, Askautrud, Hanne A., additional, Pennington, Caroline J., additional, Pedersen, Tanja X., additional, Christensen, Ib J., additional, Edwards, Dylan R., additional, Werb, Zena, additional, and Lund, Leif R., additional

Published
2008
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23. DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance.

Author

Cyll K, Skaaheim Haug E, Pradhan M, Vlatkovic L, Carlsen B, Löffeler S, Kildal W, Skogstad K, Hauge Torkelsen F, Syvertsen RA, Askautrud HA, Liestøl K, Kleppe A, and Danielsen HE

Abstract

Background: Current risk stratification tools for prostate cancer patients under active surveillance (AS) may inadequately identify those needing treatment. We investigated DNA ploidy and PTEN as potential biomarkers to predict aggressive disease in AS patients., Methods: We assessed DNA ploidy by image cytometry and PTEN protein expression by immunohistochemistry in 3197 tumour-containing tissue blocks from 558 patients followed in AS at a Norwegian local hospital. The primary endpoint was treatment, with treatment failure (biochemical recurrence or initiation of salvage therapy) as the secondary endpoint., Results: The combined DNA ploidy and PTEN (DPP) status at diagnosis was associated with treatment-free survival in univariable- and multivariable analysis, with a HR for DPP-aberrant vs. DPP-normal tumours of 2.12 (p < 0.0001) and 1.94 (p < 0.0001), respectively. Integration of DNA ploidy and PTEN status with the Cancer of the Prostate Risk Assessment (CAPRA) score improved risk stratification (c-index difference = 0.025; p = 0.0033). Among the treated patients, those with DPP-aberrant tumours exhibited a significantly higher likelihood of treatment failure (HR 2.01; p = 0.027)., Conclusions: DNA ploidy and PTEN could serve as additional biomarkers to identify AS patients at increased risk of developing aggressive disease, enabling earlier intervention for nearly 50% of the patients that will eventually receive treatment with current protocol., (© 2024. The Author(s).)

Published
2024
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