28 results on '"Yadav, Sarika"'
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2. Recent advances in the synthesis and applications of porous zirconium phosphate
- Author
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Yadav, Sarika, Beniwal, Naveen, Rekha, Pawan, and Singh, Lovjeet
- Published
- 2022
- Full Text
- View/download PDF
3. Conceptualizing network approaches for a successful farm entrepreneurship using ATLAS.ti®
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Gulsia, Oshin and Yadav, Sarika
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- 2023
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- View/download PDF
4. Sunset Yellow protects against oxidative damage and exhibits chemoprevention in chemically induced skin cancer model
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Singh, Saurabh, primary, Yadav, Sarika, additional, Cavallo, Celine, additional, Mourya, Durgesh, additional, Singh, Ishu, additional, Kumar, Vijay, additional, Shukla, Sachin, additional, Shukla, Pallavi, additional, Chaudhary, Romil, additional, Maurya, Gyan Prakash, additional, Müller, Ronja Lea Jennifer, additional, Rohde, Lilly, additional, Mishra, Aradhana, additional, Wolkenhauer, Olaf, additional, Gupta, Shailendra, additional, and Tripathi, Anurag, additional
- Published
- 2024
- Full Text
- View/download PDF
5. A review on cobalt phosphate-based materials as emerging catalysts for water splitting
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Rekha, Pawan, Yadav, Sarika, and Singh, Lovjeet
- Published
- 2021
- Full Text
- View/download PDF
6. MANAGEMENT OF DADRU KUSHTHA THROUGH AYURVEDA – A CASE REPORT
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Gautam, Apeksha, yadav, sarika, C.R Yadav, Gautam, Apeksha, yadav, sarika, and C.R Yadav
- Abstract
Skin being the largest and a protective covering of all our internal organs is susceptible to many harmful environmental factors causing different kinds of bacterial, viral and fungal infections. All the skin disease in Ayurveda has been classified into Mahakushtha and Kshudra Kushtha. Dadru is one among them. As per modern perspective “Superficial fungal infection of skin” is the most common dermatological manifestation affecting up to 15% of world‟s population in all age groups. In present time, antifungal treatment is based on systemic and topical medications which may lead to many side effects and relapse too. Fungal infections are more demoralizing to the patients due to their appearance, recurrence, chronicity, and negative psychological impact. Keeping this fact in mind below mentioned study drafted to focuses on Ayurvedic Shamana and Shodhan Chikitsa in Dadru Kushtha. AIM AND OBJECTIVES –To evaluate the effect of Shodhana and Shamana Chikitsa in Dadru Kushtha. MATERIAL AND METHODS- It will be collected from classical Ayurvedic texts as well from previous research works / thesis, Internet sources, research articles and modern sciences text. DISSCUSSION AND CONCLUSIONS- On the basis of signs and symptoms we can correlated the Dadru Kushtha to Tinea Cruris. In This case report, a 67 yr old male patient came with complaints of Dadru Kushtha, which is closely similar to the presentation of Tinea Cruris infection. The present case showed significant improvement with Ayurvedic Shodhan, Shaman and Bahiparimarjan (topical) Chikitsa in Dadru.
- Published
- 2024
7. Achieving cost efficiency through increased inventory leanness: Evidence from manufacturing industry
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Mor Rahul S, Kumar Dinesh, Yadav Sarika, and Jaiswal Swatantra Kumar
- Subjects
inventory management ,abc ,ved analysis ,manufacturing industry ,lean production ,Machine design and drawing ,TJ227-240 ,Engineering machinery, tools, and implements ,TA213-215 - Abstract
Inventory management’s fundamental problem starts with maintaining equilibrium among the operating efficiency, cost of investment, and other allied costs with extensive inventories to keep the actual conflicts at the minimum while optimizing the inventory holding levels. But, inventory management practices have not been well exploited in various manufacturing industries yet. In this study, inventory management tools, i.e., ABC and VED analysis, have been applied in the manufacturing industry, considering 146 items as raw material for an assembly. A total of 15 items under ‘AV’ class have been identified that consume 82.05 % of the total cost, and these items need strict control and frequent ordering. Sigma level of suppliers is also calculated, which comes out to be 2.36, and it must be improved to reduce the overall inventory cost.
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- 2021
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- View/download PDF
8. Amine-functionalized single-layered 2D nanosheets of α-zirconium phosphate for highly efficient removal of Pb2+ ions and Congo red dye
- Author
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Yadav, Sarika, primary, Das, Jasasmita, additional, Chaurasia, Satyendra Prasad, additional, Singh, Lovjeet, additional, and Rekha, Pawan, additional
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- 2023
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- View/download PDF
9. Yadav, Sarika
- Author
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Yadav, Sarika and Yadav, Sarika
- Published
- 2023
10. Effectiveness of Distraction Technique on Pain Reduction After Administration Subcutaneous Injection Among Children in Immunization Rooms
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Yadav, Sarika, Shokeen, Jyoti, Yadav, Sarika, and Shokeen, Jyoti
- Abstract
Pain is described as "an unpleasant, subjective sensory and emotional experience associated with existing or potential tissue damage, or described in terms of such damage," according to the International Association for the Study of Pain (IASP). Suffering results from untreated or ineffectively treated pain. The method of administering medication subcutaneously, which is frequently done by nurses, is associated with discomfort, pain, and injury to the tissue that is being injected. The primary goal of the study was to determine whether using a distraction approach helped children in the immunisation rooms of particular hospitals in Gurugram feel less discomfort after receiving a subcutaneous injection. Materials and Methods: 60 children were chosen by the purposive selection strategy from the hospital Gurugram's immunization rooms. The chosen individuals are then split into two equally sized groups. Results: In the assessment, the experimental group's mean score on the pre-facing rating scale was 6.93, while the control group's was 7.13, with an SD of 1.252. The experimental group's mean score on the post-faces rating scale is 2.00, whereas the control group's is 6.47, with a standard deviation of 1.548. Conclusion : The outcome demonstrates a movement in the sample's level of pain (hurts worse, hurts a lot, hurts a little more, hurts even more, hurts a little, doesn't hurt) in favour of the experimental group. When compared to the control group, it is because of the distraction strategy (an electronic moving toy).
- Published
- 2023
11. INVESTIGATION OF ANTICANCER ACTIVITY ON CURCUMIN DENDRIMERIC NANOFORMULATION
- Author
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Poonam Yadav, Sarika Chaturvedi
- Abstract
Curcumin (diferuloylmethane) is a polyphenol derivedfrom the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulatetranscription factors NF-κB, AP-1 and Egr-1; down-regulate theexpression of COX2, LOX, NOS, MMP-9, uPA, TNF,chemokines, cell surface adhesion molecules and cyclin D1;down-regulate growth factor receptors (such as EGFR andHER2); and inhibit the activity of c-Jun N-terminal kinase,protein tyrosine kinases and protein serine/threonine kinases. One draw-back holding curcumin back is its insolublility in water and therefore has poor absorption and subsequently poor bioavailability. Dendrimer, being well defined and highly branched macromolecule, their multifunctionality and specific shape have been recognized as powerful tool in drug delivery. Polyamidation (PAMAM) dendrimers consist of core dendr-termini (i.e. DAB-dendr-(NH2)64) is a diaminobutanecore dendritic poly(propylene mine) having 64 primary amine termini, also named as DAB-dendr-(PA)64, where PA stands for polyamine, and its repeating units and terminal groups potent for interaction of oppositely charged component and produces surfactant like effects by forming a nanoparticles for drug delivery. In the context of drug delivery, the use of fatty acids as permeation enhancer limits the metabolism of drug in liver when administered orally and allowed for plasma binding in blood readily. The application f this study could be sustained for oral delivery and improved absorption through gastrointestinal tract for overall enhancement in therapeutic efficacy. Based on these reports, the present study is designed to overcome pharmacokinetic drawbacks by conjugating with dendrimer and understanding there physicochemical properties of curcumin/dendrimer/fatty acids complex system and to evaluate its suitability for sustaineddrug release, which is further allowed for oral drug delivery for screening as potent anticancer agents by using in vitro and in vivo model.
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- 2023
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12. Acetaminophen modulates the ratio of Group 2 innate lymphoid cells and regulatory Innate lymphoid cells in Ovalbumin sensitization mice model.
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Yadav, Sarika and Tripathi, Anurag
- Subjects
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ACETAMINOPHEN , *LYMPHOID tissue , *OVALBUMINS , *ANALGESICS , *IMMUNOLOGY - Abstract
Acetaminophen (APAP) is a widely used drug known for its analgesic and antipyretic properties. However, its exact mechanism of action is still unclear and has been primarily associated with its effects on COX enzymes and serotonergic pathways. Till date, the immunological mechanisms affected by APAP has gained only inadequate attention. A distinct group of immune cells called Group 2 Innate Lymphoid Cells (ILC2s) are known to play an important role in type 2 cytokine-mediated immunity and their regulatory dysfunction is associated with numerous type 2 pathologies, such as allergy. Conversely, another class of recently characterized Innate Lymphoid Cells called Innate Regulatory Cells (ILCregs) suppress the activation of ILC2s. Maintaining a balance between ILC2s and ILCregs is vital for achieving a well-controlled immune response and tissue homeostasis. Recent studies have highlighted the critical role of prostaglandin D2 (PGD2) in the maturation and development of ILC2 functions. Since APAP also suppresses PGD2 synthesis, it was speculated that APAP treatment could reduce the number of ILC2s while potentially increasing the number of ILCregs. To investigate this hypothesis, here, we administered therapeutic doses of APAP to OVA-sensitized mice, a well-established model of type 2 pathological inflammation. The mice received oral doses of 200 mg/kg body wt. of APAP twice weekly, along with weekly OVA sensitizations for six weeks. The mice were sacrificed at different time points (days 14, 28 and 42) to assess the kinetics of ILC2s, ILCregs and immunoglobulins (IgE and IgG1). The results demonstrated that APAP treatment effectively suppressed OVA-induced ILC2s while significantly increasing the number of IL-10+ ILCregs. APAP exposure also led to decreased levels of serum PGD2, OVA-specific IgE and IgG1, and enhanced the level of IL-10 in OVA sensitized mice. Moreover, OVA sensitized mice treated with APAP did not develop pathological changes in spleen, when compared to OVA sensitized mice. Additionally, APAP treatment did not cause any adverse effects on mice liver in treatment groups. These preliminary findings suggest that APAP exhibits the capacity to modulate type 2 immune responses by suppressing ILC2s and inducing the expansion of IL-10+ ILCregs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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13. Effectiveness of Distraction Technique on Pain Reduction After Administration Subcutaneous Injection Among Children in Immunization Rooms
- Author
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Yadav, Sarika, primary and Shokeen, Jyoti, additional
- Published
- 2023
- Full Text
- View/download PDF
14. Immunotherapies in the treatment of immunoglobulin E‑mediated allergy: Challenges and scope for innovation (Review)
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Yadav, Sarika, primary, Singh, Saurabh, additional, Mandal, Payal, additional, and Tripathi, Anurag, additional
- Published
- 2022
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15. An Ayurvedic Management Of Sthaulya w.s.r. Obesity: A Case Study: DOI: https://doi.org/10.47223/IRJAY.2021.4201
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Sharma, Manish Kumar, Sharma, Ramakant, Yadav, Sarika, Sharma, Manish Kumar, Sharma, Ramakant, and Yadav, Sarika
- Abstract
Now a day’s peoples are not conscious about their health. In today's era, obesity is growing very fast due to lifestyle changes. According to W.H.O obesity is the fifth leading risk for global deaths. The double burden of the disease was more observed in lower and middle-income countries. Many diseases arise due to obesity like Diabetes, Hypertension, Heart disease, etc. in modern medicine there is no treatment for obesity. In Ayurveda obesity can be correlated with Sthaulya or Meda Vriddhi. A 42-year-old patient rush to Ayurvedic hospital for better treatment with Sthaulya (obesity), Daurbalya (Debility), Swas krichta (Shortness of breath), Ati-Kshudha, (excessive eating) and Ati-Pipasa (excessive thirst) etc. The patient got a surprising change in his subjective and objective criteria by administering some Ayurvedic medicines and changes in his daily routine.
- Published
- 2021
16. Rasayana : A Safe Guarder Towards Non-Communicable Disease-Review Article: DOI: https://doi.org/10.47223/IRJAY.2021.41221
- Author
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Sv, Suvitha, Yadav, Sarika, Yadav, Chhaju Ram, Sv, Suvitha, Yadav, Sarika, and Yadav, Chhaju Ram
- Abstract
Non communicable diseases are one of the major challenging issues facing worldwide, especially in developing countries in the 21st century, not only in terms of human sufferings but also its badly affecting the socioeconomic development of the country. According to the WHO report, NCD’s are collectively responsible for the death of around 41 million people each year, equivalent to 71% of all deaths worldwide. Also, they report that if timely intervention is not done for the prevention and control of NCD's, the death rate will increase to 55 million by 2030. Due to the unplanned rapid urbanization, globalisation of unhealthy lifestyles and population ageing, people are more prone to lifestyle disorders such as cardiovascular disease, respiratory disorders, cancers, diabetes etc. Being a part of the health-care delivery system, this is the time to re-analyse the health management system and look back at the philosophy of prevention and preservation as the first step to treatment. Ayurveda is the system which focuses mainly on preventive aspects and considered it as prime or foremost objective. Various diet and regimens are mentioned in Ayurveda to maintain good healthy life style such as Dinacharya, Ritucharya, Sadvritta, Pathyaapathya, Aharavidhi, Aharakalpana, Dharaniya and adharaniya vega, Sodhana ,Achara Rasayana, Rasayana etc.Among that, Rasayana tantra is one among the Astanga of Ayurveda which highly stresses preservation of health and prevention of disease. Based on our today’s hurry burry lifestyle, it’s the basic need for everyone to follow and include this Rasayana therapy in our day-to-day schedule to maintain health and prevent various lifestyle disorders. Rasayana is an effective preventive technique towards non-communicable disease.
- Published
- 2021
17. Rachanatmak and KriyatmakReview of Twachain Ayurveda with Reference to Skin: DOI: https://doi.org/10.47223/IRJAY.2021.41220
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Upadhyaya, Nilkanth, Yadav, Sarika, Yadav, Chhaju Ram, Upadhyaya, Nilkanth, Yadav, Sarika, and Yadav, Chhaju Ram
- Abstract
Ayurveda, the world's utmost ancient science of life, focuses on preventing disease along with treating it. In Ayurveda, Twacha is described as outermost covering and protective layer of the body. Acharya Charaka describes Twacha is the Mula of Mamsavaha Srotas and Upadhatu of Mamsa Dhatu. Twacha is the Adhishthana of Sparshanendriya. Ayurveda describes six or seven distinct layers of the skin, each with its own structure and function. The layers are designed in such a way that each one supports the layer above it. In Ayurvedic classics, various opinions regarding Twacha Uttapati, Twacha Stara and associated disorders are mentioned The seven layers of Twacha proclaimed by Sushruta, corresponds perfectly with the seven skin layers, accepted by western medicine also. Acharya Charaka describes six layers of Twacha and named first two layers while remaining four layers have been described in the term of disease in particular layer. Twak is a reflector of the total health and well-being of an individual. The incidence and impact of diseases of skin are increasing day by day. Disease conditions of Twak cause physical, mental, social andspiritual disharmonies in a person. Hence the necessity of detailed study and analysis of the concept of the Twacha, its Rachanatmak and Kriyatmak aspect is of utmost importance and immense necessary.
- Published
- 2021
18. Clinical Experience on Effect of Ayurveda In Vyanga W.S.R. Melasma
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Sharma, Manish Kumar, Yadav, C R, Yadav, Sarika, Sharma, Manish Kumar, Yadav, C R, and Yadav, Sarika
- Abstract
Now a day’s importance of beauty is increasing day by day. People are highly conscious for their looks. They are using various cosmetics not only for treatment purpose but as an essential part of their daily routine, so natural beauty is getting spoiled due to the harmful chemicals. In modern medical science topical steroids and cosmetic surgery have been described in the management of Vyanga or melisma. But all these procedures are complicated technical ones which need expertise help or costly affairs which demands a lot of time and money. Ayurveda mentions a large number of medicines for skin care including massage with local application of paste etc. which makes face smooth, soft and glowing.in Ayurveda Vyanga or melasma is a kshudra roga (Minor Diseases). A 24 year old boy rush to ayurvedic hospital for better treatment with blackish spots, dryness, itching, and burning sensation but there are no any systemic effects for long days back and earlier he was taken modern medicine such as steroidal antibiotics drugs. Removing the steroids and antibiotics the patient advised to take Ayurveda medicines and Mukh Lepa (face pack) for thirty days. Patient subjective criteria, objective criteria have significant change in before and after treatment without any untoward and side effect. 
- Published
- 2021
19. An Ayurvedic Management Of Sthaulya w.s.r. Obesity: A Case Study
- Author
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Sharma, Manish Kumar, Sharma, Ramakant, Yadav, Sarika, Sharma, Manish Kumar, Sharma, Ramakant, and Yadav, Sarika
- Abstract
Now a day’s peoples are not conscious about their health. In today's era, obesity is growing very fast due to lifestyle changes. According to W.H.O obesity is the fifth leading risk for global deaths. The double burden of the disease was more observed in lower and middle-income countries. Many diseases arise due to obesity like Diabetes, Hypertension, Heart disease, etc. in modern medicine there is no treatment for obesity. In Ayurveda obesity can be correlated with Sthaulya or Meda Vriddhi. A 42-year-old patient rush to Ayurvedic hospital for better treatment with Sthaulya (obesity), Daurbalya (Debility), Swas krichta (Shortness of breath), Ati-Kshudha, (excessive eating) and Ati-Pipasa (excessive thirst) etc. The patient got a surprising change in his subjective and objective criteria by administering some Ayurvedic medicines and changes in his daily routine. 
- Published
- 2021
20. Rachanatmak and Kriyatmak Review of Twacha in Ayurveda with Reference to Skin
- Author
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Upadhyaya, Nilkanth, Yadav, Sarika, Yadav, Chhaju Ram, Upadhyaya, Nilkanth, Yadav, Sarika, and Yadav, Chhaju Ram
- Abstract
Ayurveda, the world's utmost ancient science of life, focuses on preventing disease along with treating it. In Ayurveda, Twacha is described as outermost covering and protective layer of the body. Acharya Charaka describes Twacha is the Mula of Mamsavaha Srotas and Upadhatu of Mamsa Dhatu. Twacha is the Adhishthana of Sparshanendriya. Ayurveda describes six or seven distinct layers of the skin, each with its own structure and function. The layers are designed in such a way that each one supports the layer above it. In Ayurvedic classics, various opinions regarding Twacha Uttapati, Twacha Stara and associated disorders are mentioned The seven layers of Twacha proclaimed by Sushruta, corresponds perfectly with the seven skin layers, accepted by western medicine also. Acharya Charaka describes six layers of Twacha and named first two layers while remaining four layers have been described in the term of disease in particular layer. Twak is a reflector of the total health and well-being of an individual. The incidence and impact of diseases of skin are increasing day by day. Disease conditions of Twak cause physical, mental, social and spiritual disharmonies in a person. Hence the necessity of detailed study and analysis of the concept of the Twacha, its Rachanatmak and Kriyatmak aspect is of utmost importance and immense necessary. 
- Published
- 2021
21. Rasayana : A Safe Guarder Towards Non-Communicable Disease Review Article
- Author
-
Sv, Suvitha, Yadav, Sarika, Yadav, Chhaju Ram, Sv, Suvitha, Yadav, Sarika, and Yadav, Chhaju Ram
- Abstract
Non communicable diseases are one of the major challenging issues facing worldwide, especially in developing countries in the 21st century, not only in terms of human sufferings but also its badly affecting the socioeconomic development of the country. According to the WHO report, NCD’s are collectively responsible for the death of around 41 million people each year, equivalent to 71% of all deaths worldwide. Also, they report that if timely intervention is not done for the prevention and control of NCD's, the death rate will increase to 55 million by 2030. Due to the unplanned rapid urbanization, globalisation of unhealthy lifestyles and population ageing, people are more prone to lifestyle disorders such as cardiovascular disease, respiratory disorders, cancers, diabetes etc. Being a part of the health-care delivery system, this is the time to re-analyse the health management system and look back at the philosophy of prevention and preservation as the first step to treatment. Ayurveda is the system which focuses mainly on preventive aspects and considered it as prime or foremost objective. Various diet and regimens are mentioned in Ayurveda to maintain good healthy life style such as Dinacharya, Ritucharya, Sadvritta, Pathya apathya, Aharavidhi, Aharakalpana, Dharaniya and adharaniya vega, Sodhana ,Achara Rasayana, Rasayana etc.Among that, Rasayana tantra is one among the Astanga of Ayurveda which highly stresses preservation of health and prevention of disease. Based on our today’s hurry burry lifestyle, it’s the basic need for everyone to follow and include this Rasayana therapy in our day-to-day schedule to maintain health and prevent various lifestyle disorders. Rasayana is an effective preventive technique towards non-communicable disease. 
- Published
- 2021
22. Concept Of Ahara With Respect To Prakriti :A Review
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Gupta, Preeti Kumari, Yadav, Sarika, Gupta, Preeti Kumari, and Yadav, Sarika
- Abstract
In Ayurveda system of medicine ,the whole concept of health and disease, prevention and management is based on type of constitution and it is rooted through Tridosha theory of Ayurveda. Thus Ayurveda is only applied science which is still in practice having unbroken continuity. Dietetics can be defined as the branch of knowledge concerned with Diet & its effects on health .According to WHO the enjoyment of the highest attainable standard of health is one of the fundamental rights of every human being. Ayurveda the “Science of life” is a system of medicine that utilizes various therapies including diet ,herbal preprations and yoga to restore harmony balance within the body. It focuses more on the healthy living and well being. One of the main goals of Ayurveda is to maintain health of a healthy individual and to attain the health in the diseased. Diet is mentioned in 3 sub – pillar (sub tripods of life), since it is responsible is for growth & development of the human body. One of the important concepts in Ayurveda is “Prakriti ”the innate nature of an individual & is determined at the time of conception itself & remains throughout the life. Knowing of Prakriti helps in maintaining the health and preventing the disease. Ayurveda prescribes various foods and lifestyles According to one’s Prakriti and suggests that one should follow these guidelines to prevent various disorders and to promote health. In this era of lifestyle disorders in order to improve the quality of life & to bring down the cost of health care one should know about his Prakriti & the diet suitable for his body constitution .Here by this paper is intended to explain the concepts of diet in Ayurveda in a backlight of Prakriti. 
- Published
- 2020
23. A Pathophysiological Aspect Of Asthi-Majjakshaya W.S.R. To Osteoporosis
- Author
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Gill, Gurpreet Kaur, Yadav, Chhaju Ram, Yadav, Sarika, Gill, Gurpreet Kaur, Yadav, Chhaju Ram, and Yadav, Sarika
- Abstract
Nearly 1 million folks annually report taking time away from work to treat and recover from musculoskeletal pain or loss of function due to overexertion. Osteoporosis is a major and emerging health problem worldwide. It affects an estimated 75 million people in United States, Europe and Japan combined. Osteoporosis is a disease that is characterized by low bone mass, deterioration of bone tissue, and disruption of bone microarchitecture: it can lead to compromised bone strength and an increase in the risk of fractures. There is no actual or relevant clinical entity mentioned in classics which can be correlated with osteoporosis term coined by contemporary science. In Ayurveda, Asthikshaya and Asthisaushirya may be discussed in this regard. The etiological factors for Asthikshaya and Asthisaushirya are assessed on the principles of Ashrayashrayi Bhava and in context of Majjakshaya. According to Ashrayashrayi Bhava, Asthi Dhatu is the seat of Vata Dosha and Asthi & Vata are inversely proportional to each other regarding increase and decrease. Increase of Vata leads to decrease of Asthi, therefore causes Asthikshaya. Asthisaushirya is not mentioned as a separate condition however as a symptom of Majjakshaya. Majjakshaya may take place after Asthikshaya as per the basic principles of Anulomakshaya. Since there is decrease of bone tissue in both the conditions, i.e., osteopenia and osteoporosis, it can be considered as Asthi-Majjakshaya attributable to its core of pathogenesis: 1) degeneration of bone tissue and 2) vitiation of Vata, the classical aspects of Asthi Majjakshaya can be implemented in the disease osteoporosis. 
- Published
- 2020
24. Prevalence of anaemia and its association with dietary habits among pregnant women in the urban area of Haryana
- Author
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Kumar, Tarun, primary, Grover, Kashish, additional, Doda, Aashima, additional, Bhutani, Rashi, additional, Yadav, Sarika, additional, Kaushal, Pankaj, additional, Kapoor, Roopam, additional, and Sharma, Sandeep, additional
- Published
- 2020
- Full Text
- View/download PDF
25. TOPICAL EMULGEL OF TOLNAFTATE WITH PENETRATION ENHANCER: DEVELOPMENT, CHARACTERISATION AND ANTIFUNGAL ACTIVITY
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Siddhant Yadav, Sarika Wairkar
- Subjects
Tolnaftate, emulgel, Eucalyptus oil, antifungal activity, drug diffusion - Abstract
Tolnaftate, an antifungal agent, has poor solubility and scarce permeability. The main objective of the study was to formulate and evaluate emulgel of Tolnaftate for improved topical drug delivery. Emulgel was formulated by preparing Tolnaftate emulsion and incorporated into Carbopol-940 gel base with two different penetration enhancers i.e Eucalyptus oil (EO) and Transcutol at concentration of 1%, 3% and 5% w/w separately. The formulations were evaluated for physic-chemical properties, in vitro drug release, ex vivo diffusion studies and antifungal activity against Candida albicans. The satisfactory physicochemical parameters were exhibited by optimised emulgel formulation containing 5 % EO (Batch-F7). Further, it showed 88.09% ± 0.24 in vitro drug release and 74.87% ± 0.73 ex vivo diffusion at the end of 8 hours which were considerably higher than emulgel without penetration enhancer. When assessed for antifungal activity, the zone of inhibition of Batch-F7 was significantly improved as compared to pure drug, emulgel without EO. This may be attributed to increased penetration of emulgel in fungi cells in presence of EO which translated into efficient antifungal activity. Therefore, it can be concluded that Tolnaftate emulgel was successfully prepared with simple and commercially feasible manufacturing process and can serve as potential topical delivery of Tolnaftate.
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- 2017
- Full Text
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26. Prevalence of anaemia and its association with dietary habits among pregnant women in the urban area of Haryana.
- Author
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Grover, Kashish, Kumar, Tarun, Doda, Aashima, Bhutani, Rashi, Yadav, Sarika, Kaushal, Pankaj, Kapoor, Roopam, and Sharma, Sandeep
- Subjects
FOOD habits ,PREGNANT women ,CITIES & towns ,ANEMIA ,IRON deficiency ,ORAL habits - Abstract
Introduction: Anaemia is a major health problem in India especially among pregnant women and nutritional anaemia, primarily iron deficiency, is the most common type of anaemia caused primarily due to iron deficiency. About 58% of pregnant women in India are anaemic and it is estimated that anaemia is the underlying cause of 20–40% of cases of maternal deaths. Therefore, the present study was planned to study the prevalence of anaemia among pregnant women and to explore the relationship between anaemia during pregnancy and different dietary factors. Aim and Objective: To study the prevalence of anaemia and dietary habits among pregnant women in an urban slum of Haryana. Materials and Methods: A cross-sectional study was carried out among pregnant women in the urban field practise area of Pt. B.D. Sharma PGIMS, Rohtak. All Pregnant women registered in 2018 were interviewed using a semi-structured pretested questionnaire. Observations were interpreted as per the WHO criteria. The data were analysed by SPSS statistical software version 20. Results: Out of 408 study participants, 348 (85.3%) were anaemic with mild, moderate and severe anaemia in 80 (19.6%), 244 (59.8%) and 24 (5.9%), respectively. More than half (50.5%), of the anaemic mothers, were found in the first trimester, respectively. The association of vegetarian diet and tea consumption was statistically significant with the severity of anaemia. (P < 0.05). Conclusion: The present findings showed a high prevalence of anaemia and unhealthy dietary habits significantly associated with it among pregnant women. Efforts to identify anaemia that may be responsive to modifiable factors such as diet to improve health outcomes are needed. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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- View/download PDF
27. Argemone oil, an edible oil adulterant, induces systemic immunosuppression in Balb/c mice in an oral 28 days repeated dose toxicity study
- Author
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Mandal, Payal, primary, Tewari, Prachi, additional, Kumar, Sachin, additional, Yadav, Sarika, additional, Ayanur, Anjaneya, additional, Chaturvedi, Rajnish K., additional, Das, Mukul, additional, and Tripathi, Anurag, additional
- Published
- 2018
- Full Text
- View/download PDF
28. Plant Glycomics: Advances and Applications
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Yadav, Sarika, Yadav, Dinesh K., Yadav, Neelam, Khurana, S. M. Paul, Yadav, Sarika, Yadav, Dinesh K., Yadav, Neelam, and Khurana, S. M. Paul
- Abstract
Glycomics, the study of entire complement of sugars in an organism, helps to analyze the interaction of sugar with other macromolecules like carbohydrates, proteins, and nucleic acid. Greater structural complexity, nonlinear relationship of glycans with genome, and difficulty in isolation, characterization, and synthesis of complex oligosaccharides pose a significant challenge to glycomics. The isolation of plant glycoconjugates from natural sources is a complex process due to the lack of high-throughput user-friendly tools. Recent chemical advances have opened new and exciting possibilities in obtaining pure and chemically defined glycan moieties. Chromatographic techniques, tandem mass spectrometry, MALDI-mass spectrometry, ESI-mass spectrometry, NMR spectroscopy, and carbohydrate/lectin microarray are important tools for glycomics. Glycogene microarrays are useful to identify differentially expressed glycosylation-related genes and to study glycan biosynthesis, structure, and function. Efficient glycoinformatics have considerably enhanced the glycomic research by improving the data quality and reducing experimental costs. Glycans including lectins provide both structural and functional diversity to plants and are useful in transgenic technologies to increase resistance to pathogens and pests. Plant glycomics find their applications in biopharming and biopharmaceutics and provides a novel area of advanced glycome research to understand structure–function relationships of glycans. Unraveling the mysteries of glycomics would indeed be very beneficial as sugars play key role in many biological processes such as signaling, stress responses, and immunity.
- Published
- 2015
- Full Text
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