1. Direct Visualization of Walking Motions of PhotocontrolledNanomachine on the DNA Nanostructure.
- Author
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Yangyang Yang, Marisa A. Goetzfried, Kumi Hidaka, Mingxu You, Weihong Tan, Hiroshi Sugiyama, and Masayuki Endo
- Subjects
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NANOSTRUCTURES , *DNA , *PYRENE , *DISULFIDES , *SCISSION (Chemistry) , *ULTRAVIOLET radiation - Abstract
A light-driven artificial molecularnanomachine was constructed based on DNA scaffolding. Pyrene-modifiedwalking strands and disulfide bond-connected stator strands, employedas anchorage sites to support walker movement, were assembled intoa 2D DNA tile. Pyrene molecules excited by photoirradiation at 350nm induced cleavage of disulfide bond-connected stator strands, enablingthe DNA walker to migrate from one cleaved stator to the next on theDNA tile. The time-dependent movement of the walker was observed andthe entire walking process of the walker was characterized by distributionof the walker-stator duplex at four anchorage sites on the tile under different irradiation times.Importantly, the light-fuelled mechanical movements on DNA tile werefirst visualized in real time during UV irradiation using high-speedatomic force microscopy (HS-AFM). [ABSTRACT FROM AUTHOR]
- Published
- 2015
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