1. Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6.
- Author
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Georgiades, Stelios, Boyle, Michael, Szatmari, Peter, Hanna, Steven, Duku, Eric, Zwaigenbaum, Lonnie, Bryson, Susan, Fombonne, Eric, Volden, Joanne, Mirenda, Pat, Smith, Isabel, Roberts, Wendy, Vaillancourt, Tracy, Waddell, Charlotte, Bennett, Teresa, Elsabbagh, Mayada, and Thompson, Ann
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GENETICS of autism , *AGE factors in disease , *ALGORITHMS , *ANALYSIS of variance , *AUTISM , *CHILD Behavior Checklist , *COMMUNICATIVE competence , *CONCEPTUAL structures , *FACTOR analysis , *INTERVIEWING , *LONGITUDINAL method , *MATHEMATICAL models of psychology , *RESEARCH funding , *PHENOTYPES , *REPEATED measures design , *CROSS-sectional method , *DESCRIPTIVE statistics , *SYMPTOMS , *CHILDREN - Abstract
The latent class structure of autism symptoms from the time of diagnosis to age 6 years was examined in a sample of 280 children with autism spectrum disorder. Factor mixture modeling was performed on 26 algorithm items from the Autism Diagnostic Interview - Revised at diagnosis (Time 1) and again at age 6 (Time 2). At Time 1, a '2-factor/3-class' model provided the best fit to the data. At Time 2, a '2-factor/2-class' model provided the best fit to the data. Longitudinal (repeated measures) analysis of variance showed that the '2-factor/3-class' model derived at the time of diagnosis allows for the identification of a subgroup of children (9 % of sample) who exhibit notable reduction in symptom severity. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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