11 results on '"Johnson, Warren E."'
Search Results
2. Comparative genomics reveals insights into avian genome evolution and adaptation
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Zhang, Guojie, Li, Cai, Li, Qiye, Li, Bo, Larkin, Denis M., Lee, Chul, Storz, Jay F., Antunes, Agostinho, Greenwold, Matthew J., Meredith, Robert W., Ödeen, Anders, Cui, Jie, Zhou, Qi, Xu, Luohao, Pan, Hailin, Wang, Zongji, Jin, Lijun, Zhang, Pei, Hu, Haofu, Yang, Wei, Hu, Jiang, Xiao, Jin, Yang, Zhikai, Liu, Yang, Xie, Qiaolin, Yu, Hao, Lian, Jinmin, Wen, Ping, Zhang, Fang, Li, Hui, Zeng, Yongli, Xiong, Zijun, Liu, Shiping, Zhou, Long, Huang, Zhiyong, An, Na, Wang, Jie, Zheng, Qiumei, Xiong, Yingqi, Wang, Guangbiao, Wang, Bo, Wang, Jingjing, Fan, Yu, da Fonseca, Rute R., Alfaro-Núñez, Alonzo, Schubert, Mikkel, Orlando, Ludovic, Mourier, Tobias, Howard, Jason T., Ganapathy, Ganeshkumar, Pfenning, Andreas, Whitney, Osceola, Rivas, Miriam V., Hara, Erina, Smith, Julia, Farré, Marta, Narayan, Jitendra, Slavov, Gancho, Romanov, Michael N, Borges, Rui, Machado, João Paulo, Khan, Imran, Springer, Mark S., Gatesy, John, Hoffmann, Federico G., Opazo, Juan C., Håstad, Olle, Sawyer, Roger H., Kim, Heebal, Kim, Kyu-Won, Kim, Hyeon Jeong, Cho, Seoae, Li, Ning, Huang, Yinhua, Bruford, Michael W., Zhan, Xiangjiang, Dixon, Andrew, Bertelsen, Mads F., Derryberry, Elizabeth, Warren, Wesley, Wilson, Richard K, Li, Shengbin, Ray, David A., Green, Richard E., O'Brien, Stephen J., Griffin, Darren, Johnson, Warren E., Haussler, David, Ryder, Oliver A., Willerslev, Eske, Graves, Gary R., Alström, Per, Fjeldså, Jon, Mindell, David P., Edwards, Scott V., Braun, Edward L., Rahbek, Carsten, Burt, David W., Houde, Peter, Zhang, Yong, Yang, Huanming, Wang, Jian, Consortium, Avian Genome, Jarvis, Erich D., Gilbert, M. Thomas P., and Wang, Jun
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- 2014
3. Tissue sampling methods and standards for vertebrate genomics
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Wong Pamela BY, Wiley Edward O, Johnson Warren E, Ryder Oliver A, O’Brien Stephen J, Haussler David, Koepfli Klaus-Peter, Houck Marlys L, Perelman Polina, Mastromonaco Gabriela, Bentley Andrew C, Venkatesh Byrappa, Zhang Ya-ping, and Murphy Robert W
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Genome 10K ,Sequencing ,Vertebrates ,Genomics ,Tissue sampling ,Tissue storage ,Cell line ,Tissue culture ,RNA ,DNA ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract The recent rise in speed and efficiency of new sequencing technologies have facilitated high-throughput sequencing, assembly and analyses of genomes, advancing ongoing efforts to analyze genetic sequences across major vertebrate groups. Standardized procedures in acquiring high quality DNA and RNA and establishing cell lines from target species will facilitate these initiatives. We provide a legal and methodological guide according to four standards of acquiring and storing tissue for the Genome 10K Project and similar initiatives as follows: four-star (banked tissue/cell cultures, RNA from multiple types of tissue for transcriptomes, and sufficient flash-frozen tissue for 1 mg of DNA, all from a single individual); three-star (RNA as above and frozen tissue for 1 mg of DNA); two-star (frozen tissue for at least 700 μg of DNA); and one-star (ethanol-preserved tissue for 700 μg of DNA or less of mixed quality). At a minimum, all tissues collected for the Genome 10K and other genomic projects should consider each species’ natural history and follow institutional and legal requirements. Associated documentation should detail as much information as possible about provenance to ensure representative sampling and subsequent sequencing. Hopefully, the procedures outlined here will not only encourage success in the Genome 10K Project but also inspire the adaptation of standards by other genomic projects, including those involving other biota.
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- 2012
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4. The evolutionary history of extinct and living lions.
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de Manuel, Marc, Barnett, Ross, Sandoval-Velasco, Marcela, Nobuyuki Yamaguchi, Vieira, Filipe Garrett, Lisandra Zepeda Mendoza, M., Shiping Liu, Martin, Michael D., Sinding, Mikkel-Holger S., Mak, Sarah S. T., Carøe, Christian, Shanlin Liu, Chunxue Guo, Jiao Zheng, Zazula, Grant, Baryshnikov, Gennady, Eizirik, Eduardo, Koepfli, Klaus-Peter, Johnson, Warren E., and Antunes, Agostinho
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LIONS ,HISTORICAL reenactments ,POPULATION differentiation ,CURRENT distribution ,GENE flow - Abstract
Lions are one of the world’s most iconic megafauna, yet little is known about their temporal and spatial demographic history and population differentiation. We analyzed a genomic dataset of 20 specimens: two ca. 30,000-y-old cave lions (Panthera leo spelaea), 12 historic lions (Panthera leo leo/Panthera leo melanochaita) that lived between the 15th and 20th centuries outside the current geographic distribution of lions, and 6 present-day lions from Africa and India. We found that cave and modern lions shared an ancestor ca. 500,000 y ago and that the 2 lineages likely did not hybridize following their divergence. Within modern lions, we found 2 main lineages that diverged ca. 70,000 y ago, with clear evidence of subsequent gene flow. Our data also reveal a nearly complete absence of genetic diversity within Indian lions, probably due to well-documented extremely low effective population sizes in the recent past. Our results contribute toward the understanding of the evolutionary history of lions and complement conservation efforts to protect the diversity of this vulnerable species. [ABSTRACT FROM AUTHOR]
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- 2020
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5. Bone-associated gene evolution and the origin of flight in birds.
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Machado, João Paulo, Johnson, Warren E., Gilbert, M. Thomas P., Guojie Zhang, Jarvis, Erich D., O'Brien, Stephen J., and Antunes, Agostinho
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GENOMICS , *ANALYSIS of bones , *VERTEBRATE evolution , *VERTEBRATES , *BIRDS , *MAMMALS - Abstract
Background: Bones have been subjected to considerable selective pressure throughout vertebrate evolution, such as occurred during the adaptations associated with the development of powered flight. Powered flight evolved independently in two extant clades of vertebrates, birds and bats. While this trait provided advantages such as in aerial foraging habits, escape from predators or long-distance travels, it also imposed great challenges, namely in the bone structure. Results: We performed comparative genomic analyses of 89 bone-associated genes from 47 avian genomes (including 45 new), 39 mammalian, and 20 reptilian genomes, and demonstrate that birds, after correcting for multiple testing, have an almost two-fold increase in the number of bone-associated genes with evidence of positive selection (~52.8 %) compared with mammals (~30.3 %). Most of the positive-selected genes in birds are linked with bone regulation and remodeling and thirteen have been linked with functional pathways relevant to powered flight, including bone metabolism, bone fusion, muscle development and hyperglycemia levels. Genes encoding proteins involved in bone resorption, such as TPP1, had a high number of sites under Darwinian selection in birds. Conclusions: Patterns of positive selection observed in bird ossification genes suggest that there was a period of intense selective pressure to improve flight efficiency that was closely linked with constraints on body size. [ABSTRACT FROM AUTHOR]
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- 2016
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6. Evolutionary Genomics and Adaptive Evolution of the Hedgehog Gene Family (Shh, Ihh and Dhh) in Vertebrates.
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Pereira, Joana, Johnson, Warren E., O’Brien, Stephen J., Jarvis, Erich D., Zhang, Guojie, Gilbert, M. Thomas P., Vasconcelos, Vitor, and Antunes, Agostinho
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BIOLOGICAL evolution , *GENETICS , *VERTEBRATES , *HEDGEHOG signaling proteins , *GENETIC code , *CELLULAR signal transduction , *GENE expression - Abstract
The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two active domains that act as signalling molecules during embryo development, namely for the development of the nervous and skeletal systems and the formation of the testis cord. While only one Hh gene is found typically in invertebrate genomes, most vertebrates species have three (Sonic hedgehog – Shh; Indian hedgehog – Ihh; and Desert hedgehog – Dhh), each with different expression patterns and functions, which likely helped promote the increasing complexity of vertebrates and their successful diversification. In this study, we used comparative genomic and adaptive evolutionary analyses to characterize the evolution of the Hh genes in vertebrates following the two major whole genome duplication (WGD) events. To overcome the lack of Hh-coding sequences on avian publicly available databases, we used an extensive dataset of 45 avian and three non-avian reptilian genomes to show that birds have all three Hh paralogs. We find suggestions that following the WGD events, vertebrate Hh paralogous genes evolved independently within similar linkage groups and under different evolutionary rates, especially within the catalytic domain. The structural regions around the ion-binding site were identified to be under positive selection in the signaling domain. These findings contrast with those observed in invertebrates, where different lineages that experienced gene duplication retained similar selective constraints in the Hh orthologs. Our results provide new insights on the evolutionary history of the Hh gene family, the functional roles of these paralogs in vertebrate species, and on the location of mutational hotspots. [ABSTRACT FROM AUTHOR]
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- 2014
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7. A Molecular Phylogeny of Living Primates.
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Perelman, Polina, Johnson, Warren E., Roos, Christian, Seuańnez, Hector N., Horvath, Julie E., Moreira, Miguel A. M., Kessing, Bailey, Pontius, Joan, Roelke, Melody, Rumpler, Yves, Schneider, Maria Paula C., Silva, Artur, O'Brien, Stephen J., and Pecon-Slattery, Jill
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MOLECULAR phylogeny , *PRIMATES , *GENOMICS , *SPECIES , *ZOONOSES , *FLYING lemurs , *SCANDENTIA , *LAGOMORPHA - Published
- 2011
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8. BIG CAT GENOMICS.
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O'Brien, Stephen J. and Johnson, Warren E.
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POPULATION , *GENOMICS , *ALGORITHMS , *GENETICS , *SPECIES , *MOLECULAR genetics - Abstract
Advances in population and quantitative genomics, aided by the computational algorithms that employ genetic theory and practice, are now being applied to biological questions that surround free-ranging species not traditionally suitable for genetic enquiry. Here we review how applications of molecular genetic tools have been used to describe the natural history, present status, and future disposition of wild cat species. Insight into phylogenetic hierarchy, demographic contractions, geographic population substructure, behavioral ecology, and infectious diseases have revealed strategies for survival and adaptation of these fascinating predators. Conservation, stabilization, and management of the big cats are important areas that derive benefit from the genome resources expanded and applied to highly successful species, imperiled by an expanding human population. [ABSTRACT FROM AUTHOR]
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- 2005
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9. Camelid Genetics and Reproductive Biotechnologies.
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Johnson, Warren E.
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ALPACA , *CAMELIDAE , *GENETICS , *GENOMICS , *BIOTECHNOLOGY - Abstract
The article offers information on alpaca, one of seven camelids that are found in some of the world's most arid ecosystems. Topics discussed include the increasing practice of alpaca husbandry and the emerging camelid genomic tools. Also mentioned is the second Camelid Genetics and Reproductive Biotechnologies meeting that was held on September 16-18, 2011 in anticipation of the completion of the alpaca genome.
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- 2014
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10. Evolution of feline immunodeficiency virus in Felidae: Implications for human health and wildlife ecology
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Pecon-Slattery, Jill, Troyer, Jennifer L., Johnson, Warren E., and O’Brien, Stephen J.
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CARNIVORA , *GENETICS , *GENOMICS , *CATS - Abstract
Abstract: Genetic analyses of feline immunodeficiency viruses provide significant insights on the worldwide distribution and evolutionary history of this emerging pathogen. Large-scale screening of over 3000 samples from all species of Felidae indicates that at least some individuals from most species possess antibodies that cross react to FIV. Phylogenetic analyses of genetic variation in the pol-RT gene demonstrate that FIV lineages are species-specific and suggest that there has been a prolonged period of viral-host co-evolution. The clinical effects of FIV specific to species other than domestic cat are controversial. Comparative genomic analyses of all full-length FIV genomes confirmed that FIV is host specific. Recently sequenced lion subtype E is marginally more similar to Pallas cat FIV though env is more similar to that of domestic cat FIV, indicating a possible recombination between two divergent strains in the wild. Here we review global patterns of FIV seroprevalence and endemnicity, assess genetic differences within and between species-specific FIV strains, and interpret these with patterns of felid speciation to propose an ancestral origin of FIV in Africa followed by interspecies transmission and global dissemination to Eurasia and the Americas. Continued comparative genomic analyses of full-length FIV from all seropositive animals, along with whole genome sequence of host species, will greatly advance our understanding of the role of recombination, selection and adaptation in retroviral emergence. [Copyright &y& Elsevier]
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- 2008
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11. Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens.
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Barnett, Ross, Westbury, Michael V., Sandoval-Velasco, Marcela, Vieira, Filipe Garrett, Jeon, Sungwon, Zazula, Grant, Martin, Michael D., Ho, Simon Y.W., Mather, Niklas, Gopalakrishnan, Shyam, Ramos-Madrigal, Jazmín, de Manuel, Marc, Zepeda-Mendoza, M. Lisandra, Antunes, Agostinho, Baez, Aldo Carmona, De Cahsan, Binia, Larson, Greger, O'Brien, Stephen J., Eizirik, Eduardo, and Johnson, Warren E.
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GENOMICS , *SHOTGUN sequencing , *MITOCHONDRIAL DNA , *CUSPIDS , *CATS , *INTROGRESSION (Genetics) , *ANIMAL offspring sex ratio - Abstract
Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [ 1–4 ]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [ 5 ]. Previous mitochondrial DNA phylogenies suggested that it was a highly divergent sister lineage to all extant cat species [ 6–8 ]. However, mitochondrial phylogenies can be misled by hybridization [ 9 ], incomplete lineage sorting (ILS), or sex-biased dispersal patterns [ 10 ], which might be especially relevant for Homotherium since widespread mito-nuclear discrepancies have been uncovered in modern cats [ 10 ]. To examine the evolutionary history of Homotherium , we generated a ∼7x nuclear genome and a ∼38x exome from H. latidens using shotgun and target-capture sequencing approaches. Phylogenetic analyses reveal Homotherium as highly divergent (∼22.5 Ma) from living cat species, with no detectable signs of gene flow. Comparative genomic analyses found signatures of positive selection in several genes, including those involved in vision, cognitive function, and energy consumption, putatively consistent with diurnal activity, well-developed social behavior, and cursorial hunting [ 5 ]. Finally, we uncover relatively high levels of genetic diversity, suggesting that Homotherium may have been more abundant than the limited fossil record suggests [ 3 , 4 , 11–14 ]. Our findings complement and extend previous inferences from both the fossil record and initial molecular studies, enhancing our understanding of the evolution and ecology of this remarkable lineage. • Nuclear genome and exome analyses of extinct scimitar-toothed cat, Homotherium latidens • Homotherium was a highly divergent lineage from all living cat species (∼22.5 Ma) • Genetic adaptations to cursorial and diurnal hunting behaviors • Relatively high levels of genetic diversity in this individual Here, Barnett et al. sequence the nuclear genome of Homotherium latidens through a combination of shotgun and target-capture approaches. Analyses confirm Homotherium to be a highly divergent lineage from all living cat species (∼22.5 Ma) and reveal genes under selection putatively related to a cursorial and diurnal hunting behavior. [ABSTRACT FROM AUTHOR]
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- 2020
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