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25 results on '"Nishimura, Goshi"'

5. Real-world Treatment Outcomes of the EXTREME Regimen as First-line Therapy for Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck: A Multi-center Retrospective Cohort Study in Japan

Author

SANO, DAISUKE, primary, FUJISAWA, TAKUO, additional, TOKUHISA, MOTOHIKO, additional, SHIMIZU, MINAKI, additional, SAKAGAMI, TOMOFUMI, additional, HATANO, TAKASHI, additional, NISHIMURA, GOSHI, additional, ICHIKAWA, YASUSHI, additional, IWAI, HIROSHI, additional, and ORIDATE, NOBUHIKO, additional

Published
2019
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9. Postoperative Bio-Chemoradiotherapy Using Cetuximab and Docetaxel in Patients With Cis-Platinum–Intolerant Core High-Risk Head and Neck Cancer: Protocol of a Phase 2 Nonrandomized Clinical Trial

Author

Nishimura, Goshi, primary, Hatakeyama, Hiromitsu, additional, Shiono, Osamu, additional, Taguri, Masataka, additional, Komatsu, Masanori, additional, Sano, Daisuke, additional, Sakuma, Naoko, additional, Yabuki, Kenichiro, additional, Arai, Yasuhiro, additional, Shibata, Kunihiko, additional, Chiba, Yoshihiro, additional, Tanabe, Teruhiko, additional, and Oridate, Nobuhiko, additional

Published
2018
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14. The Accuracy of Evaluating the Response of Metastatic Lymph Nodes after Concurrent Chemoradiotherapy in Patients with Head and Neck Squamous Cell Carcinoma

Author

Nishimura, Goshi, primary, Komatsu, Masanori, additional, Taguchi, Takahide, additional, Takahashi, Masahiro, additional, Sano, Daisuke, additional, Sakuma, Naoko, additional, Arai, Yasuhiro, additional, Takahashi, Hideaki, additional, Tanaka, Yasuko, additional, Sawakuma, Kae, additional, and Oridate, Nobuhiko, additional

Published
2014
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22. Regulation of apoptosis by respiration: cytochrome crelease by respiratory substrates

Author

Nishimura, Goshi, Proske, Rita J., Doyama, Hiroko, and Higuchi, Masahiro

Abstract

Cytochrome crelease from mitochondria is essential for apoptosis. Using human myelogenous leukemia ML‐1a, its respiration‐deficient and reconstituted cells, we demonstrated that respiratory function is essential for tumor necrosis factor‐induced cytochrome crelease. In a cell free system using mitochondrial fraction from ML‐1a, initiation of respiration by substrates for complexes I, II, and III but not IV released cytochrome c, suggesting that reduction of coenzyme Q or complex III is essential for cytochrome crelease. In the same system, disruption of mitochondrial outer membrane was neither enough nor the cause for cytochrome crelease by succinate. These observations define an early pathway in which a change in respiration releases cytochrome c.

Published
2001
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23. The Second-Look Procedure for Transoral Videolaryngoscopic Surgery for T1 and T2 Laryngeal, Oropharyngeal, and Hypopharyngeal Cancer Patients: Protocol for a Nonrandomized Clinical Trial.

Author

Nishimura, Goshi, Sano, Daisuke, Yabuki, Kenichiro, Arai, Yasuhiro, Chiba, Yoshihiro, Tanabe, Teruhiko, and Oridate, Nobuhiko

Abstract

Background: Transoral videolaryngoscopic surgery (TOVS) has been widely applied for early T stage head and neck cancer. The resection is performed with a minimum safety margin for function preservation under a limited surgical field of view, making it difficult to be certain of complete resection. Objective: Our aim is the evaluation of the completeness of resection by initial TOVS resection, and the possibility of primary control by TOVS alone, allowing for repeat procedures for function preserving treatment in early T stage laryngeal, oropharyngeal, and hypopharyngeal cancer patients. Methods: Patients are treated by TOVS for the primary site with or without neck dissection. Patients are divided in two groups based on the results of the pathological evaluation of the surgical specimen; the control group in which the resection is considered to be complete, and the intervention (second-look procedure) group in which incomplete tumor resection is suspected. The predictive factors for the possibility of complete resection by TOVS will then be analyzed. Results: Patient enrollment started on January 1, 2014, and closed on March 31, 2016, with 54 patients. The control group consists of 27 patients, the intervention group is 21 patients, and 6 patients were excluded. There were no clinical differences between the control and intervention groups. The observation period will end on December 31, 2018. Conclusions: TOVS has potential for both definitive resection and function preservation with minimal invasiveness. Identifying the limitations of TOVS is beneficial to ensure accurate treatment selection in early T stage head and neck cancer patients. Trial Registration: UMIN Clinical Trials Registry: UMIN000012485; https://upload.umin.ac.jp/cgi-open-bin/ctr%5Fe/ctr%5Fview.cgi? recptno=R000014472 (Archived by WebCite at http://www.webcitation.org/6v1b741Iw) [ABSTRACT FROM AUTHOR]

Published
2017
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24. Treatment evaluation of metastatic lymph nodes after concurrent chemoradiotherapy in patients with head and neck squamous cell carcinoma.

Author

Nishimura G, Matsuda H, Taguchi T, Takahashi M, Komatsu M, Sano D, Sakuma N, Arai Y, and Takahashi H

Subjects
Adult, Aged, Aged, 80 and over, Biopsy, Fine-Needle methods, Carcinoma, Squamous Cell diagnostic imaging, Combined Modality Therapy, Female, Fluorodeoxyglucose F18, Head and Neck Neoplasms diagnostic imaging, Humans, Lymph Nodes diagnostic imaging, Lymphatic Metastasis, Magnetic Resonance Imaging, Male, Middle Aged, Positron-Emission Tomography, Radiopharmaceuticals, Retrospective Studies, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Head and Neck Neoplasms pathology, Head and Neck Neoplasms therapy, Lymph Nodes pathology
Abstract

Background: Concurrent chemoradiotherapy (CCRT) is used to treat advanced head and neck cancer. The accuracy of evaluating lymph nodes metastases following CCRT is important for subsequent therapy., Patients and Methods: Patients were divided into two groups, the complete response (CR) and the non-CR groups, as determined by imaging and fine-needle aspiration cytology (FNAC) performed 4-8 weeks after the CCRT, and the findings were compared with the clinical characteristics., Results: The sensitivity and the specificity of each evaluation method were as follows: 52.9% and 74.2%, respectively, for computer tomography (CT) and magnetic resonance imaging (MRI); 88.2% and 66.1% for ultrasonography (US); 35.3% and 96.0% for fluorodeoxyglucose-positron emission tomography (FDG-PET) or PET-CT; and 71.4% and 95.6% for FNAC., Conclusion: To evaluate the response of lymph node(s) treated by CCRT, US is useful as a positive screening tool and FDG-PET and PET-CT as negative screening tools. FNAC is useful in evaluating suspicious lymph nodes in both positive and negative cases.

Published
2012

25. Efficacy of concurrent chemoradiotherapy for T1 and T2 laryngeal squamous cell carcinoma regarding organ preservation.

Author

Nishimura G, Tsukuda M, Mikami Y, Matsuda H, Horiuchi C, Taguchi T, Takahashi M, Kawakami M, Watanabe M, Niho T, Abo H, and Yamomoto S

Subjects
Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Antineoplastic Combined Chemotherapy Protocols adverse effects, Carboplatin administration & dosage, Carboplatin adverse effects, Carcinoma, Squamous Cell pathology, Combined Modality Therapy, Female, Humans, Laryngeal Neoplasms pathology, Laryngeal Neoplasms radiotherapy, Male, Middle Aged, Neoplasm Staging, Tegafur administration & dosage, Tegafur adverse effects, Thyroid Gland drug effects, Thyroid Gland radiation effects, Uracil administration & dosage, Uracil adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell radiotherapy, Laryngeal Neoplasms drug therapy
Abstract

Background: Although the survival rate of early-stage laryngeal squamous cell carcinoma (SCC) patients treated by radiotherapy (RT) is sufficient, the larynx preservation rate is unsatisfactory. To improve the larynx preservation rate, such patients have been treated by RT with chemotherapeutic agents., Patients and Methods: RT with or without uracil-tegafur (UFT) was performed for T1 cases, and UFT and carboplatin for T2 cases., Results: In T1 cases, 30 patients received RT and 16 patients received concurrent chemoradiotherapy (CCRT). In T2 cases, 28 patients received RT and 45 patients received CCRT. There were no significant differences in the response and survival rates between the treatment methods both in T1 and T2 cases. The 5-year larynx preservation survival rate was improved significantly by CCRT in T2 cases (66.7% vs. 93.3%; p < 0.01)., Conclusion: CCRT for early-stage laryngeal SCC patients was efficacious to improve the larynx preservation survival rate.

Published
2009

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